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    [{"orgOrder":0,"company":"Chimerix","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Dociparstat","moa":"Heparanase","graph1":"Oncology","graph2":"Phase III","graph3":"Chimerix","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Chimerix \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Chimerix \/ Inapplicable"},{"orgOrder":0,"company":"Chimerix","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Dociparstat Sodium","moa":"heparin derivatives","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II\/ Phase 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Pharmaceuticals"},{"orgOrder":0,"company":"Chimerix","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Dordaviprone","moa":"DRD2","graph1":"Oncology","graph2":"Phase III","graph3":"Chimerix","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Chimerix \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Chimerix \/ Inapplicable"},{"orgOrder":0,"company":"Chimerix","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Dordaviprone","moa":"DRD2","graph1":"Oncology","graph2":"Phase III","graph3":"Chimerix","amount2":0,"highestDevelopmentShortName":"Ph 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\/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Chimerix \/ Inapplicable"},{"orgOrder":0,"company":"Chimerix","sponsor":"Chimerix","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Dordaviprone","moa":"Dopamine D2 receptor (D2R)","graph1":"Oncology","graph2":"Phase II","graph3":"Chimerix","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Chimerix \/ Chimerix","highestDevelopmentStatusID":"8","companyTruncated":"Chimerix \/ Chimerix"},{"orgOrder":0,"company":"Chimerix","sponsor":"Oncoceutics Inc","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Acquisition","leadProduct":"Dordaviprone","moa":"DRD2","graph1":"Oncology","graph2":"Phase 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I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Chimerix \/ National Institutes of Health","highestDevelopmentStatusID":"6","companyTruncated":"Chimerix \/ National Institutes of Health"},{"orgOrder":0,"company":"Chimerix","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Brincidofovir","moa":"DNA polymerase","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase I","graph3":"Chimerix","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Chimerix \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Chimerix \/ Inapplicable"}]

    Find Clinical Drug Pipeline Developments & Deals by Chimerix

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                            01

                            Chimerix

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                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Jazz Pharmaceuticals

                            Deal Size : $935.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Jazz Pharmaceuticals Completes Acquisition of Chimerix

                            Details : Through the acquisition, Jazz will strengthen it's oncology pipeline, which includes ONC201 (dordaviprone). It is being evaluated in the late-stage for the treatment of H3 K27M-mutant diffuse glioma.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : $935.0 million

                            April 21, 2025

                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Jazz Pharmaceuticals

                            Deal Size : $935.0 million

                            Deal Type : Acquisition

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                            02

                            Chimerix

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                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Jazz Pharmaceuticals

                            Deal Size : $935.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Jazz Pharmaceuticals to Acquire Chimerix, Further Diversifying Oncology Portfolio

                            Details : Through the acquisition, Jazz will strengthen it's oncology pipeline, which includes ONC201 (dordaviprone). It is being in the evaluated late-stage for the treatment of H3 K27M-mutant diffuse glioma.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : $935.0 million

                            March 05, 2025

                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Jazz Pharmaceuticals

                            Deal Size : $935.0 million

                            Deal Type : Acquisition

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                            03

                            Chimerix

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                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Chimerix Announces FDA Acceptance and Priority Review of NDA for Dordaviprone

                            Details : ONC201 (dordaviprone) is a novel first-in-class small molecule imipridone that selectively targets the mitochondrial protease ClpP and dopamine receptor D2 for recurrent H3 K27M-Mutant diffuse glioma.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 18, 2025

                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Chimerix

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                            ESCRS
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                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Chimerix Submits Dordaviprone NDA for Accelerated Approval Of Recurrent Diffuse Glioma

                            Details : ONC201 (dordaviprone) is a novel first-in-class small molecule imipridone that selectively targets the mitochondrial protease ClpP and dopamine receptor D2 for recurrent H3 K27M-Mutant diffuse glioma.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 30, 2024

                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Chimerix

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                            ESCRS
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                            Chimerix

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                            ESCRS
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                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Chimerix to Submit Dordaviprone for Accelerated Approval in for H3 K27M-Mutant Glioma

                            Details : ONC201 (dordaviprone) targets the targets the mitochondrial protease ClpP and dopamine receptor D2. It is being evaluated for the treatment of recurrent H3 K27M-mutant diffuse glioma.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 09, 2024

                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Chimerix

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                            ESCRS
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                            Chimerix

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                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Recipient : University of Nebraska

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of ONC201 for Refractory Meningioma

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 28, 2023

                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Recipient : University of Nebraska

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Chimerix

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                            ESCRS
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                            Chimerix

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                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 14, 2022

                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Chimerix

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                            ESCRS
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                            Lead Product(s) : Brincidofovir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Approved FDF

                            Sponsor : BARDA

                            Deal Size : $374.5 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Chimerix Awarded BARDA Contract for TEMBEXA as Medical Countermeasure for Smallpox

                            Details : Collaboration with BARDA for the development of TEMBEXA (brincidofovir) has provided the United States government with a second therapeutic option to ensure the federal government’s readiness for a potential smallpox emergency.

                            Product Name : Tembexa

                            Product Type : Other Small Molecule

                            Upfront Cash : $238.0 million

                            August 29, 2022

                            Lead Product(s) : Brincidofovir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Approved FDF

                            Sponsor : BARDA

                            Deal Size : $374.5 million

                            Deal Type : Agreement

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                            09

                            Chimerix

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                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Chimerix Announces Successful Launch of ONC201 Phase 3 ACTION Study at Society for Neuro-Oncology Conference a...

                            Details : ONC201 is a new drug candidate that kills cancer cells but not normal cells in laboratory studies and has been previously evaluated in a phase I clinical trial in advanced cancer patients.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 12, 2022

                            Lead Product(s) : Dordaviprone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Chimerix

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                            ESCRS
                            Not Confirmed

                            Chimerix

                            U.S.A arrow
                            ESCRS
                            Not Confirmed
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                            Lead Product(s) : Brincidofovir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Approved FDF

                            Sponsor : Public Health Agency of Canada

                            Deal Size : $25.3 million

                            Deal Type : Agreement

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                            Chimerix Announces TEMBEXA Procurement Agreement for Approximately $25.3 Million with Public Health Agency of ...

                            Details : Chimerix signed a contract agreement to procure TEMBEXA® (brincidofovir). Execution of this contract will be the responsibility of Chimerix, as it is expected to substantially occur prior to the close of the pending transaction with Emergent BioSolution...

                            Product Name : Tembexa

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            June 24, 2022

                            Lead Product(s) : Brincidofovir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Approved FDF

                            Sponsor : Public Health Agency of Canada

                            Deal Size : $25.3 million

                            Deal Type : Agreement

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