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Squibb","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2023","type":"Inapplicable","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Approved FDF","graph3":"2Seventy Bio","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"2Seventy Bio \/ 2Seventy Bio","highestDevelopmentStatusID":"15","companyTruncated":"2Seventy Bio \/ 2Seventy Bio"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Bristol Myers Squibb","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2022","type":"Inapplicable","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Approved FDF","graph3":"2Seventy 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Bio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2022","type":"Inapplicable","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Approved FDF","graph3":"2Seventy Bio","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"2Seventy Bio \/ Undisclosed","highestDevelopmentStatusID":"15","companyTruncated":"2Seventy Bio \/ Undisclosed"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2021","type":"Inapplicable","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Approved FDF","graph3":"2Seventy Bio","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"2Seventy Bio \/ Undisclosed","highestDevelopmentStatusID":"15","companyTruncated":"2Seventy Bio \/ Undisclosed"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Bristol Myers Squibb","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2023","type":"Inapplicable","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Approved FDF","graph3":"2Seventy Bio","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"2Seventy Bio \/ 2Seventy Bio","highestDevelopmentStatusID":"15","companyTruncated":"2Seventy Bio \/ 2Seventy Bio"},{"orgOrder":0,"company":"Bluebird Bio","sponsor":"Bristol Myers Squibb","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2020","type":"Inapplicable","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Approved FDF","graph3":"Bluebird Bio","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Bluebird Bio \/ Bluebird Bio","highestDevelopmentStatusID":"15","companyTruncated":"Bluebird Bio \/ Bluebird Bio"},{"orgOrder":0,"company":"Bluebird Bio","sponsor":"Bristol Myers Squibb","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2020","type":"Collaboration","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Phase III","graph3":"Bluebird Bio","amount2":0.20000000000000001,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0.20000000000000001,"dosageForm":"Infusion","sponsorNew":"Bluebird Bio \/ Bristol Myers Squibb","highestDevelopmentStatusID":"10","companyTruncated":"Bluebird Bio \/ Bristol Myers Squibb"},{"orgOrder":0,"company":"Bluebird Bio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2020","type":"Inapplicable","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Phase III","graph3":"Bluebird Bio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Bluebird Bio \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Bluebird Bio \/ Undisclosed"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Bristol Myers Squibb","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2023","type":"Inapplicable","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Approved FDF","graph3":"2Seventy Bio","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"2Seventy Bio \/ 2Seventy Bio","highestDevelopmentStatusID":"15","companyTruncated":"2Seventy Bio \/ 2Seventy Bio"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Bristol Myers Squibb","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2023","type":"Inapplicable","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Approved FDF","graph3":"2Seventy Bio","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"2Seventy Bio \/ 2Seventy Bio","highestDevelopmentStatusID":"15","companyTruncated":"2Seventy Bio \/ 2Seventy Bio"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Goldman Sachs & Co","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2023","type":"Public Offering","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Approved FDF","graph3":"2Seventy Bio","amount2":0.13,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0.13,"dosageForm":"Infusion","sponsorNew":"2Seventy Bio \/ Goldman Sachs & Co","highestDevelopmentStatusID":"15","companyTruncated":"2Seventy Bio \/ Goldman Sachs & Co"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Regeneron Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2024","type":"Acquisition","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Approved FDF","graph3":"2Seventy Bio","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"2Seventy Bio \/ Regeneron Pharmaceuticals","highestDevelopmentStatusID":"15","companyTruncated":"2Seventy Bio \/ Regeneron Pharmaceuticals"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Bristol Myers Squibb","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2025","type":"Acquisition","leadProduct":"Idecabtagene Vicleucel","moa":"Tumor necrosis factor receptor superfamily member 17","graph1":"Oncology","graph2":"Approved FDF","graph3":"2Seventy 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Disease","graph2":"Undisclosed","graph3":"2Seventy Bio","amount2":0.040000000000000001,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Genetic Disease","amount2New":0.040000000000000001,"dosageForm":"Undisclosed","sponsorNew":"2Seventy Bio \/ 2Seventy Bio","highestDevelopmentStatusID":"1","companyTruncated":"2Seventy Bio \/ 2Seventy Bio"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Novo Nordisk","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2022","type":"Collaboration","leadProduct":"MegaTAL mRNA","moa":"Undisclosed","graph1":"Genetic Disease","graph2":"Undisclosed","graph3":"2Seventy Bio","amount2":0.040000000000000001,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Genetic Disease","amount2New":0.040000000000000001,"dosageForm":"Undisclosed","sponsorNew":"2Seventy Bio \/ Novo Nordisk","highestDevelopmentStatusID":"1","companyTruncated":"2Seventy Bio \/ Novo Nordisk"},{"orgOrder":0,"company":"Bluebird Bio","sponsor":"Akamis Bio","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Undisclosed","year":"2021","type":"Inapplicable","leadProduct":"NG-347","moa":"||Undisclosed","graph1":"Oncology","graph2":"IND Enabling","graph3":"Bluebird Bio","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Bluebird Bio \/ Bluebird Bio","highestDevelopmentStatusID":"5","companyTruncated":"Bluebird Bio \/ Bluebird Bio"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Medigene","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"GERMANY","productType":"Undisclosed","year":"2023","type":"Partnership","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I","graph3":"2Seventy Bio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"2Seventy Bio \/ 2Seventy Bio","highestDevelopmentStatusID":"6","companyTruncated":"2Seventy Bio \/ 2Seventy Bio"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Novo Nordisk","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Undisclosed","year":"2023","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Genetic Disease","graph2":"Preclinical","graph3":"2Seventy Bio","amount2":0.040000000000000001,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Genetic Disease","amount2New":0.040000000000000001,"dosageForm":"Undisclosed","sponsorNew":"2Seventy Bio \/ Novo Nordisk","highestDevelopmentStatusID":"4","companyTruncated":"2Seventy Bio \/ Novo Nordisk"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"JW 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Disease","amount2New":0.040000000000000001,"dosageForm":"Undisclosed","sponsorNew":"2Seventy Bio \/ Novo Nordisk","highestDevelopmentStatusID":"4","companyTruncated":"2Seventy Bio \/ Novo Nordisk"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Through the acquisition, BMS will gain full control of Abecma (idecabtagene vicleucel), which is indicated for the treatment of relapsed/refractory multiple myeloma.

                          Product Name : Abecma

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : $286.0 million

                          March 10, 2025

                          Lead Product(s) : Idecabtagene Vicleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Bristol Myers Squibb

                          Deal Size : $286.0 million

                          Deal Type : Acquisition

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                          02

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Abecma (idecabtagene vicleucel) is a CAR T cell therapy which binds to BCMA on the surface of multiple myeloma cells. It is being evaluated for newly diagnosed multiple myeloma.

                          Product Name : Abecma

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          September 25, 2024

                          Lead Product(s) : Idecabtagene Vicleucel,Fludarabine Phosphate,Lenalidomide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Recipient : Bristol Myers Squibb

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Novo has acquired the Hemophilia A program and rights to 2seventy’s in vivo gene editing technology for autologous or allogeneic cell therapies of immune cells for the treatment of autoimmune disease.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          June 26, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Preclinical

                          Sponsor : Novo Nordisk

                          Deal Size : $40.0 million

                          Deal Type : Divestment

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                          04

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Abecma (idecabtagene vicleucel) is a CAR T cell therapy for multiple myeloma, approved for treating triple-class exposed relapsed or refractory patients.

                          Product Name : Abecma

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          April 05, 2024

                          Lead Product(s) : Idecabtagene Vicleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Recipient : Bristol Myers Squibb

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Proceeds will fund commercial launches of FDA-approved gene therapies, including Lyfgenia for sickle cell disease, Zynteglo for beta-thalassemia, and Skysona for cerebral adrenoleukodystrophy.

                          Product Name : Lovo-cel

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          March 18, 2024

                          Lead Product(s) : Lovotibeglogene Autotemcel

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Approved FDF

                          Sponsor : Hercules Capital

                          Deal Size : Undisclosed

                          Deal Type : Financing

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                          06

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Bluebird Bio will commercialize Lyfgenia (lovotibeglogene autotemcelsickle) for sickle cell disease patients with vaso-occlusive events.

                          Product Name : Lovo-cel

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          March 11, 2024

                          Lead Product(s) : Lovotibeglogene Autotemcel

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Approved FDF

                          Sponsor : Medicaid

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          07

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Regeneron will have full development and commercialization rights to its pipeline of investigational immune cell therapies, including Abecma (idecabtagene vicleucel).

                          Product Name : Abecma

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : $5.0 million

                          January 30, 2024

                          Lead Product(s) : Idecabtagene Vicleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          08

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : bluebird will support commercialization and manufacturing for its three approved gene therapies, Zynteglo (betibeglogene autotemcel) for beta-thalassemia, Skysona (elivaldogene autotemcel) and Lyfgenia (lovotibeglogene autotemcel) for sickle cell disease...

                          Product Name : Zynteglo

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          December 18, 2023

                          Lead Product(s) : Betibeglogene Autotemcel

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Approved FDF

                          Sponsor : Goldman Sachs & Co

                          Deal Size : Undisclosed

                          Deal Type : Public Offering

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                          09

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Abecma (idecabtagene vicleucel) is a BCMA directed CAR-T cell immunotherapy, for patients with relapsed or refractory multiple myeloma (RRMM) who have received at least two prior therapies, including an immunomodulatory agent, a proteasome inhibitor, and...

                          Product Name : Abecma

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          December 11, 2023

                          Lead Product(s) : Idecabtagene Vicleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Recipient : Bristol Myers Squibb

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : FDA approved, Casgevy(exagamglogene autotemcel) and Lyfgenia(lovotibeglogene autotemcel), representing the first cell-based gene therapies for the treatment of sickle cell disease (SCD) in patients 12 years and older.

                          Product Name : Lyfgenia

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          December 08, 2023

                          Lead Product(s) : Lovotibeglogene Autotemcel

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Approved FDF

                          Recipient : Vertex Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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