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Blackstone Life Sciences","highestDevelopmentStatusID":"7","companyTruncated":"Blackstone Life Sciences \/ Blackstone Life Sciences"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Uniquity Bio","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2024","type":"Inapplicable","leadProduct":"Solrikitug","moa":"CRLF2","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II","graph3":"Blackstone Life Sciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Blackstone Life Sciences \/ Blackstone Life Sciences","highestDevelopmentStatusID":"8","companyTruncated":"Blackstone Life Sciences \/ Blackstone Life Sciences"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Uniquity Bio","pharmaFlowCategory":"D","therapeuticArea":"Pulmonary\/Respiratory 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Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Collaboration","leadProduct":"Inclisiran","moa":"PCSK9 mRNA","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved FDF","graph3":"Blackstone Life Sciences","amount2":2,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":2,"dosageForm":"Injection","sponsorNew":"Blackstone Life Sciences \/ Blackstone Life Sciences","highestDevelopmentStatusID":"15","companyTruncated":"Blackstone Life Sciences \/ Blackstone Life Sciences"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Reata Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Miscellaneous","year":"2020","type":"Financing","leadProduct":"Bardoxolone Methyl","moa":"Peroxisome proliferator-activated receptor gamma | Keap1\/Nrf2 | Inhibitor of nuclear factor kappa B kinase beta subunit","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Blackstone Life Sciences","amount2":0.34999999999999998,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0.34999999999999998,"dosageForm":"Capsule","sponsorNew":"Blackstone Life Sciences \/ Blackstone Life Sciences","highestDevelopmentStatusID":"10","companyTruncated":"Blackstone Life Sciences \/ Blackstone Life Sciences"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Alnylam Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Financing","leadProduct":"Vutrisiran Sodium","moa":"Transthyretin mRNA","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase III","graph3":"Blackstone Life Sciences","amount2":0.14999999999999999,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0.14999999999999999,"dosageForm":"Injection","sponsorNew":"Blackstone Life Sciences \/ Blackstone Life Sciences","highestDevelopmentStatusID":"10","companyTruncated":"Blackstone Life Sciences \/ Blackstone Life Sciences"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Moderna Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vaccine","year":"2024","type":"Financing","leadProduct":"Seasonal Influenza Vaccine","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Phase III","graph3":"Blackstone Life Sciences","amount2":0.75,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0.75,"dosageForm":"Injection","sponsorNew":"Blackstone Life Sciences \/ Blackstone Life Sciences","highestDevelopmentStatusID":"10","companyTruncated":"Blackstone Life Sciences \/ Blackstone Life Sciences"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          OPRD
                          Not Confirmed
                          OPRD
                          Not Confirmed

                          Details : The financing will support the launch of the pediatric indication for Afrezza (insulin). It is being indicated for the treatment of diabetes mellitus.

                          Product Name : Afrezza

                          Product Type : Hormone

                          Upfront Cash : Undisclosed

                          August 06, 2025

                          Lead Product(s) : Insulin

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Approved FDF

                          Recipient : Mannkind

                          Deal Size : Undisclosed

                          Deal Type : Financing

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                          02

                          OPRD
                          Not Confirmed
                          OPRD
                          Not Confirmed

                          Details : MK-8226 (solrikitug), is a highly potent anti-TSLP monoclonal antibody, which is being evaluated in early-stage clinical trial for the treatment of chronic obstructive pulmonary disease and asthma.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          May 15, 2024

                          Lead Product(s) : Solrikitug

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase I

                          Recipient : Uniquity Bio

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          OPRD
                          Not Confirmed
                          OPRD
                          Not Confirmed

                          Details : The financing aims to fund the clinical development of MK-8226 (solrikitug), which is being evaluated in the early-stage clinical trial for chronic obstructive pulmonary disease and asthma.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Undisclosed

                          May 15, 2024

                          Lead Product(s) : Solrikitug

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase I

                          Recipient : Uniquity Bio

                          Deal Size : $300.0 million

                          Deal Type : Financing

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                          04

                          OPRD
                          Not Confirmed
                          OPRD
                          Not Confirmed

                          Details : Proceeds will fund Moderna's influenza program, including mRNA-1010, a quadrivalent flu vaccine encoding hemagglutinin (HA) glycoproteins for four strains, administered intramuscularly.

                          Product Name : Undisclosed

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          March 27, 2024

                          Lead Product(s) : Seasonal Influenza Vaccine

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase III

                          Recipient : Moderna Therapeutics

                          Deal Size : $750.0 million

                          Deal Type : Financing

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                          05

                          OPRD
                          Not Confirmed
                          OPRD
                          Not Confirmed

                          Details : The proceeds will be used to fund the ongoing operations of the company, including Galafold (migalastat), a small molecule and the first and only oral therapy for adults with Fabry disease and an amenable GLA variant.

                          Product Name : Galafold

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          October 02, 2023

                          Lead Product(s) : Migalastat

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Approved FDF

                          Recipient : Amicus Therapeutics

                          Deal Size : $30.0 million

                          Deal Type : Financing

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                          06

                          OPRD
                          Not Confirmed
                          OPRD
                          Not Confirmed

                          Details : The financing will be used for the continued pipeline advancement and further development of its cell-free protein synthesis and site-specific conjugation technologies, including VAX-24, a Phase 3 ready, 24-valent next-generation pneumococcal conjugate v...

                          Product Name : Undisclosed

                          Product Type : Vaccine

                          Upfront Cash : $140.0 million

                          June 26, 2023

                          Lead Product(s) : 24-Valent Pneumococcal Conjugate Vaccine

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Recipient : Sutro Biopharma

                          Deal Size : $390.0 million

                          Deal Type : Collaboration

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                          07

                          OPRD
                          Not Confirmed
                          OPRD
                          Not Confirmed

                          Details : The strategic financing will support the acceleration of PTC’s robust and diversified pipeline having lead asset Translarna (ataluren), business development opportunities and general corporate purposes.

                          Product Name : Translarna

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          October 27, 2022

                          Lead Product(s) : Ataluren

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Approved FDF

                          Recipient : PTC Therapeutics

                          Deal Size : $50.0 million

                          Deal Type : Collaboration

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                          08

                          OPRD
                          Not Confirmed
                          OPRD
                          Not Confirmed

                          Details : The restructured agreement allows for a return on capital already invested by Blackstone, and also provides Blackstone with option to make a passive financial investment in nadofaragene firadonavec (rAd-IFN/Syn3) upon achievement of a specified regulator...

                          Product Name : Adstiladrin

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          October 17, 2022

                          Lead Product(s) : Nadofaragene Firadenovec

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Recipient : Ferring Pharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          09

                          OPRD
                          Not Confirmed
                          OPRD
                          Not Confirmed

                          Details : For the Sarclisa® subcutaneous formulation delivery, Sanofi has partnered with drug delivery technology innovator company to advance the development of a subcutaneous delivery for Sarclisa® with the goal of offering a unique patient-centric treatment e...

                          Product Name : Sarclisa

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Undisclosed

                          March 15, 2022

                          Lead Product(s) : Isatuximab,Dexamethasone,Pomalidomide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Recipient : Sanofi

                          Deal Size : $330.0 million

                          Deal Type : Collaboration

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                          10

                          OPRD
                          Not Confirmed
                          OPRD
                          Not Confirmed

                          Details : Obecabtagene Autoleucel (Obe-cel) is a CD19 CAR T cell investigational therapy designed to overcome the limitations in clinical activity and safety compared to current CD19 CAR T cell therapies used in adult ALL and B-NHL.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          November 08, 2021

                          Lead Product(s) : Obecabtagene Autoleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Autolus Therapeutics

                          Deal Size : $250.0 million

                          Deal Type : Acquisition

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