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[{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Alnylam Pharmaceuticals","pharmaFlowCategory":"D","amount":"$2,000.0 million","upfrontCash":"Undisclosed","newsHeadline":"Blackstone and Alnylam Enter Into $2 Billion Strategic Financing Collaboration to Accelerate the Advancement of RNAi Therapeutics","therapeuticArea":"Cardiology\/Vascular Diseases","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"April 2020","url1":"","url2":"","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase III"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Reata Pharmaceuticals","pharmaFlowCategory":"D","amount":"$350.0 million","upfrontCash":"Undisclosed","newsHeadline":"Reata Pharmaceuticals, Inc. and Blackstone Life Sciences Announce $350 Million Strategic Investment","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"June 2020","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Phase III"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Takeda Pharmaceutical","pharmaFlowCategory":"D","amount":"$2,300.0 million","upfrontCash":"Undisclosed","newsHeadline":"Takeda to Divest its Japan Consumer Health Care Business Unit to Blackstone for JPY 242.0 Billion","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Approved","country":"U.S.A","productType":"Small molecule","productStatus":"Approved","date":"August 2020","url1":"","url2":"","graph1":"Ophthalmology","graph2":"Approved"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Alnylam Pharmaceuticals","pharmaFlowCategory":"D","amount":"$150.0 million","upfrontCash":"Undisclosed","newsHeadline":"Blackstone and Alnylam Close $150 Million R&D Financing to Advance RNAi Therapeutics for Cardiovascular Disease","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"August 2020","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Phase III"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Medtronic Plc","pharmaFlowCategory":"D","amount":"$337.0 million","upfrontCash":"Undisclosed","newsHeadline":"Medtronic Announces a $337 Million Product Investment from Blackstone Life Sciences to Expand Development of Future Diabetes Technologies","therapeuticArea":"Endocrinology","highestDevelopmentStatus":"Approved","country":"U.S.A","productType":"Peptide","productStatus":"Approved","date":"June 2020","url1":"","url2":"","graph1":"Endocrinology","graph2":"Approved"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Autolus Therapeutics","pharmaFlowCategory":"D","amount":"$250.0 million","upfrontCash":"Undisclosed","newsHeadline":"Blackstone Life Sciences to Invest up to $250 Million in Autolus Therapeutics to Develop Obe-cel in Adult Acute Lymphoblastic Leukemia (ALL) and Advance Broader Platform","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"U.S.A","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"November 2021","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I\/ Phase II"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Sanofi","pharmaFlowCategory":"D","amount":"$330.0 million","upfrontCash":"Undisclosed","newsHeadline":"Sanofi Announces \u20ac300 Million Collaboration with Blackstone Life Sciences to Advance an Innovative Treatment for Multiple Myeloma","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"Approved","date":"March 2022","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Ferring Pharmaceuticals","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"Ferring Pharmaceuticals and Blackstone Life Sciences Restructure Novel Gene Therapy Collaboration","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"October 2022","url1":"","url2":"","graph1":"Oncology","graph2":"Phase III"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"PTC Therapeutics","pharmaFlowCategory":"D","amount":"$50.0 million","upfrontCash":"Undisclosed","newsHeadline":"PTC Therapeutics Announces Strategic Financing Collaboration with Blackstone with up to $1 Billion in Funding","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Approved","country":"U.S.A","productType":"Small molecule","productStatus":"Approved","date":"October 2022","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Approved"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Sutro Biopharma","pharmaFlowCategory":"D","amount":"$390.0 million","upfrontCash":"$140.0 million","newsHeadline":"Sutro Biopharma and Blackstone Announce Royalty Financing Collaboration","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Vaccine","productStatus":"New Molecular Entity","date":"June 2023","url1":"","url2":"","graph1":"Infections and Infectious Diseases","graph2":"Phase II"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Amicus Therapeutics","pharmaFlowCategory":"D","amount":"$30.0 million","upfrontCash":"Undisclosed","newsHeadline":"Amicus Therapeutics and Blackstone Enter into $430 Million Strategic Financing Collaboration","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Approved","country":"U.S.A","productType":"Small molecule","productStatus":"Approved","date":"October 2023","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Approved"},{"orgOrder":0,"company":"Blackstone Life Sciences","sponsor":"Moderna Therapeutics","pharmaFlowCategory":"D","amount":"$750.0 million","upfrontCash":"Undisclosed","newsHeadline":"Blackstone Life Sciences Announces Collaboration to Support Moderna\u2019s Influenza Program","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Vaccine","productStatus":"New Molecular Entity","date":"March 2024","url1":"","url2":"","graph1":"Infections and Infectious Diseases","graph2":"Phase III"}]

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            Details:

            The net proceeds will be used to fund Moderna’s influenza program, including mRNA-1010, a quadrivalent seasonal influenza vaccine encoding hemagglutinin (HA) glycoproteins of four flu strains administered intramuscularly.

            Lead Product(s): mRNA-1010

            Therapeutic Area: Infections and Infectious Diseases Product Name: mRNA-1010

            Highest Development Status: Phase III Product Type: Vaccine

            Recipient: Moderna Therapeutics

            Deal Size: $750.0 million Upfront Cash: Undisclosed

            Deal Type: Financing March 27, 2024

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            The proceeds will be used to fund the ongoing operations of the company, including Galafold (migalastat), a small molecule and the first and only oral therapy for adults with Fabry disease and an amenable GLA variant.

            Lead Product(s): Migalastat

            Therapeutic Area: Genetic Disease Product Name: Galafold

            Highest Development Status: Approved Product Type: Small molecule

            Recipient: Amicus Therapeutics

            Deal Size: $30.0 million Upfront Cash: Undisclosed

            Deal Type: Financing October 02, 2023

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            The financing will be used for the continued pipeline advancement and further development of its cell-free protein synthesis and site-specific conjugation technologies, including VAX-24, a Phase 3 ready, 24-valent next-generation pneumococcal conjugate vaccine.

            Lead Product(s): 24-valent Pneumococcal Conjugate Vaccine

            Therapeutic Area: Infections and Infectious Diseases Product Name: VAX-24

            Highest Development Status: Phase II Product Type: Vaccine

            Recipient: Sutro Biopharma

            Deal Size: $390.0 million Upfront Cash: $140.0 million

            Deal Type: Collaboration June 26, 2023

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            The strategic financing will support the acceleration of PTC’s robust and diversified pipeline having lead asset Translarna (ataluren), business development opportunities and general corporate purposes.

            Lead Product(s): Ataluren

            Therapeutic Area: Genetic Disease Product Name: Translarna

            Highest Development Status: Approved Product Type: Small molecule

            Recipient: PTC Therapeutics

            Deal Size: $50.0 million Upfront Cash: Undisclosed

            Deal Type: Collaboration October 27, 2022

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            The restructured agreement allows for a return on capital already invested by Blackstone, and also provides Blackstone with option to make a passive financial investment in nadofaragene firadonavec (rAd-IFN/Syn3) upon achievement of a specified regulatory event.

            Lead Product(s): Nadofaragene Firadonavec

            Therapeutic Area: Oncology Product Name: rAd-IFN/Syn3

            Highest Development Status: Phase III Product Type: Cell and Gene therapy

            Recipient: Ferring Pharmaceuticals

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration October 17, 2022

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            For the Sarclisa® subcutaneous formulation delivery, Sanofi has partnered with drug delivery technology innovator company to advance the development of a subcutaneous delivery for Sarclisa® with the goal of offering a unique patient-centric treatment experience.

            Lead Product(s): Isatuximab,Pomalidomide,Dexamethasone

            Therapeutic Area: Oncology Product Name: Sarclisa

            Highest Development Status: Phase I Product Type: Large molecule

            Recipient: Sanofi

            Deal Size: $330.0 million Upfront Cash: Undisclosed

            Deal Type: Collaboration March 15, 2022

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            Obecabtagene Autoleucel (Obe-cel) is a CD19 CAR T cell investigational therapy designed to overcome the limitations in clinical activity and safety compared to current CD19 CAR T cell therapies used in adult ALL and B-NHL.

            Lead Product(s): Obecabtagene Autoleucel

            Therapeutic Area: Oncology Product Name: Obe-cel

            Highest Development Status: Phase I/ Phase II Product Type: Cell and Gene therapy

            Recipient: Autolus Therapeutics

            Deal Size: $250.0 million Upfront Cash: Undisclosed

            Deal Type: Acquisition November 08, 2021

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            The portfolio to be divested includes a variety of over-the-counter medicines and health products. TCHC’s strong regional brands include Alinamin, and Benza.

            Lead Product(s): Fursultiamine

            Therapeutic Area: Ophthalmology Product Name: Alinamin

            Highest Development Status: Approved Product Type: Small molecule

            Recipient: Takeda Pharmaceutical

            Deal Size: $2,300.0 million Upfront Cash: Undisclosed

            Deal Type: Divestment August 24, 2020

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            The investment includes up to $70 million to support the ongoing HELIOS-B Phase 3 study of vutrisiran in ATTR amyloidosis patients with cardiomyopathy, and up to $80 million to support Phase 2 & Phase 3 development of ALN-AGT, in development for the treatment of hypertension.

            Lead Product(s): Vutrisiran

            Therapeutic Area: Genetic Disease Product Name: Undisclosed

            Highest Development Status: Phase III Product Type: Large molecule

            Recipient: Alnylam Pharmaceuticals

            Deal Size: $150.0 million Upfront Cash: Undisclosed

            Deal Type: Financing August 17, 2020

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            Funding will support Medtronic's Diabetes R&D, including a series of near-term programs such as the MiniMed™ 780G insulin pump system, its Personalized Closed Loop (PCL) system, extended wear infusion set, and Zeus and Synergy sensors.

            Lead Product(s): Insulin

            Therapeutic Area: Endocrinology Product Name: MiniMed 780G

            Highest Development Status: Approved Product Type: Peptide

            Recipient: Medtronic Plc

            Deal Size: $337.0 million Upfront Cash: Undisclosed

            Deal Type: Funding June 12, 2020

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