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[{"orgOrder":0,"company":"Apogee Therapeutics","sponsor":"Jefferies","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"Apogee Takes Aim at Regeneron, Lilly as it Readies IPO","therapeuticArea":"Dermatology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"June 2023","url1":"","url2":"","graph1":"Dermatology","graph2":"Preclinical"},{"orgOrder":0,"company":"Apogee Therapeutics","sponsor":"Jefferies","pharmaFlowCategory":"D","amount":"$263.1 million","upfrontCash":"Undisclosed","newsHeadline":"Apogee Therapeutics to Raise up to $263.1M in IPO","therapeuticArea":"Dermatology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"July 2023","url1":"","url2":"","graph1":"Dermatology","graph2":"Preclinical"},{"orgOrder":0,"company":"Apogee Therapeutics","sponsor":"Jefferies","pharmaFlowCategory":"D","amount":"$300.0 million","upfrontCash":"Undisclosed","newsHeadline":"Apogee Therapeutics, Inc. Announces Pricing of Upsized Initial Public Offering","therapeuticArea":"Dermatology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"July 2023","url1":"","url2":"","graph1":"Dermatology","graph2":"Preclinical"},{"orgOrder":0,"company":"Apogee Therapeutics","sponsor":"Jefferies","pharmaFlowCategory":"D","amount":"$345.0 million","upfrontCash":"Undisclosed","newsHeadline":"Apogee Therapeutics, Inc. Announces Closing of Upsized Initial Public Offering and Full Exercise of the Underwriters Option to Purchase Additional Shares","therapeuticArea":"Dermatology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"July 2023","url1":"","url2":"","graph1":"Dermatology","graph2":"Preclinical"},{"orgOrder":0,"company":"Apogee Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Apogee Announces First Participants Dosed Ahead of Schedule in Phase 1 Trial of APG777, its Novel Half-life Extended Anti-IL-13 Antibody for the Treatment of Atopic Dermatitis and Other Inflammatory Diseases","therapeuticArea":"Dermatology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"August 2023","url1":"","url2":"","graph1":"Dermatology","graph2":"Phase I"},{"orgOrder":0,"company":"Apogee Therapeutics","sponsor":"Jefferies","pharmaFlowCategory":"D","amount":"$420.0 million","upfrontCash":"Undisclosed","newsHeadline":"Apogee Therapeutics, Inc. Announces Pricing of Upsized $420 Million Underwritten Public Offering","therapeuticArea":"Dermatology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"March 2024","url1":"","url2":"","graph1":"Dermatology","graph2":"Phase I"},{"orgOrder":0,"company":"Apogee Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Apogee Therapeutics Announces First Participants Dosed in Phase 1 Trial of APG808, its Novel Half-life Extended IL-4RR\u03b1 Antibody for the Treatment of Chronic Obstructive Pulmonary Disease (COPD) and Other Inflammatory Diseases","therapeuticArea":"Pulmonary\/Respiratory Diseases","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"March 2024","url1":"","url2":"","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase I"},{"orgOrder":0,"company":"Apogee Therapeutics","sponsor":"Jefferies","pharmaFlowCategory":"D","amount":"$483.0 million","upfrontCash":"Undisclosed","newsHeadline":"Apogee Therapeutics, Inc. Announces Closing of Upsized Public Offering and Full Exercise of the Underwriters\u2122 Option to Purchase Additional Shares for Gross Proceeds of $483 Million","therapeuticArea":"Dermatology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"March 2024","url1":"","url2":"","graph1":"Dermatology","graph2":"Phase I"}]

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            Details:

            APG808 is a novel subcutaneous extended half-life monoclonal antibody (mAb) targeting IL-4Rα, which is being developed as a treatment for people living with moderate-to-severe COPD, asthma and other I&I diseases.

            Lead Product(s): APG808

            Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: APG808

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 25, 2024

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            Details:

            The company intends to use the proceeds to fund our clinical trials and manufacturing ofits APG777 program, a novel, subcutaneous monoclonal antibody with an extended half-life, targeting interleukin(IL)-13, aimed at addressing moderate-to-severe atopic dermatitis and asthma.

            Lead Product(s): APG777

            Therapeutic Area: Dermatology Product Name: APG777

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Jefferies

            Deal Size: $483.0 million Upfront Cash: Undisclosed

            Deal Type: Public Offering March 12, 2024

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            The net proceeds will be used in the clinical advancement of Apogee lead product APG777, which is being evaluated in Phase I clinical trial studies for the treatment of Atopic dermatitis and also including Asthma.

            Lead Product(s): APG777

            Therapeutic Area: Dermatology Product Name: APG777

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Jefferies

            Deal Size: $420.0 million Upfront Cash: Undisclosed

            Deal Type: Public Offering March 07, 2024

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            Details:

            APG777 is a novel, subcutaneous extended half-life monoclonal antibody targeting IL-13 – a critical cytokine in inflammation and a primary driver of Atopic Dermatitis and Other Inflammatory Diseases.

            Lead Product(s): APG777

            Therapeutic Area: Dermatology Product Name: APG777

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 07, 2023

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            Details:

            The net proceeds will fund company's clinical trials, including a potential Phase 2 trial, and manufacturing of its APG777, APG808, APG990 and APG222 programs, fund its preclinical studies, clinical trials.

            Lead Product(s): APG777

            Therapeutic Area: Dermatology Product Name: APG777

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Jefferies

            Deal Size: $345.0 million Upfront Cash: Undisclosed

            Deal Type: Public Offering July 18, 2023

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            Details:

            The net proceeds will fund company's clinical trials, including a potential Phase 2 trial, and manufacturing of its APG777, APG808, APG990 and APG222 programs, fund its preclinical studies, clinical trials.

            Lead Product(s): APG777

            Therapeutic Area: Dermatology Product Name: APG777

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Jefferies

            Deal Size: $300.0 million Upfront Cash: Undisclosed

            Deal Type: Public Offering July 13, 2023

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            Details:

            The net proceeds will fund company's clinical trials, including a potential Phase 2 trial, and manufacturing of its APG777, APG808, APG990 and APG222 programs, fund its preclinical studies, clinical trials.

            Lead Product(s): APG777

            Therapeutic Area: Dermatology Product Name: APG777

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Jefferies

            Deal Size: $263.1 million Upfront Cash: Undisclosed

            Deal Type: Public Offering July 10, 2023

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            Details:

            The net proceeds will fund the company's preclinical studies, clinical trials, including a potential Phase 2 trial, and manufacturing of its APG777 program, a subcutaneous extended half-life monoclonal antibody targeting IL-13, being developed for inflammatory and immunological diseases.

            Lead Product(s): APG777

            Therapeutic Area: Dermatology Product Name: APG777

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Jefferies

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Public Offering June 23, 2023

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