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AbbVie Announces European Commission Approval of SKYRIZI® (risankizumab) for the Treatment of Moderate to Severe Active Crohn's Disease

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SKYRIZI® (risankizumab) is the first specific interleukin-23 (IL-23) inhibitor for the treatment of adults with moderately to severely active Crohn's disease who have had inadequate response, lost response or were intolerant to conventional or biologic therapy.

Lead Product(s): Risankizumab

Therapeutic Area: Gastroenterology Product Name: Skyrizi

Highest Development Status: Approved Product Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 23, 2022

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Genmab Announces U.S. Food and Drug Administration Accepts for Priority Review Biologics License Application (BLA) for Epcoritamab (DuoBody®-CD3xCD20) for the Treatment of...

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DuoBody (epcoritamab) is an investigational IgG1-bispecific antibody,designed to direct cytotoxic T cells selectively to elicit an immune response towards target cell types.

Lead Product(s): Epcoritamab

Therapeutic Area: Oncology Product Name: DuoBody

Highest Development Status: Phase III Product Type: Large molecule

Recipient: Genmab

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 21, 2022

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AbbVie Announces Late-Breaking Results from Phase 2 Exploratory NOVA Trial of Novel Investigational Neurotoxin AGN-151607 for the Prevention of Postoperative Atrial Fibrill...

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In a post hoc analysis of CABG patients aged 65 years and older treated with 125 units of AGN-151607, a botulinum toxin type A, is a novel investigational neurotoxin the study found a greater risk reduction at 51 percent compared to placebo (nominal p<0.01).

Lead Product(s): Botulinum toxin type A

Therapeutic Area: Cardiology/Vascular Diseases Product Name: AGN-151607

Highest Development Status: Phase II Product Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 07, 2022

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Inventiva Provides An Update On The Development Of Cedirogant By AbbVie

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Cedirogant (ABBV-157) is an orally available retinoic acid-related orphan receptor gamma (RORγ) inverse-agonist, small molecule for the treatment of chronic plaque psoriasis.

Lead Product(s): Cedirogant

Therapeutic Area: Dermatology Product Name: ABBV-157

Highest Development Status: Phase II Product Type: Small molecule

Recipient: Inventiva Pharma

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Termination October 31, 2022

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AbbVie Announces Submissions of Regulatory Applications for Epcoritamab (DuoBody®-CD3xCD20) for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) ...

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Epcoritamab is an investigational IgG1-bispecific antibody created using Genmab's proprietary DuoBody® technology. Genmab's DuoBody®-CD3 technology is designed to direct cytotoxic T-cells selectively to elicit an immune response toward target cell types.

Lead Product(s): Epcoritamab

Therapeutic Area: Oncology Product Name: Gen3013

Highest Development Status: Phase III Product Type: Large molecule

Recipient: Genmab

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 28, 2022

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AbbVie to Present Data from Extensive Portfolio at American College of Gastroenterology Annual Scientific Meeting

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CREON (pancrelipase) is prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis, swelling of pancreas that lasts a long time, removal of some or all of pancreas, or other conditions.

Lead Product(s): Pancrelipase

Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: Creon

Highest Development Status: Approved Product Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 24, 2022

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RINVOQ® (Upadacitinib) Receives Its Sixth U.S. FDA Approval

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RINVOQ® (upadacitinib), is a selective JAK inhibitor that is being studied in several immune-mediated inflammatory diseases. Based on enzymatic and cellular assays, RINVOQ demonstrated greater inhibitory potency for JAK-1 vs JAK-2, JAK-3, and TYK-2.

Lead Product(s): Upadacitinib

Therapeutic Area: Immunology Product Name: Rinvoq

Highest Development Status: Approved Product Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 21, 2022

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AbbVie Acquires DJS Antibodies, Further Strengthening Immunology Pipeline

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Under the terms of the agreement, AbbVie will pay DJS. DJS shareholders remain eligible for potential additional payments upon the achievement of certain development milestones related to the success of the DJS-002 program.

Lead Product(s): DJS-002

Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: DJS-002

Highest Development Status: Preclinical Product Type: Large molecule

Recipient: DJS Antibodies

Deal Size: Undisclosed Upfront Cash: $255.0 million

Deal Type: Acquisition October 20, 2022

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AbbVie Highlights Robust Gastroenterology Portfolio with New Data in Crohn's Disease and Ulcerative Colitis at the UEG Week 2022

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Primary results from the 12-week U-EXCEL induction study on the efficacy and safety of Rinvoq (upadacitinib) induction therapy in patients with moderate to severe Crohn's disease who had inadequate response or intolerance to conventional or biologic therapy.

Lead Product(s): Upadacitinib

Therapeutic Area: Gastroenterology Product Name: Rinvoq

Highest Development Status: Approved Product Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 29, 2022

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AbbVie Secures Positive CHMP Opinion for Risankizumab (SKYRIZI®) for the Treatment of Adults with Moderate to Severe Crohn's Disease

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SKYRIZI® (risankizumab) is an interleukin-23 inhibitor that selectively blocks IL-23 by binding to its p19 subunit.11,16 IL-23, a cytokine involved in inflammatory processes, is thought to be linked to a number of chronic immune-mediated diseases, including Crohn's disease.

Lead Product(s): Risankizumab

Therapeutic Area: Gastroenterology Product Name: Skyrizi

Highest Development Status: Approved Product Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 19, 2022

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