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    Looking for Solubilizers? Find Solubilizers Agents used in Carbamazepine to address drug delivery challenges on PharmaCompass.

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    Nippon provides high-performance, high-value-added cosmetic, pharmaceutical, and industrial raw materials.
    Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
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    01 Evonik (5)

    02 Nanjing Well Pharmaceutical (11)

    03 Alcedo Pharmachem (3)

    04 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd (1)

    05 BASF (44)

    06 Gangwal Chemicals (14)

    07 Microlex e.U (1)

    08 Nanjing Bold Chemical (3)

    09 Seppic (6)

    10 The Dow Chemical Company (1)

    11 Ulanqab Kema New Material (3)

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    01 Capsule (15)

    02 Cream / Lotion / Ointment (6)

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    Nanjing Well Pharmaceutical

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      POLOXAMER 188

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      Applications:

      Poloxamer 188 is used as a solubilizer and wetting agent in oral dosage forms such as tablets and topical formulations such as creams, gels, lotions, and ointments. It is also used as a coating plasticizer for oral solids.

      Ingredient(s): Poloxamer 188

      Dosage Form: Cream / Lotion / Ointment, Gel, Injectable / Parenteral, Tablet

      Category: Parenteral, Solubilizers, Topical

      Route of Administration (Grade): Parenteral, Oral, Topical
      Pharmacopoeia Reference: ChP/USP/EP

      Technical Specifications: NA

      Nanjing Well Poloxamer 188

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      Evonik

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      EUDRAGIT® L 100-55

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      Applications:

      EUDRAGIT® L 100-55 polymer is used in delayed, sustained-release coatings to enhance solubility of poorly soluble drugs such as tablets, capsules, etc.

      Ingredient(s): Methacrylic Acid - Ethyl Acrylate Copolymer

      Dosage Form: Capsule, Granule / Pellet, Tablet

      Category: Controlled & Modified Release, Solubilizers

      Route of Administration (Grade): Oral
      Pharmacopoeia Reference: NA

      Technical Specifications: Available as powder; Other grades- EUDRAGIT® L 30 D-55

      EUDRAGIT® L 100-55

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      Evonik

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      EUDRAGIT® RL 100

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      Applications:

      EUDRAGIT® RL, an insoluble, highly permeable polymer used in combination with EUDRAGIT® RS in customized release drugs such as tablets, capsules, etc.

      Ingredient(s): Ammonia Methacrylate Copolymer Type A

      Dosage Form: Capsule, Tablet

      Category: Controlled & Modified Release, Solubilizers

      Route of Administration (Grade): Oral
      Pharmacopoeia Reference: NA

      Technical Specifications: Other grades- EUDRAGIT® RL 12,5, EUDRAGIT® RL 30 D, EUDRAGIT® RL PO

      EUDRAGIT® RL 100

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      Nanjing Well Pharmaceutical

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        SORBITAN LAURATE

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        Applications:

        Sorbitan Laurate is used as a solubilizer and wetting agent in oral dosage forms such as tablets. It is also used in topical dosage forms such as creams, lotions, ointments, and gels.

        Ingredient(s): Sorbitan Laurate

        Dosage Form: Cream / Lotion / Ointment, Gel, Tablet

        Category: Solubilizers, Topical

        Route of Administration (Grade): Oral, Topical
        Pharmacopoeia Reference: ChP/USP/EP

        Technical Specifications: NA

        Nanjing Well Sorbitan Laurate

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        Nanjing Well Pharmaceutical

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          OLEIC ACID

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          Applications:

          Oleic acid is used as a solubilizer (wetting agent) in parenteral dosage forms. It is also used as a co-emulsifier, plasticizer, and film agent in softgel capsules, and emulsions and as a transdermal penetration enhancer in topical formulations.

          Ingredient(s): Oleic Acid Excipient

          Dosage Form: Capsule, Emulsion, Injectable / Parenteral, Softgels

          Category: Emulsifying Agents, Film Formers & Plasticizers, Parenteral, Solubilizers

          Route of Administration (Grade): Parenteral, Oral
          Pharmacopoeia Reference: USP/EP/ChP

          Technical Specifications: NA

          Nanjing Oleic Acid

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          Gangwal Chemicals

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            CAPTISOL

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            Applications:

            Chemical structure was rationally designed to maximize safety and optimize interaction to improve the solubility, stability, bio availability or lessen volatility, irritation, smell or taste.

            Ingredient(s): Betadex Sulfobutyl Ether Sodium Excipient

            Dosage Form: Capsule, Injectable / Parenteral, Nasal Solution, Ophthalmic Solution, Tablet, Topical Film

            Category: Dry Powder Inhalation, Emulsifying Agents, Parenteral, Solubilizers, Taste Masking, Thickeners and Stabilizers

            Route of Administration (Grade): Parenteral, Oral, Ophthalmic, Nasal, Topical, Oral and Inhalation.
            Pharmacopoeia Reference: USP NF

            Technical Specifications: Captisol® is a polyanionic beta-cyclodextrin derivative with a sodium sulfonate salt separated from the lipophilic cavity by a butyl ether spacer group, or sulfobutylether (SBE).
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            Ulanqab Kema New Material

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              POVIDONE

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              Applications:

              Povidone excipient is used as a binder in oral solid dosage forms such as effervescent tablets and sustained-release capsules. It is also used in the formation of direct compression granules and tablets.

              Ingredient(s): Povidone

              Dosage Form: Capsule, Granule / Pellet, Tablet

              Category: Direct Compression, Fillers, Diluents & Binders

              Route of Administration (Grade): Oral
              Pharmacopoeia Reference: Not Available

              Technical Specifications: Not Available
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              The Dow Chemical Company

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              AFFINISOL HPMC HME

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              Applications:

              Solubility enhancement, Spray-Dried Dispersion (SDD), Hot Melt Extrusion (HME)

              Ingredient(s): Hydroxypropyl Methylcellulose

              Dosage Form: Tablet

              Category: Solubilizers

              Route of Administration (Grade): Not Available
              Pharmacopoeia Reference: Not Available

              Technical Specifications: Not Available
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              Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

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                POVIDONE

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                Applications:

                Disintegrant; Dissolution enhancer; Suspending Agent, Tablet Binder.

                Ingredient(s): Povidone

                Dosage Form: Tablet

                Category: Disintegrants & Superdisintegrants, Fillers, Diluents & Binders, Solubilizers

                Route of Administration (Grade): Not Available
                Pharmacopoeia Reference: USP/BP/EP/CP

                Technical Specifications: Not Available
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                Nanjing Bold Chemical

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                  POLOXAMER 188

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                  Applications:

                  Poloxamer 188 provides better storage stability. It is used as solubilizers for liquid preparation & oral care products, matrix materials for ointment & gel.

                  Ingredient(s): Poloxamer 188

                  Dosage Form: Cream / Lotion / Ointment, Granule / Pellet, Tablet

                  Category: Solubilizers, Thickeners and Stabilizers

                  Route of Administration (Grade): Oral & Parenteral
                  Pharmacopoeia Reference: Not Available

                  Technical Specifications: Not Available
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                  Alcedo Pharmachem

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                    LUMACRI

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                    Applications:

                    It is an anionic copolymer used in delayed and sustained release coatings to enhance solubility for poorly soluble drugs in solid oral dosage forms such as tablets, capsules, etc.

                    Ingredient(s): Methacrylic Acid - Ethyl Acrylate Copolymer

                    Dosage Form: Capsule, Granule / Pellet, Tablet

                    Category: Coating Systems & Additives, Controlled & Modified Release, Solubilizers

                    Route of Administration (Grade): Oral
                    Pharmacopoeia Reference: NA

                    Technical Specifications: NA
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                    BASF

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                    KOLLISOLV MCT 70

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                    Applications:

                    Oil fill & solubilizer for lipophilic drugs, Water barrier-repairing, emollient film-former on skin

                    Ingredient(s): Medium Chain Triglycerides

                    Dosage Form: Emulsion, Softgel Capsule

                    Category: Solubilizers, Topical

                    Route of Administration (Grade): Not Available
                    Pharmacopoeia Reference: Ph. Eur., USP/NF

                    Technical Specifications: Not Available
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                    Microlex e.U

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                      MICROLEX® PVD K30

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                      Applications:

                      It is among the most commonly used solid dispersion carrires to solubilize poorly soluble drugs, It can stabilize amorphous drugs in polymer dispersions and maintain supersaturation of API, aqueous solutions by preventing precipitation/crystallization

                      Ingredient(s): Povidone

                      Dosage Form: Tablet

                      Category: Solubilizers

                      Route of Administration (Grade): Oral
                      Pharmacopoeia Reference: Monograph- USP/NF, JP/JPE

                      Technical Specifications: Also Available as Microlex® PVD K90.
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                      BASF

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                      KOLLISOLV PG

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                      Applications:

                      Liquid plasticizer with high ADI, hydrophilic solvent & humectant in emulsions, skin penetration enhancer in topical formulaitons.

                      Ingredient(s): Propylene Glycol

                      Dosage Form: Capsule, Emulsion, Softgel Capsule, Solution, Tablet, Topical Film

                      Category: Film Formers & Plasticizers, Solubilizers, Topical

                      Route of Administration (Grade): Not Available
                      Pharmacopoeia Reference: Ph. Eur., JP, FCC, USP

                      Technical Specifications: Not Available
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                      Gangwal Chemicals

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                        POLYQUID PA-100

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                        Applications:

                        Enteric, Delayed Release Matrix and Solubility Enhancement

                        Ingredient(s): Methacrylic Acid - Ethyl Acrylate Copolymer

                        Dosage Form: Capsule, Tablet

                        Category: Coating Systems & Additives, Controlled & Modified Release, Solubilizers

                        Route of Administration (Grade): Oral
                        Pharmacopoeia Reference: Multicompendial

                        Technical Specifications: Methylacryli acid and Ethyl Acrylate copolymer (1:1) Type A
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                        Seppic

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                        MONTANE 20 PHA PREMIUM

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                        Applications:

                        Non-ionic lipophilic surfactant, emulsifier.

                        Ingredient(s): Sorbitan Laurate

                        Dosage Form: Capsule, Cream / Lotion / Ointment, Emulsion, Spray, Syrup, Tablet

                        Category: Emulsifying Agents, Film Formers & Plasticizers, Topical

                        Route of Administration (Grade): Topical, Oral
                        Pharmacopoeia Reference: Ph.Eur, USP-NF

                        Technical Specifications: HLB: 9; EXCiPACT
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                        Gangwal Chemicals

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                          MONTANE 20 PHA PREMIUM

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                          Applications:

                          Sorbitan esters, such as sorbitan monolaurate is mainly used as surfactants or emulsifying agents in the preparation of emulsions, creams, and ointments for pharmaceutical and cosmetic use and also as a solubilizer in various injections.

                          Ingredient(s): Sorbitan Monolaurate

                          Dosage Form: Cream / Lotion / Ointment, Emulsion, Injectable / Parenteral, Tablet

                          Category: Emulsifying Agents, Solubilizers, Surfactant & Foaming Agents, Topical

                          Route of Administration (Grade): Oral, Parenteral, Topical
                          Pharmacopoeia Reference: USP-NF, EP, JP

                          Technical Specifications: Non-Ionic Lipophilic Surfactant; Emulsifier (w/o emulsions)
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                          Gangwal Chemicals

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                            KOVIDONE-K

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                            Applications:

                            Kovidone- K series products posses excellent binding, film-forming, dispersing, and thickning properties and are widely used in the following dosage forms. Binder, Solubilizer, Coating agent, Suspending, Stabilizing or viscocity modifying agent

                            Ingredient(s): Crospovidone, Povidone

                            Dosage Form: Capsule, Tablet

                            Category: Coating Systems & Additives, Fillers, Diluents & Binders, Film Formers & Plasticizers, Solubilizers, Thickeners and Stabilizers

                            Route of Administration (Grade): Oral
                            Pharmacopoeia Reference: USP-NF, EP, BP, IP, JP, FCC

                            Technical Specifications: PVP K-K-30/ K-17/ K19/ K25/ K90
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                            BASF

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                            KOLLIDON 30

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                            Applications:

                            Solubilization, dispersion, crystallization inhibition, instant release matrices & spray drying

                            Ingredient(s): Povidone

                            Dosage Form: Capsule, Tablet, Transdermal Patch, Transdermal patches

                            Category: Controlled & Modified Release, Solubilizers

                            Route of Administration (Grade): Not Available
                            Pharmacopoeia Reference: Ph. Eur., USP, JP: Povidone

                            Technical Specifications: Not Available
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                            BASF

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                            KOLLISOLV PEG 400

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                            Applications:

                            Liquid plasticizer, Solvent for oral and topical applications, Hydrophilic fill for solubilization of hydrophilic APIs.

                            Ingredient(s): Polyethylene Glycol 400

                            Dosage Form: Capsule, Cream / Lotion / Ointment, Emulsion, Gel, Solution, Tablet

                            Category: Solubilizers

                            Route of Administration (Grade): Not Available
                            Pharmacopoeia Reference: Ph. Eur., JP, FCC, USP

                            Technical Specifications: Not Available
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                            BASF

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                            KOLLIDON 90 F

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                            Applications:

                            Tablet binding, thickener, stabilizers of suspensions, reduces sedimentation, crystallization inhibition.

                            Ingredient(s): Povidone

                            Dosage Form: Capsule, Granule / Pellet, Softgel Capsule, Suspension, Tablet

                            Category: Fillers, Diluents & Binders, Granulation, Solubilizers

                            Route of Administration (Grade): Not Available
                            Pharmacopoeia Reference: Ph. Eur., USP, JP: Povidone

                            Technical Specifications: Not Available
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                            BASF

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                            SOLUPLUS

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                            Applications:

                            Solubility and bioavailability enhancement, ideal for hot melt extrusion (HME)

                            Ingredient(s): polyethylene glycol, Polyvinyl Acetate

                            Dosage Form: Solution, Tablet, Topical Film, Transdermal Patch

                            Category: Controlled & Modified Release, Granulation, Solubilizers

                            Route of Administration (Grade): Not Available
                            Pharmacopoeia Reference: Polyvinyl caprolactam – polyvinyl acetate – polyethylene glycol graft copolymer

                            Technical Specifications: Not Available
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                            BASF

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                            KOLLISOLV PEG 300

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                            Applications:

                            Liquid plasticizer, solvent for oral and topical applications, hydrophilic fill for solubilization of hydrophilic APIs.

                            Ingredient(s): Polyethylene Glycol 300

                            Dosage Form: Emulsion, Gel, Solution

                            Category: Solubilizers

                            Route of Administration (Grade): Not Available
                            Pharmacopoeia Reference: Ph. Eur., JP, FCC, USP

                            Technical Specifications: Not Available
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                            BASF

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                            KOLLIDON 17 PF

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                            Applications:

                            Solubilizing matrix, crystallization inhibitor & stabilizer in injectables and ophthalmic products

                            Ingredient(s): Povidone

                            Dosage Form: Capsule, Emulsion, Softgel Capsule, Solution, Tablet, Transdermal patches

                            Category: Parenteral, Solubilizers

                            Route of Administration (Grade): Not Available
                            Pharmacopoeia Reference: Ph. Eur., USP: Povidone; JPE: Povidone K 17

                            Technical Specifications: Not Available
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                            BASF

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                            KOLLIDON 12 PF

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                            Applications:

                            Solubilizing matrix, crystallization inhibitor & stabilizer in injectables and ophthalmic products

                            Ingredient(s): Povidone

                            Dosage Form: Capsule, Emulsion, Granule / Pellet, Softgel Capsule, Solution, Tablet, Transdermal patches

                            Category: Parenteral, Solubilizers

                            Route of Administration (Grade): Not Available
                            Pharmacopoeia Reference: Ph. Eur., USP, JP

                            Technical Specifications: Not Available
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                            BASF

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                            KOLLISOLV PEG 600

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                            Applications:

                            Hydrophilic fill for solubilization of hydrophilic APIs.

                            Ingredient(s): Polyethylene Glycol 600

                            Dosage Form: Softgel Capsule

                            Category: Solubilizers

                            Route of Administration (Grade): Not Available
                            Pharmacopoeia Reference: Ph. Eur., JP, FCC, USP

                            Technical Specifications: Not Available
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