Also known as: 869884-78-6, Rx-1741, Rx-103, N-[[(5s)-3-[2-fluoro-4'-[[(1h-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]acetamide, Rx103, Rx-01_667

Molecular Formula

C₂₂H₂₃FN₆O₃

Molecular Weight

438.5 g/mol

InChI Key

BTTNOGHPGJANSW-IBGZPJMESA-N

FDA UNII

53PC6LO35W

Radezolid has been used in trials studying the treatment of Abscess, Bacterial Skin Diseases, Streptococcal Infections, Infectious Skin Diseases, and Staphylococcal Skin Infections, among others.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[[(5S)-3-[3-fluoro-4-[4-[(2H-triazol-4-ylmethylamino)methyl]phenyl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

2.1.2 InChI

InChI=1S/C22H23FN6O3/c1-14(30)25-12-19-13-29(22(31)32-19)18-6-7-20(21(23)8-18)16-4-2-15(3-5-16)9-24-10-17-11-26-28-27-17/h2-8,11,19,24H,9-10,12-13H2,1H3,(H,25,30)(H,26,27,28)/t19-/m0/s1

2.1.3 InChI Key

BTTNOGHPGJANSW-IBGZPJMESA-N

2.1.4 Canonical SMILES

CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CNCC4=NNN=C4)F

2.1.5 Isomeric SMILES

CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)C3=CC=C(C=C3)CNCC4=NNN=C4)F

2.2 Other Identifiers

2.2.1 UNII

53PC6LO35W

2.3 Synonyms

2.3.1 MeSH Synonyms

1. N-((3-(2-fluoro-4'-(((1h-1,2,3-triazol-5-ylmethyl)amino)methyl)(1,1'-biphenyl)-4-yl)-2-oxo-5-oxazolidinyl)methyl)acetamide

2. Rx 1741

3. Rx-1741

4. Rx1741

2.3.2 Depositor-Supplied Synonyms

1. 869884-78-6

2. Rx-1741

3. Rx-103

4. N-[[(5s)-3-[2-fluoro-4'-[[(1h-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]acetamide

5. Rx103

6. Rx-01_667

7. 53pc6lo35w

8. Mmv688327

9. Rx-013

10. Rx1741

11. (s)-n-((3-(4'-((((1h-1,2,3-triazol-5-yl)methyl)amino)methyl)-2-fluoro-[1,1'-biphenyl]-4-yl)-2-oxooxazolidin-5-yl)methyl)acetamide

12. N-[[(5s)-3-[3-fluoro-4-[4-[(2h-triazol-4-ylmethylamino)methyl]phenyl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

13. N-{[(5s)-3-(2-fluoro-4'-{[(1h-1,2,3-triazol-5-ylmethyl)amino]methyl}biphenyl-4-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

14. Radezolid [usan]

15. And Rx-01_667

16. Rx-o1_667

17. Radezolid [usan:inn]

18. Unii-53pc6lo35w

19. Rx 1741

20. (5s)-n-[3-(2-fluoro-4'-{[(1h-[1,2,3]triazol-4-ylmethyl)-amino]-methyl)-biphenyl-4-yl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

21. (5s)-n-[3-(2-fluoro-4'-{[(1h-[1,2,3]triazol-4-ylmethyl)-amino]-methyl}-biphenyl-4-yl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

22. N-(((5s)-3-(2-fluoro-4'-(((1h-1,2,3-triazol-5-ylmethyl)amino)methyl)biphenyl-4-yl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide

23. Rd8

24. Radezolid [inn]

25. Radezolid (usan/inn)

26. Radezolid [who-dd]

27. Chembl455461

28. Schembl1035776

29. Schembl10109382

30. Gtpl10849

31. Dtxsid301007238

32. Ex-a1247

33. Zinc40379938

34. Cs-0688

35. Db12339

36. Rx-01-667

37. Ac-36840

38. Hy-14800

39. D09369

40. A902025

41. Q7280139

42. Acetamide, N-(((5s)-3-(2-fluoro-4'-(((1h-1,2,3-triazol-5-ylmethyl)amino)methyl)(1,1'-biphenyl)-4-yl)-2-oxo-5-oxazolidinyl)methyl)-

43. N-((3-(2-fluoro-4'-(((1h-1,2,3-triazol-5-ylmethyl)amino)methyl)(1,1'-biphenyl)-4-yl)-2-oxo-5-oxazolidinyl)methyl)acetamide

44. N-({(5s)-3-[2-fluoro-4'-({[(1h-1,2,3-triazol-4-yl)methyl]amino}methyl)[1,1'-biphenyl]-4-yl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide

45. N-[[(5s)-3-[3-fluoro-4-[4-[(1h-triazol-5-ylmethylamino)methyl]phenyl]phenyl]-2-oxo-oxazolidin-5-yl]methyl]acetamide

46. N-{ [(5s)-3-(2-fluoro-4'-{[(1h-1,2,3-triazol-5-ylmethyl)amino]methyl}biphenyl-4-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

2.4 Create Date

2006-10-26

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₃FN₆O₃
Molecular Weight	438.5 g/mol
XLogP3	1.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	8
Exact Mass	438.18156678 g/mol
Monoisotopic Mass	438.18156678 g/mol
Topological Polar Surface Area	112 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	647
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

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RX 1741

RX 1741

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