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    Monepantel

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

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    $ API Ref.Price (USD/KG) : 6,680Xls

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    2D Structure
    Also known as: 887148-69-8, Monepantel [inn], Aad1566, Chebi:78621, 82ma79vj33, N-(2-cyano-1-((2s)-5-cyano-2-(trifluoromethyl)phenoxy)propan-2-yl)-4-(trifluoromethylsulfanyl)benzamide
    Molecular Formula
    C20H13F6N3O2S
    Molecular Weight
    473.4  g/mol
    InChI Key
    WTERNLDOAPYGJD-SFHVURJKSA-N
    FDA UNII
    82MA79VJ33
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-[(2S)-2-cyano-1-[5-cyano-2-(trifluoromethyl)phenoxy]propan-2-yl]-4-(trifluoromethylsulfanyl)benzamide
    2.1.2 InChI
    InChI=1S/C20H13F6N3O2S/c1-18(10-28,11-31-16-8-12(9-27)2-7-15(16)19(21,22)23)29-17(30)13-3-5-14(6-4-13)32-20(24,25)26/h2-8H,11H2,1H3,(H,29,30)/t18-/m0/s1
    2.1.3 InChI Key
    WTERNLDOAPYGJD-SFHVURJKSA-N
    2.1.4 Canonical SMILES
    CC(COC1=C(C=CC(=C1)C#N)C(F)(F)F)(C#N)NC(=O)C2=CC=C(C=C2)SC(F)(F)F
    2.1.5 Isomeric SMILES
    C[C@@](COC1=C(C=CC(=C1)C#N)C(F)(F)F)(C#N)NC(=O)C2=CC=C(C=C2)SC(F)(F)F
    2.2 Other Identifiers
    2.2.1 UNII
    82MA79VJ33
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 887148-69-8

    2. Monepantel [inn]

    3. Aad1566

    4. Chebi:78621

    5. 82ma79vj33

    6. N-(2-cyano-1-((2s)-5-cyano-2-(trifluoromethyl)phenoxy)propan-2-yl)-4-(trifluoromethylsulfanyl)benzamide

    7. Zolvix

    8. Benzamide, N-[(1s)-1-cyano-2-[5-cyano-2-(trifluoromethyl)phenoxy]-1-methylethyl]-4-[(trifluoromethyl)thio]-

    9. N-[(2s)-2-cyano-1-[5-cyano-2-(trifluoromethyl)phenoxy]propan-2-yl]-4-(trifluoromethylsulfanyl)benzamide

    10. Monepantelum

    11. Unii-82ma79vj33

    12. Benzamide, N-((1s)-1-cyano-2-(5-cyano-2-(trifluoromethyl)phenoxy)-1-methylethyl)-4-((trifluoromethyl)thio)-

    13. Monepantel [mi]

    14. Chembl256563

    15. Schembl1547706

    16. Zolvix Component Monepantel

    17. Zinc29045455

    18. Monepantel Component Of Zolvix

    19. Cs-6054

    20. Monepantel [ema Epar Veterinary]

    21. Ncgc00522551-01

    22. Hy-14774

    23. A901727

    24. Q27147876

    25. Benzamide, N-[(1s)-1-cyano-2-[5-cyano-2-(trifluoromethyl)phenoxy]-1-methylethyl]-4-[(trifluoromethyl)thio]-;monepantel

    26. N-[(1s)-1-cyano-2-(5-cyano-2-trifluoromethyl-phenoxy)-1-methyl-ethyl]-4-trifluoromethylsulfanyl-benzamide

    27. N-{(2s)-2-cyano-1-[5-cyano-2-(trifluoromethyl)phenoxy]propan-2-yl}-4-[(trifluoromethyl)sulfanyl]benzamide

    2.4 Create Date
    2009-11-19
    3 Chemical and Physical Properties
    Molecular Weight 473.4 g/mol
    Molecular Formula C20H13F6N3O2S
    XLogP35.2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count11
    Rotatable Bond Count6
    Exact Mass473.06326681 g/mol
    Monoisotopic Mass473.06326681 g/mol
    Topological Polar Surface Area111 Ų
    Heavy Atom Count32
    Formal Charge0
    Complexity763
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Zolvix oral solution is a broad spectrum anthelmintic for the treatment and control of gastro-intestinal nematode infections and associated diseases in sheep including lambs, hoggets, breeding rams and ewes.

    Spectrum of activity includes fourth larvae and adults of:

    - Haemonchus contortus*;

    - Teladorsagia circumcincta*;

    - Teladorsagia trifurcata*;

    - Teladorsagia davtiani*;

    - Trichostrongylus axei*;

    - Trichostrongylus colubriformis;

    - Trichostrongylus vitrinus;

    - Cooperia curticei;

    - Cooperia oncophora;

    - Nematodirus battus;

    - Nematodirus filicollis;

    - Nematodirus spathiger;

    - Chabertia ovina;

    - Oesophagostomum venulosum.

    * including inhibited larvae.

    The veterinary medicinal product is effective against strains of these parasites resistant to (pro)benzimidazoles, levamisole, morantel, macrocyclic lactones and H. contortus strains resistant to salicylanilides.

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    QP52AX09