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    [{"orgOrder":0,"company":"Neurizon Therapeutics","sponsor":"FightMND | Calvary Health Care Bethlehem | Macquarie University","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"AUSTRALIA","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Monepantel","moa":"DEG-3\/DES-2 type nAChR","graph1":"Neurology","graph2":"Phase I","graph3":"Neurizon Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Neurizon Therapeutics \/ FightMND | Calvary Health Care Bethlehem | Macquarie University","highestDevelopmentStatusID":"6","companyTruncated":"Neurizon Therapeutics \/ FightMND | Calvary Health Care Bethlehem | Macquarie University"},{"orgOrder":0,"company":"Neurizon Therapeutics","sponsor":"Calvary Health Care Bethlehem | Macquarie University","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"AUSTRALIA","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Monepantel","moa":"DEG-3\/DES-2 type nAChR","graph1":"Neurology","graph2":"Phase I","graph3":"Neurizon Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Neurizon Therapeutics \/ Calvary Health Care Bethlehem | Macquarie University","highestDevelopmentStatusID":"6","companyTruncated":"Neurizon Therapeutics \/ Calvary Health Care Bethlehem | Macquarie University"},{"orgOrder":0,"company":"PharmAust","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"AUSTRALIA","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Monepantel","moa":"DEG-3\/DES-2 type nAChR","graph1":"Neurology","graph2":"Phase I","graph3":"PharmAust","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"PharmAust \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"PharmAust \/ Inapplicable"},{"orgOrder":0,"company":"Neurizon Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"AUSTRALIA","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Monepantel","moa":"DEG-3\/DES-2 type nAChR","graph1":"Neurology","graph2":"Phase I","graph3":"Neurizon Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Neurizon Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Neurizon Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Neurizon Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"AUSTRALIA","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Monepantel","moa":"DEG-3\/DES-2 type nAChR","graph1":"Neurology","graph2":"Phase I","graph3":"Neurizon Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Neurizon Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Neurizon Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Neurizon Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"AUSTRALIA","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Monepantel","moa":"DEG-3\/DES-2 type nAChR","graph1":"Neurology","graph2":"Phase I","graph3":"Neurizon Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Neurizon Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Neurizon Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Elanco","sponsor":"Neurizon Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Licensing Agreement","leadProduct":"Monepantel","moa":"DEG-3\/DES-2 type nAChR","graph1":"Neurology","graph2":"Phase I","graph3":"Elanco","amount2":0.080000000000000002,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0.080000000000000002,"dosageForm":"Tablet","sponsorNew":"Elanco \/ Neurizon Therapeutics","highestDevelopmentStatusID":"6","companyTruncated":"Elanco \/ Neurizon Therapeutics"}]

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                            01

                            Elanco

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                            Elanco

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                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Neurizon Therapeutics

                            Deal Size : $79.9 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Neurizon Enters into Global License with Elanco to Accelerate Commercialisation of NUZ-001

                            Details : Elanco is licensing its data and rights regarding monepantel, to Neurizon, which is developing NUZ-001 as a potential treatment for ALS and other neurodegenerative diseases in humans.

                            Product Name : NUZ-001

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            July 02, 2025

                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Neurizon Therapeutics

                            Deal Size : $79.9 million

                            Deal Type : Licensing Agreement

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                            02

                            Neurizon Therapeutics

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                            Neurizon Therapeutics

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                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Neurizon Files IND Application to Support HEALEY ALS Platform Trial

                            Details : NUZ-001 (S-Monepantel) works by targetin TDP-43 protein aggregation, bein investigated for patients with amyotrophic lateral sclerosis.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 18, 2024

                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Neurizon Therapeutics

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                            Neurizon Therapeutics

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                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Neurizon’s NUZ-001 Reduces ALS TDP-43 Aggregation in Preclinical Studies

                            Details : NUZ-001(monepantel) has an unique mechanism of action in preventing the aggregation of TAR DNA-binding protein 43 (TDP-43), a key pathological feature of Amyotrophic lateral sclerosis.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 19, 2024

                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Neurizon Therapeutics

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                            Neurizon Therapeutics

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                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Neurizon Therapeutics Receives Orphan Product Designation for NUZ-001 in Europe

                            Details : Neurizon received OMPD for its lead drug candidate, NUZ-001, which is being evaluated for the treatment of Amyotrophic Lateral Sclerosis.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 11, 2024

                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            PharmAust

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                            PharmAust

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                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            PharmAust announces positive Phase 1 MEND Study Top-Line Results in MND / ALS

                            Details : PPL-1 (monepantel) is a positive allosteric modulator of DEG-3/DES-2 type nicotinic acetylcholine receptors (nAChRs). It is being evaluated for motor neurone disease & amyotrophic lateral sclerosis.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 28, 2024

                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Neurizon Therapeutics

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                            Neurizon Therapeutics

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                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Calvary Health Care Bethlehem | Macquarie University

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            An Open Label Extension Study of Monepantel in Individuals With Motor Neurone Disease

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 20, 2023

                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Calvary Health Care Bethlehem | Macquarie University

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Neurizon Therapeutics

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                            Neurizon Therapeutics

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                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : FightMND | Calvary Health Care Bethlehem | Macquarie University

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of Monepantel in Individuals With Motor Neurone Disease

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 20, 2021

                            Lead Product(s) : Monepantel

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : FightMND | Calvary Health Care Bethlehem | Macquarie University

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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