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    Lucitanib

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    DIGITAL CONTENT

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    2D Structure
    Also known as: 1058137-23-7, E-3810, E-3810 amine, E-3810 free base, Al-3810, Pp449xa4bh
    Molecular Formula
    C26H25N3O4
    Molecular Weight
    443.5  g/mol
    InChI Key
    CUDVHEFYRIWYQD-UHFFFAOYSA-N
    FDA UNII
    PP449XA4BH
    Lucitanib is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. Lucitanib inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide
    2.1.2 InChI
    InChI=1S/C26H25N3O4/c1-28-25(30)19-5-3-4-16-12-17(6-7-18(16)19)33-22-8-11-29-21-14-24(23(31-2)13-20(21)22)32-15-26(27)9-10-26/h3-8,11-14H,9-10,15,27H2,1-2H3,(H,28,30)
    2.1.3 InChI Key
    CUDVHEFYRIWYQD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CNC(=O)C1=CC=CC2=C1C=CC(=C2)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC
    2.2 Other Identifiers
    2.2.1 UNII
    PP449XA4BH
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Al-3810

    2. E-3810

    2.3.2 Depositor-Supplied Synonyms

    1. 1058137-23-7

    2. E-3810

    3. E-3810 Amine

    4. E-3810 Free Base

    5. Al-3810

    6. Pp449xa4bh

    7. 6-((7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-n-methyl-1-naphthamide

    8. Chebi:65209

    9. 6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-n-methylnaphthalene-1-carboxamide

    10. Co-3810

    11. S 80881

    12. S-80881

    13. 1-naphthalenecarboxamide, 6-((7-((1-aminocyclopropyl)methoxy)-6-methoxy-4-quinolinyl)oxy)-n-methyl-

    14. 6-((7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-n-methylnaphthalene-1-carboxamide

    15. 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-n-methyl-1-naphthamide

    16. Chembl2180605

    17. Lucitanib [inn]

    18. 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-n-methylnaphthalene-1-carboxamide

    19. Lucitanib [usan:inn]

    20. Unii-pp449xa4bh

    21. Lucitanib(e3810)

    22. E-3810; Lucitanib

    23. Lucitanib (usan/inn)

    24. Lucitanib [usan]

    25. Lucitanib [who-dd]

    26. Schembl381394

    27. Gtpl7649

    28. Chembl2220486

    29. E 3810;e3810;lucitanib

    30. Dtxsid30147356

    31. Amy24149

    32. Bcp05747

    33. Ex-a2052

    34. Bdbm50399539

    35. Nsc782762

    36. Nsc800786

    37. Zinc77024213

    38. Bcp9000632

    39. Cs-0782

    40. Db11845

    41. Nsc-782762

    42. Nsc-800786

    43. Sb16928

    44. 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-n-methyl-1-naphthamide

    45. Ncgc00378878-02

    46. Ncgc00378878-03

    47. Ac-35833

    48. As-82279

    49. Da-33429

    50. Hy-15391

    51. Ft-0704073

    52. D11762

    53. E-3810e-3810

    54. Q27082198

    55. 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxy-quinolin-4-yloxy)-n-methyl-1-naphthamide

    56. 3zc

    2.4 Create Date
    2008-11-17
    3 Chemical and Physical Properties
    Molecular Weight 443.5 g/mol
    Molecular Formula C26H25N3O4
    XLogP33.6
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count7
    Exact Mass443.18450629 g/mol
    Monoisotopic Mass443.18450629 g/mol
    Topological Polar Surface Area95.7 Ų
    Heavy Atom Count33
    Formal Charge0
    Complexity686
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1