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    Hetrombopag olamine

    PharmaCompass
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    2D Structure
    Also known as: Hetrombopag diolamine, 1257792-42-9, Shr8735 olamine, Hetrombopag ethanolamine, Shr-8735 olamine, V45t2i862x
    Molecular Formula
    C29H36N6O7
    Molecular Weight
    580.6  g/mol
    InChI Key
    RKEJRDZRWWDSRX-UHFFFAOYSA-N
    FDA UNII
    V45T2I862X
    Hetrombopag Olamine is the orally active ethanolamine salt of hetrombopag, a small-molecule, nonpeptide thrombopoietin receptor (TPO-R or CD110) agonist, with megakaryopoiesis-stimulating activity. Upon oral administration, hetrombopag targets, binds to and stimulates the transmembrane domain of the platelet TPO-R, a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. This may prevent or treat chemotherapy-induced thrombocytopenia.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    bis(2-aminoethanol);5-[2-hydroxy-3-[[5-methyl-3-oxo-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazol-4-yl]diazenyl]phenyl]furan-2-carboxylic acid
    2.1.2 InChI
    InChI=1S/C25H22N4O5.2C2H7NO/c1-14-22(24(31)29(28-14)17-10-9-15-5-2-3-6-16(15)13-17)27-26-19-8-4-7-18(23(19)30)20-11-12-21(34-20)25(32)33;2*3-1-2-4/h4,7-13,28,30H,2-3,5-6H2,1H3,(H,32,33);2*4H,1-3H2
    2.1.3 InChI Key
    RKEJRDZRWWDSRX-UHFFFAOYSA-N
    2.2 Other Identifiers
    2.2.1 UNII
    V45T2I862X
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. Hetrombopag Diolamine

    2. 1257792-42-9

    3. Shr8735 Olamine

    4. Hetrombopag Ethanolamine

    5. Shr-8735 Olamine

    6. V45t2i862x

    7. Unii-v45t2i862x

    8. (z)-5-(2-hydroxy-3-(2- (3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen- 2-yl)-1h-pyrazol-4(5h)-ylidene)hydrazinyl)phenyl) Furan-2-carboxylic Acid Diethanolamine

    9. Rafutrombopag Diolamine

    10. Rafutrombopag Olamine

    11. Orb1986927

    12. Schembl1706508

    13. Schembl1706884

    14. Schembl31679698

    15. Glxc-10341

    16. Hetrombopag Olamine [who-dd]

    17. Akos040748526

    18. Da-77338

    19. Q27291517

    20. 2-aminoethanol 5-{2-hydroxy-3-[5-methyl-3-oxo-2-(5,6,7,8-tetrahydro-naphthalen-2-yl)-2,3-dihydro-1h-pyrazol-4-ylazo]-phenyl}-furan-2-carboxylic Acid

    21. 2-aminoethanol;5-[2-hydroxy-3-[[5-methyl-3-oxo-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-1h-pyrazol-4-yl]diazenyl]phenyl]furan-2-carboxylic Acid

    2.4 Create Date
    2019-01-15
    3 Chemical and Physical Properties
    Molecular Weight 580.6 g/mol
    Molecular Formula C29H36N6O7
    Hydrogen Bond Donor Count7
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count7
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area220
    Heavy Atom Count42
    Formal Charge0
    Complexity870
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
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