Find Hetrombopag olamine manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Hetrombopag diolamine, 1257792-42-9, Shr8735 olamine, Hetrombopag ethanolamine, Shr-8735 olamine, V45t2i862x
Molecular Formula
C29H36N6O7
Molecular Weight
580.6  g/mol
InChI Key
RKEJRDZRWWDSRX-UHFFFAOYSA-N
FDA UNII
V45T2I862X

Hetrombopag olamine
Hetrombopag Olamine is the orally active ethanolamine salt of hetrombopag, a small-molecule, nonpeptide thrombopoietin receptor (TPO-R or CD110) agonist, with megakaryopoiesis-stimulating activity. Upon oral administration, hetrombopag targets, binds to and stimulates the transmembrane domain of the platelet TPO-R, a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. This may prevent or treat chemotherapy-induced thrombocytopenia.
1 2D Structure

Hetrombopag olamine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
bis(2-aminoethanol);5-[2-hydroxy-3-[[5-methyl-3-oxo-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazol-4-yl]diazenyl]phenyl]furan-2-carboxylic acid
2.1.2 InChI
InChI=1S/C25H22N4O5.2C2H7NO/c1-14-22(24(31)29(28-14)17-10-9-15-5-2-3-6-16(15)13-17)27-26-19-8-4-7-18(23(19)30)20-11-12-21(34-20)25(32)33;2*3-1-2-4/h4,7-13,28,30H,2-3,5-6H2,1H3,(H,32,33);2*4H,1-3H2
2.1.3 InChI Key
RKEJRDZRWWDSRX-UHFFFAOYSA-N
2.2 Other Identifiers
2.2.1 UNII
V45T2I862X
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Hetrombopag Diolamine

2. 1257792-42-9

3. Shr8735 Olamine

4. Hetrombopag Ethanolamine

5. Shr-8735 Olamine

6. V45t2i862x

7. Unii-v45t2i862x

8. (z)-5-(2-hydroxy-3-(2- (3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen- 2-yl)-1h-pyrazol-4(5h)-ylidene)hydrazinyl)phenyl) Furan-2-carboxylic Acid Diethanolamine

9. Rafutrombopag Diolamine

10. Rafutrombopag Olamine

11. Orb1986927

12. Schembl1706508

13. Schembl1706884

14. Schembl31679698

15. Glxc-10341

16. Hetrombopag Olamine [who-dd]

17. Akos040748526

18. Da-77338

19. Q27291517

20. 2-aminoethanol 5-{2-hydroxy-3-[5-methyl-3-oxo-2-(5,6,7,8-tetrahydro-naphthalen-2-yl)-2,3-dihydro-1h-pyrazol-4-ylazo]-phenyl}-furan-2-carboxylic Acid

21. 2-aminoethanol;5-[2-hydroxy-3-[[5-methyl-3-oxo-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-1h-pyrazol-4-yl]diazenyl]phenyl]furan-2-carboxylic Acid

2.4 Create Date
2019-01-15
3 Chemical and Physical Properties
Molecular Weight 580.6 g/mol
Molecular Formula C29H36N6O7
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count12
Rotatable Bond Count7
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area220
Heavy Atom Count42
Formal Charge0
Complexity870
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3

ABOUT THIS PAGE

Looking for 1257792-42-9 / Hetrombopag olamine API manufacturers, exporters & distributors?

Hetrombopag olamine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Hetrombopag olamine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Hetrombopag olamine manufacturer or Hetrombopag olamine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Hetrombopag olamine manufacturer or Hetrombopag olamine supplier.

API | Excipient name

Hetrombopag olamine

Synonyms

Hetrombopag diolamine, 1257792-42-9, Shr8735 olamine, Hetrombopag ethanolamine, Shr-8735 olamine, V45t2i862x

Cas Number

1257792-42-9

Unique Ingredient Identifier (UNII)

V45T2I862X

About Hetrombopag olamine

Hetrombopag Olamine is the orally active ethanolamine salt of hetrombopag, a small-molecule, nonpeptide thrombopoietin receptor (TPO-R or CD110) agonist, with megakaryopoiesis-stimulating activity. Upon oral administration, hetrombopag targets, binds to and stimulates the transmembrane domain of the platelet TPO-R, a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. This may prevent or treat chemotherapy-induced thrombocytopenia.

Hetrombopag olamine Manufacturers

A Hetrombopag olamine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hetrombopag olamine, including repackagers and relabelers. The FDA regulates Hetrombopag olamine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hetrombopag olamine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Hetrombopag olamine Suppliers

A Hetrombopag olamine supplier is an individual or a company that provides Hetrombopag olamine active pharmaceutical ingredient (API) or Hetrombopag olamine finished formulations upon request. The Hetrombopag olamine suppliers may include Hetrombopag olamine API manufacturers, exporters, distributors and traders.

Hetrombopag olamine GMP

Hetrombopag olamine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Hetrombopag olamine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Hetrombopag olamine GMP manufacturer or Hetrombopag olamine GMP API supplier for your needs.

Hetrombopag olamine CoA

A Hetrombopag olamine CoA (Certificate of Analysis) is a formal document that attests to Hetrombopag olamine's compliance with Hetrombopag olamine specifications and serves as a tool for batch-level quality control.

Hetrombopag olamine CoA mostly includes findings from lab analyses of a specific batch. For each Hetrombopag olamine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Hetrombopag olamine may be tested according to a variety of international standards, such as European Pharmacopoeia (Hetrombopag olamine EP), Hetrombopag olamine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hetrombopag olamine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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