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    Famitinib

    DEVELOPMENTS

    PharmaCompass
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    2D Structure
    Also known as: 1044040-56-3, Shr1020, Shr-1020, Famitinib, (z), 945380-27-8, Unii-768fw21j3l
    Molecular Formula
    C23H27FN4O2
    Molecular Weight
    410.5  g/mol
    InChI Key
    GKEYKDOLBLYGRB-LGMDPLHJSA-N
    FDA UNII
    768FW21J3L
    FAMITINIB is a small molecule drug with a maximum clinical trial phase of III (across all indications) and has 17 investigational indications.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-[2-(diethylamino)ethyl]-2-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-3-methyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4-one
    2.1.2 InChI
    InChI=1S/C23H27FN4O2/c1-4-27(5-2)10-11-28-9-8-19-21(23(28)30)14(3)20(25-19)13-17-16-12-15(24)6-7-18(16)26-22(17)29/h6-7,12-13,25H,4-5,8-11H2,1-3H3,(H,26,29)/b17-13-
    2.1.3 InChI Key
    GKEYKDOLBLYGRB-LGMDPLHJSA-N
    2.2 Other Identifiers
    2.2.1 UNII
    768FW21J3L
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 5-(2-(diethylamino)ethyl0-2-9(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl)-3-methyl-6,7-dihydro-1h-pyrrolo(3,2-c)pyridin-4(5h)-one

    2. Shr1020

    2.3.2 Depositor-Supplied Synonyms

    1. 1044040-56-3

    2. Shr1020

    3. Shr-1020

    4. Famitinib, (z)

    5. 945380-27-8

    6. Unii-768fw21j3l

    7. 768fw21j3l

    8. Famitinib [inn]

    9. Famitinib [who-dd]

    10. Chembl1278146

    11. Shr 1020

    12. 5-[2-(diethylamino)ethyl]-2-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-3-methyl-6,7-dihydro-1h-pyrrolo[3,2-c]pyridin-4-one

    13. Compound 9 [pmid: 21028894]

    14. Compound 9 (pmid: 21028894)

    15. (z)-5-(2-(diethylamino)ethyl)-2-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-3-methyl-6,7-dihydro-1h-pyrrolo(3,2-c)pyridin-4(5h)-one

    16. 4h-pyrrolo(3,2-c)pyridin-4-one, 5-(2-(diethylamino)ethyl)-2-((5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-1,5,6,7-tetrahydro-3-methyl-

    17. 4h-pyrrolo(3,2-c)pyridin-4-one, 5-(2-(diethylamino)ethyl)-2-((z)-(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-1,5,6,7-tetrahydro-3-methyl-

    18. 5-(2-(diethylamino)ethyl)-2-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-3-methyl-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one

    19. 5-(2-(diethylamino)ethyl0-2-9(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl)-3-methyl-6,7-dihydro-1h-pyrrolo(3,2-c)pyridin-4(5h)-one

    20. 5-(2-diethylaminoethyl)-2-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-3-methyl-6,7-dihydro-1h-pyrrolo[4,5-c]pyridin-4-one

    21. (3z)-3-((5-(2-(diethylamino)ethyl)-3-methyl-4-oxo-1h,4h,5h,6h,7h-pyrrolo(3,2-c)pyridin-2-yl)methylidene)-5-fluoro-2,3-dihydro-1h-indol-2-one

    22. (3z)-3-({5-[2-(diethylamino)ethyl]-3-methyl-4-oxo-1h,4h,5h,6h,7h-pyrrolo[3,2-c]pyridin-2-yl}methylidene)-5-fluoro-2,3-dihydro-1h-indol-2-one

    23. 5-(2-diethylaminoethyl)-2-((z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl)-3-methyl-6,7-dihydro-1h-pyrrolo(4,5-c)pyridin-4-one

    24. Famitinib (standard)

    25. Starbld0044024

    26. Famitinib (shr1020)

    27. Schembl137251

    28. Gtpl7886

    29. Ex-a6762

    30. Bdbm50331023

    31. Db11741

    32. Hy-108713r

    33. Da-63367

    34. Ms-27081

    35. Ns00072868

    36. G14485

    37. Q27077275

    38. (z)-2-(5-fluoro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-5-(2-diethylaminoethyl)-3-methyl-1,5,6,7-tetrahydropyrrolo-[3,2-c]pyridin-4-one

    39. (z)-5-(2-(diethylamino)ethyl)-2-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-3-methyl-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one

    2.4 Create Date
    2007-08-13
    3 Chemical and Physical Properties
    Molecular Weight 410.5 g/mol
    Molecular Formula C23H27FN4O2
    XLogP32.5
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count6
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area68.4
    Heavy Atom Count30
    Formal Charge0
    Complexity695
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
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