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    Delpazolid

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 1219707-39-7, Lcb01-0371, Lcb-01-0371, Lcb-010371, 43ep6xv33e, (5r)-3-[3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4-yl)phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
    Molecular Formula
    C14H17FN4O3
    Molecular Weight
    308.31  g/mol
    InChI Key
    QLUWQAFDTNAYPN-LLVKDONJSA-N
    FDA UNII
    43EP6XV33E
    Lcb01 0371 is under investigation in clinical trial NCT01554995 (A Clinical Study, Randomized, Double-blind, Placebo-controlled, Single Dose Study).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (5R)-3-[3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4-yl)phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
    2.1.2 InChI
    InChI=1S/C14H17FN4O3/c1-17-4-5-18(9-16-17)13-3-2-10(6-12(13)15)19-7-11(8-20)22-14(19)21/h2-3,6,9,11,20H,4-5,7-8H2,1H3/t11-/m1/s1
    2.1.3 InChI Key
    QLUWQAFDTNAYPN-LLVKDONJSA-N
    2.1.4 Canonical SMILES
    CN1CCN(C=N1)C2=C(C=C(C=C2)N3CC(OC3=O)CO)F
    2.1.5 Isomeric SMILES
    CN1CCN(C=N1)C2=C(C=C(C=C2)N3C[C@@H](OC3=O)CO)F
    2.2 Other Identifiers
    2.2.1 UNII
    43EP6XV33E
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Lcb01-0371

    2.3.2 Depositor-Supplied Synonyms

    1. 1219707-39-7

    2. Lcb01-0371

    3. Lcb-01-0371

    4. Lcb-010371

    5. 43ep6xv33e

    6. (5r)-3-[3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4-yl)phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one

    7. (5r)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1h)-yl)phenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one

    8. (5r)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one

    9. (r)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1h)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one

    10. 2-oxazolidinone, 3-(4-(5,6-dihydro-1-methyl-1,2,4-triazin-4(1h)-yl)-3-fluorophenyl)-5-(hydroxymethyl)-, (5r)-

    11. Unii-43ep6xv33e

    12. (5r)-3-[3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1h)-yl)phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one

    13. (5r)-3-[3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4-yl)phenyl]-5-(hydroxymethyl)oxazolidin-2-one

    14. Delpazolid [inn]

    15. Delpazolid [who-dd]

    16. Delpazolid (lcb01-0371)

    17. Chembl1673408

    18. Schembl11969210

    19. Gtpl10999

    20. Bcp25650

    21. Ex-a1715

    22. Db13077

    23. Lcb-01,0371

    24. Ac-33876

    25. Hy-100180

    26. Cs-0018175

    27. Q27258646

    2.4 Create Date
    2009-09-28
    3 Chemical and Physical Properties
    Molecular Weight 308.31 g/mol
    Molecular Formula C14H17FN4O3
    XLogP30.6
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count3
    Exact Mass308.12846858 g/mol
    Monoisotopic Mass308.12846858 g/mol
    Topological Polar Surface Area68.6 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity450
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    Protein Synthesis Inhibitors

    Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)