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Chemistry

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Also known as: 108-93-0, Cyclohexyl alcohol, Hexahydrophenol, 1-cyclohexanol, Hydrophenol, Hydroxycyclohexane
Molecular Formula
C6H12O
Molecular Weight
100.16  g/mol
InChI Key
HPXRVTGHNJAIIH-UHFFFAOYSA-N
FDA UNII
8E7S519M3P

Cyclohexanol
Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.
1 2D Structure

Cyclohexanol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
cyclohexanol
2.1.2 InChI
InChI=1S/C6H12O/c7-6-4-2-1-3-5-6/h6-7H,1-5H2
2.1.3 InChI Key
HPXRVTGHNJAIIH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CCC(CC1)O
2.2 Other Identifiers
2.2.1 UNII
8E7S519M3P
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cyclohexanols

2.3.2 Depositor-Supplied Synonyms

1. 108-93-0

2. Cyclohexyl Alcohol

3. Hexahydrophenol

4. 1-cyclohexanol

5. Hydrophenol

6. Hydroxycyclohexane

7. Hexalin

8. Hydralin

9. Adronal

10. Naxol

11. Adronol

12. Anol

13. Cykloheksanol

14. Cicloesanolo

15. Phenol, Hexahydro-

16. Cicloesanolo [italian]

17. Cykloheksanol [polish]

18. Cyclohexanone Cyclohexanol Mixture

19. Cyclohexan-1-ol

20. Nsc 403656

21. Mfcd00003855

22. Chebi:18099

23. 8e7s519m3p

24. Nsc-403656

25. Cxl

26. Cyclohexanols

27. Dsstox_cid_1894

28. Dsstox_rid_76390

29. Dsstox_gsid_21894

30. Hydroxycyclohexane; Nsc 403656; Nsc 54711; Naxol; Phenol, Hexahydro-

31. Cas-108-93-0

32. Hsdb 61

33. Ccris 5896

34. Einecs 203-630-6

35. Brn 0906744

36. Cylcohexanol

37. Unii-8e7s519m3p

38. Ai3-00040

39. Cyclohexyl-alcohol

40. Cyclohexane, Hydroxy-

41. Bdbm5

42. Cyanomethylthioacetic Acid

43. Cyclohexanol [mi]

44. Bmse000431

45. Wln: L6tj Aq

46. Cyclohexanol [hsdb]

47. Ec 203-630-6

48. Schembl5545

49. 4-06-00-00020 (beilstein Handbook Reference)

50. Mls001055343

51. Bidd:er0291

52. Chembl32010

53. Cyclohexanol, P.a., 99.0%

54. Dtxsid4021894

55. Cyclohexanol, Analytical Standard

56. Hms3039k08

57. Zinc1532765

58. Tox21_201481

59. Tox21_302803

60. Bbl013186

61. Cyclohexanol, Reagentplus(r), 99%

62. Nsc403656

63. Stl163965

64. Akos000119038

65. Zinc100502981

66. Db03703

67. Rp10050

68. Ncgc00090982-01

69. Ncgc00090982-02

70. Ncgc00256434-01

71. Ncgc00259032-01

72. Smr000677941

73. Cyclohexanol, Puriss., >=99.0% (gc)

74. Cyclohexanol, Saj First Grade, >=95.0%

75. Db-040851

76. Cs-0017198

77. Cyclohexanol, Jis Special Grade, >=98.0%

78. Ft-0624192

79. Ft-0641073

80. Cyclohexanol, Vetec(tm) Reagent Grade, 98%

81. C00854

82. Q423282

83. Q-200903

84. F0001-0184

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 100.16 g/mol
Molecular Formula C6H12O
XLogP31.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass100.088815002 g/mol
Monoisotopic Mass100.088815002 g/mol
Topological Polar Surface Area20.2 Ų
Heavy Atom Count7
Formal Charge0
Complexity46.1
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Absorption, Distribution and Excretion

The substance can be absorbed into the body by inhalation and by ingestion.

International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card on Cyclohexanol (November 1998). Available from, as of May 20, 2010: https://www.inchem.org/pages/icsc.html


Animal expt ... In large doses ... /cyclohexanol/ is readily absorbed from the skin ... .

Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 386


Following oral admin ... to rabbits, cmpd is excreted in urine in conjugation with sulfuric & glucuronic acids. Similar results were obtained when animals were subjected to repeated inhalation of cmpd.

Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4648


... Rabbits exposed to lowest concn ... 145 ppm cyclohexanol in air, showed no incr in conjugation of urinary sulfates but excreted 5 times normal amt glucuronic acid.

Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4648


... Incr in glucuronic acid in urine was paralleled by a decr in percentage of inorg sulfates. ... That the urinary sulfate ratio became normal when exposure ceased ... led ... to ... /conclusion/ that there was no prolonged retention in organism.

Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 386


4.2 Metabolism/Metabolites

Cyclohexane was hydroxylated to cyclohexanol by rat liver microsomes in presence of NADPH & oxygen. Pretreatment with phenobarbital at 80 mg/kg/day ip stimulated activity 6-fold, while benzopyrene pretreatment at 20 mg/kg ip lowered cyclohexane hydroxylation.

PMID:4388853 ULLRICH V; HOPPE-SEYLER'S Z PHYSIOL CHEM 350 (3): 357 (1969)


Cyclohexanol was identified as the urinary metabolite after admin of cyclohexylamine hydrochloride to rats, rabbits, & guinea pigs (50-500 mg/kg, orally or ip) and humans (25 or 200 mg, orally).

PMID:4655821 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174231 RENWICK AG, RT WILLIAMS; BIOCHEM J 129 (4): 857 (1972)


Fed to rabbits, /cyclohexanol/ ... Is mostly excreted as the glucuronide conjugate (60% of the dose), but a small amt is oxidized further into trans-cyclohexane-1,2-diol (6%).

Parke, D. V. The Biochemistry of Foreign Compounds. Oxford: Pergamon Press, 1968., p. 222


Hepatic NAD-dependent alcohol dehydrogenase ... is responsible for metabolism of ... cyclohexanol ...

Testa, B. and P. Jenner. Drug Metabolism: Chemical & Biochemical Aspects. New York: Marcel Dekker, Inc., 1976., p. 310


For more Metabolism/Metabolites (Complete) data for Cyclohexanol (8 total), please visit the HSDB record page.


4.3 Biological Half-Life

No reports found; [TDR, p. 430]

TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 430


ABOUT THIS PAGE

Looking for 108-93-0 / Cyclohexanol API manufacturers, exporters & distributors?

Cyclohexanol manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Cyclohexanol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cyclohexanol manufacturer or Cyclohexanol supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cyclohexanol manufacturer or Cyclohexanol supplier.

PharmaCompass also assists you with knowing the Cyclohexanol API Price utilized in the formulation of products. Cyclohexanol API Price is not always fixed or binding as the Cyclohexanol Price is obtained through a variety of data sources. The Cyclohexanol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Cyclohexanol

Synonyms

108-93-0, Cyclohexyl alcohol, Hexahydrophenol, 1-cyclohexanol, Hydrophenol, Hydroxycyclohexane

Cas Number

108-93-0

Unique Ingredient Identifier (UNII)

8E7S519M3P

About Cyclohexanol

Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.

Cyclohexanol Manufacturers

A Cyclohexanol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cyclohexanol, including repackagers and relabelers. The FDA regulates Cyclohexanol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cyclohexanol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cyclohexanol Suppliers

A Cyclohexanol supplier is an individual or a company that provides Cyclohexanol active pharmaceutical ingredient (API) or Cyclohexanol finished formulations upon request. The Cyclohexanol suppliers may include Cyclohexanol API manufacturers, exporters, distributors and traders.

click here to find a list of Cyclohexanol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cyclohexanol USDMF

A Cyclohexanol DMF (Drug Master File) is a document detailing the whole manufacturing process of Cyclohexanol active pharmaceutical ingredient (API) in detail. Different forms of Cyclohexanol DMFs exist exist since differing nations have different regulations, such as Cyclohexanol USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Cyclohexanol DMF submitted to regulatory agencies in the US is known as a USDMF. Cyclohexanol USDMF includes data on Cyclohexanol's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cyclohexanol USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Cyclohexanol suppliers with USDMF on PharmaCompass.

Cyclohexanol GMP

Cyclohexanol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cyclohexanol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cyclohexanol GMP manufacturer or Cyclohexanol GMP API supplier for your needs.

Cyclohexanol CoA

A Cyclohexanol CoA (Certificate of Analysis) is a formal document that attests to Cyclohexanol's compliance with Cyclohexanol specifications and serves as a tool for batch-level quality control.

Cyclohexanol CoA mostly includes findings from lab analyses of a specific batch. For each Cyclohexanol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cyclohexanol may be tested according to a variety of international standards, such as European Pharmacopoeia (Cyclohexanol EP), Cyclohexanol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cyclohexanol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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