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    Symbiotica delivers high-quality APIs through advanced R&D, GMP-certified manufacturing, & trusted global pharmaceutical partnerships.

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    About

    Symbiotica is a Malaysia-based manufacturer of high-quality Active Pharmaceutical Ingredients (APIs), specialising in steroidal, hormonal, and niche non-steroidal compounds for global pharmaceutical markets. With over 25 years of industry expertise, we serve 250+ clients across 80+ countries through PIC/S GMP, USFDA, PMDA certified facilities. Our tailored API solutions are driven by strong R&D, stringent quality systems, and regulatory compliance, delivering reliable and innovative pharmaceutical solutions worldwide. Note: Product(s) under patent(s) are offered only for R&D purposes as per the Patent Act & not for commercial sale.

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    Symbiotica Speciality Ingredients Sdn BhdMalaysia Flag
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    Country
    Malaysia
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    13, Lorong Perusahaan Sg. Lokan 2,Taman Industri Sg. Lokan,13800, Butterworth,...
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    Telephone
    +604-518 9000
    Client Email
    Email
    symbioti@symbiotica.com.my
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    Website
    http://www.symbiotica.com.my
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    https://www.linkedin.com/company/symbioticasi/
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    http://www.youtube.com/@SymbioticaAPI
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    Product List 2026

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    DATA COMPILATION #PharmaFlow

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    Chinese FDA-registered generic facilities gain steam, India maintains lead with 396 facilities

    Chinese FDA-registered generic facilities gain steam, India maintains lead with 396 facilities

    Every year, the US Food and Drug Administration (FDA) publishes the user fee amounts it will collect from manufacturers of pharmaceuticals, generic drugs, biosimilars and medical devices in the coming financial year. The fee for fiscal year 2025 under the Generic Drug User Fee Act (GDUFA) was published on July 31, 2024.The GDUFA, established in 2012, authorizes FDA to assess and collect fees from drug manufacturers to expedite the delivery of safe, high-quality, and affordable generic drugs to the American public.The FDA’s facility payments list under GDUFA reveals that as of November 14, 2024, 1,397 facilities had paid their registration fees for financial year 2025. Of these facilities, 707 or 50.6 percent are active pharmaceutical ingredients (API) facilities, 405 or 29 percent are finished dosage forms (FDF) facilities, 69 (4.9 percent) are facilities that produce both APIs and FDFs, and 216 (15.5 percent) are contract manufacturing services (CMO) sites.Teva Pharmaceuticals, with 29 facility registrations, led the list of companies, followed by Aurobindo Pharma, Sun Pharma, and Dr. Reddy's Laboratories. Fiscal year Facility Registrations 2016 1,425 2017 1,442 2018 1,269 2019 1,286 2020 1,300 2021 1,340 2022 1,385 2023 1,394 2024 1,447 2025 1,397  Generic Drug Facilities Registered with the US FDA for FY2025 (Free Excel Available)India continues to lead with 396 facilities, US and China follow India maintains its dominance in total facility registrations with the FDA, registering 396 facilities for FY2025. This includes 214 API facilities, 135 FDF facilities, 21 facilities engaged in both API and FDF activities, and 26 CMO facilities.The United States holds the second position with 328 facilities, while China strengthened its third position with 197 facilities.With 214 API facilities, India continues to have the largest share of API manufacturing sites, outmatching the combined total of China (128) and the US (83), which together account for 211 facilities. Among European manufacturers, Italy leads with 59 API manufacturing sites, followed by Spain (30) and Germany (25).The US has maintained its lead in FDF facilities with 143 sites, followed closely by India with 135 sites and China with 45 sites. Country API FDF Both CMO Total India 214 135 21 26 396 US 83 143 13 89 328 China 128 45 12 12 197 Italy 59 3 2 19 83 Germany 25 4 1 15 45 Spain 30 9 1 4 44 Canada 7 17   13 37 Taiwan 9 6 5 4 24 Switzerland 15 4   4 23 France 16     6 22 Japan 18   1   19 United Kingdom 12 1   2 15 Mexico 9 1   1 11 Ireland 5 5   1 11   Generic Drug Facilities Registered with the US FDA for FY2025 (Free Excel Available) GDUFA III user fee rates increase across categories for FY25The GDUFA, which was reauthorized on September 30, 2022 (as GDUFA III), continues with provisions that will last until September 30, 2027. In July 2024, the FDA published updated user fee rates for FY2025.The facility fees have seen increases across all categories. API facility fees increased by 3 percent for domestic sites (to US$ 41,580) and 2 percent for foreign sites (to US$ 56,580). FDF facility fees rose by 5 percent for both domestic (to US$ 231,952) and foreign sites (to US$ 246,952). CMO facility fees increased by 5 percent for domestic sites (to US$ 55,668) and 4 percent for foreign sites (to US$ 70,668).Additionally, the fee for large-, medium- and small-sized drug applicants has increased by over 9 percent, compared to the 7 percent increase seen in 2023. Generic Drug Facilities Registered with the US FDA for FY2025 (Free Excel Available) China leads new facility registrations as FDA records 41 new units in FY25Out of the total 1,397 facilities registered for FY2025, 41 were new registrations (going by Facility FDA Establishment Identifier numbers). China led the way with 13 new facilities, followed closely by India with 11 new facilities, while the US secured the third position with eight new facilities.The new registrations included 15 API facilities, 13 CMO facilities, 12 FDF facilities, and one facility engaged in both API and FDF activities. Chinese companies dominated the new FDF registrations with six facilities: Chengdu Shuode Pharma, Chengdu Suncadia Medicine, Cipla (Jiangsu), GE Healthcare (Shanghai), Luoxin Aurovitas Pharma (Chengdu), and Zhejiang Xianju Pharma.India added two new FDF facilities through Eugia Steriles and Zydus Pharma. Malaysia registered two FDF facilities through Novugen Pharma and Novugen Oncology, while Turkey’s Insud Pharma subsidiary Exeltis and US’ RK Pharma registered one FDF facility each.The 13 new CMO facilities included, Acme Generics, Emcure, Esjay Pharma, Fordoz Pharma, Fourrts Laboratories, Laboratoires KABS, PharmaMax, Quality Packaging Specialists International, Ritsa Pharma, Shanghai Aucyun Pharma, Sichuan Huiyu Pharma, Taejoon Pharm, and Tubilux Pharma.In the API category, the 15 new registrations included Acharya Chemicals, Hainan Poly Pharma, CBL Patras, EUROAPI, Hybio Pharma, Medilux Laboratories, Metrochem API, Purolite, Chengdu Easton Biopharma, Sionc Pharma, Smithfield Bioscience, Xttrium Laboratories, Zhejiang Hengkang Pharma, Moehs Iberica and Shilpa Pharma. Armstrong Pharmaceuticals registered the sole facility for both APIs and FDFs.So far, 92 facilities have not renewed their registration. Among these was a facility owned by Sandoz subsidiary Eon Labs in Wilson, North Carolina (US), which is permanently closed. In fact, the geographical distribution of non-renewals shows that 30 facilities were from the US, while India and China accounted for 14 and nine non-renewals respectively. Generic Drug Facilities Registered with the US FDA for FY2025 (Free Excel Available) Our viewThe FY 2025 GDUFA facility registration data indicates a continued strong presence of Indian manufacturers in the US generic drug market, particularly in API production. However, China's leadership in new facility registrations, especially in FDF manufacturing, suggests that the global generic drug supply chain landscape may evolve considerably in the coming years. 
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    USDMF

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    Symbiotica Speciality Ingredients Sdn Bhd

    GDUFA

    DMF Review : N/A

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    DMF Number : 24486

    Submission : 2010-10-12

    Status : Active

    Type : II

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    Clobetasol Propionate

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    GDUFA

    DMF Review : N/A

    Rev. Date :

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    DMF Number : 24015

    Submission : 2010-07-23

    Status : Active

    Type : II

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    Dexamethasone Sodium Phosphate

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    GDUFA

    DMF Review : Complete

    Rev. Date : 2024-11-21

    Pay. Date : 2023-09-21

    DMF Number : 24215

    Submission : 2010-09-22

    Status : Active

    Type : II

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    GDUFA

    DMF Review : N/A

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    DMF Number : 25275

    Submission : 2011-07-25

    Status : Active

    Type : II

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    Halobetasol Propionate

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    GDUFA

    DMF Review : N/A

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    DMF Number : 30906

    Submission : 2016-08-22

    Status : Active

    Type : II

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    Hydrocortisone Valerate Usp

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    Symbiotica Speciality Ingredients Sdn Bhd

    GDUFA

    DMF Review : Complete

    Rev. Date : 2017-11-07

    Pay. Date : 2017-06-05

    DMF Number : 31423

    Submission : 2017-02-01

    Status : Active

    Type : II

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    Mometasone Furoate

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    GDUFA

    DMF Review : Complete

    Rev. Date : 2020-09-09

    Pay. Date : 2020-01-31

    DMF Number : 26153

    Submission : 2012-06-01

    Status : Active

    Type : II

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    CEP/COS

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    Symbiotica Speciality Ingredients Sdn Bhd

    Certificate Numbers : CEP 2011-005 - Rev 02

    Status : Valid

    Issue Date : 2024-12-23

    Type : Chemical

    Substance Number : 809

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    Betamethasone sodium phosphate

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    Symbiotica Speciality Ingredients Sdn Bhd

    Certificate Numbers : R1-CEP 2013-326 - Rev 00

    Status : Valid

    Issue Date : 2020-10-27

    Type : Chemical

    Substance Number : 810

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    Betamethasone valerate

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    Symbiotica Speciality Ingredients Sdn Bhd

    Certificate Numbers : R1-CEP 2008-215 - Rev 00

    Status : Valid

    Issue Date : 2015-06-26

    Type : Chemical

    Substance Number : 811

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    Clobetasol propionate

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    Symbiotica Speciality Ingredients Sdn Bhd

    Certificate Numbers : R1-CEP 2009-221 - Rev 00

    Status : Valid

    Issue Date : 2015-10-19

    Type : Chemical

    Substance Number : 2127

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    Dexamethasone sodium phosphate

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    Symbiotica Speciality Ingredients Sdn Bhd

    Certificate Numbers : R1-CEP 2006-184 - Rev 00

    Status : Valid

    Issue Date : 2013-10-03

    Type : Chemical

    Substance Number : 549

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    Symbiotica Speciality Ingredients Sdn Bhd

    Certificate Numbers : R1-CEP 2016-116 - Rev 00

    Status : Valid

    Issue Date : 2023-08-01

    Type : Chemical

    Substance Number : 2766

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    Mometasone furoate

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    Certificate Numbers : R1-CEP 2009-313 - Rev 01

    Status : Valid

    Issue Date : 2018-10-11

    Type : Chemical

    Substance Number : 1449

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    Mometasone furoate monohydrate

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    Symbiotica Speciality Ingredients Sdn Bhd

    Certificate Numbers : R0-CEP 2021-006 - Rev 00

    Status : Valid

    Issue Date : 2022-02-08

    Type : Chemical

    Substance Number : 2858

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    Prednicarbate

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    Symbiotica Speciality Ingredients Sdn Bhd

    Certificate Numbers : CEP 2024-038 - Rev 00

    Status : Valid

    Issue Date : 2026-03-17

    Type : Chemical

    Substance Number : 1467

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    Prednisolone acetate

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    Symbiotica Speciality Ingredients Sdn Bhd

    Certificate Numbers : R1-CEP 2014-138 - Rev 00

    Status : Valid

    Issue Date : 2022-06-20

    Type : Chemical

    Substance Number : 734

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    Symbiotica Speciality Ingredients Sdn Bhd is a supplier offers 67 products (APIs, Excipients or Intermediates).

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