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Chemistry

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Also known as: 638-94-8, Prednacinolone, Locapred, Desowen, Desonate, Topifug
Molecular Formula
C24H32O6
Molecular Weight
416.5  g/mol
InChI Key
WBGKWQHBNHJJPZ-LECWWXJVSA-N
FDA UNII
J280872D1O

Desonide
A nonfluorinated corticosteroid anti-inflammatory agent used topically for DERMATOSES.
Desonide is a Corticosteroid. The mechanism of action of desonide is as a Corticosteroid Hormone Receptor Agonist.
1 2D Structure

Desonide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
2.1.2 InChI
InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1
2.1.3 InChI Key
WBGKWQHBNHJJPZ-LECWWXJVSA-N
2.1.4 Canonical SMILES
CC1(OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C)C
2.1.5 Isomeric SMILES
C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)CCC5=CC(=O)C=C[C@]35C)O
2.2 Other Identifiers
2.2.1 UNII
J280872D1O
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Desocort

2. Desone

3. Desowen

4. Locapred

5. Locatop

6. Prednacinolone

7. Tridsonit

8. Tridesilon

2.3.2 Depositor-Supplied Synonyms

1. 638-94-8

2. Prednacinolone

3. Locapred

4. Desowen

5. Desonate

6. Topifug

7. Desonida

8. Desonidum

9. Tridesilon

10. Apolar

11. Verdeso

12. D-2083

13. Steroderm

14. Sterax

15. Desfluorotriamcinolone Acetonide

16. 16alpha-hydroxyprednisole-16,17-acetonide

17. Tridesonit

18. D2083

19. Desilux

20. 16alpha,17alpha-isopropylidenedioxyprednisolone

21. Chebi:204734

22. 16alpha-hydroxyprednisolone-16alpha,17-acetonide

23. J280872d1o

24. Nsc-759226

25. Hamiltoderm

26. Flusemidon

27. Reticus

28. Zotinar

29. 11beta,21-dihydroxy-16alpha,17-isopropylidenedioxypregna-1,4-diene-3,20-dione

30. 11beta,21-dihydroxy-16alpha,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

31. 11beta,21-dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione

32. Dsstox_cid_26756

33. Dsstox_rid_81880

34. Dsstox_gsid_46756

35. (1s,2s,4r,8s,9s,11s,12s,13r)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one

36. D 2083

37. Desonidum [inn-latin]

38. Desonida [inn-spanish]

39. Desonide [usan:inn:ban]

40. Cas-638-94-8

41. Desowen (tn)

42. Verdeso (tn)

43. Mfcd00866151

44. 16-alpha-hydroxyprednisole-16,17-acetonide

45. Unii-j280872d1o

46. Ncgc00167983-01

47. Ncgc00274065-01

48. Einecs 211-351-6

49. Desonide (usp/inn)

50. Desonide [usan]

51. Desonide [inn]

52. Desonide [mi]

53. Desonide [vandf]

54. Desonide [mart.]

55. Desonide [usp-rs]

56. Desonide [who-dd]

57. Schembl3631

58. 11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-acetal With Acetone

59. Desonide [orange Book]

60. Gtpl7066

61. Desonide [usp Impurity]

62. Chembl1201109

63. Desonide [usp Monograph]

64. Dtxsid7046756

65. Hms3715p20

66. 11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-acetal With Acetone

67. Bcp04201

68. Hy-b0248

69. Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11.beta.,16.alpha.)-

70. Tridesilon Component Desonide

71. Zinc4212851

72. Tox21_112603

73. 16alpha-hydroxyprednisolone Acetonide

74. S1701

75. Akos037643323

76. Tox21_112603_1

77. Ccg-221279

78. Db01260

79. Desonide Component Of Tridesilon

80. Nsc 759226

81. (4ar,4bs,5s,6as,6bs,9ar,10as,10bs)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2h-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

82. As-13892

83. Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-

84. Budesonide Impurity F [ep Impurity]

85. D5578

86. D03696

87. F20496

88. Ab01274712-01

89. Ab01274712_02

90. 638d948

91. Prednisolone-16,17-acetonide, 16-alpha-hydroxy-

92. Q904011

93. Q-101382

94. Brd-k21528677-001-03-6

95. 16?,17-[1-methylethylidenebis(oxy)]-11?,21-dihydroxypregna-1,4-diene-3,20-dione

96. (11beta,16alpha)-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna -1,4-diene-3,20-dione

97. (1s,2s,4r,8s,9s,11s,12s,13r)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

98. 16alpha,17-[1-methylethylidenebis(oxy)]-11beta,21-dihydroxypregna-1,4-diene-3,20-dione (desonide)

2.4 Create Date
2005-12-16
3 Chemical and Physical Properties
Molecular Weight 416.5 g/mol
Molecular Formula C24H32O6
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass416.21988874 g/mol
Monoisotopic Mass416.21988874 g/mol
Topological Polar Surface Area93.1 Ų
Heavy Atom Count30
Formal Charge0
Complexity873
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 8  
Drug NameDesonate
PubMed HealthDesonide (On the skin)
Drug ClassesCorticosteroid, Strong
Drug LabelDesonate contains desonide [(pregna-1, 4-diene-3, 20-dione,11, 21-dihydroxy-16, 17-[(1-methylethylidene) bis(oxy)]-,(11,16)]- a synthetic nonfluorinated corticosteroid for topical dermatologic use. Chemically, desonide is C24H32O6. It has the fol...
Active IngredientDesonide
Dosage FormGel
RouteTopical
Strength0.05%
Market StatusPrescription
CompanyBayer Hlthcare

2 of 8  
Drug NameDesonide
Drug LabelVERDESO Foam is a white to off-white petrolatum-based emulsion aerosol foam containing the active ingredient desonide, a low-potency topical corticosteroid.Chemically, desonide is (11,16)-11,21-dihydroxy-16,17-[(1-methylethylidene)-bis(oxy)]-pregna-1...
Active IngredientDesonide
Dosage FormLotion; Ointment; Cream
RouteTopical
Strength0.05%
Market StatusPrescription
CompanyFougera Pharms; Perrigo New York; Taro

3 of 8  
Drug NameDesowen
Drug LabelDesOwen Cream 0.05%, Ointment 0.05%, and Lotion 0.05% contain desonide (Pregna-1,4-diene-3,20-dione,11,21-dihydroxy-16,17 [(1methylethylidene) bis(oxy)]-,(11,16)- a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corti...
Active IngredientDesonide
Dosage FormLotion; Ointment; Cream
RouteTopical
Strength0.05%
Market StatusPrescription
CompanyGalderma Labs

4 of 8  
Drug NameVerdeso
PubMed HealthDesonide (On the skin)
Drug ClassesCorticosteroid, Strong
Drug LabelVERDESO Foam is a white to off-white petrolatum-based emulsion aerosol foam containing the active ingredient desonide, a low-potency topical corticosteroid.Chemically, desonide is (11,16)-11,21-dihydroxy-16,17-[(1-methylethylidene)-bis(oxy)]-pregna-1...
Active IngredientDesonide
Dosage FormAerosol, foam
RouteTopical
Strength0.05%
Market StatusPrescription
CompanyAqua Pharms

5 of 8  
Drug NameDesonate
PubMed HealthDesonide (On the skin)
Drug ClassesCorticosteroid, Strong
Drug LabelDesonate contains desonide [(pregna-1, 4-diene-3, 20-dione,11, 21-dihydroxy-16, 17-[(1-methylethylidene) bis(oxy)]-,(11,16)]- a synthetic nonfluorinated corticosteroid for topical dermatologic use. Chemically, desonide is C24H32O6. It has the fol...
Active IngredientDesonide
Dosage FormGel
RouteTopical
Strength0.05%
Market StatusPrescription
CompanyBayer Hlthcare

6 of 8  
Drug NameDesonide
Drug LabelVERDESO Foam is a white to off-white petrolatum-based emulsion aerosol foam containing the active ingredient desonide, a low-potency topical corticosteroid.Chemically, desonide is (11,16)-11,21-dihydroxy-16,17-[(1-methylethylidene)-bis(oxy)]-pregna-1...
Active IngredientDesonide
Dosage FormLotion; Ointment; Cream
RouteTopical
Strength0.05%
Market StatusPrescription
CompanyFougera Pharms; Perrigo New York; Taro

7 of 8  
Drug NameDesowen
Drug LabelDesOwen Cream 0.05%, Ointment 0.05%, and Lotion 0.05% contain desonide (Pregna-1,4-diene-3,20-dione,11,21-dihydroxy-16,17 [(1methylethylidene) bis(oxy)]-,(11,16)- a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corti...
Active IngredientDesonide
Dosage FormLotion; Ointment; Cream
RouteTopical
Strength0.05%
Market StatusPrescription
CompanyGalderma Labs

8 of 8  
Drug NameVerdeso
PubMed HealthDesonide (On the skin)
Drug ClassesCorticosteroid, Strong
Drug LabelVERDESO Foam is a white to off-white petrolatum-based emulsion aerosol foam containing the active ingredient desonide, a low-potency topical corticosteroid.Chemically, desonide is (11,16)-11,21-dihydroxy-16,17-[(1-methylethylidene)-bis(oxy)]-pregna-1...
Active IngredientDesonide
Dosage FormAerosol, foam
RouteTopical
Strength0.05%
Market StatusPrescription
CompanyAqua Pharms

4.2 Drug Indication

For the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatose.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Desonide is a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents.


5.2 MeSH Pharmacological Classification

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
DESONIDE
5.3.2 FDA UNII
J280872D1O
5.3.3 Pharmacological Classes
Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]
5.4 ATC Code

D07AB08

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


D - Dermatologicals

D07 - Corticosteroids, dermatological preparations

D07A - Corticosteroids, plain

D07AB - Corticosteroids, moderately potent (group ii)

D07AB08 - Desonide


S - Sensory organs

S01 - Ophthalmologicals

S01B - Antiinflammatory agents

S01BA - Corticosteroids, plain

S01BA11 - Desonide


5.5 Absorption, Distribution and Excretion

Absorption

Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin may increase percutaneous absorption.


5.6 Mechanism of Action

Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The drug binds to cytosolic glucocorticoid receptors. This complex migrates to the nucleus and binds to genetic elements on the DNA. This activates and represses various genes. However corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.


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04-Jan-2022
23-Jul-2025
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DOSAGE - CREAM;TOPICAL - 0.05%

USFDA APPLICATION NUMBER - 17010

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DOSAGE - OINTMENT;TOPICAL - 0.05%

USFDA APPLICATION NUMBER - 17426

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DOSAGE - GEL;TOPICAL - 0.05% **Federal Regist...DOSAGE - GEL;TOPICAL - 0.05% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21844

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ABOUT THIS PAGE

Looking for 638-94-8 / Desonide API manufacturers, exporters & distributors?

Desonide manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Desonide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Desonide manufacturer or Desonide supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Desonide manufacturer or Desonide supplier.

PharmaCompass also assists you with knowing the Desonide API Price utilized in the formulation of products. Desonide API Price is not always fixed or binding as the Desonide Price is obtained through a variety of data sources. The Desonide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Desonide

Synonyms

638-94-8, Prednacinolone, Locapred, Desowen, Desonate, Topifug

Cas Number

638-94-8

Unique Ingredient Identifier (UNII)

J280872D1O

About Desonide

A nonfluorinated corticosteroid anti-inflammatory agent used topically for DERMATOSES.

Desonide Manufacturers

A Desonide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Desonide, including repackagers and relabelers. The FDA regulates Desonide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Desonide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Desonide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Desonide Suppliers

A Desonide supplier is an individual or a company that provides Desonide active pharmaceutical ingredient (API) or Desonide finished formulations upon request. The Desonide suppliers may include Desonide API manufacturers, exporters, distributors and traders.

click here to find a list of Desonide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Desonide USDMF

A Desonide DMF (Drug Master File) is a document detailing the whole manufacturing process of Desonide active pharmaceutical ingredient (API) in detail. Different forms of Desonide DMFs exist exist since differing nations have different regulations, such as Desonide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Desonide DMF submitted to regulatory agencies in the US is known as a USDMF. Desonide USDMF includes data on Desonide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Desonide USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Desonide suppliers with USDMF on PharmaCompass.

Desonide WC

A Desonide written confirmation (Desonide WC) is an official document issued by a regulatory agency to a Desonide manufacturer, verifying that the manufacturing facility of a Desonide active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Desonide APIs or Desonide finished pharmaceutical products to another nation, regulatory agencies frequently require a Desonide WC (written confirmation) as part of the regulatory process.

click here to find a list of Desonide suppliers with Written Confirmation (WC) on PharmaCompass.

Desonide NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Desonide as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Desonide API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Desonide as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Desonide and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Desonide NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Desonide suppliers with NDC on PharmaCompass.

Desonide GMP

Desonide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Desonide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Desonide GMP manufacturer or Desonide GMP API supplier for your needs.

Desonide CoA

A Desonide CoA (Certificate of Analysis) is a formal document that attests to Desonide's compliance with Desonide specifications and serves as a tool for batch-level quality control.

Desonide CoA mostly includes findings from lab analyses of a specific batch. For each Desonide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Desonide may be tested according to a variety of international standards, such as European Pharmacopoeia (Desonide EP), Desonide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Desonide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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