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Chemistry

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Also known as: Vosaroxin, 175414-77-4, Sns-595, Ag-7352, Ag 7352, Spc-595
Molecular Formula
C18H19N5O4S
Molecular Weight
401.4  g/mol
InChI Key
XZAFZXJXZHRNAQ-STQMWFEESA-N
FDA UNII
K6A90IIZ19

Vosaroxin
Vosaroxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, hence reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure.
1 2D Structure

Vosaroxin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,8-naphthyridine-3-carboxylic acid
2.1.2 InChI
InChI=1S/C18H19N5O4S/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26)/t12-,13-/m0/s1
2.1.3 InChI Key
XZAFZXJXZHRNAQ-STQMWFEESA-N
2.1.4 Canonical SMILES
CNC1CN(CC1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O
2.1.5 Isomeric SMILES
CN[C@H]1CN(C[C@@H]1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
K6A90IIZ19
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1,4-dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid

2. Ag 7352

3. Ag-7352

4. Ag7352

5. Sns-595

6. Vosaroxin

2.3.2 Depositor-Supplied Synonyms

1. Vosaroxin

2. 175414-77-4

3. Sns-595

4. Ag-7352

5. Ag 7352

6. Spc-595

7. Vosaroxin (usan)

8. Vosaroxin [usan]

9. K6a90iiz19

10. 7-((3s,4s)-3-methoxy-4-(methylamino)pyrrolidin-1-yl)-4-oxo-1-(thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid

11. Quinprezo

12. 174726-60-4

13. 7-((3s,4s)-3-methoxy-4-(methylamino)pyrrolidin-1-yl)-4-oxo-1-(thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid.

14. Trans-7-(3-methoxy-4-(methylamino)pyrrolidin-1-yl)-4-oxo-1-(thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid

15. Sns 595

16. Spc 595

17. Vosaroxin [usan:inn]

18. Unii-k6a90iiz19

19. 7-[(3s,4s)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,8-naphthyridine-3-carboxylic Acid

20. Ag7352

21. 1,4-dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid

22. Vosaroxin [inn]

23. (+)-ag-7352

24. Vosaroxin [mart.]

25. Vosaroxin [who-dd]

26. Chembl68117

27. Schembl674441

28. Dtxsid50938662

29. Ex-a847

30. Voreloxin;sns-595;ag 7352

31. Mfcd13185156

32. Nsc760764

33. Zinc26186622

34. Akos030526660

35. Cs-0790

36. Db11999

37. Nsc-760764

38. Ac-36005

39. Hy-10534

40. Vosaroxin Hydrochloride, >=98% (hplc)

41. Sw219924-1

42. D08024

43. A911613

44. J-690243

45. Q18395775

46. (+)-7-((3s,4s)-3-methoxy-4-(methylamino)pyrrolidin-1-yl)-4-oxo-1-(thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid

47. (+)-7-[3(s)-methoxy-4(s)-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(2-thiazolyl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid

48. 1,8-naphthyridine-3-carboxylic Acid, 1,4-dihydro-7-((3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-

49. 1,8-naphthyridine-3-carboxylic Acid, 1,4-dihydro-7-(3-methoxy-4-(methylamino)-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-, (3s-trans)-

50. 7-[(3s,4s)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic Acid

51. 960398-99-6

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 401.4 g/mol
Molecular Formula C18H19N5O4S
XLogP3-0.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Exact Mass401.11577528 g/mol
Monoisotopic Mass401.11577528 g/mol
Topological Polar Surface Area136 Ų
Heavy Atom Count28
Formal Charge0
Complexity662
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of acute myeloid leukaemia


5 Pharmacology and Biochemistry
5.1 ATC Code

L - Antineoplastic and immunomodulating agents

L01 - Antineoplastic agents

L01X - Other antineoplastic agents

L01XX - Other antineoplastic agents

L01XX53 - Vosaroxin


ABOUT THIS PAGE

Looking for 175414-77-4 / Vosaroxin API manufacturers, exporters & distributors?

Vosaroxin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Vosaroxin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Vosaroxin manufacturer or Vosaroxin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vosaroxin manufacturer or Vosaroxin supplier.

PharmaCompass also assists you with knowing the Vosaroxin API Price utilized in the formulation of products. Vosaroxin API Price is not always fixed or binding as the Vosaroxin Price is obtained through a variety of data sources. The Vosaroxin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Vosaroxin

Synonyms

175414-77-4, Sns-595, Ag-7352, Ag 7352, Spc-595, Vosaroxin (usan)

Cas Number

175414-77-4

Unique Ingredient Identifier (UNII)

K6A90IIZ19

About Vosaroxin

Vosaroxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, hence reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure.

Vosaroxin Manufacturers

A Vosaroxin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vosaroxin, including repackagers and relabelers. The FDA regulates Vosaroxin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vosaroxin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Vosaroxin Suppliers

A Vosaroxin supplier is an individual or a company that provides Vosaroxin active pharmaceutical ingredient (API) or Vosaroxin finished formulations upon request. The Vosaroxin suppliers may include Vosaroxin API manufacturers, exporters, distributors and traders.

Vosaroxin GMP

Vosaroxin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vosaroxin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vosaroxin GMP manufacturer or Vosaroxin GMP API supplier for your needs.

Vosaroxin CoA

A Vosaroxin CoA (Certificate of Analysis) is a formal document that attests to Vosaroxin's compliance with Vosaroxin specifications and serves as a tool for batch-level quality control.

Vosaroxin CoA mostly includes findings from lab analyses of a specific batch. For each Vosaroxin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vosaroxin may be tested according to a variety of international standards, such as European Pharmacopoeia (Vosaroxin EP), Vosaroxin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vosaroxin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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