Find Vilaprisan manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 1262108-14-4, Vilaprisan [inn], Bay1002670, In59k53gi9, Bay-1002670, (8s,11r,13s,14s,17s)-17-hydroxy-13-methyl-11-(4-methylsulfonylphenyl)-17-(1,1,2,2,2-pentafluoroethyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Molecular Formula
C27H29F5O4S
Molecular Weight
544.6  g/mol
InChI Key
JUFWQQVHQFDUOD-ANRPBIDPSA-N
FDA UNII
IN59K53GI9

Vilaprisan
Vilaprisan is an orally available progestin and selective progesterone receptor modulator (SPRM), with potential anti-progesterone and antineoplastic activities. Upon oral administration, vilaprisan competitively binds to the progesterone receptor (PR) in progesterone-responsive tissue and inhibits PR-mediated gene expression. This interferes with progesterone activity in the reproductive system and may inhibit PR-mediated proliferative effects in cells overexpressing PRs. As a result, this agent may suppress ovulation and inhibit proliferation of endometrial tissue or uterine fibroid formation.
1 2D Structure

Vilaprisan

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-(4-methylsulfonylphenyl)-17-(1,1,2,2,2-pentafluoroethyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
2.1.2 InChI
InChI=1S/C27H29F5O4S/c1-24-14-21(15-3-7-18(8-4-15)37(2,35)36)23-19-10-6-17(33)13-16(19)5-9-20(23)22(24)11-12-25(24,34)26(28,29)27(30,31)32/h3-4,7-8,13,20-22,34H,5-6,9-12,14H2,1-2H3/t20-,21+,22-,24-,25-/m0/s1
2.1.3 InChI Key
JUFWQQVHQFDUOD-ANRPBIDPSA-N
2.1.4 Canonical SMILES
CC12CC(C3=C4CCC(=O)C=C4CCC3C1CCC2(C(C(F)(F)F)(F)F)O)C5=CC=C(C=C5)S(=O)(=O)C
2.1.5 Isomeric SMILES
C[C@]12C[C@@H](C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(C(C(F)(F)F)(F)F)O)C5=CC=C(C=C5)S(=O)(=O)C
2.2 Other Identifiers
2.2.1 UNII
IN59K53GI9
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bay 1002670

2.3.2 Depositor-Supplied Synonyms

1. 1262108-14-4

2. Vilaprisan [inn]

3. Bay1002670

4. In59k53gi9

5. Bay-1002670

6. (8s,11r,13s,14s,17s)-17-hydroxy-13-methyl-11-(4-methylsulfonylphenyl)-17-(1,1,2,2,2-pentafluoroethyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

7. 19-norpregna-4,9-dien-3-one, 20,20,21,21,21-pentafluoro-17-hydroxy-11-(4-(methylsulfonyl)phenyl)-, (11beta,17alpha)-

8. 19-norpregna-4,9-dien-3-one, 20,20,21,21,21-pentafluoro-17-hydroxy-11-[4-(methylsulfonyl)phenyl]-, (11beta,17alpha)-

9. Unii-in59k53gi9

10. Bay 1002670

11. Vilaprisan [jan]

12. Vilaprisan [usan:inn]

13. Vilaprisan [usan]

14. Vilaprisan [who-dd]

15. Vilaprisan (jan/usan/inn)

16. Schembl2121854

17. Chembl3989936

18. Dtxsid201110777

19. Bcp24069

20. Db11971

21. 20,20,21,21,21-pentafluoro-17-hydroxy-11beta-(4-(methanesulfonyl)phenyl)-19-nor-17alpha-pregna-4,9-dien-3-one

22. Ac-30930

23. D11181

24. Q27280805

25. (8s,11r,13s,14s,17r)-17-hydroxy-13-methyl-11-(4-(methylsulfonyl)phenyl)-17-(perfluoroethyl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-3-one

26. 19-norpregna-4,9-dien-3-one, 20,20,21,21,21-pentafluoro-17-hydroxy-11-(4-(methylsulfonyl)phenyl)-, (11.beta.,17.alpha.)-

27. 20,20,21,21,21-pentafluoro-17-hydroxy-11.beta.-(4-(methanesulfonyl)phenyl)-19-nor-17.alpha.-pregna-4,9-dien-3-one

28. Bay1002670; Bay-1002670; Bay 1002670; Bay-10-02670; Bay10-02670; Bay 10-02670

2.4 Create Date
2011-03-14
3 Chemical and Physical Properties
Molecular Weight 544.6 g/mol
Molecular Formula C27H29F5O4S
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count3
Exact Mass544.17067139 g/mol
Monoisotopic Mass544.17067139 g/mol
Topological Polar Surface Area79.8 Ų
Heavy Atom Count37
Formal Charge0
Complexity1140
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1262108-14-4 / Vilaprisan API manufacturers, exporters & distributors?

Vilaprisan manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Vilaprisan API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Vilaprisan manufacturer or Vilaprisan supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Vilaprisan manufacturer or Vilaprisan supplier.

PharmaCompass also assists you with knowing the Vilaprisan API Price utilized in the formulation of products. Vilaprisan API Price is not always fixed or binding as the Vilaprisan Price is obtained through a variety of data sources. The Vilaprisan Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Vilaprisan

Synonyms

1262108-14-4, Vilaprisan [inn], Bay1002670, In59k53gi9, Bay-1002670, (8s,11r,13s,14s,17s)-17-hydroxy-13-methyl-11-(4-methylsulfonylphenyl)-17-(1,1,2,2,2-pentafluoroethyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Cas Number

1262108-14-4

Unique Ingredient Identifier (UNII)

IN59K53GI9

About Vilaprisan

Vilaprisan is an orally available progestin and selective progesterone receptor modulator (SPRM), with potential anti-progesterone and antineoplastic activities. Upon oral administration, vilaprisan competitively binds to the progesterone receptor (PR) in progesterone-responsive tissue and inhibits PR-mediated gene expression. This interferes with progesterone activity in the reproductive system and may inhibit PR-mediated proliferative effects in cells overexpressing PRs. As a result, this agent may suppress ovulation and inhibit proliferation of endometrial tissue or uterine fibroid formation.

Vilaprisan Manufacturers

A Vilaprisan manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Vilaprisan, including repackagers and relabelers. The FDA regulates Vilaprisan manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Vilaprisan API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Vilaprisan Suppliers

A Vilaprisan supplier is an individual or a company that provides Vilaprisan active pharmaceutical ingredient (API) or Vilaprisan finished formulations upon request. The Vilaprisan suppliers may include Vilaprisan API manufacturers, exporters, distributors and traders.

Vilaprisan GMP

Vilaprisan Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Vilaprisan GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Vilaprisan GMP manufacturer or Vilaprisan GMP API supplier for your needs.

Vilaprisan CoA

A Vilaprisan CoA (Certificate of Analysis) is a formal document that attests to Vilaprisan's compliance with Vilaprisan specifications and serves as a tool for batch-level quality control.

Vilaprisan CoA mostly includes findings from lab analyses of a specific batch. For each Vilaprisan CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Vilaprisan may be tested according to a variety of international standards, such as European Pharmacopoeia (Vilaprisan EP), Vilaprisan JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Vilaprisan USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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