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Chemistry

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Also known as: 60-54-8, Deschlorobiomycin, Tetracyclinum, Achromycin, Tetracyclin, Sumycin
Molecular Formula
C22H24N2O8
Molecular Weight
444.4  g/mol
InChI Key
NWXMGUDVXFXRIG-WESIUVDSSA-N
FDA UNII
F8VB5M810T

Tetracycline
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Tetracycline is a Tetracycline-class Antimicrobial.
1 2D Structure

Tetracycline

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
2.1.2 InChI
InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25-26,29,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
2.1.3 InChI Key
NWXMGUDVXFXRIG-WESIUVDSSA-N
2.1.4 Canonical SMILES
CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
2.1.5 Isomeric SMILES
C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
2.2 Other Identifiers
2.2.1 UNII
F8VB5M810T
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4 Epitetracycline

2. 4-epitetracycline

3. Achromycin

4. Achromycin V

5. Hostacyclin

6. Sustamycin

7. Tetrabid

8. Tetracycline Hydrochloride

9. Tetracycline Monohydrochloride

10. Topicycline

2.3.2 Depositor-Supplied Synonyms

1. 60-54-8

2. Deschlorobiomycin

3. Tetracyclinum

4. Achromycin

5. Tetracyclin

6. Sumycin

7. Abramycin

8. Tsiklomitsin

9. Cyclopar

10. Ambramycin

11. Liquamycin

12. Panmycin

13. Tetracyn

14. Tetrazyklin

15. Achromycin V

16. Hostacyclin

17. Omegamycin

18. Tetradecin

19. Tetraverine

20. Tsiklomistsin

21. Vetacyclinum

22. Tetrafil

23. Cefracycline

24. Criseociclina

25. Abricycline

26. Agromicina

27. Ambramicina

28. Biocycline

29. Ciclibion

30. Copharlan

31. Democracin

32. Lexacycline

33. Limecycline

34. Mericycline

35. Micycline

36. Orlycycline

37. Polycycline

38. Polyotic

39. Purocyclina

40. Roviciclina

41. Solvocin

42. Tetrabon

43. Tetracycl

44. Amycin

45. Veracin

46. Sk-tetracycline

47. Tetracycline Ii

48. Tetra-co

49. Tetracyclinehydrate

50. Cyclomycin

51. Sumycin Syrup

52. Tetracycline I

53. Bio-tetra

54. (4s,4as,5as,6s,12as)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

55. Tetracycline Base

56. Chebi:27902

57. Piracaps (base)

58. Centet (base)

59. Polycycline (van)

60. (4s,4as,5as,12as)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

61. Nsc-108579

62. Cefracycline Suspension

63. Liquamycin (veterinary)

64. Polycycline (antibiotic)

65. F8vb5m810t

66. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4s,4as,5as,6s,12as)-

67. Tetraciclina

68. Tetracycline (internal Use)

69. Supramycin

70. Vetquamycin-324 (free Base)

71. 60-54-8 (free Base)

72. E701

73. Achromycin (naphthacene Derivative)

74. Nsc 108579

75. T-125

76. Hsdb 3188

77. 6-methyl-1,11-dioxy-2-naphthacenecarboxamide

78. Tetracyclinum [inn-latin]

79. Tetraciclina [inn-spanish]

80. (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide

81. Sumycin (tn)

82. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4s-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-

83. Unii-f8vb5m810t

84. Economycin

85. Vetquamycin

86. Brodspec

87. Tetracycline (jan/usp/inn)

88. Ccris 9483

89. Sr-01000000212

90. Nsc108579

91. Tetrabid Organon

92. Ala-tet

93. Tetracycline [usp:inn:ban:jan]

94. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-

95. Einecs 200-481-9

96. Mfcd00151232

97. Spectrum_001034

98. Prestwick0_000140

99. Prestwick1_000140

100. Prestwick2_000140

101. Prestwick3_000140

102. Spectrum2_001329

103. Spectrum3_000565

104. Spectrum4_000352

105. Spectrum5_001112

106. Tetracycline [mi]

107. Dsstox_cid_3645

108. Tetracycline [inn]

109. Tetracycline [jan]

110. Ec 200-481-9

111. Tetracycline [hsdb]

112. Schembl3098

113. Dsstox_rid_77127

114. Tetracycline [vandf]

115. Dsstox_gsid_23645

116. Bspbio_000220

117. Bspbio_001950

118. Kbiogr_000783

119. Kbioss_001514

120. Tetracycline [mart.]

121. Bidd:gt0653

122. Divk1c_000827

123. Schembl537050

124. Tetracycline [who-dd]

125. Spbio_001457

126. Spbio_002159

127. Bpbio1_000242

128. Schembl2116649

129. Schembl2116661

130. Dtxsid7023645

131. Schembl21271987

132. Gtpl10927

133. Kbio1_000827

134. Kbio2_001514

135. Kbio2_004082

136. Kbio2_006650

137. Kbio3_001450

138. Tetracycline [green Book]

139. Ninds_000827

140. Hms2090b04

141. Tetracycline [orange Book]

142. Tetracycline, >=98.0% (nt)

143. Tetracycline [ep Monograph]

144. Tetracycline [usp Impurity]

145. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4s-(4.alpha.,4a.alpha.,5a.alpha.,6.beta.,12a.alpha.))-

146. Hy-a0107

147. Pylera Component Tetracycline

148. Rkl10088

149. Tetracycline [usp Monograph]

150. Tetracycline, >=88.0% (hplc)

151. Tox21_300150

152. Bdbm50237605

153. S4490

154. Zinc84441937

155. Akos024277860

156. Akos026749977

157. Zinc100303069

158. Zinc102229720

159. Cs-8188

160. Db00759

161. Tetracycline Component Of Pylera

162. Cas-60-54-8

163. Idi1_000827

164. Ncgc00017323-03

165. Ncgc00017323-04

166. Ncgc00017323-05

167. Ncgc00017323-07

168. Ncgc00017323-15

169. Ncgc00142507-02

170. Ncgc00254063-01

171. 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,1 0,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

172. Bt166207

173. Sbi-0051530.p003

174. Lymecycline Impurity H [ep Impurity]

175. T3971

176. C06570

177. D00201

178. Ab00053550-04

179. Ab00053550_05

180. Ab00053550_06

181. Q193045

182. Sr-01000000212-3

183. Z2144222809

184. Oxytetracycline Hydrochloride Impurity B [ep Impurity]

185. (4r,4as,5as,6s,12as)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

186. (4s,4as,5as,6s,12as)-2-[amino(hydroxy)methylene]-4beta-(dimethylamino)-1,2,3,4,4a,5,5a,6,11,12a-decahydro-6alpha,10,12,12abeta-tetrahydroxy-6-methylnaphthacene-1,3,11-trione

187. (4s,4as,5as,6s,12as)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide

2.4 Create Date
2011-12-26
3 Chemical and Physical Properties
Molecular Weight 444.4 g/mol
Molecular Formula C22H24N2O8
XLogP3-2
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count9
Rotatable Bond Count2
Exact Mass444.15326573 g/mol
Monoisotopic Mass444.15326573 g/mol
Topological Polar Surface Area182 Ų
Heavy Atom Count32
Formal Charge0
Complexity971
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameAchromycin v
Drug LabelTetracycline is a yellow, odorless, crystalline powder. Tetracycline is stable in air but exposure to strong sunlight causes it to darken. Its potency is affected in solutions of pH below 2 and is rapidly destroyed by alkali hydroxide solutions. Tetr...
Active IngredientTetracycline hydrochloride
Dosage FormCapsule
RouteOral
Strength250mg; 500mg
Market StatusPrescription
CompanyHeritage Pharms

2 of 2  
Drug NameAchromycin v
Drug LabelTetracycline is a yellow, odorless, crystalline powder. Tetracycline is stable in air but exposure to strong sunlight causes it to darken. Its potency is affected in solutions of pH below 2 and is rapidly destroyed by alkali hydroxide solutions. Tetr...
Active IngredientTetracycline hydrochloride
Dosage FormCapsule
RouteOral
Strength250mg; 500mg
Market StatusPrescription
CompanyHeritage Pharms

4.2 Therapeutic Uses

Antibiotics, Tetracycline; Protein Synthesis Inhibitors

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


Tetracycline hydrochloride ointment is used in the prophylaxis of minor bacterial skin infections and in the treatment of dermal ulcer. /Tetracycline hydrochloride; NOT included in US product labeling/

USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 2818


Tetracycline hydrochloride ointment is indicated in the topical treatment of minor skin infections caused by streptococci, staphylococci, and other susceptible organisms. /Tetracycline hydrochloride; Included in US product labeling/

USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 2818


Tetracycline hydrochloride for topical solution is indicated for the topical treatment of acne vulgaris. It may be effective in grades II and III acne, which are characterized by inflammatory lesions such as papules and pustules. /Tetracycline hydrochloride; Included in US product labeling/

USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 2818


For more Therapeutic Uses (Complete) data for TETRACYCLINE (37 total), please visit the HSDB record page.


4.3 Drug Warning

EXCEPT FOR LOCAL USE IN EYE, TOPICAL USE OF TETRACYCLINES IS NOT RECOMMENDED. /TETRACYCLINES/

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1127


MICROORGANISMS THAT HAVE BECOME INSENSITIVE TO ONE TETRACYCLINE FREQUENTLY EXHIBIT RESISTANCE TO OTHERS. /TETRACYCLINES/

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1126


CROSS-SENSITIZATION AMONG VARIOUS TETRACYCLINES IS COMMON . /TETRACYCLINES/

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1130


... NAUSEA, VOMITING, POLYURIA, POLYDIPSIA, PROTEINURIA, ACIDOSIS, GLYCOSURIA, & GROSS AMINOACIDURIA, A FORM OF FANCONI SYNDROME, HAS BEEN OBSERVED IN PT INGESTING OUTDATED, & DEGRADED TETRACYCLINE.

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1130


For more Drug Warnings (Complete) data for TETRACYCLINE (31 total), please visit the HSDB record page.


4.4 Drug Indication

Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical organisms (C. pneumoniae, M. pneumoniae, L. pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Tetracycline is a short-acting antibiotic that inhibits bacterial growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. It also binds to some extent to the 50S ribosomal subunit. This binding is reversible in nature. Additionally tetracycline may alter the cytoplasmic membrane of bacteria causing leakage of intracellular contents, such as nucleotides, from the cell.


5.2 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
TETRACYCLINE
5.3.2 FDA UNII
F8VB5M810T
5.3.3 Pharmacological Classes
Chemical Structure [CS] - Tetracyclines
5.4 ATC Code

D06AA04

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


A - Alimentary tract and metabolism

A01 - Stomatological preparations

A01A - Stomatological preparations

A01AB - Antiinfectives and antiseptics for local oral treatment

A01AB13 - Tetracycline


D - Dermatologicals

D06 - Antibiotics and chemotherapeutics for dermatological use

D06A - Antibiotics for topical use

D06AA - Tetracycline and derivatives

D06AA04 - Tetracycline


J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01A - Tetracyclines

J01AA - Tetracyclines

J01AA07 - Tetracycline


S - Sensory organs

S01 - Ophthalmologicals

S01A - Antiinfectives

S01AA - Antibiotics

S01AA09 - Tetracycline


S - Sensory organs

S02 - Otologicals

S02A - Antiinfectives

S02AA - Antiinfectives

S02AA08 - Tetracycline


S - Sensory organs

S03 - Ophthalmological and otological preparations

S03A - Antiinfectives

S03AA - Antiinfectives

S03AA02 - Tetracycline


5.5 Absorption, Distribution and Excretion

Absorption

Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.


Route of Elimination

They are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations in a biologically active form.


ALL TETRACYCLINES ARE ADEQUATELY BUT INCOMPLETELY ABSORBED FROM GI TRACT. MOST ABSORPTION TAKES PLACE FROM STOMACH & UPPER SMALL INTESTINE & IS GREATEST IN FASTING STATE. /TETRACYCLINES/

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1126


... /TETRACYCLINE IS/ VERY INCOMPLETELY ABSORBED. AFTER SINGLE ORAL DOSE PEAK PLASMA CONCN ARE ATTAINED IN 2-4 HR. ... ADMIN OF 250 MG EVERY 6 HR PRODUCES PEAK PLASMA CONCN OF APPROX 2-2.5 UG/ML.

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1126


THE PRIMARY ROUTE OF ELIMINATION FOR MOST TETRACYCLINES IS THE KIDNEY, ALTHOUGH THEY ARE ALSO CONCENTRATED IN THE LIVER AND EXCRETED BY ... BILE, INTO INTESTINE, FROM WHICH THEY ARE PARTIALLY REABSORBED. /TETRACYCLINES/

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1126


ELIMINATION FROM INTESTINAL TRACT OCCURS EVEN WHEN DRUGS ARE GIVEN PARENTERALLY, AS RESULT OF EXCRETION IN BILE. /TETRACYCLINES/

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1123


For more Absorption, Distribution and Excretion (Complete) data for TETRACYCLINE (16 total), please visit the HSDB record page.


5.6 Metabolism/Metabolites

Not metabolized


5.7 Biological Half-Life

6-12 hours


/IT HAS HALF-LIFE/ IN RANGE OF 6-12 HR...

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1126


Tetracycline was encapsulated in erythrocytes by a dialysis technique. On encapsulation of (14)C sucrose and (3)H tetracycline, the drug concn (0.2 mg/ml of erythrocytes) decreased the tetracycline encapsulation, but not (14)C sucrose. Carrier erythrocytes containing tetracycline reinjected in calves were studied for their pharmacokinetic constants. the drug half-life was 6.7 hr with an overall elimination constant of 0.104 hr.

PMID:6731978 DeLoach JR, Wagner GG; Am J Vet Res 45 (4): 640-642 (1984)


The serum half-life...is 6-12 hr in adults with normal renal funtion and is reported to be 57-120 hr in patients with severe renal impairment.

McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 97. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 1997 (Plus Supplements)., p. 385


5.8 Mechanism of Action

Tetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.


TETRACYCLINES ARE THOUGHT TO INHIBIT PROTEIN SYNTH BY BINDING SPECIFICALLY TO 30 S RIBOSOMES AND PREVENTING ACCESS OF AMINOACYL TRNA TO... MRNA-RIBOSOME COMPLEX. /TETRACYCLINES/

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1125


... IT IS POSSIBLE THAT REVERSIBLY BOUND ANTIBIOTIC IS RESPONSIBLE FOR ANTIBACTERIAL ACTION. /TETRACYCLINES/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1185


TETRACYCLINE COMBINES WITH CELLULAR & INTRACELLULAR MATERIAL TO FORM A FLUOROPHORE WHICH UNDER UV LIGHT GLOWS WITH YELLOW-GOLD FLUORESCENCE. THE FLUOROPHORE REMAINS IN BONE FOR MANY MO.

Thienes, C., and T.J. Haley. Clinical Toxicology. 5th ed. Philadelphia: Lea and Febiger, 1972., p. 141


PHOTOALLERGIC REACTIONS ARE BELIEVED TO RESULT FROM LIGHT ENERGY ACTING ON OR ALTERING DRUG & SKIN PROTEINS IN SUCH MANNER AS TO FORM AN ANTIGEN. THESE ERUPTIONS REQUIRE PREVIOUS CONTACT WITH OFFENDING SUBSTANCE, ARE NOT DOSE-RELATED, & EXHIBIT CROSS-SENSITIVITY WITH CHEM RELATED COMPD. /TETRACYCLINES/

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1276


For more Mechanism of Action (Complete) data for TETRACYCLINE (6 total), please visit the HSDB record page.


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Grade","supplierPort":"SHANGHAI","supplierAddress":"OFFICE F,32\/F, PLAZA 88 NO.88 YEUNG UK ROAD, TSUEN WAN , NT,HONG KONG SDNF CN","customerAddress":"S.NO.33\/1-A, PLOT NO. 1"}]
07-Jan-2022
28-Jul-2025
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ABOUT THIS PAGE

Looking for 60-54-8 / Tetracycline API manufacturers, exporters & distributors?

Tetracycline manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tetracycline API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tetracycline manufacturer or Tetracycline supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tetracycline manufacturer or Tetracycline supplier.

PharmaCompass also assists you with knowing the Tetracycline API Price utilized in the formulation of products. Tetracycline API Price is not always fixed or binding as the Tetracycline Price is obtained through a variety of data sources. The Tetracycline Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tetracycline

Synonyms

60-54-8, Deschlorobiomycin, Tetracyclinum, Achromycin, Tetracyclin, Sumycin

Cas Number

60-54-8

Unique Ingredient Identifier (UNII)

F8VB5M810T

About Tetracycline

A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.

Tetraciclina Manufacturers

A Tetraciclina manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tetraciclina, including repackagers and relabelers. The FDA regulates Tetraciclina manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tetraciclina API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Tetraciclina manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Tetraciclina Suppliers

A Tetraciclina supplier is an individual or a company that provides Tetraciclina active pharmaceutical ingredient (API) or Tetraciclina finished formulations upon request. The Tetraciclina suppliers may include Tetraciclina API manufacturers, exporters, distributors and traders.

click here to find a list of Tetraciclina suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tetraciclina USDMF

A Tetraciclina DMF (Drug Master File) is a document detailing the whole manufacturing process of Tetraciclina active pharmaceutical ingredient (API) in detail. Different forms of Tetraciclina DMFs exist exist since differing nations have different regulations, such as Tetraciclina USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Tetraciclina DMF submitted to regulatory agencies in the US is known as a USDMF. Tetraciclina USDMF includes data on Tetraciclina's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tetraciclina USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Tetraciclina suppliers with USDMF on PharmaCompass.

Tetraciclina GMP

Tetraciclina Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tetraciclina GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tetraciclina GMP manufacturer or Tetraciclina GMP API supplier for your needs.

Tetraciclina CoA

A Tetraciclina CoA (Certificate of Analysis) is a formal document that attests to Tetraciclina's compliance with Tetraciclina specifications and serves as a tool for batch-level quality control.

Tetraciclina CoA mostly includes findings from lab analyses of a specific batch. For each Tetraciclina CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tetraciclina may be tested according to a variety of international standards, such as European Pharmacopoeia (Tetraciclina EP), Tetraciclina JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tetraciclina USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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