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Chemistry

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Also known as: Tazobactam sodium salt, 89785-84-2, Tazobactum sodium, Tazobactam sodium [usan], Cl-307579, Tazobactam (sodium)
Molecular Formula
C10H11N4NaO5S
Molecular Weight
322.28  g/mol
InChI Key
RFMIKMMOLPNEDG-QVUDESDKSA-M
FDA UNII
UXA545ABTT

Tazobactam Sodium
A penicillanic acid and sulfone derivative and potent BETA-LACTAMASE inhibitor that enhances the activity of other anti-bacterial agents against beta-lactamase producing bacteria.
1 2D Structure

Tazobactam Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-46-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
2.1.2 InChI
InChI=1S/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1
2.1.3 InChI Key
RFMIKMMOLPNEDG-QVUDESDKSA-M
2.1.4 Canonical SMILES
CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)[O-])CN3C=CN=N3.[Na+]
2.1.5 Isomeric SMILES
C[C@@]1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)[O-])CN3C=CN=N3.[Na+]
2.2 Other Identifiers
2.2.1 UNII
UXA545ABTT
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Tazobactam

2. Ytr 830

3. Ytr 830h

4. Ytr-830

5. Ytr830

2.3.2 Depositor-Supplied Synonyms

1. Tazobactam Sodium Salt

2. 89785-84-2

3. Tazobactum Sodium

4. Tazobactam Sodium [usan]

5. Cl-307579

6. Tazobactam (sodium)

7. Ytr-830

8. Tazobactam (as Sodium)

9. Cl 307,579

10. Uxa545abtt

11. Chembl1439

12. Cl 307579

13. Chebi:85192

14. 89785-84-2 (sodium)

15. Ytr 830

16. 2-alpha-methyl-2-beta-(1,2,3-triazol-1-ylmethyl)penam-3-alpha-carboxylic Acid Sodium Salt

17. Dsstox_cid_26030

18. Dsstox_rid_81299

19. Dsstox_gsid_46030

20. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3-methyl-7-oxo-3-(1h-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, Sodium Salt, (2s,3s,5r)-

21. Sodium (2s,3s,5r)-3-methyl-7-oxo-3-(1h-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate, 4,4-dioxide

22. Sodium;(2s,3s,5r)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

23. Cas-89785-84-2

24. Unii-uxa545abtt

25. Tazobactum

26. Ncgc00159340-02

27. Schembl259991

28. Tazobactam Sodium (jan/usan)

29. Tazobactam Sodium [jan]

30. Dtxsid8046030

31. Tazobactam Sodium [vandf]

32. Tazobactam Sodium [mart.]

33. Yp-14

34. Tazobactam Sodium [who-dd]

35. Sodium (2s,3s,5r)-3-((1h-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide

36. Tazobactam Sodium Salt [mi]

37. Tox21_111584

38. Bdbm50157692

39. Mfcd00917472

40. Akos015962921

41. Akos016843926

42. Tox21_111584_1

43. Cs-w009884

44. Hy-w009168

45. Tazobactam Sodium [orange Book]

46. Zosyn Component Tazobactam Sodium

47. Ncgc00159340-05

48. Ac-18978

49. Ac-32478

50. As-56873

51. Zerbaxa Component Tazobactam Sodium

52. Tazobactam Sodium Salt, Analytical Standard

53. Tazobactam Sodium Component Of Zosyn

54. Tazobactam Sodium Component Of Zerbaxa

55. D03707

56. T-1446

57. Tazobactam Sodium Salt, Beta-lactamase Inhibitor

58. Q27158392

59. Tazobactam Sodium Salt, Antibiotic For Culture Media Use Only

60. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3-methyl-7-oxo-3-(1h-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, Sodium Salt, (2s-(2alpha,3beta,5alpha))-

61. Sodium (2s,3s,5r)-3-methyl-4,4,7-trioxo-3-[(1h-1,2,3-triazol-1-yl)methyl]-4lambda(6)-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

62. Sodium (2s,3s,5r)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

63. Sodium(2s,3s,5r)-3-((1h-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate4,4-dioxide

64. Sodium; (2s,3s,5r)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 322.28 g/mol
Molecular Formula C10H11N4NaO5S
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass322.03478492 g/mol
Monoisotopic Mass322.03478492 g/mol
Topological Polar Surface Area134 Ų
Heavy Atom Count21
Formal Charge0
Complexity579
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


beta-Lactamase Inhibitors

Endogenous substances and drugs that inhibit or block the activity of BETA-LACTAMASES. (See all compounds classified as beta-Lactamase Inhibitors.)


JDMF

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01

Discovery Europe
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Discovery Europe
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Japanese Pharmacopoeia Tazobactam "Apitoria"

Registration Number : 306MF10138

Registrant's Address : Plot No. 2, Maitrivihar, Ameerpet, Hyderabad, Telangana, INDIA.

Initial Date of Registration : 2024-10-22

Latest Date of Registration : 2024-10-22

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02

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Japanese Pharmacopoeia Tazobactam

Registration Number : 226MF10161

Registrant's Address : Plot No. 2, Maitrivihar, Ameerpet, Hyderabad Telangana, India

Initial Date of Registration : 2014-09-01

Latest Date of Registration : 2014-09-01

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03

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Discovery Europe
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Tazobactam (for manufacturing purposes only)

Registration Number : 229MF10207

Registrant's Address : Plot No. 2, Maitrivihar, Ameerpet, Hyderabad Telangana, India

Initial Date of Registration : 2017-11-30

Latest Date of Registration : 2017-11-30

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04

Discovery Europe
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Tazobactam

Registration Number : 226MF10152

Registrant's Address : via Roma, n. 108 20051 Cassina de'Pecchi (MI), Italy.

Initial Date of Registration : 2014-09-01

Latest Date of Registration : 2014-09-01

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05

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TAZOBACTAM

Registration Number : 225MF10213

Registrant's Address : No. 2 Yuli Industrial Zone, Changjiang District, Jingdezhen City 333000, Jiangxi, Chi...

Initial Date of Registration : 2013-11-20

Latest Date of Registration : 2014-09-30

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06

Discovery Europe
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Tazobactam "Otsuka Chemical"

Registration Number : 217MF10481

Registrant's Address : Osaka City, Chuo Ward, Ote-dori 3-2-27

Initial Date of Registration : 2005-09-06

Latest Date of Registration : 2010-08-10

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07

Discovery Europe
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Discovery Europe
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Japanese Pharmacopoeia Tazobactam

Registration Number : 301MF10076

Registrant's Address : Circular Economy Demonstration Park Laoling County Dezhou City, Shandong Province Chi...

Initial Date of Registration : 2019-10-18

Latest Date of Registration : 2019-10-18

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08

Discovery Europe
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Discovery Europe
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Japanese Pharmacopoeia Tazobactam

Registration Number : 226MF10155

Registrant's Address : No. 10678 Wenliang Road, Dongjia Town, Licheng District, Jinan, Shandong Province, P....

Initial Date of Registration : 2014-09-01

Latest Date of Registration : 2015-05-14

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09

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Tazobactam sodium

Registration Number : 229MF10179

Registrant's Address : No. 10678 Wenliang Road, Dongjia Town, Licheng District, Jinan, Shandong Province, P....

Initial Date of Registration : 2017-09-21

Latest Date of Registration : 2023-06-07

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10

Discovery Europe
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Tazobactam

Registration Number : 306MF10065

Registrant's Address : Bayannaoer Economy & Technology Park, Inner Mongolia-015000, P. R. China

Initial Date of Registration : 2024-05-15

Latest Date of Registration : 2024-05-15

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ADD: 888, LVYOU ROAD ,HIGH-TECH ZONE JINAN 250104 P.R. C HINA CHINA","customerAddress":"304,ATLANTA ARCADE,"}]
01-Jan-2022
27-May-2025
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - INJECTABLE;INJECTION - EQ 2GM BASE/V...DOSAGE - INJECTABLE;INJECTION - EQ 2GM BASE/VIAL;EQ 250MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50684

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DOSAGE - INJECTABLE;INJECTION - EQ 36GM BASE/...DOSAGE - INJECTABLE;INJECTION - EQ 36GM BASE/VIAL;EQ 4.5GM BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50684

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DOSAGE - INJECTABLE;INJECTION - EQ 3GM BASE/V...DOSAGE - INJECTABLE;INJECTION - EQ 3GM BASE/VIAL;EQ 375MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50684

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DOSAGE - INJECTABLE;INJECTION - EQ 4GM BASE/V...DOSAGE - INJECTABLE;INJECTION - EQ 4GM BASE/VIAL;EQ 500MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50684

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DOSAGE - INJECTABLE;INJECTION - EQ 40MG BASE/...DOSAGE - INJECTABLE;INJECTION - EQ 40MG BASE/ML;EQ 5MG BASE/ML

USFDA APPLICATION NUMBER - 50750

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DOSAGE - INJECTABLE;INJECTION - EQ 4GM BASE/1...DOSAGE - INJECTABLE;INJECTION - EQ 4GM BASE/100ML;EQ 500MG BASE/100ML

USFDA APPLICATION NUMBER - 50750

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DOSAGE - INJECTABLE;INJECTION - EQ 60MG BASE/...DOSAGE - INJECTABLE;INJECTION - EQ 60MG BASE/ML;EQ 7.5MG BASE/ML

USFDA APPLICATION NUMBER - 50750

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ABOUT THIS PAGE

Looking for 89785-84-2 / Tazobactam Sodium API manufacturers, exporters & distributors?

Tazobactam Sodium manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tazobactam Sodium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tazobactam Sodium manufacturer or Tazobactam Sodium supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tazobactam Sodium manufacturer or Tazobactam Sodium supplier.

PharmaCompass also assists you with knowing the Tazobactam Sodium API Price utilized in the formulation of products. Tazobactam Sodium API Price is not always fixed or binding as the Tazobactam Sodium Price is obtained through a variety of data sources. The Tazobactam Sodium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tazobactam Sodium

Synonyms

Tazobactam sodium salt, 89785-84-2, Tazobactum sodium, Tazobactam sodium [usan], Cl-307579, Tazobactam (sodium)

Cas Number

89785-84-2

Unique Ingredient Identifier (UNII)

UXA545ABTT

About Tazobactam Sodium

A penicillanic acid and sulfone derivative and potent BETA-LACTAMASE inhibitor that enhances the activity of other anti-bacterial agents against beta-lactamase producing bacteria.

Tazobactam Sodium Manufacturers

A Tazobactam Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tazobactam Sodium, including repackagers and relabelers. The FDA regulates Tazobactam Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tazobactam Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Tazobactam Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Tazobactam Sodium Suppliers

A Tazobactam Sodium supplier is an individual or a company that provides Tazobactam Sodium active pharmaceutical ingredient (API) or Tazobactam Sodium finished formulations upon request. The Tazobactam Sodium suppliers may include Tazobactam Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Tazobactam Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tazobactam Sodium USDMF

A Tazobactam Sodium DMF (Drug Master File) is a document detailing the whole manufacturing process of Tazobactam Sodium active pharmaceutical ingredient (API) in detail. Different forms of Tazobactam Sodium DMFs exist exist since differing nations have different regulations, such as Tazobactam Sodium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Tazobactam Sodium DMF submitted to regulatory agencies in the US is known as a USDMF. Tazobactam Sodium USDMF includes data on Tazobactam Sodium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tazobactam Sodium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Tazobactam Sodium suppliers with USDMF on PharmaCompass.

Tazobactam Sodium JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Tazobactam Sodium Drug Master File in Japan (Tazobactam Sodium JDMF) empowers Tazobactam Sodium API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Tazobactam Sodium JDMF during the approval evaluation for pharmaceutical products. At the time of Tazobactam Sodium JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Tazobactam Sodium suppliers with JDMF on PharmaCompass.

Tazobactam Sodium KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Tazobactam Sodium Drug Master File in Korea (Tazobactam Sodium KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Tazobactam Sodium. The MFDS reviews the Tazobactam Sodium KDMF as part of the drug registration process and uses the information provided in the Tazobactam Sodium KDMF to evaluate the safety and efficacy of the drug.

After submitting a Tazobactam Sodium KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Tazobactam Sodium API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Tazobactam Sodium suppliers with KDMF on PharmaCompass.

Tazobactam Sodium WC

A Tazobactam Sodium written confirmation (Tazobactam Sodium WC) is an official document issued by a regulatory agency to a Tazobactam Sodium manufacturer, verifying that the manufacturing facility of a Tazobactam Sodium active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Tazobactam Sodium APIs or Tazobactam Sodium finished pharmaceutical products to another nation, regulatory agencies frequently require a Tazobactam Sodium WC (written confirmation) as part of the regulatory process.

click here to find a list of Tazobactam Sodium suppliers with Written Confirmation (WC) on PharmaCompass.

Tazobactam Sodium NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Tazobactam Sodium as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Tazobactam Sodium API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Tazobactam Sodium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Tazobactam Sodium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Tazobactam Sodium NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Tazobactam Sodium suppliers with NDC on PharmaCompass.

Tazobactam Sodium GMP

Tazobactam Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tazobactam Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tazobactam Sodium GMP manufacturer or Tazobactam Sodium GMP API supplier for your needs.

Tazobactam Sodium CoA

A Tazobactam Sodium CoA (Certificate of Analysis) is a formal document that attests to Tazobactam Sodium's compliance with Tazobactam Sodium specifications and serves as a tool for batch-level quality control.

Tazobactam Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Tazobactam Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tazobactam Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Tazobactam Sodium EP), Tazobactam Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tazobactam Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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