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Chemistry

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Also known as: 61318-90-9, Sulconazolum, Sulconazol, Sulconazolum [inn-latin], 1-(2-((4-chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole, Sulconazol [inn-spanish]
Molecular Formula
C18H15Cl3N2S
Molecular Weight
397.7  g/mol
InChI Key
AFNXATANNDIXLG-UHFFFAOYSA-N
FDA UNII
5D9HAA5Q5S

Sulconazole
Sulconazole is a topical imidazole derivative with broad-spectrum antifungal and antibacterial activity. Sulconazole is excreted in both the feces and urine.
Sulconazole is an Azole Antifungal.
1 2D Structure

Sulconazole

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole
2.1.2 InChI
InChI=1S/C18H15Cl3N2S/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
2.1.3 InChI Key
AFNXATANNDIXLG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
2.2 Other Identifiers
2.2.1 UNII
5D9HAA5Q5S
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(beta-(4''-chlorobenzylthio)-2'4'-dichlorophenethyl)imidazole

2. Exelderm

3. Myk

4. Sulconazole Mononitrate

5. Sulconazole Nitrate

6. Sulconazole, Mononitrate, (+-)-isomer

2.3.2 Depositor-Supplied Synonyms

1. 61318-90-9

2. Sulconazolum

3. Sulconazol

4. Sulconazolum [inn-latin]

5. 1-(2-((4-chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole

6. Sulconazol [inn-spanish]

7. (+/-)-sulconazole

8. 1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole

9. 5d9haa5q5s

10. Chebi:77776

11. Sulconazole (inn)

12. 1-{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1h-imidazole

13. Sulconazole [inn]

14. 1-[2-(4-chloro-benzylsulfanyl)-2-(2,4-dichloro-phenyl)-ethyl]-1h-imidazole

15. Sulconazole [inn:ban]

16. Unii-5d9haa5q5s

17. 1h-imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-

18. 1h-imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-

19. Spectrum_001416

20. Sulconazole [mi]

21. Prestwick0_000810

22. Prestwick1_000810

23. Prestwick2_000810

24. Prestwick3_000810

25. Spectrum2_001422

26. Spectrum3_001457

27. Spectrum4_000436

28. Spectrum5_001155

29. Sulconazole [vandf]

30. Chembl1221

31. Schembl34761

32. Bspbio_000679

33. Bspbio_002953

34. Kbiogr_000792

35. Kbioss_001896

36. Sulconazole [who-dd]

37. Cid_65495

38. Divk1c_000220

39. Spbio_001524

40. Spbio_002600

41. Bpbio1_000747

42. Dtxsid8044129

43. Bdbm31770

44. Hy-b1460b

45. Kbio1_000220

46. Kbio2_001896

47. Kbio2_004464

48. Kbio2_007032

49. Kbio3_002453

50. Ninds_000220

51. (+-)-1-(2,4-dichlor-beta-((4-chlorbenzyl)thio)phenethyl)imidazol

52. (+-)-1-(2,4-dichloro-beta-((p-chlorobenzyl)thio)phenethyl)imidazole

53. Akos015961204

54. Db06820

55. 1h-imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, (+-)-

56. Idi1_000220

57. Ncgc00018250-02

58. Ac-13116

59. Sbi-0051660.p002

60. Db-053840

61. Ab00053607

62. Cs-0013811

63. Ft-0630725

64. C08076

65. D08535

66. Ab00053607_16

67. Ab00053607_17

68. Q2392530

69. Brd-a70649075-008-05-0

70. Brd-a70649075-008-17-5

71. 1-[2,4-dichloro-beta-(4-chlorobenzylthio)phenethyl]imidazole

72. 1-[beta-[(4-chlorobenzyl)thio]-2,4-dichlorophenethyl]-1h-imidazole

73. 1-(2-(4-chlorobenzylthio)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole

74. 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole

75. 1h-imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-(9ci)

76. 1h-imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, (+/-)-

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 397.7 g/mol
Molecular Formula C18H15Cl3N2S
XLogP36.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Exact Mass396.002153 g/mol
Monoisotopic Mass396.002153 g/mol
Topological Polar Surface Area43.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity379
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Sulconazole solution 1.0% is indicated for the treatment of tinea cruris and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis; and for the treatment of tinea versicolor. Effectiveness has not been proven in tinea pedis (athletes foot).


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

The function of imidazole derivatives can be attributed to their structural resemblance to purines essential to metabolism.


5.2 MeSH Pharmacological Classification

Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
SULCONAZOLE
5.3.2 FDA UNII
5D9HAA5Q5S
5.3.3 Pharmacological Classes
Chemical Structure [CS] - Azoles
5.4 ATC Code

D01AC09

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


D - Dermatologicals

D01 - Antifungals for dermatological use

D01A - Antifungals for topical use

D01AC - Imidazole and triazole derivatives

D01AC09 - Sulconazole


5.5 Absorption, Distribution and Excretion

Absorption

Total sulconazole systemic absorption after topical administration was ~8.71% of the dose.


Route of Elimination

About 6.70% of the dose was recovered in urine, and 2.01% in feces over a 7 day collection period. Radioactivity could be detected in both urine and feces at 7 days potentially due to a reservoir effect.


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API | Excipient name

Sulconazole

Synonyms

61318-90-9, Sulconazolum, Sulconazol, Sulconazolum [inn-latin], 1-(2-((4-chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole, Sulconazol [inn-spanish]

Cas Number

61318-90-9

Unique Ingredient Identifier (UNII)

5D9HAA5Q5S

About Sulconazole

Sulconazole is a topical imidazole derivative with broad-spectrum antifungal and antibacterial activity. Sulconazole is excreted in both the feces and urine.

Sulconazole Manufacturers

A Sulconazole manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sulconazole, including repackagers and relabelers. The FDA regulates Sulconazole manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sulconazole API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Sulconazole Suppliers

A Sulconazole supplier is an individual or a company that provides Sulconazole active pharmaceutical ingredient (API) or Sulconazole finished formulations upon request. The Sulconazole suppliers may include Sulconazole API manufacturers, exporters, distributors and traders.

Sulconazole GMP

Sulconazole Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sulconazole GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sulconazole GMP manufacturer or Sulconazole GMP API supplier for your needs.

Sulconazole CoA

A Sulconazole CoA (Certificate of Analysis) is a formal document that attests to Sulconazole's compliance with Sulconazole specifications and serves as a tool for batch-level quality control.

Sulconazole CoA mostly includes findings from lab analyses of a specific batch. For each Sulconazole CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sulconazole may be tested according to a variety of international standards, such as European Pharmacopoeia (Sulconazole EP), Sulconazole JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sulconazole USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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