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Chemistry

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Also known as: Sulanemadlin [inn], 6bgf28r54m, Sulanemadlin [usan], Alrn-6924, Unii-6bgf28r54m, 1451199-98-6
Molecular Formula
C95H140N20O23
Molecular Weight
1930.2  g/mol
InChI Key
VDLGAZDAHPLOIR-RLPDZDIMSA-N
FDA UNII
6BGF28R54M

Sulanemadlin
Sulanemadlin is an orally available peptide inhibitor of both murine double minute 2 (MDM2) and murine double minute X (MDMX), with potential antineoplastic activity. Upon oral administration, sulanemadlin binds to both MDM2 and MDMX and interferes with their interaction with the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 and MDMX-p53 interactions, p53 activity is restored, which leads to p53-mediated induction of tumor cell apoptosis. MDM2 and MDMX, negative regulators of p53 function, are often overexpressed in cancer cells.
1 2D Structure

Sulanemadlin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[(2S,5S,8S,11S,14S,17S,20S,24E,32R)-32-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-20-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-amino-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]-14-(3-amino-3-oxopropyl)-5-[(4-hydroxyphenyl)methyl]-8-(1H-indol-3-ylmethyl)-11,20,32-trimethyl-17-(2-methylpropyl)-3,6,9,12,15,18,33-heptaoxo-1,4,7,10,13,16,19-heptazacyclotritriacont-24-en-2-yl]propanoic acid
2.1.2 InChI
InChI=1S/C95H140N20O23/c1-50(2)44-69(106-60(13)117)88(133)113-76(59(12)116)91(136)111-72(46-61-30-24-23-25-31-61)90(135)115-95(15)43-29-22-20-18-16-17-19-21-28-42-94(14,92(137)105-58(11)82(127)103-56(9)81(126)102-55(8)80(125)101-54(7)79(124)100-53(6)78(123)99-52(5)77(97)122)114-89(134)70(45-51(3)4)108-84(129)67(38-40-74(96)119)107-83(128)57(10)104-86(131)73(48-63-49-98-66-33-27-26-32-65(63)66)110-87(132)71(47-62-34-36-64(118)37-35-62)109-85(130)68(112-93(95)138)39-41-75(120)121/h17,19,23-27,30-37,49-59,67-73,76,98,116,118H,16,18,20-22,28-29,38-48H2,1-15H3,(H2,96,119)(H2,97,122)(H,99,123)(H,100,124)(H,101,125)(H,102,126)(H,103,127)(H,104,131)(H,105,137)(H,106,117)(H,107,128)(H,108,129)(H,109,130)(H,110,132)(H,111,136)(H,112,138)(H,113,133)(H,114,134)(H,115,135)(H,120,121)/b19-17+/t52-,53+,54+,55+,56+,57+,58+,59-,67+,68+,69+,70+,71+,72+,73+,76+,94+,95-/m1/s1
2.1.3 InChI Key
VDLGAZDAHPLOIR-RLPDZDIMSA-N
2.2 Other Identifiers
2.2.1 UNII
6BGF28R54M
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Sulanemadlin [inn]

2. 6bgf28r54m

3. Sulanemadlin [usan]

4. Alrn-6924

5. Unii-6bgf28r54m

6. 1451199-98-6

7. Alrn6924

8. N-acetyl-l-leucyl-l-threonyl-l-phenylalanyl-cyclo(d-r8-l-glutamyl-ltyrosyl-ltryptophanyl-l-alanyl-l-glutaminyl-l-leucyl-l-s5)-l-alanyl-lalanyl-l-alanyl-l-alanyl-lalanyl-d-alanylamide

9. Sulanemadlin [usan:inn]

10. Alrn 6924

11. Who 11411

12. Sulanemadlin (usan/inn)

13. Alrn 6924 [who-dd]

14. Glxc-27604

15. Hy-p4210

16. Cs-0650265

17. D12399

18. C2.11,c2.4-[(4e)-undec-4-ene-1,11-diyl](n-acetyl-lleucyl-l-threonyl-l-phenylalanyl-l-alanyl-l-alpha-glutamyll-tyrosyl-l-tryptophyl-l-alanyl-l-glutaminyl-l-leucyl-d-alanyl-l-alanyl-l-alanyl-l-alanyl-l-alanyl-l-alanyl-d-alaninamide)

19. D-alaninamide, 42,112-(7e)-7-undecene-1,11-diyl-n-acetyl-l-leucyl-lthreonyl-l-phenylalanyl-l-alanyl-l-alpha-glutamyl-l-tyrosyl-l-tryptophyl-l-alanyl-l-glutaminyl-l-leucyl-d-alanyl-l-alanyl-l-alanyl-l-alanyl-l-alanyl-l-alanyl-

2.4 Create Date
2022-07-07
3 Chemical and Physical Properties
Molecular Weight 1930.2 g/mol
Molecular Formula C95H140N20O23
XLogP33.6
Hydrogen Bond Donor Count23
Hydrogen Bond Acceptor Count23
Rotatable Bond Count37
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area674
Heavy Atom Count138
Formal Charge0
Complexity4220
Isotope Atom Count0
Defined Atom Stereocenter Count18
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1451199-98-6 / Sulanemadlin API manufacturers, exporters & distributors?

Sulanemadlin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Sulanemadlin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sulanemadlin manufacturer or Sulanemadlin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sulanemadlin manufacturer or Sulanemadlin supplier.

PharmaCompass also assists you with knowing the Sulanemadlin API Price utilized in the formulation of products. Sulanemadlin API Price is not always fixed or binding as the Sulanemadlin Price is obtained through a variety of data sources. The Sulanemadlin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sulanemadlin

Synonyms

Sulanemadlin [inn], 6bgf28r54m, Sulanemadlin [usan], Alrn-6924, Unii-6bgf28r54m, 1451199-98-6

Cas Number

1451199-98-6

Unique Ingredient Identifier (UNII)

6BGF28R54M

About Sulanemadlin

Sulanemadlin is an orally available peptide inhibitor of both murine double minute 2 (MDM2) and murine double minute X (MDMX), with potential antineoplastic activity. Upon oral administration, sulanemadlin binds to both MDM2 and MDMX and interferes with their interaction with the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 and MDMX-p53 interactions, p53 activity is restored, which leads to p53-mediated induction of tumor cell apoptosis. MDM2 and MDMX, negative regulators of p53 function, are often overexpressed in cancer cells.

Sulanemadlin Manufacturers

A Sulanemadlin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sulanemadlin, including repackagers and relabelers. The FDA regulates Sulanemadlin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sulanemadlin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Sulanemadlin Suppliers

A Sulanemadlin supplier is an individual or a company that provides Sulanemadlin active pharmaceutical ingredient (API) or Sulanemadlin finished formulations upon request. The Sulanemadlin suppliers may include Sulanemadlin API manufacturers, exporters, distributors and traders.

Sulanemadlin GMP

Sulanemadlin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sulanemadlin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sulanemadlin GMP manufacturer or Sulanemadlin GMP API supplier for your needs.

Sulanemadlin CoA

A Sulanemadlin CoA (Certificate of Analysis) is a formal document that attests to Sulanemadlin's compliance with Sulanemadlin specifications and serves as a tool for batch-level quality control.

Sulanemadlin CoA mostly includes findings from lab analyses of a specific batch. For each Sulanemadlin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sulanemadlin may be tested according to a variety of international standards, such as European Pharmacopoeia (Sulanemadlin EP), Sulanemadlin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sulanemadlin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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