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Chemistry

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Also known as: 54-21-7, Sodium 2-hydroxybenzoate, Enterosalicyl, Kerasalicyl, Clin, Alysine
Molecular Formula
C7H5NaO3
Molecular Weight
160.10  g/mol
InChI Key
ABBQHOQBGMUPJH-UHFFFAOYSA-M
FDA UNII
WIQ1H85SYP

Sodium Salicylate
A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)
1 2D Structure

Sodium Salicylate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;2-hydroxybenzoate
2.1.2 InChI
InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
2.1.3 InChI Key
ABBQHOQBGMUPJH-UHFFFAOYSA-M
2.1.4 Canonical SMILES
C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]
2.2 Other Identifiers
2.2.1 UNII
WIQ1H85SYP
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Salicylate, Sodium

2.3.2 Depositor-Supplied Synonyms

1. 54-21-7

2. Sodium 2-hydroxybenzoate

3. Enterosalicyl

4. Kerasalicyl

5. Clin

6. Alysine

7. Salsonin

8. Benzoic Acid, 2-hydroxy-, Monosodium Salt

9. Enterosalil

10. Entrosalyl

11. Glutosalyl

12. Magsalyl

13. Aroall

14. Kerosal

15. Nadisal

16. Salisod

17. Idocyl Novum

18. Neo-salicyl

19. Natrum Salicylicum

20. Monosodium Salicylate

21. Salicylic Acid Sodium Salt

22. Diuretin

23. Parbocyl-rev

24. Sodium;2-hydroxybenzoate

25. Salicylate Sodium

26. Salicylic Acid, Sodium Salt

27. Sodium O-hydroxybenzoate

28. Salicylic Acid Sodium

29. Wiq1h85syp

30. O-hydroxybenzoic Acid, Sodium Salt

31. Chebi:9180

32. Nsc-202167

33. 90218-97-6

34. Benzoic Acid, 2-hydroxy-, Monosodium Salt, Coupled With 4-amino-1-naphthalenesulfonic Acid And Diazotized 2-(4-aminophenyl)-1h-benzimidazol-5-amine, Sodium Salt

35. Salicylic Acid Sodium Salt;2-hydroxybenzoic Acid Sodium Salt

36. Natrium Salicylat [german]

37. Ccris 6715

38. Einecs 200-198-0

39. Unii-wiq1h85syp

40. Nsc 202167

41. Sodium Salicylate [usp:jan]

42. Natrii Salicylas

43. Mfcd00002440

44. Sodium;2-carboxyphenolate

45. Sodium Salicylate, 99%

46. Spectrum2_001945

47. Spectrum3_000900

48. Spectrum4_000995

49. Spectrum5_001120

50. Dsstox_cid_1708

51. Ec 200-198-0

52. Schembl4603

53. Dsstox_rid_76287

54. Dsstox_gsid_21708

55. Kbiogr_001429

56. 90218-94-3

57. Spectrum1500533

58. Spbio_002009

59. Chembl447868

60. Sodium Salicylate [jan]

61. Dtxsid5021708

62. Sodium Salicylate (jp17/usp)

63. Sodium Salicylate [inci]

64. Hy-b0167a

65. Kbio3_001820

66. Natrum Salicylicum [hpus]

67. Sodium Salicylate [vandf]

68. Sodium Salicylate [mart.]

69. Hms1920p16

70. Hms2092g17

71. Salicylate Sodium [who-dd]

72. Sodium Salicylate [usp-rs]

73. Sodium Salicylate [who-ip]

74. Sodium Salicylate, P.a., 99.5%

75. Tox21_200411

76. 2-hydroxy Benzoic Acid, Sodium Salt

77. Ccg-39474

78. Akos003051698

79. Akos005766021

80. Cs-2008

81. Cas-54-21-7

82. Natrii Salicylas [who-ip Latin]

83. Salicylic Acid Sodium Salt [mi]

84. Sodium Salicylate [ep Monograph]

85. Ncgc00094780-01

86. Ncgc00094780-02

87. Ncgc00257965-01

88. Sodium Salicylate [usp Monograph]

89. Db-052516

90. Ft-0631235

91. C07587

92. D00566

93. D83111

94. Sodium Salicylate, Reagentplus(r), >=99.5%

95. Sodium Salicylate, Saj First Grade, >=99.5%

96. Sodium Salicylate, Tested According To Ph.eur.

97. Sodium Salicylate, Saj Special Grade, >=99.5%

98. 2,4-dimethoxyphenylboronicacid,pinacolester

99. Q414547

100. Sodium Salicylate, Vetec(tm) Reagent Grade, 99%

101. Sodium Salicylate, Meets Usp Testing Specifications

102. Sodium Salicylate, Puriss. P.a., >=99.5% (nt)

103. Sodium Salicylate, European Pharmacopoeia (ep) Reference Standard

104. Sodium Salicylate, United States Pharmacopeia (usp) Reference Standard

105. Benzoic Acid,2-hydroxy-,monosodium Salt,coupled With 4-amino-5-hydroxy-2,7-naphthalenedisulfonic Acid,diazotized 2-(4-aminophenyl)-1h-benzimidazol-5-amine And Diazotized 4-nitrobenzenamine,sodium

106. Sodium Salicylate, Puriss. P.a., Reag. Ph. Eur., 99.5-101.0% (calc. To The Dried Substance)

2.4 Create Date
2007-11-13
3 Chemical and Physical Properties
Molecular Weight 160.10 g/mol
Molecular Formula C7H5NaO3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass160.01363830 g/mol
Monoisotopic Mass160.01363830 g/mol
Topological Polar Surface Area60.4 Ų
Heavy Atom Count11
Formal Charge0
Complexity138
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


Cyclooxygenase Inhibitors

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)


4.2 ATC Code

N - Nervous system

N02 - Analgesics

N02B - Other analgesics and antipyretics

N02BA - Salicylic acid and derivatives

N02BA04 - Sodium salicylate


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17-Jan-2022
29-Apr-2025
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Looking for 54-21-7 / Sodium Salicylate API manufacturers, exporters & distributors?

Sodium Salicylate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Sodium Salicylate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sodium Salicylate manufacturer or Sodium Salicylate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sodium Salicylate manufacturer or Sodium Salicylate supplier.

PharmaCompass also assists you with knowing the Sodium Salicylate API Price utilized in the formulation of products. Sodium Salicylate API Price is not always fixed or binding as the Sodium Salicylate Price is obtained through a variety of data sources. The Sodium Salicylate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sodium Salicylate

Synonyms

54-21-7, Sodium 2-hydroxybenzoate, Enterosalicyl, Kerasalicyl, Clin, Alysine

Cas Number

54-21-7

Unique Ingredient Identifier (UNII)

WIQ1H85SYP

About Sodium Salicylate

A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)

Sodium Salicylate Manufacturers

A Sodium Salicylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sodium Salicylate, including repackagers and relabelers. The FDA regulates Sodium Salicylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sodium Salicylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Sodium Salicylate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Sodium Salicylate Suppliers

A Sodium Salicylate supplier is an individual or a company that provides Sodium Salicylate active pharmaceutical ingredient (API) or Sodium Salicylate finished formulations upon request. The Sodium Salicylate suppliers may include Sodium Salicylate API manufacturers, exporters, distributors and traders.

click here to find a list of Sodium Salicylate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Sodium Salicylate USDMF

A Sodium Salicylate DMF (Drug Master File) is a document detailing the whole manufacturing process of Sodium Salicylate active pharmaceutical ingredient (API) in detail. Different forms of Sodium Salicylate DMFs exist exist since differing nations have different regulations, such as Sodium Salicylate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Sodium Salicylate DMF submitted to regulatory agencies in the US is known as a USDMF. Sodium Salicylate USDMF includes data on Sodium Salicylate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Sodium Salicylate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Sodium Salicylate suppliers with USDMF on PharmaCompass.

Sodium Salicylate JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Sodium Salicylate Drug Master File in Japan (Sodium Salicylate JDMF) empowers Sodium Salicylate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Sodium Salicylate JDMF during the approval evaluation for pharmaceutical products. At the time of Sodium Salicylate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Sodium Salicylate suppliers with JDMF on PharmaCompass.

Sodium Salicylate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Sodium Salicylate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Sodium Salicylate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Sodium Salicylate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Sodium Salicylate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Sodium Salicylate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Sodium Salicylate suppliers with NDC on PharmaCompass.

Sodium Salicylate GMP

Sodium Salicylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sodium Salicylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sodium Salicylate GMP manufacturer or Sodium Salicylate GMP API supplier for your needs.

Sodium Salicylate CoA

A Sodium Salicylate CoA (Certificate of Analysis) is a formal document that attests to Sodium Salicylate's compliance with Sodium Salicylate specifications and serves as a tool for batch-level quality control.

Sodium Salicylate CoA mostly includes findings from lab analyses of a specific batch. For each Sodium Salicylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sodium Salicylate may be tested according to a variety of international standards, such as European Pharmacopoeia (Sodium Salicylate EP), Sodium Salicylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sodium Salicylate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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