Find Silodosin manufacturers, exporters & distributors on PharmaCompass

Question

Looking for 160970-54-7 / Silodosin API manufacturers, exporters & distributors?

API | Excipient name

Silodosin

Synonyms

160970-54-7, Rapaflo, Urief, Silodyx, Urorec, Kmd-3213

Cas Number

160970-54-7

Unique Ingredient Identifier (UNII)

CUZ39LUY82

About Silodosin

Silodosin is an orally available, alpha-1 adrenoreceptor (alpha-1a) selective antagonist that can be used to relieve symptoms of benign prostate hyperplasia (BPH). Upon administration, silodosin selectively binds alpha-1a receptors located in the human prostate and bladder with high affinity and blocks signaling pathways mediated by alpha-1a. Blockade of these receptors causes smooth muscle relaxation, lowers intraurethral pressure, and results in improved urine flow and a reduction in the symptoms of BPH, such as difficulty with urinating, painful urination, urinary frequency and incomplete bladder emptying. In addition, silodosin may be used to improve lower urinary tract symptoms, which can occur after receiving radiation therapy for prostate cancer.

score 41 · Accepted Answer

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Molecular Formula	C₂₅H₃₂F₃N₃O₄
Molecular Weight	495.5 g/mol
XLogP3	3.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	13
Exact Mass	495.23449100 g/mol
Monoisotopic Mass	495.23449100 g/mol
Topological Polar Surface Area	97 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	654
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

1 of 2
Drug Name	Rapaflo
PubMed Health	Silodosin (By mouth)
Drug Classes	Benign Prostatic Hypertrophy Agent
Drug Label	RAPAFLO is the brand name for silodosin, a selective antagonist of alpha-1 adrenoreceptors. The chemical name of silodosin is 1-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide...
Active Ingredient	Silodosin
Dosage Form	Capsule
Route	Oral
Strength	8mg; 4mg
Market Status	Prescription
Company	Watson Labs

2 of 2
Drug Name	Rapaflo
PubMed Health	Silodosin (By mouth)
Drug Classes	Benign Prostatic Hypertrophy Agent
Drug Label	RAPAFLO is the brand name for silodosin, a selective antagonist of alpha-1 adrenoreceptors. The chemical name of silodosin is 1-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide...
Active Ingredient	Silodosin
Dosage Form	Capsule
Route	Oral
Strength	8mg; 4mg
Market Status	Prescription
Company	Watson Labs

Find Silodosin manufacturers, exporters & distributors on PharmaCompass

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CAPSULE;ORAL - 4MG

CAPSULE;ORAL - 8MG

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