Find Roflumilast manufacturers, exporters & distributors on PharmaCompass

Question

Looking for 162401-32-3 / Roflumilast API manufacturers, exporters & distributors?

API | Excipient name

Roflumilast

Synonyms

162401-32-3, Daxas, 3-(cyclopropylmethoxy)-n-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide, Daliresp, By217, Byk20869

Cas Number

162401-32-3

Unique Ingredient Identifier (UNII)

0P6C6ZOP5U

About Roflumilast

Roflumilast is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities. Upon administration, roflumilast and its active metabolite roflumilast N-oxide selectively and competitively bind to and inhibit PDE4, which leads to an increase of both intracellular levels of cyclic-3',5'-adenosine monophosphate (cAMP) and cAMP-mediated signaling. cAMP prevents phosphorylation of spleen tyrosine kinase (SYK) and abrogates activation of the PI3K/AKT/mTOR signaling pathway, which may result in the induction of apoptosis. PDE4, a member of the PDE superfamily that hydrolyses cAMP and 3',5'-cyclic guanosine monophosphate (cGMP) to their inactive 5' monophosphates, is upregulated in a variety of cancers and may contribute to chemoresistance; it also plays a key role in inflammation, especially in inflammatory airway diseases.

score 78 · Accepted Answer

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Molecular Formula	C₁₇H₁₄Cl₂F₂N₂O₃
Molecular Weight	403.2 g/mol
XLogP3	4.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	402.0349540 g/mol
Monoisotopic Mass	402.0349540 g/mol
Topological Polar Surface Area	60.4 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	475
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

1 of 2
Drug Name	Daliresp
PubMed Health	Roflumilast (By mouth)
Drug Classes	Respiratory Agent
Drug Label	The active ingredient in DALIRESP tablets is roflumilast. Roflumilast and its active metabolite (roflumilast N-oxide) are selective phosphodiesterase 4 (PDE4) inhibitors. The chemical name of roflumilast is N-(3,5-dichloropyridin-4-yl)-3-cyclopropylm...
Active Ingredient	Roflumilast
Dosage Form	Tablet
Route	Oral
Strength	500mcg
Market Status	Prescription
Company	Forest Res Inst

2 of 2
Drug Name	Daliresp
PubMed Health	Roflumilast (By mouth)
Drug Classes	Respiratory Agent
Drug Label	The active ingredient in DALIRESP tablets is roflumilast. Roflumilast and its active metabolite (roflumilast N-oxide) are selective phosphodiesterase 4 (PDE4) inhibitors. The chemical name of roflumilast is N-(3,5-dichloropyridin-4-yl)-3-cyclopropylm...
Active Ingredient	Roflumilast
Dosage Form	Tablet
Route	Oral
Strength	500mcg
Market Status	Prescription
Company	Forest Res Inst

Find Roflumilast manufacturers, exporters & distributors on PharmaCompass

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CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

35 API Suppliers

12 USDMF

3 EU WC

5 KDMF

14 NDC API

19 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

129 Drugs in Development

INTERMEDIATES

7 Intermediate Suppliers

FINISHED DOSAGE FORMULATIONS

70 FDF Dossiers

26 FDA Orange Book

31 Europe

4 Canada

1 South Africa

8 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 250MCG

TABLET;ORAL - 500MCG

RELATED EXCIPIENT COMPANIES

3 SPI Pharma

1 Boai NKY Pharmaceuticals Ltd

2 Gangwal Healthcare

1 Nanjing Well Pharmaceutical

2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

1 Ashland

9 BASF

2 DFE Pharma

1 Gangwal Chemicals

2 Ingredion Pharma Solutions

9 Kerry

8 Microlex e.U

1 Neelkanth MineChem

1 Nitika Pharmaceutical Specialities

1 Novo Excipients

1 Pharmatrans-Sanaq

4 Pluviaendo

1 Prachin Chemical

6 Roquette

1 Seppic

2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Sigachi Industries

1 Silverline Chemicals

1 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

31 Fillers, Diluents & Binders

13 Granulation

12 Direct Compression

8 Lubricants & Glidants

6 Solubilizers

4 Co-Processed Excipients

4 Thickeners and Stabilizers

4 Disintegrants & Superdisintegrants

3 Chewable & Orodispersible Aids

3 Taste Masking

3 Parenteral

3 Controlled & Modified Release

2 Emulsifying Agents

1 Coating Systems & Additives

1 Film Formers & Plasticizers

DIGITAL CONTENT

115 News #PharmaBuzz

GLOBAL SALES INFORMATION

9 US Medicaid Prescriptions

3 Regulatory FDF Prices

10 Annual Reports

MARKET PLACE

17 APIs

1 FDF Dossiers

PATENTS & EXCLUSIVITIES

76 US Patents

5 US Exclusivities

8 Health Canada Patents