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Chemistry

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Also known as: Rifaxidin, Rifacol, 80621-81-4, Rifamycin l 105, Xifaxan, Rifamycin l 105sv
Molecular Formula
C43H51N3O11
Molecular Weight
785.9  g/mol
InChI Key
NZCRJKRKKOLAOJ-XRCRFVBUSA-N
FDA UNII
L36O5T016N

Rifaximin
A synthetic rifamycin derivative and anti-bacterial agent that is used for the treatment of GASTROENTERITIS caused by ESCHERICHIA COLI INFECTIONS. It may also be used in the treatment of HEPATIC ENCEPHALOPATHY.
Rifaximin is a Rifamycin Antibacterial.
1 2D Structure

Rifaximin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1(35),2,4,9,19,21,25(36),26(34),28,30,32-undecaen-13-yl] acetate
2.1.2 InChI
InChI=1S/C43H51N3O11/c1-19-14-16-46-28(18-19)44-32-29-30-37(50)25(7)40-31(29)41(52)43(9,57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18,20,22-24,27,35-36,39,48-51H,1-10H3,(H,45,53)/b12-11+,17-15+,21-13-/t20-,22+,23+,24+,27-,35-,36+,39+,43-/m0/s1
2.1.3 InChI Key
NZCRJKRKKOLAOJ-XRCRFVBUSA-N
2.1.4 Canonical SMILES
CC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)C
2.1.5 Isomeric SMILES
C[C@H]1/C=C/C=C(\C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)O[C@@](C4=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)/C
2.2 Other Identifiers
2.2.1 UNII
L36O5T016N
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4c)rifamycin

2. L 105

3. L-105

4. L105

5. Redactiv

6. Xifaxan

2.3.2 Depositor-Supplied Synonyms

1. Rifaxidin

2. Rifacol

3. 80621-81-4

4. Rifamycin L 105

5. Xifaxan

6. Rifamycin L 105sv

7. Fatroximin

8. Rifaximine

9. Normix

10. Rifaximina

11. Xifaxsan

12. L-105

13. Rifamixin

14. Rifaximine [french]

15. Rifaximinum [latin]

16. Rifaximina [spanish]

17. Ritacol

18. Chebi:75246

19. 4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin Sv

20. L36o5t016n

21. Rifaximin (xifaxan)

22. Nsc-758957

23. Rifaximinum

24. Brn 3584528

25. (2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,15-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)furo[2'',3'':7',8']naphtho[1',2':4,5]imidazo[1,2-a]pyridin-25-yl Acetate

26. C43h51n3o11

27. Rifaxin

28. Redactiv

29. Ido[1,2-a]benzimidazol-25-yl Acetate

30. (2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)-25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2h)-dione

31. L 105sv

32. L 105 (ansamacrolide Antibiotic)

33. L 105

34. Rifaximinun

35. Flonorm

36. Lumenax

37. Spiraxin

38. Lormyx

39. Rifaximin [usan:inn:ban]

40. Unii-l36o5t016n

41. 5-yl Acetate

42. Ncgc00095842-01

43. (2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)-25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2h)-dione

44. (2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,15-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-e]pyr

45. Xifaxan (tn)

46. Mfcd00864973

47. Rifaximin [inn]

48. Rifaximin [jan]

49. Rifaximin [mi]

50. Rifaximin [usan]

51. Rifaximin [vandf]

52. Rifaximin [mart.]

53. Alpha-0817185

54. Rifaximin [who-dd]

55. Chembl1617

56. Dsstox_cid_25998

57. Dsstox_rid_81280

58. Dsstox_gsid_45998

59. (2s,16z,18e,20s,21s,22r,23r,24r,25s,26s,27s,28e)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2h)-dione, 25-acetate

60. Rifaximin (jan/usan/inn)

61. Schembl124066

62. Rifaximin [ep Impurity]

63. Rifaximin [orange Book]

64. Dtxsid7045998

65. Rifaximin [ep Monograph]

66. Gtpl12012

67. Hms3715b19

68. 88747-56-2

69. Tox21_111529

70. Bdbm50347620

71. S1790

72. Akos015963053

73. Zinc169621200

74. Ccg-221129

75. Db01220

76. Nsc 758957

77. Rifaximin 100 Microg/ml In Acetonitrile

78. 2,7-(epoxy(1,11,13)pentadecatrienoimino)furo(2'',3'':7',8')naphth(1',2':4,5)imidazo(1,2-a)pyridine-1,15(2h)-dione, 25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-, ( 2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)-

79. 2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2h)-dione, 25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-, (2s-(2r*,16z,18e,20r*,21r*,22s*,23s*,24s*,25r*,26s*,27r*,28e))-

80. Ac-19112

81. Cas-80621-81-4

82. L/105

83. D02554

84. Ab01209738-01

85. Ab01209738-03

86. Ab01209738_04

87. Rifaximin, Antibiotic For Culture Media Use Only

88. 621r814

89. Q416073

90. Q-201671

91. (2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-1,1

92. (7s,11s,12r,13s,14r,15r,16r,17s,18s)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.1^{4,7}.0^{5,35}.0^{26,34}.0^{27,32}]heptatriaconta-1,3,5(35),9,19,21,25(36),26(34),28,30,32-undecaen-13-yl Acetate

93. [(7s,9e,11s,12r,13s,14r,15r,16r,17s,18s,19e,21z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1(35),2,4,9,19,21,25(36),26(34),28,30,32-undecaen-13-yl] Acetate

94. 2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2h)-dione, 25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-, (2s,16z,18e,20s,21s,22r,23r,24r,25s,26r,27s,28e)-

95. 5-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)furo[2'',3'':7',8']naphtho[1',2':4,5]imidazo[1,2-a]pyridin-2

2.4 Create Date
2006-04-28
3 Chemical and Physical Properties
Molecular Weight 785.9 g/mol
Molecular Formula C43H51N3O11
XLogP36.9
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count12
Rotatable Bond Count3
Exact Mass785.35235945 g/mol
Monoisotopic Mass785.35235945 g/mol
Topological Polar Surface Area198 Ų
Heavy Atom Count57
Formal Charge0
Complexity1590
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count3
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameXifaxan
PubMed HealthRifaximin (By mouth)
Drug ClassesAntibiotic
Drug LabelXIFAXAN tablets contain rifaximin, a non-aminoglycoside semi-synthetic, nonsystemic antibiotic derived from rifamycin SV. Rifaximin is a structural analog of rifampin. The chemical name for rifaximin is (2 ,16 ,18 ,20 ,21 ,22 ,23 ,24 ,25 ,26 ,27...
Active IngredientRifaximin
Dosage FormTablet
RouteOral
Strength200mg; 550mg
Market StatusPrescription
CompanySalix Pharms

2 of 2  
Drug NameXifaxan
PubMed HealthRifaximin (By mouth)
Drug ClassesAntibiotic
Drug LabelXIFAXAN tablets contain rifaximin, a non-aminoglycoside semi-synthetic, nonsystemic antibiotic derived from rifamycin SV. Rifaximin is a structural analog of rifampin. The chemical name for rifaximin is (2 ,16 ,18 ,20 ,21 ,22 ,23 ,24 ,25 ,26 ,27...
Active IngredientRifaximin
Dosage FormTablet
RouteOral
Strength200mg; 550mg
Market StatusPrescription
CompanySalix Pharms

4.2 Drug Indication

Rifaximin has multiple indications by the FDA: for the treatment of patients (12 years of age) with traveller's diarrhea caused by noninvasive strains of Escherichia coli; for the reduction of overt hepatic encephalopathy recurrence in patients 18 years of age; and in May 2015 it was approved for irritable bowel syndrome with diarrhea (IBS-D) treatment in adult men and women.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Rifaximin is a structural analog of rifampin and a non-systemic, gastrointestinal site-specific antibiotic. This non-systemic property of the drug is due to the addition of a pyridoimidazole ring, which renders it non-absorbable. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis and contributes to restore intestinal microflora imbalance. Other studies have also shown rifaximin to be an pregnane X receptor (PXR) activator. As PXR is responsible for inhibiting the proinflammatory transcription factor NF-kappa B (NF-B) and is inhibited in inflammatory bowel disease (IBD), rifaximin was proven to be effective for the treatment of IBS-D.


5.2 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


Gastrointestinal Agents

Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
RIFAXIMIN
5.3.2 FDA UNII
L36O5T016N
5.3.3 Pharmacological Classes
Rifamycins [CS]; Rifamycin Antibacterial [EPC]
5.4 ATC Code

A07AA11

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


A - Alimentary tract and metabolism

A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents

A07A - Intestinal antiinfectives

A07AA - Antibiotics

A07AA11 - Rifaximin


D - Dermatologicals

D06 - Antibiotics and chemotherapeutics for dermatological use

D06A - Antibiotics for topical use

D06AX - Other antibiotics for topical use

D06AX11 - Rifaximin


5.5 Absorption, Distribution and Excretion

Absorption

Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.


Route of Elimination

In a mass balance study, after administration of 400 mg 14C-rifaximin orally to healthy volunteers, of the 96.94% total recovery, 96.62% of the administered radioactivity was recovered in feces almost exclusively as the unchanged drug and 0.32% was recovered in urine mostly as metabolites with 0.03% as the unchanged drug.Rifaximin accounted for 18% of radioactivity in plasma. This suggests that the absorbed rifaximin undergoes metabolism with minimal renal excretion of the unchanged drug


5.6 Metabolism/Metabolites

In vitro drug interactions studies have shown that rifaximin, at concentrations ranging from 2 to 200 ng/mL, did not inhibit human hepatic cytochrome P450 isoenzymes: 1A2, 2A6, 2B6, 2C9, 2C19, 2D6, 2E1, and 3A4. In an in vitro hepa-tocyte induction model, rifaximin was shown to induce cytochrome P450 3A4 (CYP3A4), an isoenzyme which rifampin is known to induce.


5.7 Biological Half-Life

Approximately 6 hours.


5.8 Mechanism of Action

Rifaximin acts by inhibiting RNA synthesis in susceptible bacteria by binding to the beta-subunit of bacterial deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme. This binding blocks translocation, which stops transcription.


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05-Jan-2022
28-Apr-2025
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Drugs in Development

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Details:

Xifaxan-Generic (rifaximin) is a rifamycin antibacterial indicated for the treatment of irritable bowel syndrome with diarrhoea (IBS-D) in adults.


Lead Product(s): Rifaximin

Therapeutic Area: Gastroenterology Brand Name: Xifaxan-Generic

Study Phase: Approved FDFProduct Type: Antibiotic

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable June 02, 2025

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01

Global DDF Summit
Not Confirmed
Global DDF Summit
Not Confirmed

Details : Xifaxan-Generic (rifaximin) is a rifamycin antibacterial indicated for the treatment of irritable bowel syndrome with diarrhoea (IBS-D) in adults.

Product Name : Xifaxan-Generic

Product Type : Antibiotic

Upfront Cash : Inapplicable

June 02, 2025

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Details:

XIFAXAN (rifaximin) is a 2 week prescription treatment that provided up to 6 months of relief from IBS-D symptoms of abdominal pain and diarrhea in a clinical trial.


Lead Product(s): Rifaximin

Therapeutic Area: Gastroenterology Brand Name: Xifaxan-Generic

Study Phase: UndisclosedProduct Type: Antibiotic

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable November 08, 2022

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02

Alvogen

U.S.A
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Global DDF Summit
Not Confirmed

Alvogen

U.S.A
arrow
Global DDF Summit
Not Confirmed

Details : XIFAXAN (rifaximin) is a 2 week prescription treatment that provided up to 6 months of relief from IBS-D symptoms of abdominal pain and diarrhea in a clinical trial.

Product Name : Xifaxan-Generic

Product Type : Antibiotic

Upfront Cash : Inapplicable

November 08, 2022

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Details:

XIFAXAN (rifaximin) 200 mg tablets are indicated for travelers diarrhea. XIFAXAN (rifaximin) 550 mg tablets are indicated for reduction in risk of overt hepatic encephalopathy recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea in adults.


Lead Product(s): Rifaximin

Therapeutic Area: Infections and Infectious Diseases Brand Name: Xifaxan-Generic

Study Phase: Approved FDFProduct Type: Antibiotic

Sponsor: Bausch Health

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable September 09, 2022

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Alvogen

U.S.A
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Alvogen

U.S.A
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Not Confirmed

Details : XIFAXAN (rifaximin) 200 mg tablets are indicated for travelers diarrhea. XIFAXAN (rifaximin) 550 mg tablets are indicated for reduction in risk of overt hepatic encephalopathy recurrence in adults and for the treatment of irritable bowel syndrome with di...

Product Name : Xifaxan-Generic

Product Type : Antibiotic

Upfront Cash : Inapplicable

September 09, 2022

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Details:

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.


Lead Product(s): Rifaximin

Therapeutic Area: Neurology Brand Name: Xifaxan

Study Phase: Approved FDFProduct Type: Antibiotic

Sponsor: Salix Pharmaceuticals

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable July 28, 2022

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Bausch Health

Canada
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Not Confirmed

Bausch Health

Canada
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Not Confirmed

Details : XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

Product Name : Xifaxan

Product Type : Antibiotic

Upfront Cash : Inapplicable

July 28, 2022

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Details:

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.


Lead Product(s): Rifaximin

Therapeutic Area: Neurology Brand Name: Xifaxan

Study Phase: Approved FDFProduct Type: Antibiotic

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable July 04, 2022

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Global DDF Summit
Not Confirmed
Global DDF Summit
Not Confirmed

Details : XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

Product Name : Xifaxan

Product Type : Antibiotic

Upfront Cash : Inapplicable

July 04, 2022

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Details:

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.


Lead Product(s): Rifaximin

Therapeutic Area: Neurology Brand Name: Xifaxan

Study Phase: Approved FDFProduct Type: Antibiotic

Sponsor: Bausch Health

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable June 20, 2022

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Global DDF Summit
Not Confirmed
Global DDF Summit
Not Confirmed

Details : XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

Product Name : Xifaxan

Product Type : Antibiotic

Upfront Cash : Inapplicable

June 20, 2022

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Details:

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.


Lead Product(s): Rifaximin

Therapeutic Area: Neurology Brand Name: Xifaxan

Study Phase: Approved FDFProduct Type: Antibiotic

Sponsor: Bausch Health

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable May 18, 2022

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Global DDF Summit
Not Confirmed
Global DDF Summit
Not Confirmed

Details : XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

Product Name : Xifaxan

Product Type : Antibiotic

Upfront Cash : Inapplicable

May 18, 2022

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Details:

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.


Lead Product(s): Rifaximin

Therapeutic Area: Neurology Brand Name: Xifaxan

Study Phase: Approved FDFProduct Type: Antibiotic

Sponsor: Bausch Health

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable October 25, 2021

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Global DDF Summit
Not Confirmed
Global DDF Summit
Not Confirmed

Details : XIFAXAN® (rifaximin) 550 mg tablets are indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults and for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

Product Name : Xifaxan

Product Type : Antibiotic

Upfront Cash : Inapplicable

October 25, 2021

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Details:

Salix going present two scientific posters featuring rifaximin data at the American Association for the Study of Liver Diseases (AASLD) annual meeting, The Liver Meeting Digital Experience, which will take place.


Lead Product(s): Rifaximin

Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Brand Name: Xifaxan

Study Phase: Phase IIProduct Type: Antibiotic

Sponsor: Bausch Health

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable November 11, 2020

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Global DDF Summit
Not Confirmed
Global DDF Summit
Not Confirmed

Details : Salix going present two scientific posters featuring rifaximin data at the American Association for the Study of Liver Diseases (AASLD) annual meeting, The Liver Meeting Digital Experience, which will take place.

Product Name : Xifaxan

Product Type : Antibiotic

Upfront Cash : Inapplicable

November 11, 2020

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Details:

Company plans to start a Phase 2 trial in the first half of 2021 evaluating a novel rifaximin formulation for a potential sickle cell disease treatment.


Lead Product(s): Rifaximin

Therapeutic Area: Genetic Disease Brand Name: Xifaxan

Study Phase: Phase IIProduct Type: Antibiotic

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable October 29, 2020

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Bausch Health

Canada
arrow
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Not Confirmed

Bausch Health

Canada
arrow
Global DDF Summit
Not Confirmed

Details : Company plans to start a Phase 2 trial in the first half of 2021 evaluating a novel rifaximin formulation for a potential sickle cell disease treatment.

Product Name : Xifaxan

Product Type : Antibiotic

Upfront Cash : Inapplicable

October 29, 2020

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Registration Country : Iran

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Rifaximin

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Dosage Strength : 200MG

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Approval Date :

Application Number :

Regulatory Info : EU Dossier Readiness-Q1 2020

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Rifaximin

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Dosage Form : Film Coated Tablet

Dosage Strength : 550MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : EU Dossier Readiness-Q1 2020

Registration Country : Germany

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Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

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Regulatory Info : EU Dossier Readiness-Q1 2020

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Rifaximin

Brand Name :

Dosage Form : Film Coated Tablet

Dosage Strength : 200MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : EU Dossier Readiness-Q1 2020

Registration Country : Germany

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Registration Country : Germany

Rifaximin

Brand Name :

Dosage Form : Film Coated Tablet

Dosage Strength : 550MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : EU Dossier Readiness-Q1 2020

Registration Country : Germany

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07

Pharmathen SA

Greece
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Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

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Regulatory Info :

Registration Country : Greece

Rifaximin

Brand Name :

Dosage Form : Tablet

Dosage Strength : 200MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Greece

Pharmathen

08

Pharmathen SA

Greece
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPharmathen provides life cycle Management solutions for branded pharma, as well as to develop & establish new technology platforms.

Flag Greece
Digital Content Digital Content

Regulatory Info :

Registration Country : Greece

Rifaximin

Brand Name :

Dosage Form : Tablet

Dosage Strength : 550MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Greece

Pharmathen

09

Grunenthal

Germany
Global DDF Summit
Not Confirmed
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Grunenthal

Germany
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Not Confirmed

Rifaximin

Brand Name : Rifacol

Dosage Form : Rifaximin 60Ml 100Mg/Ml Oral Use

Dosage Strength : os grat suspe 60 ml 2 g/100 ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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Rifaximin

Brand Name :

Dosage Form : Film Coated Tablet

Dosage Strength : 550MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

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Europe

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Registration Country : Germany

Rifaximin

Brand Name :

Dosage Form : Film Coated Tablet

Dosage Strength : 200MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : EU Dossier Readiness-Q1 2020

Registration Country : Germany

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02

  • fda
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  • WHO-GMP

Virtual BoothWe are the TIEFENBACHER GROUP, Health Pioneers since 1963.

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Regulatory Info : EU Dossier Readiness-Q1 2020

Registration Country : Germany

Rifaximin

Brand Name :

Dosage Form : Film Coated Tablet

Dosage Strength : 550MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : EU Dossier Readiness-Q1 2020

Registration Country : Germany

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rifaximin

Brand Name : Tixteller

Dosage Form : FILM COATED PILL

Dosage Strength : 550 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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Rifaximin

Brand Name : Normix

Dosage Form : Rifaximin 200Mg 12 Combined Oral Use

Dosage Strength : 12 cpr riv 200 mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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Rifaximin

Brand Name : Normix

Dosage Form : Rifaximin 60Ml 100Mg/Ml Oral Use

Dosage Strength : os grat suspe 60 ml 2 g/100 ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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Rifaximin

Brand Name : Xifaxan

Dosage Form : Film-Coated Tablets

Dosage Strength : 550mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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Rifaximin

Brand Name : Rifacol

Dosage Form : Rifaximin 200Mg 12 Combined Oral Use

Dosage Strength : AD 12 cpr riv 200 mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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Rifaximin

Brand Name : Rifacol

Dosage Form : Rifaximin 60Ml 100Mg/Ml Oral Use

Dosage Strength : os grat suspe 60 ml 2 g/100 ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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Norgine BV

Netherlands
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Norgine BV

Netherlands
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rifaximin

Brand Name : Xifaxan

Dosage Form : FILM COATED PILL

Dosage Strength : 550 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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Norgine BV

Netherlands
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Norgine BV

Netherlands
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Rifaximin

Brand Name : Xifaxan

Dosage Form : Antic-calc Tablet, Film Coated

Dosage Strength : 550 mg

Packaging : Blister

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - 200MG

USFDA APPLICATION NUMBER - 21361

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DOSAGE - TABLET;ORAL - 550MG

USFDA APPLICATION NUMBER - 21361

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ABOUT THIS PAGE

Looking for 80621-81-4 / Rifaximin API manufacturers, exporters & distributors?

Rifaximin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Rifaximin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Rifaximin manufacturer or Rifaximin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Rifaximin manufacturer or Rifaximin supplier.

PharmaCompass also assists you with knowing the Rifaximin API Price utilized in the formulation of products. Rifaximin API Price is not always fixed or binding as the Rifaximin Price is obtained through a variety of data sources. The Rifaximin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Rifaximin

Synonyms

Rifaxidin, Rifacol, 80621-81-4, Rifamycin l 105, Xifaxan, Rifamycin l 105sv

Cas Number

80621-81-4

Unique Ingredient Identifier (UNII)

L36O5T016N

About Rifaximin

A synthetic rifamycin derivative and anti-bacterial agent that is used for the treatment of GASTROENTERITIS caused by ESCHERICHIA COLI INFECTIONS. It may also be used in the treatment of HEPATIC ENCEPHALOPATHY.

Rifamixin Manufacturers

A Rifamixin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rifamixin, including repackagers and relabelers. The FDA regulates Rifamixin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rifamixin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Rifamixin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Rifamixin Suppliers

A Rifamixin supplier is an individual or a company that provides Rifamixin active pharmaceutical ingredient (API) or Rifamixin finished formulations upon request. The Rifamixin suppliers may include Rifamixin API manufacturers, exporters, distributors and traders.

click here to find a list of Rifamixin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Rifamixin USDMF

A Rifamixin DMF (Drug Master File) is a document detailing the whole manufacturing process of Rifamixin active pharmaceutical ingredient (API) in detail. Different forms of Rifamixin DMFs exist exist since differing nations have different regulations, such as Rifamixin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Rifamixin DMF submitted to regulatory agencies in the US is known as a USDMF. Rifamixin USDMF includes data on Rifamixin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Rifamixin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Rifamixin suppliers with USDMF on PharmaCompass.

Rifamixin JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Rifamixin Drug Master File in Japan (Rifamixin JDMF) empowers Rifamixin API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Rifamixin JDMF during the approval evaluation for pharmaceutical products. At the time of Rifamixin JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Rifamixin suppliers with JDMF on PharmaCompass.

Rifamixin KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Rifamixin Drug Master File in Korea (Rifamixin KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Rifamixin. The MFDS reviews the Rifamixin KDMF as part of the drug registration process and uses the information provided in the Rifamixin KDMF to evaluate the safety and efficacy of the drug.

After submitting a Rifamixin KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Rifamixin API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Rifamixin suppliers with KDMF on PharmaCompass.

Rifamixin CEP

A Rifamixin CEP of the European Pharmacopoeia monograph is often referred to as a Rifamixin Certificate of Suitability (COS). The purpose of a Rifamixin CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Rifamixin EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Rifamixin to their clients by showing that a Rifamixin CEP has been issued for it. The manufacturer submits a Rifamixin CEP (COS) as part of the market authorization procedure, and it takes on the role of a Rifamixin CEP holder for the record. Additionally, the data presented in the Rifamixin CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Rifamixin DMF.

A Rifamixin CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Rifamixin CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Rifamixin suppliers with CEP (COS) on PharmaCompass.

Rifamixin WC

A Rifamixin written confirmation (Rifamixin WC) is an official document issued by a regulatory agency to a Rifamixin manufacturer, verifying that the manufacturing facility of a Rifamixin active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Rifamixin APIs or Rifamixin finished pharmaceutical products to another nation, regulatory agencies frequently require a Rifamixin WC (written confirmation) as part of the regulatory process.

click here to find a list of Rifamixin suppliers with Written Confirmation (WC) on PharmaCompass.

Rifamixin NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Rifamixin as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Rifamixin API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Rifamixin as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Rifamixin and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Rifamixin NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Rifamixin suppliers with NDC on PharmaCompass.

Rifamixin GMP

Rifamixin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Rifamixin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rifamixin GMP manufacturer or Rifamixin GMP API supplier for your needs.

Rifamixin CoA

A Rifamixin CoA (Certificate of Analysis) is a formal document that attests to Rifamixin's compliance with Rifamixin specifications and serves as a tool for batch-level quality control.

Rifamixin CoA mostly includes findings from lab analyses of a specific batch. For each Rifamixin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Rifamixin may be tested according to a variety of international standards, such as European Pharmacopoeia (Rifamixin EP), Rifamixin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rifamixin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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