Prucalopride Succinate

Synopsis, Chemistry

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Also known as: 179474-85-2, Resolor, Prucalopride succinat, Prucalopride (succinate), R-108512, Butanedioic acid 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide

Molecular Formula

C₂₂H₃₂ClN₃O₇

Molecular Weight

486.0 g/mol

InChI Key

QZRSNVSQLGRAID-UHFFFAOYSA-N

FDA UNII

4V2G75E1CK

1 2D Structure

Prucalopride Succinate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;butanedioic acid

2.1.2 InChI

InChI=1S/C18H26ClN3O3.C4H6O4/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14;5-3(6)1-2-4(7)8/h11-12H,2-10,20H2,1H3,(H,21,23);1-2H2,(H,5,6)(H,7,8)

2.1.3 InChI Key

QZRSNVSQLGRAID-UHFFFAOYSA-N

2.1.4 Canonical SMILES

COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

4V2G75E1CK

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-amino-5-chloro-n-(1-(3-methoxypropyl)-4-piperidinyl)-2,3-dihydro-1-benzofuran-7-carboxamide

2. Motegrity

3. Prucalopride

4. R 093877

5. R093877

6. Resolor

7. Resotran

8. Resotrans

2.3.2 Depositor-Supplied Synonyms

1. 179474-85-2

2. Resolor

3. Prucalopride Succinat

4. Prucalopride (succinate)

5. R-108512

6. Butanedioic Acid 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide

7. Prucalopride Succinate [usan]

8. Prucalopride (as Succinate)

9. 4v2g75e1ck

10. 179474-85-2 (succinate)

11. 4-amino-5-chloro-n-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide Succinate

12. Butanedioic Acid, Compd. With 4-amino-5-chloro-2,3-dihydro-n-(1-(3-methoxypropyl)-4-piperidinyl)-7-benzofurancarboxamide (1:1)

13. Butanedioic Acid, Compd. With 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (1:1)

14. Prucalopride Succinate (usan)

15. Resotran

16. 4-amino-5-chloro-n-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;butanedioic Acid

17. Resolor (tn)

18. Unii-4v2g75e1ck

19. R-93877

20. Resolor Succinate

21. Motegrity (tn)

22. Prucalopridesuccinate

23. R 108512

24. Mls006011219

25. Schembl1230437

26. Chembl2105748

27. Dtxsid701027749

28. Hms3652b21

29. Hms3885j13

30. Bcp09320

31. Mfcd00948731

32. S4247

33. Akos015994741

34. Prucalopride Succinate [mart.]

35. Ccg-269590

36. Cs-3907

37. Ks-1283

38. Prucalopride Succinate [who-dd]

39. 4-amino-5-chloro-n-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide,butanedioic Acid

40. Ac-29960

41. Butanedioic Acid 4-amino-5-chloro-2,3-dihydro-n-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarb

42. Hy-12694

43. Smr004702981

44. Db-065276

45. Prucalopride Succinate [orange Book]

46. Ft-0745512

47. Sw219198-1

48. D10152

49. A812449

50. J-519956

51. Q27260539

52. B0084-470898

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₃₂ClN₃O₇
Molecular Weight	486.0 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	9
Exact Mass	485.1928781 g/mol
Monoisotopic Mass	485.1928781 g/mol
Topological Polar Surface Area	151 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	538
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Resolor is indicated for symptomatic treatment of chronic constipation in adults in whom laxatives fail to provide adequate relief.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Laxatives

Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION. (See all compounds classified as Laxatives.)

Serotonin 5-HT4 Receptor Agonists

Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT4 RECEPTORS. (See all compounds classified as Serotonin 5-HT4 Receptor Agonists.)

5.2 ATC Code

A06AX05