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Chemistry

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Also known as: Prn1371, 1802929-43-6, Prn-1371, S3ope9ia3q, 6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one, Unii-s3ope9ia3q
Molecular Formula
C26H30Cl2N6O4
Molecular Weight
561.5  g/mol
InChI Key
PUIXMSRTTHLNKI-UHFFFAOYSA-N
FDA UNII
S3OPE9IA3Q

Prn1371
pan FGFR Inhibitor PRN1371 is a highly specific covalent inhibitor of human fibroblast growth factor receptor types 1, 2, 3 and 4 (FGFR1-4) with potential antiangiogenic and antineoplastic activities. FGFR1-4 tyrosine kinase inhibitor PRN1371 specifically binds to a conserved cysteine residue in the glycine-rich loop in FGFRs and inhibits their tyrosine kinase activity, which may result in the inhibition of both tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases, which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation, proliferation and survival, and in tumor angiogenesis. This agent potently inhibits FGFR1-4 but does not inhibit other tyrosine kinases, even those that share the conserved cysteine, which may improve therapeutic responses and decrease toxicity when compared with less selective inhibitors.
1 2D Structure

Prn1371

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one
2.1.2 InChI
InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)
2.1.3 InChI Key
PUIXMSRTTHLNKI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CNC1=NC=C2C=C(C(=O)N(C2=N1)CCCN3CCN(CC3)C(=O)C=C)C4=C(C(=CC(=C4Cl)OC)OC)Cl
2.2 Other Identifiers
2.2.1 UNII
S3OPE9IA3Q
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido(2,3-d)pyrimidin-7(8h)-one

2. Prn1371

2.3.2 Depositor-Supplied Synonyms

1. Prn1371

2. 1802929-43-6

3. Prn-1371

4. S3ope9ia3q

5. 6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one

6. Unii-s3ope9ia3q

7. Gtpl9788

8. Chembl4068509

9. Schembl16993012

10. Us9567334, Example 6

11. Prn 1371 [who-dd]

12. Bdbm286984

13. Bcp20493

14. Ex-a2927

15. Nsc801089

16. S8578

17. Ccg-270053

18. Cs-7485

19. Nsc-801089

20. Compound 34 [pmid: 28665128]

21. Ac-35543

22. Bp179867

23. Hy-101768

24. J3.662.238e

25. C92492

26. A936037

27. Q29213602

28. Pyrido(2,3-d)pyrimidin-7(8h)-one, 6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-(3-(4-(1-oxo-2-propen-1-yl)-1-piperazinyl)propyl)-

2.4 Create Date
2016-02-23
3 Chemical and Physical Properties
Molecular Weight 561.5 g/mol
Molecular Formula C26H30Cl2N6O4
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass560.1705588 g/mol
Monoisotopic Mass560.1705588 g/mol
Topological Polar Surface Area100 Ų
Heavy Atom Count38
Formal Charge0
Complexity870
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1802929-43-6 / Prn1371 API manufacturers, exporters & distributors?

Prn1371 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Prn1371 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Prn1371 manufacturer or Prn1371 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Prn1371 manufacturer or Prn1371 supplier.

PharmaCompass also assists you with knowing the Prn1371 API Price utilized in the formulation of products. Prn1371 API Price is not always fixed or binding as the Prn1371 Price is obtained through a variety of data sources. The Prn1371 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Prn1371

Synonyms

1802929-43-6, Prn-1371, S3ope9ia3q, 6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one, Unii-s3ope9ia3q, Gtpl9788

Cas Number

1802929-43-6

Unique Ingredient Identifier (UNII)

S3OPE9IA3Q

About Prn1371

pan FGFR Inhibitor PRN1371 is a highly specific covalent inhibitor of human fibroblast growth factor receptor types 1, 2, 3 and 4 (FGFR1-4) with potential antiangiogenic and antineoplastic activities. FGFR1-4 tyrosine kinase inhibitor PRN1371 specifically binds to a conserved cysteine residue in the glycine-rich loop in FGFRs and inhibits their tyrosine kinase activity, which may result in the inhibition of both tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases, which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation, proliferation and survival, and in tumor angiogenesis. This agent potently inhibits FGFR1-4 but does not inhibit other tyrosine kinases, even those that share the conserved cysteine, which may improve therapeutic responses and decrease toxicity when compared with less selective inhibitors.

Prn1371 Manufacturers

A Prn1371 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Prn1371, including repackagers and relabelers. The FDA regulates Prn1371 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Prn1371 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Prn1371 Suppliers

A Prn1371 supplier is an individual or a company that provides Prn1371 active pharmaceutical ingredient (API) or Prn1371 finished formulations upon request. The Prn1371 suppliers may include Prn1371 API manufacturers, exporters, distributors and traders.

Prn1371 GMP

Prn1371 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Prn1371 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Prn1371 GMP manufacturer or Prn1371 GMP API supplier for your needs.

Prn1371 CoA

A Prn1371 CoA (Certificate of Analysis) is a formal document that attests to Prn1371's compliance with Prn1371 specifications and serves as a tool for batch-level quality control.

Prn1371 CoA mostly includes findings from lab analyses of a specific batch. For each Prn1371 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Prn1371 may be tested according to a variety of international standards, such as European Pharmacopoeia (Prn1371 EP), Prn1371 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Prn1371 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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