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    Chemistry

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    Also known as: 380917-97-5, Fycompa, E2007, Er-155055-90, E-2007, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
    Molecular Formula
    C23H15N3O
    Molecular Weight
    349.4  g/mol
    InChI Key
    PRMWGUBFXWROHD-UHFFFAOYSA-N
    FDA UNII
    H821664NPK
    Perampanel
    Perampanel is an orally active, non-competitive, and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, with anti-epileptic activity. Although the mechanism of action through which perampanel exerts its antiepileptic effect has not been fully elucidated, this agent antagonizes the AMPA subtype of the excitatory glutamate receptor found on postsynaptic neurons in the central nervous system (CNS). This antagonistic action prevents AMPA receptor activation by glutamate and results in the inhibition of neuronal excitation, repetitive neuronal firing, and the stabilization of hyper-excited neural membranes. Glutamate, the primary excitatory neurotransmitter in the CNS, plays an important role in various neurological disorders caused by neuronal hyperexcitation.
    Perampanel is a Noncompetitive AMPA Glutamate Receptor Antagonist. The mechanism of action of perampanel is as an AMPA Receptor Antagonist, and UGT2B7 Inhibitor, and UGT1A9 Inhibitor, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C8 Inhibitor.
    1 2D Structure

    Perampanel

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(2-oxo-1-phenyl-5-pyridin-2-ylpyridin-3-yl)benzonitrile
    2.1.2 InChI
    InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
    2.1.3 InChI Key
    PRMWGUBFXWROHD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
    2.2 Other Identifiers
    2.2.1 UNII
    H821664NPK
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one

    2. E-2007

    3. E2007

    4. Er-155055-90

    5. Fycompa

    6. Perampanel Hydrate

    7. Perampanel Hydrate (4:3)

    2.3.2 Depositor-Supplied Synonyms

    1. 380917-97-5

    2. Fycompa

    3. E2007

    4. Er-155055-90

    5. E-2007

    6. 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one

    7. E 2007

    8. Perampanel (usan)

    9. Chebi:71013

    10. Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)-

    11. 2-(2-oxo-1-phenyl-5-pyridin-2-ylpyridin-3-yl)benzonitrile

    12. H821664npk

    13. Perampanel [usan]

    14. Fycompa (tn)

    15. 5'-(2-cyanophenyl)-1'-phenyl-2,3'-bipyridinyl-6'(1'h)-one

    16. 2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile

    17. 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile

    18. Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl(2,3'-bipyridin)-5'-yl)-

    19. Perampanel [usan:inn]

    20. Perampanelum

    21. Unii-h821664npk

    22. Perampanel(e2007

    23. Perampanel [mi]

    24. Perampanel [inn]

    25. Perampanel [vandf]

    26. Perampanel [who-dd]

    27. Schembl194370

    28. Gtpl7050

    29. Chembl1214124

    30. Perampanel [orange Book]

    31. Dtxsid80191501

    32. Bcp06505

    33. Ex-a2128

    34. Bdbm50184410

    35. Zinc30691797

    36. Akos016340421

    37. Ch-0056

    38. Cs-1160

    39. Db08883

    40. Sb16816

    41. Ncgc00378863-02

    42. Ac-27375

    43. Am806751

    44. Hy-14745

    45. D08964

    46. Q868658

    47. 2-(6-oxo-1-phenyl-1,6-dihydro-[2,3-bipyridin]-5-yl)benzonitrile

    48. 3-(2-cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one

    49. 1174302-51-2

    50. 6zp

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 349.4 g/mol
    Molecular Formula C23H15N3O
    XLogP33.4
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count3
    Exact Mass349.121512110 g/mol
    Monoisotopic Mass349.121512110 g/mol
    Topological Polar Surface Area57 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity664
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameFycompa
    PubMed HealthPerampanel (By mouth)
    Drug ClassesAnticonvulsant, Central Nervous System Agent
    Drug LabelFYCOMPA tablets contain perampanel, a non-competitive AMPA receptor antagonist. Perampanel is described chemically as 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile hydrate (4:3).The molecular formula is C23H15N3O 3/4H2O,...
    Active IngredientPerampanel
    Dosage FormTablet
    RouteOral
    Strength8mg; 4mg; 12mg; 6mg; 2mg; 10mg
    Market StatusPrescription
    CompanyEisai

    2 of 2  
    Drug NameFycompa
    PubMed HealthPerampanel (By mouth)
    Drug ClassesAnticonvulsant, Central Nervous System Agent
    Drug LabelFYCOMPA tablets contain perampanel, a non-competitive AMPA receptor antagonist. Perampanel is described chemically as 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile hydrate (4:3).The molecular formula is C23H15N3O 3/4H2O,...
    Active IngredientPerampanel
    Dosage FormTablet
    RouteOral
    Strength8mg; 4mg; 12mg; 6mg; 2mg; 10mg
    Market StatusPrescription
    CompanyEisai

    4.2 Drug Indication

    Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.

    FDA Label

    Fycompa is indicated for the adjunctive treatment of partial-onset seizures with or without secondarily generalised seizures in adult and adolescent patients from 12 years of age with epilepsy.

    Fycompa is indicated for the adjunctive treatment of primary generalised tonic-clonic seizures in adult and adolescent patients from 12 years of age with idiopathic generalised epilepsy.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Perampanel is involved in inhibiting neuronal excitation in the central nervous system leading to such effects as decreased pyschomotor performance.

    5.2 FDA Pharmacological Classification
    5.2.1 Active Moiety
    PERAMPANEL
    5.2.2 FDA UNII
    H821664NPK
    5.2.3 Pharmacological Classes
    Cytochrome P450 2C8 Inhibitors [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]; Noncompetitive AMPA Glutamate Receptor Antagonist [EPC]; UGT1A9 Inhibitors [MoA]; UGT2B7 Inhibitors [MoA]; AMPA Receptor Antagonists [MoA]
    5.3 ATC Code

    N03AX22

    N03AX22

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    N - Nervous system

    N03 - Antiepileptics

    N03A - Antiepileptics

    N03AX - Other antiepileptics

    N03AX22 - Perampanel

    5.4 Absorption, Distribution and Excretion

    Absorption

    After oral adminitration, perampanel is absorbed rapidly and completely.

    Route of Elimination

    Perampanel is eliminated mostely in the feces (48%) and to a lesser exten in the urine (22%).

    Volume of Distribution

    The volume of distribution of perampanel was not quantified.

    Clearance

    In healthy patients, perampanel has a clearance of about 12 mL/min.

    5.5 Metabolism/Metabolites

    Perampanel is highly metabolized by CYP3A4 and/or CYP3A5 primary oxidation and by sequential glucuronidation.

    5.6 Biological Half-Life

    Perampanel has a long elmination half-life of about 105 hours.

    5.7 Mechanism of Action

    The exact mechanism of action of perampanel in seizures is not yet determined, but it is known that perampanel decreases neuronal excitation by non-competitive ihibition of the AMPA receptor.

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    ABOUT THIS PAGE

    Looking for 380917-97-5 / Perampanel API manufacturers, exporters & distributors?

    Perampanel manufacturers, exporters & distributors 1

    48

    PharmaCompass offers a list of Perampanel API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Perampanel manufacturer or Perampanel supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Perampanel manufacturer or Perampanel supplier.

    PharmaCompass also assists you with knowing the Perampanel API Price utilized in the formulation of products. Perampanel API Price is not always fixed or binding as the Perampanel Price is obtained through a variety of data sources. The Perampanel Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Perampanel

    Synonyms

    380917-97-5, Fycompa, E2007, Er-155055-90, E-2007, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one

    Cas Number

    380917-97-5

    Unique Ingredient Identifier (UNII)

    H821664NPK

    About Perampanel

    Perampanel is an orally active, non-competitive, and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, with anti-epileptic activity. Although the mechanism of action through which perampanel exerts its antiepileptic effect has not been fully elucidated, this agent antagonizes the AMPA subtype of the excitatory glutamate receptor found on postsynaptic neurons in the central nervous system (CNS). This antagonistic action prevents AMPA receptor activation by glutamate and results in the inhibition of neuronal excitation, repetitive neuronal firing, and the stabilization of hyper-excited neural membranes. Glutamate, the primary excitatory neurotransmitter in the CNS, plays an important role in various neurological disorders caused by neuronal hyperexcitation.

    Perampanel Manufacturers

    A Perampanel manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Perampanel, including repackagers and relabelers. The FDA regulates Perampanel manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Perampanel API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Perampanel manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Perampanel Suppliers

    A Perampanel supplier is an individual or a company that provides Perampanel active pharmaceutical ingredient (API) or Perampanel finished formulations upon request. The Perampanel suppliers may include Perampanel API manufacturers, exporters, distributors and traders.

    click here to find a list of Perampanel suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Perampanel USDMF

    A Perampanel DMF (Drug Master File) is a document detailing the whole manufacturing process of Perampanel active pharmaceutical ingredient (API) in detail. Different forms of Perampanel DMFs exist exist since differing nations have different regulations, such as Perampanel USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Perampanel DMF submitted to regulatory agencies in the US is known as a USDMF. Perampanel USDMF includes data on Perampanel's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Perampanel USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Perampanel suppliers with USDMF on PharmaCompass.

    Perampanel KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Perampanel Drug Master File in Korea (Perampanel KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Perampanel. The MFDS reviews the Perampanel KDMF as part of the drug registration process and uses the information provided in the Perampanel KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Perampanel KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Perampanel API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Perampanel suppliers with KDMF on PharmaCompass.

    Perampanel WC

    A Perampanel written confirmation (Perampanel WC) is an official document issued by a regulatory agency to a Perampanel manufacturer, verifying that the manufacturing facility of a Perampanel active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Perampanel APIs or Perampanel finished pharmaceutical products to another nation, regulatory agencies frequently require a Perampanel WC (written confirmation) as part of the regulatory process.

    click here to find a list of Perampanel suppliers with Written Confirmation (WC) on PharmaCompass.

    Perampanel NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Perampanel as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Perampanel API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Perampanel as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Perampanel and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Perampanel NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Perampanel suppliers with NDC on PharmaCompass.

    Perampanel GMP

    Perampanel Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Perampanel GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Perampanel GMP manufacturer or Perampanel GMP API supplier for your needs.

    Perampanel CoA

    A Perampanel CoA (Certificate of Analysis) is a formal document that attests to Perampanel's compliance with Perampanel specifications and serves as a tool for batch-level quality control.

    Perampanel CoA mostly includes findings from lab analyses of a specific batch. For each Perampanel CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Perampanel may be tested according to a variety of international standards, such as European Pharmacopoeia (Perampanel EP), Perampanel JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Perampanel USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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