Find Navoximod manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 1402837-78-8, Ido-in-7, Gdc-0919, Navoximod [usan], Navoximod (free base), Nlg-919
Molecular Formula
C18H21FN2O2
Molecular Weight
316.4  g/mol
InChI Key
YGACXVRLDHEXKY-LHPNLFKDSA-N
FDA UNII
926SHL95NC

Navoximod
Navoximod is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities. Upon administration, navoximod targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing tumor cells. IDO1 is overexpressed by a variety of tumor cell types and plays an important role in immunosuppression. Tryptophan depletion is associated with immunosuppression caused by T-cell suppression.
1 2D Structure

Navoximod

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[(1R)-2-[(5S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl]-1-hydroxyethyl]cyclohexan-1-ol
2.1.2 InChI
InChI=1S/C18H21FN2O2/c19-14-3-1-2-13-16-9-20-10-21(16)15(18(13)14)8-17(23)11-4-6-12(22)7-5-11/h1-3,9-12,15,17,22-23H,4-8H2/t11?,12?,15-,17+/m0/s1
2.1.3 InChI Key
YGACXVRLDHEXKY-LHPNLFKDSA-N
2.1.4 Canonical SMILES
C1CC(CCC1C(CC2C3=C(C=CC=C3F)C4=CN=CN24)O)O
2.1.5 Isomeric SMILES
C1CC(CCC1[C@@H](C[C@H]2C3=C(C=CC=C3F)C4=CN=CN24)O)O
2.2 Other Identifiers
2.2.1 UNII
926SHL95NC
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5h-imidazo(5,1-a)isoindole-5-ethanol, 6-fluoro-alpha-(trans-4-hydroxycyclohexyl)-, (alphar,5s)-

2. Gdc-0919

3. Trans-4-((1r)-2-((5s)-6-fluoro-5h-imidazo(5,1-a)isoindol-5-yl)-1-hydroxyethyl)cyclohexanol

2.3.2 Depositor-Supplied Synonyms

1. 1402837-78-8

2. Ido-in-7

3. Gdc-0919

4. Navoximod [usan]

5. Navoximod (free Base)

6. Nlg-919

7. 926shl95nc

8. Ro7077339-001

9. Rg6078

10. Rg-6078

11. Ro7077339

12. Ro-7077339

13. 4-[(1r)-2-[(5s)-6-fluoro-5h-imidazo[5,1-a]isoindol-5-yl]-1-hydroxyethyl]cyclohexan-1-ol

14. Trans-4-((1r)-2-((5s)-6-fluoro-5h-imidazo(5,1-a)isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol

15. Trans-4-{(1r)-2-[(5s)-6-fluoro-5h-imidazo[5,1-a]isoindol-5-yl]-1-hydroxyethyl}cyclohexan-1-ol

16. Nlg-919 Navoximod

17. Navoximod [inn]

18. Navoximod (usan/inn)

19. Navoximod [who-dd]

20. Unii-926shl95nc

21. Chembl3989951

22. Chembl4530496

23. Schembl13469854

24. Schembl13469866

25. Schembl15511408

26. Bdbm370551

27. Bdbm370555

28. Ex-a4607

29. Nlg-?919

30. Nlg-?919gdc-0919

31. Hy-18770b

32. S8957

33. Zinc253387955

34. Cs-5088

35. Db15439

36. Us10233190, Example 1484

37. Us10233190, Example 1488

38. Ac-35763

39. D11255

40. Navoximod;gdc-0919;ido-in-7;nlg-1488

41. Q27271481

42. (1r,4r)-4-((r)-2-((s)-6-fluoro-5h-imidazo[5,1- A]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol

43. (1s,4s)-4-((r)-2-((s)-6-fluoro-5h-imidazo[5,1- A]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol

44. 1402836-86-5

45. 5h-imidazo(5,1-a)isoindole-5-ethanol, 6-fluoro-.alpha.-(trans-4-hydroxycyclohexyl)-, (.alpha.r,5s)-

46. 5h-imidazo(5,1-a)isoindole-5-ethanol, 6-fluoro-alpha-(trans-4-hydroxycyclohexyl)-, (alphar,5s)-

47. Trans-4-((1r)-2-((5s)-6-fluoro-5h-imidazo(5,1-a)isoindol-5-yl)-1-hydroxyethyl)cyclohexanol

2.4 Create Date
2013-03-21
3 Chemical and Physical Properties
Molecular Weight 316.4 g/mol
Molecular Formula C18H21FN2O2
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass316.15870608 g/mol
Monoisotopic Mass316.15870608 g/mol
Topological Polar Surface Area58.3 Ų
Heavy Atom Count23
Formal Charge0
Complexity416
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1402836-86-5 / Navoximod API manufacturers, exporters & distributors?

Navoximod manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Navoximod API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Navoximod manufacturer or Navoximod supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Navoximod manufacturer or Navoximod supplier.

PharmaCompass also assists you with knowing the Navoximod API Price utilized in the formulation of products. Navoximod API Price is not always fixed or binding as the Navoximod Price is obtained through a variety of data sources. The Navoximod Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Navoximod

Synonyms

1402837-78-8, Ido-in-7, Gdc-0919, Navoximod [usan], Navoximod (free base), Nlg-919

Cas Number

1402836-86-5

Unique Ingredient Identifier (UNII)

926SHL95NC

About Navoximod

Navoximod is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities. Upon administration, navoximod targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing tumor cells. IDO1 is overexpressed by a variety of tumor cell types and plays an important role in immunosuppression. Tryptophan depletion is associated with immunosuppression caused by T-cell suppression.

Navoximod Manufacturers

A Navoximod manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Navoximod, including repackagers and relabelers. The FDA regulates Navoximod manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Navoximod API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Navoximod Suppliers

A Navoximod supplier is an individual or a company that provides Navoximod active pharmaceutical ingredient (API) or Navoximod finished formulations upon request. The Navoximod suppliers may include Navoximod API manufacturers, exporters, distributors and traders.

Navoximod GMP

Navoximod Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Navoximod GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Navoximod GMP manufacturer or Navoximod GMP API supplier for your needs.

Navoximod CoA

A Navoximod CoA (Certificate of Analysis) is a formal document that attests to Navoximod's compliance with Navoximod specifications and serves as a tool for batch-level quality control.

Navoximod CoA mostly includes findings from lab analyses of a specific batch. For each Navoximod CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Navoximod may be tested according to a variety of international standards, such as European Pharmacopoeia (Navoximod EP), Navoximod JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Navoximod USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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