Find Mocetinostat manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

API REF. PRICE (USD/KG)

$
$ 0

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Regulatory FDF Prices

NA

API/FDF Prices: Book a Demo to
explore the features and consider
upgrading later

MARKET PLACE

0

API

0

FDF

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 726169-73-9, Mgcd0103, Mgcd-0103, Mgcd 0103, N-(2-aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide, N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide
Molecular Formula
C23H20N6O
Molecular Weight
396.4  g/mol
InChI Key
HRNLUBSXIHFDHP-UHFFFAOYSA-N
FDA UNII
A6GWB8T96J

Mocetinostat
Mocetinostat is a rationally designed, orally available, Class 1-selective, small molecule, 2-aminobenzamide HDAC inhibitor with potential antineoplastic activity. Mocetinostat binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur through the induction of apoptosis, differentiation, cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down regulation of growth factors, oxidative stress, and autophagy, among others. Overexpression of Class I HDACs 1, 2 and 3 has been found in many tumors and has been correlated with a poor prognosis.
1 2D Structure

Mocetinostat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide
2.1.2 InChI
InChI=1S/C23H20N6O/c24-19-5-1-2-6-21(19)28-22(30)17-9-7-16(8-10-17)14-27-23-26-13-11-20(29-23)18-4-3-12-25-15-18/h1-13,15H,14,24H2,(H,28,30)(H,26,27,29)
2.1.3 InChI Key
HRNLUBSXIHFDHP-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC3=NC=CC(=N3)C4=CN=CC=C4
2.2 Other Identifiers
2.2.1 UNII
A6GWB8T96J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Mg 0103

2. Mg 4230

3. Mg 4915

4. Mg 5026

5. Mg-0103

6. Mg-4230

7. Mg-4915

8. Mg-5026

9. Mg0103

10. Mg4230

11. Mg4915

12. Mg5206

13. Mgcd 0103

14. Mgcd-0103

15. Mgcd0103

16. N-(2-aminophenyl)-4-((4-pyridin-3-ylpyrimidin-2-ylamino)methyl)benzamide

2.3.2 Depositor-Supplied Synonyms

1. 726169-73-9

2. Mgcd0103

3. Mgcd-0103

4. Mgcd 0103

5. N-(2-aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide

6. N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide

7. Mocetinostat (mgcd0103)

8. 9003-99-0

9. Mg0103

10. Mocetinostat (mgcd-0103)

11. Mg 0103

12. Mocetinostat (mgcd0103, Mg0103)

13. A6gwb8t96j

14. Chembl272980

15. Mg-0103

16. N-(2-aminophenyl)-4-((4-pyridin-3-ylpyrimidin-2-ylamino)methyl)benzamide

17. 726169-73-9 (free Base)

18. Mocetinostat (usan/inn)

19. N-(2-aminophenyl)-4-(((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)benzamide

20. N-(2-aminophenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide

21. N-(2-aminophenyl)-4-[[[4-(3-pyridyl)pyrimidin-2-yl]amino]methyl]benzamide

22. N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide

23. Benzamide, N-(2-aminophenyl)-4-(((4-(3-pyridinyl)-2-pyrimidinyl)amino)methyl)-

24. Mocetinostat [usan]

25. Mocetinostat [usan:inn]

26. Unii-a6gwb8t96j

27. Mgcd0103 (mocetinostat)

28. Horseradish Peroxidase

29. Myeloperoxidase (usan)

30. Mgcd010,3mocetinostat

31. Mocetinostat [inn]

32. Mgcd0103 - Mocetinostat

33. Mls006010181

34. Mocetinostat [who-dd]

35. Schembl157027

36. Gtpl7008

37. Bdbm24624

38. Chebi:94525

39. Dtxsid80222945

40. Ex-a049

41. Bcpp000163

42. Hms3426i07

43. Hms3654k06

44. Bcp01814

45. Bbl102287

46. Mfcd10565970

47. Nsc760143

48. S1122

49. Stl556086

50. Zinc13986811

51. Akos016340325

52. Bcp9000925

53. Bd-0114

54. Ccg-208763

55. Cs-0502

56. Db11830

57. Nsc-760143

58. Sb16666

59. Ncgc00263182-01

60. Ncgc00263182-02

61. Ncgc00263182-11

62. Ac-30281

63. Hy-12164

64. Smr004701289

65. Ft-0627651

66. Ft-0741876

67. Sw218130-2

68. Ec-000.2284

69. D09641

70. D09643

71. 169m739

72. Au-004/43508107

73. Q424869

74. J-522866

75. Brd-k16485616-001-01-4

76. Brd-k16485616-001-04-8

77. N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide

78. N-(2-aminophenyl)-4-({[4-(3-pyridinyl)-2-pyrimidinyl]amino}methyl)benzamide

79. N-(2-aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide;mgcd0103;mocetinostat;mgcd0103(mocetinostat)

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 396.4 g/mol
Molecular Formula C23H20N6O
XLogP32.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass396.16985928 g/mol
Monoisotopic Mass396.16985928 g/mol
Topological Polar Surface Area106 Ų
Heavy Atom Count30
Formal Charge0
Complexity538
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Pharmacology

All HDAC inhibitors induce histone H3 hyperacetylation, correlating with inhibition of proliferation, induction of cell differentiation and apoptosis.


4.2 MeSH Pharmacological Classification

Histone Deacetylase Inhibitors

Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains. (See all compounds classified as Histone Deacetylase Inhibitors.)


4.3 Mechanism of Action

Mocetinostat is a novel isotypic-selective inhibitor of the enzyme histone deacetylase (HDAC). HDAC inhibitors act by turning on tumour suppressor genes that have been inappropriately turned off. Tumour suppressor genes are a natural defense against cancer. It is therefore hypothesized that specifically inhibiting those HDACs involved in cancer with Mocetinostat may restore normal cell function and reduce or inhibit tumour growth.


Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Looking for 726169-73-9 / Mocetinostat API manufacturers, exporters & distributors?

Mocetinostat manufacturers, exporters & distributors 1

71

PharmaCompass offers a list of Mocetinostat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Mocetinostat manufacturer or Mocetinostat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Mocetinostat manufacturer or Mocetinostat supplier.

PharmaCompass also assists you with knowing the Mocetinostat API Price utilized in the formulation of products. Mocetinostat API Price is not always fixed or binding as the Mocetinostat Price is obtained through a variety of data sources. The Mocetinostat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Mocetinostat

Synonyms

726169-73-9, Mgcd0103, Mgcd-0103, Mgcd 0103, N-(2-aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide, N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide

Cas Number

726169-73-9

Unique Ingredient Identifier (UNII)

A6GWB8T96J

About Mocetinostat

Mocetinostat is a rationally designed, orally available, Class 1-selective, small molecule, 2-aminobenzamide HDAC inhibitor with potential antineoplastic activity. Mocetinostat binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur through the induction of apoptosis, differentiation, cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down regulation of growth factors, oxidative stress, and autophagy, among others. Overexpression of Class I HDACs 1, 2 and 3 has been found in many tumors and has been correlated with a poor prognosis.

Mocetinostat Manufacturers

A Mocetinostat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Mocetinostat, including repackagers and relabelers. The FDA regulates Mocetinostat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Mocetinostat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Mocetinostat Suppliers

A Mocetinostat supplier is an individual or a company that provides Mocetinostat active pharmaceutical ingredient (API) or Mocetinostat finished formulations upon request. The Mocetinostat suppliers may include Mocetinostat API manufacturers, exporters, distributors and traders.

Mocetinostat GMP

Mocetinostat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Mocetinostat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Mocetinostat GMP manufacturer or Mocetinostat GMP API supplier for your needs.

Mocetinostat CoA

A Mocetinostat CoA (Certificate of Analysis) is a formal document that attests to Mocetinostat's compliance with Mocetinostat specifications and serves as a tool for batch-level quality control.

Mocetinostat CoA mostly includes findings from lab analyses of a specific batch. For each Mocetinostat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Mocetinostat may be tested according to a variety of international standards, such as European Pharmacopoeia (Mocetinostat EP), Mocetinostat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Mocetinostat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty