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Chemistry

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Also known as: 857890-39-2, Lenvima, Lenvatinibmesylate, Lenvatinib mesilate, Lenvatinib mesylate [usan], E7080 mesylate
Molecular Formula
C22H23ClN4O7S
Molecular Weight
523.0  g/mol
InChI Key
HWLFIUUAYLEFCT-UHFFFAOYSA-N
FDA UNII
3J78384F61

Lenvatinib Mesylate
Lenvatinib Mesylate is a synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. E7080 blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis.
1 2D Structure

Lenvatinib Mesylate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide;methanesulfonic acid
2.1.2 InChI
InChI=1S/C21H19ClN4O4.CH4O3S/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11;1-5(2,3)4/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28);1H3,(H,2,3,4)
2.1.3 InChI Key
HWLFIUUAYLEFCT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl.CS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
3J78384F61
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)-7-hydroxy-6-quinolinecarboxamide

2. 4-(3-chloro-4-((cyclopropylaminocarbonyl)amino)phenoxy)-7-methoxy-6-quinolinecarboxamide

3. 4-(3-chloro-4-(n'-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide

4. E 7080

5. E-7080

6. E-7080 Mesylate

7. E7080

8. E7080 Mesylate

9. Er-203492-00

10. Lenvatinib

11. Lenvatinib Mesilate

12. Lenvatinib Metabolite M2

13. Lenvatinib Methanesulfonate

14. Lenvima

15. N-(4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)-n'-cyclopropylurea Monomethanesulfonate

2.3.2 Depositor-Supplied Synonyms

1. 857890-39-2

2. Lenvima

3. Lenvatinibmesylate

4. Lenvatinib Mesilate

5. Lenvatinib Mesylate [usan]

6. E7080 Mesylate

7. Lenvatinib (mesylate)

8. Unii-3j78384f61

9. E-7080 Mesylate

10. Chebi:85995

11. 857890-39-2 (mesylate)

12. 3j78384f61

13. Lenvatinib Mesilate (jan)

14. Lenvatinib Mesylate (usan)

15. N-(4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)-n'-cyclopropylurea Monomethanesulfonate

16. Lenvatinib Mesilate [jan]

17. 4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide Mesylate

18. 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide;methanesulfonic Acid

19. 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide Monomethanesulfonate

20. Lenvima (tn)

21. E7080mesylate

22. E7080 (mesylate)

23. Lenvatinib Methanesulfonate

24. Lenvatinib Mesylate- Bio-x

25. Schembl865174

26. Amy385

27. Chembl2105704

28. Dtxsid90235081

29. Bcp11858

30. Hy-10981a

31. Lenvatinib Mesilate [who-dd]

32. Mfcd18633219

33. Ccg-269873

34. Sb16581

35. Lenvatinib Methanesulfonate [mi]

36. Lenvatinib Mesylate [orange Book]

37. Ac-30100

38. Bl166696

39. Ds-19245

40. Cs-0030963

41. S5240

42. D09920

43. A900902

44. Q27158839

45. 4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide Methanesulfonate

46. 6-carbamoyl-4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinolin-1-ium Methanesulfonate

47. 6-quinolinecarboxamide, 4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)- 7-methoxy-, Methanesulfonate (1:1)

48. 6-quinolinecarboxamide, 4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)-7-methoxy-, Methanesulfonate (1:1)

49. Methanesulfonic Acid--4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide (1/1)

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 523.0 g/mol
Molecular Formula C22H23ClN4O7S
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass522.0975980 g/mol
Monoisotopic Mass522.0975980 g/mol
Topological Polar Surface Area178 Ų
Heavy Atom Count35
Formal Charge0
Complexity727
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

Lenvima is indicated as monotherapy for the treatment of adult patients with progressive, locally advanced or metastatic, differentiated (papillary/follicular/Hrthle cell) thyroid carcinoma (DTC), refractory to radioactive iodine (RAI).

Lenvima is indicated as monotherapy for the treatment of adult patients with advanced or unresectable hepatocellular carcinoma (HCC) who have received no prior systemic therapy.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


5.2 ATC Code

L01XE


API SUPPLIERS

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Dr. Reddy's Laboratories

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Shandong Loncom Pharmaceutical

China

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Sumar Biotech

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Sichuan Qingmu Pharmaceutical

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Dr. Reddy's Laboratories

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Sun Pharmaceutical Industries Limi...

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Sun Pharmaceutical Industries Limi...

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MSN Laboratories

India

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MSN Laboratories

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MSN Laboratories

India

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MSN Laboratories

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Shilpa Medicare

India

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Shilpa Medicare

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Olon S.p.A

Italy

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USDMF

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DMF Review : Complete

Rev. Date : 2021-11-30

Pay. Date : 2021-11-08

DMF Number : 36031

Submission : 2021-06-30

Status : Active

Type : II

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DMF Review : Complete

Rev. Date : 2018-10-24

Pay. Date : 2018-08-09

DMF Number : 32905

Submission : 2018-06-26

Status : Active

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DMF Review : N/A

Rev. Date :

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DMF Number : 41489

Submission : 2025-03-24

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Type : II

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DMF Review : Complete

Rev. Date : 2022-01-24

Pay. Date : 2021-12-16

DMF Number : 36197

Submission : 2021-12-22

Status : Active

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Hetero Labs Ltd

India

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DMF Review : Complete

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Pay. Date : 2025-04-11

DMF Number : 39887

Submission : 2024-04-30

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Type : II

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Rev. Date : 2019-03-25

Pay. Date : 2018-11-19

DMF Number : 33017

Submission : 2018-08-07

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DMF Review : Complete

Rev. Date : 2023-03-31

Pay. Date : 2023-03-17

DMF Number : 35779

Submission : 2021-03-29

Status : Active

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Olon Spa

Italy

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Olon Spa

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Olon Spa

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Olon Spa

Italy
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Pay. Date : 2024-09-30

DMF Number : 37347

Submission : 2022-07-28

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DMF Review : Complete

Rev. Date : 2018-11-20

Pay. Date : 2018-09-04

DMF Number : 33083

Submission : 2018-09-04

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Lenvatinib Mesylate IH

Date of Issue : 2022-06-07

Valid Till : 2025-07-07

Written Confirmation Number : WC-0067

Address of the Firm : Chemical Technical Operations Unit-VI, APIIC Industrial Estate, Pydibhimavaram V...

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Lenvatinib Mesylate IH

Date of Issue : 2022-06-06

Valid Till : 2025-06-07

Written Confirmation Number : WC-0039A

Address of the Firm : Unit-I, Plot Nos., 137,138,145 & 146, Sri Venkateswara Cooperative Industrial Es...

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Lenvatinib Mesylate IH

Date of Issue : 2022-09-02

Valid Till : 2025-05-05

Written Confirmation Number : WC-0349

Address of the Firm : Unit-II, Sy. No. 50, Kardanur (Village), Patancheru (Mandai), Sangareddy Distric...

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Lenvatinib Mesylate DMSO Solvate IH

Date of Issue : 2022-09-02

Valid Till : 2025-05-05

Written Confirmation Number : WC-0349

Address of the Firm : Unit-II, Sy. No. 50, Kardanur (Village), Patancheru (Mandai), Sangareddy Distric...

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Natco Pharma

India
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Natco Pharma

India
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Lenvatinib Mesylate IH

Date of Issue : 2022-09-16

Valid Till : 2025-06-12

Written Confirmation Number : WC-0372n

Address of the Firm : S.No.73/1A, 74/7B, 78/1 B, 79/1, 2B, 3, 4B, 5, 6A, 6B, 7, 80/1, 2, 3, 4, 84/1, 2...

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Lenvatinib Mesylate IH

Date of Issue : 2022-07-27

Valid Till : 2025-07-02

Written Confirmation Number : WC-0147

Address of the Firm : Plot No. 33, 33A, 40-47, Block C,D,E,H,I,AM, Chicksugur-584134, District-Raichur...

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KDMF

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Lenvatinib mesylate

Registrant Name : Pami Future Co., Ltd.

Registration Date : 2024-10-25

Registration Number : No. 574-26-ND

Manufacturer Name : Dr. Reddy's Laboratories Lim...

Manufacturer Address : CTO Unit-VI, APIIC Industrial Estate, Pydibhimavaram Village, Ranasthalam Mandal, Sri...

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Eisai

Japan
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Eisai

Japan
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Lenvatinib mesylate

Registrant Name : Korea Ezai Co., Ltd.

Registration Date : 2015-10-07

Registration Number : No. 3834-5-ND

Manufacturer Name : Kashima Plant, Eisai Co., Lt...

Manufacturer Address : 22 Sunayama, Kamisu-shi, Ibaraki-ken 314-0255

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Lenvatinib mesylate

Registrant Name : Kukjeon Pharmaceutical Co., Ltd.

Registration Date : 2025-02-10

Registration Number : No. 674-4-ND(A)

Manufacturer Name : MSN Laboratories Private Lim...

Manufacturer Address : Unit-II, Sy. No. 50, 53, 53/A, 54 & 54/A, Kardanur (Village), Patancheru (Mandal), Sa...

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Lenvatinib mesylate

Registrant Name : Grace Farm

Registration Date : 2023-08-07

Registration Number : No. 674-4-ND

Manufacturer Name : MSN Laboratories Private Lim...

Manufacturer Address : Unit-II, Sy. No. 50, 53, 53/A, 54 & 54/A, Kardanur (Village), Patancheru (Mandal), Sa...

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NDC API

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LENVATINIB MESYLATE

NDC Package Code : 71796-005

Start Marketing Date : 2018-06-26

End Marketing Date : 2026-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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LENVATINIB MESYLATE

NDC Package Code : 54893-0077

Start Marketing Date : 2018-08-06

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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LENVATINIB MESYLATE

NDC Package Code : 54893-0112

Start Marketing Date : 2021-03-29

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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Olon S.p.A.

Italy
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Olon S.p.A.

Italy
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LENVATINIB MESYLATE

NDC Package Code : 17337-0314

Start Marketing Date : 2022-05-18

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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Olon S.p.A.

Italy
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Olon S.p.A.

Italy
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LENVATINIB MESYLATE

NDC Package Code : 17337-0099

Start Marketing Date : 2021-10-05

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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LENVATINIB MESYLATE

NDC Package Code : 82920-036

Start Marketing Date : 2022-08-15

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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Listed Suppliers

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Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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Lenvatinib Mesylate

About the Company : Founded in 1984, DRL is well-known for its generic APIs and its track record in drug product development. It is one of the earliest pharma API manufacturers with a diverse portfoli...

Founded in 1984, DRL is well-known for its generic APIs and its track record in drug product development. It is one of the earliest pharma API manufacturers with a diverse portfolio that provides high-quality, low-cost APIs to leading pharma companies in 80+ countries. It has 8 USFDA-inspected facilities – 6 in India & 1 each in Mexico & the UK & are inspected by international regulatory authorities on a regular basis. Its facilities are supplemented by formulation facilities that provide a wide range of dosage forms. Product(s) under patent(s) are offered only for R&D purposes U/S 107A of the Patent Act and not for commercial sale
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Virtual BoothShandong Loncom is an R&D-focused manufacturer of Anti-cancer APIs.

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Lenvatinib Mesylate

About the Company : Established in May 2012, Shandong Loncom Pharmaceutical operates as a fully owned subsidiary of Shandong Bestcomm Pharmaceutical Co., Ltd. Situated in the Qihe Economic Development...

Established in May 2012, Shandong Loncom Pharmaceutical operates as a fully owned subsidiary of Shandong Bestcomm Pharmaceutical Co., Ltd. Situated in the Qihe Economic Development Zone, Shandong Province, Shandong Loncom has operational API pilot tests and production bases adhering to international standards. With 13 production lines dedicated to oral solid preparations, oral liquid preparations and API, it is actively expanding its preparation workshops for small-volume injections, soft capsules, eye drops, topical medicines and innovative drug R&D centres.
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Virtual BoothSumar Biotech work together to Innovate & Manufacture Semi-synthetic, Synthetic & Fermentation API.

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Lenvatinib Mesylate

About the Company : Sumar Biotech LLP, registered in January 2018, is a startup approved by the Gujarat State Biotechnology Mission. It was founded by emerging entrepreneurs and a team of young yet ex...

Sumar Biotech LLP, registered in January 2018, is a startup approved by the Gujarat State Biotechnology Mission. It was founded by emerging entrepreneurs and a team of young yet experienced research scientists and manufacturing professionals. We work together to innovate and manufacture semi-synthetic, synthetic, and fermentation-based APIs. Our R&D facility is equipped with state-of-the-art technology for synthesis, extraction, isolation, and purification of products from the upstream (fermentation) process. Our team is also involved in developing and implementing new ideas in process chemistry for various therapeutic molecules.
Sumar Biotech

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  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSichuan Qingmu Pharmaceutical offers reliable CDMO support and high-quality APIs for regulated markets.

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Digital Content Digital Content

Lenvatinib Mesilate

About the Company : Sichuan Qingmu Pharmaceutical Co., Ltd. is an innovation-driven pharmaceutical company focused on regulated markets. We specialize in the R&D and manufacturing of generic APIs and ...

Sichuan Qingmu Pharmaceutical Co., Ltd. is an innovation-driven pharmaceutical company focused on regulated markets. We specialize in the R&D and manufacturing of generic APIs and advanced intermediates, and also offer high-quality CDMO/CMO services for small-molecule drugs. Qingmu has been inspected and approved by global regulatory authorities such as the US FDA, Korea MFDS, and China NMPA, and has earned client approvals across the U.S., Europe, Japan, and China. With strong technical capabilities and a commitment to international quality standards, we support customers from early development through to commercial supply.
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Lenvatinib Mesylate

About the Company : Alembic Pharmaceuticals Limited is a leading pharmaceutical company in India. The Company is vertically integrated with the ability to develop, manufacture and market pharmaceutica...

Alembic Pharmaceuticals Limited is a leading pharmaceutical company in India. The Company is vertically integrated with the ability to develop, manufacture and market pharmaceutical products, pharmaceutical substances and Intermediates.
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Lenvatinib Mesylate

About the Company : Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Ex...

Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Excipients, Herbal extracts, Formulation of Chinese & Western Medicine. With abundant economic strength, the group has successfully developed to a pharmaceutical group enterprise wich intergrets operation of medicine & related products, processing & manufacturing, and importation & exportation together.
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Lenvatinib Mesylate

About the Company : Established in 2010, Mac-Chem is a NMM Group company. Mac-Chem is focused on oncology and other niche specialty APIs. It supplies quality APIs to the top 15 oncology players in Ind...

Established in 2010, Mac-Chem is a NMM Group company. Mac-Chem is focused on oncology and other niche specialty APIs. It supplies quality APIs to the top 15 oncology players in India. It is also the sole manufacturer of some of the molecules in the oncology segment and general segment. The company’s investments are mostly geared toward exports, especially to regulated markets. Mac-Chem has a cGMP-compliant manufacturing facility near Mumbai in India. The company’s facility is USFDA, EDQM, COFEPRIS, ANVISA, MFDS-Korea, WHO-GMP-approved and ISO-certified. Mac-Chem enjoys a global reach, serving more than 40 countries.
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Lenvatinib Mesylate

About the Company : Parsian Pharmaceutical is dedicated to improving health outcomes by offering high-quality, effective pharmaceutical products. With a strong commitment to research, innovation, and ...

Parsian Pharmaceutical is dedicated to improving health outcomes by offering high-quality, effective pharmaceutical products. With a strong commitment to research, innovation, and quality, Parsian Pharmaceutical develops and manufactures a broad range of medications designed to meet international standards and address diverse therapeutic needs. Serving both local and global markets, Parsian Pharmaceutical strives to be a trusted healthcare partner, providing reliable, accessible solutions that enhance patient care and contribute to a healthier society.
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Lenvatinib Mesylate

About the Company : Hope Chem is dedicated to manufacturing, marketing, and CMO service of Active Pharmaceutical Ingredients (APIs), Intermediates, and Specialty Chemicals since the year 2010. Current...

Hope Chem is dedicated to manufacturing, marketing, and CMO service of Active Pharmaceutical Ingredients (APIs), Intermediates, and Specialty Chemicals since the year 2010. Currently, they have exclusive partnerships with multiple, state-of-the-art and GMP-compliant manufacturers in China and abroad to service our esteemed partners for competitive, long-term & stable supplies. The main products are APIs and intermediates of antiviral drug substances and anti-inflammatory, analgesic, and non-steroidal pharmaceuticals.
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Lenvatinib Mesylate

About the Company : We are a world class innovation driven specialty pharmaceutical company with integrated Research, Development, Manufacturing and Marketing of Quality affordable medicines for a Hea...

We are a world class innovation driven specialty pharmaceutical company with integrated Research, Development, Manufacturing and Marketing of Quality affordable medicines for a Healthier Tomorrow. We always strive to focus on area of unmet medical need and leverages our expertise to bring in solutions that improve people’s health better around the world. We are committed to expand the horizons of healthcare by embracing new technologies, touching millions of lives with good health & partnering for a better tomorrow.
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Drugs in Development

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Details:

LENVIMA (lenvatinib) capsule is an orally available multiple receptor tyrosine kinase inhibitor that inhibits the VEGF receptors and is being evaluated in combination with pembrolizumab in patients with Metastatic Non-Small Cell Lung Cancer.


Lead Product(s): Lenvatinib Mesylate,Pembrolizumab

Therapeutic Area: Oncology Brand Name: Lenvima

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Merck & Co

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable September 22, 2023

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Eisai

Japan
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Peptide Process CMC
Not Confirmed

Eisai

Japan
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Peptide Process CMC
Not Confirmed

Details : LENVIMA (lenvatinib) capsule is an orally available multiple receptor tyrosine kinase inhibitor that inhibits the VEGF receptors and is being evaluated in combination with pembrolizumab in patients with Metastatic Non-Small Cell Lung Cancer.

Product Name : Lenvima

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

September 22, 2023

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Details:

LENVIMA (lenvatinib) Capsule is an orally available multiple receptor tyrosine kinase inhibitor that inhibits the VEGF receptors and evaluating in combination with pembrolizumab in patients With metastatic head and neck squamous cell carcinoma.


Lead Product(s): Lenvatinib Mesylate,Pembrolizumab

Therapeutic Area: Oncology Brand Name: Lenvima

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Merck & Co

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable August 25, 2023

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Eisai

Japan
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Peptide Process CMC
Not Confirmed

Eisai

Japan
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Peptide Process CMC
Not Confirmed

Details : LENVIMA (lenvatinib) Capsule is an orally available multiple receptor tyrosine kinase inhibitor that inhibits the VEGF receptors and evaluating in combination with pembrolizumab in patients With metastatic head and neck squamous cell carcinoma.

Product Name : Lenvima

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

August 25, 2023

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Details:

Lenvima® (lenvatinib), discovered and developed by Eisai, is an orally available multiple receptor tyrosine kinase inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4).


Lead Product(s): Lenvatinib Mesylate,Pembrolizumab

Therapeutic Area: Oncology Brand Name: Lenvima

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable May 26, 2023

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Eisai

Japan
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Peptide Process CMC
Not Confirmed

Eisai

Japan
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Peptide Process CMC
Not Confirmed

Details : Lenvima® (lenvatinib), discovered and developed by Eisai, is an orally available multiple receptor tyrosine kinase inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGF...

Product Name : Lenvima

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

May 26, 2023

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Details:

Lenvima (lenvatinib) is a RTK inhibitor that inhibits the kinase activities of VEGF receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). It also inhibits pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellular functions.


Lead Product(s): Lenvatinib Mesylate,Pembrolizumab

Therapeutic Area: Oncology Brand Name: Lenvima

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable January 18, 2023

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Eisai

Japan
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Peptide Process CMC
Not Confirmed

Eisai

Japan
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Peptide Process CMC
Not Confirmed

Details : Lenvima (lenvatinib) is a RTK inhibitor that inhibits the kinase activities of VEGF receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). It also inhibits pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellu...

Product Name : Lenvima

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 18, 2023

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Details:

In final analysis, there was improvement for one of dual primary endpoints, overall survival, for patients treated with Lenvima (Lenvatinib) plus KEYTRUDA versus Lenvima monotherapy; however, results did not meet statistical significance per pre-specified statistical plan.


Lead Product(s): Lenvatinib Mesylate,Pembrolizumab

Therapeutic Area: Oncology Brand Name: Lenvima

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Merck & Co

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable December 09, 2022

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Eisai

Japan
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Peptide Process CMC
Not Confirmed

Eisai

Japan
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Peptide Process CMC
Not Confirmed

Details : In final analysis, there was improvement for one of dual primary endpoints, overall survival, for patients treated with Lenvima (Lenvatinib) plus KEYTRUDA versus Lenvima monotherapy; however, results did not meet statistical significance per pre-specifie...

Product Name : Lenvima

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

December 09, 2022

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Details:

Final analyses of the RWD study showed that 72.4% of patients treated with LENVIMA (Lenvatinib), a multiple receptor tyrosine kinase inhibitor had Best Overall Response (BOR) reported as a complete (26.9%) or partial (45.5%) response.


Lead Product(s): Lenvatinib Mesylate,Inapplicable

Therapeutic Area: Oncology Brand Name: Lenvima

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable October 21, 2022

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Eisai

Japan
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Peptide Process CMC
Not Confirmed

Eisai

Japan
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Not Confirmed

Details : Final analyses of the RWD study showed that 72.4% of patients treated with LENVIMA (Lenvatinib), a multiple receptor tyrosine kinase inhibitor had Best Overall Response (BOR) reported as a complete (26.9%) or partial (45.5%) response.

Product Name : Lenvima

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

October 21, 2022

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Details:

Two Mini-Oral Presentations on the Pivotal Phase 3 CLEAR and Study 309/KEYNOTE-775 Trials Demonstrate the clinical benefit of lenvima (lenvatinib) plus pembrolizumab and the combination’s potential across difficult-to-treat cancers.


Lead Product(s): Lenvatinib Mesylate,Pembrolizumab

Therapeutic Area: Oncology Brand Name: Lenvima

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable June 09, 2022

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Eisai

Japan
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Peptide Process CMC
Not Confirmed

Eisai

Japan
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Peptide Process CMC
Not Confirmed

Details : Two Mini-Oral Presentations on the Pivotal Phase 3 CLEAR and Study 309/KEYNOTE-775 Trials Demonstrate the clinical benefit of lenvima (lenvatinib) plus pembrolizumab and the combination’s potential across difficult-to-treat cancers.

Product Name : Lenvima

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

June 09, 2022

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CS1003 (nofazinlimab) is a humanized recombinant IgG4 monoclonal antibody targeting human programmed cell death protein 1 (PD-1) being developed in combination with lenvatinib as first-line treatment for patients with advanced hepatocellular carcinoma.


Lead Product(s): Nofazinlimab,Lenvatinib Mesylate

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: Phase IIIProduct Type: Antibody

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable March 18, 2022

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Peptide Process CMC
Not Confirmed

Details : CS1003 (nofazinlimab) is a humanized recombinant IgG4 monoclonal antibody targeting human programmed cell death protein 1 (PD-1) being developed in combination with lenvatinib as first-line treatment for patients with advanced hepatocellular carcinoma.

Product Name : Undisclosed

Product Type : Antibody

Upfront Cash : Inapplicable

March 18, 2022

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Details:

The approval is based on results from the pivotal Phase 3 CLEAR (Study 307)/KEYNOTE581 trial, in which LENVIMA plus KEYTRUDA demonstrated statistically significant improvements versus sunitinib in the primary efficacy outcome measure of progression-free survival (PFS).


Lead Product(s): Lenvatinib Mesylate,Pembrolizumab

Therapeutic Area: Oncology Brand Name: Lenvima

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable February 25, 2022

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Eisai

Japan
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Peptide Process CMC
Not Confirmed

Eisai

Japan
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Peptide Process CMC
Not Confirmed

Details : The approval is based on results from the pivotal Phase 3 CLEAR (Study 307)/KEYNOTE581 trial, in which LENVIMA plus KEYTRUDA demonstrated statistically significant improvements versus sunitinib in the primary efficacy outcome measure of progression-free ...

Product Name : Lenvima

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

February 25, 2022

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INTERMEDIATE SUPPLIERS

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CAS Number : 857890-39-2

End Use API : Lenvatinib Mesylate

About The Company : Jinan Xinke Pharmaceutical Science and Technology Co., Ltd. (XKPHARM) is an innovation driven company, headquartered in Jinan city, Shandong province, China and...

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FDF Dossiers

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Eisai Inc

U.S.A
Peptide Process CMC
Not Confirmed
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Eisai Inc

U.S.A
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Peptide Process CMC
Not Confirmed

LENVATINIB MESYLATE

Brand Name : LENVIMA

Dosage Form : CAPSULE;ORAL

Dosage Strength : EQ 4MG BASE

Packaging :

Approval Date : 2015-02-13

Application Number : 206947

Regulatory Info : RX

Registration Country : USA

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Eisai Inc

U.S.A
Peptide Process CMC
Not Confirmed
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Eisai Inc

U.S.A
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Peptide Process CMC
Not Confirmed

LENVATINIB MESYLATE

Brand Name : LENVIMA

Dosage Form : CAPSULE;ORAL

Dosage Strength : EQ 10MG BASE

Packaging :

Approval Date : 2015-02-13

Application Number : 206947

Regulatory Info : RX

Registration Country : USA

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Eisai Inc

U.S.A
Peptide Process CMC
Not Confirmed
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Eisai Inc

U.S.A
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Peptide Process CMC
Not Confirmed

lenvatinibmesilat

Brand Name : LENVIMA

Dosage Form : HARD CAPSULES

Dosage Strength : 4 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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Eisai Inc

U.S.A
Peptide Process CMC
Not Confirmed
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Eisai Inc

U.S.A
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Peptide Process CMC
Not Confirmed

LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 20MG/DOSE

Packaging : 60

Approval Date :

Application Number : 2450305

Regulatory Info :

Registration Country : Canada

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Eisai Inc

U.S.A
Peptide Process CMC
Not Confirmed
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Eisai Inc

U.S.A
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Peptide Process CMC
Not Confirmed

LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 10MG/DOSE

Packaging : 30

Approval Date :

Application Number : 2450321

Regulatory Info :

Registration Country : Canada

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Eisai Inc

U.S.A
Peptide Process CMC
Not Confirmed
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Eisai Inc

U.S.A
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Peptide Process CMC
Not Confirmed

LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 8MG/DOSE

Packaging : 60X4MG

Approval Date :

Application Number : 2468220

Regulatory Info :

Registration Country : Canada

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Eisai Inc

U.S.A
Peptide Process CMC
Not Confirmed
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Eisai Inc

U.S.A
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Peptide Process CMC
Not Confirmed

LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 18MG/DOSE

Packaging : 60X4MG & 30X10MG

Approval Date :

Application Number : 2468239

Regulatory Info :

Registration Country : Canada

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Eisai Inc

U.S.A
Peptide Process CMC
Not Confirmed
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Eisai Inc

U.S.A
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Peptide Process CMC
Not Confirmed

LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 4MG/DOSE

Packaging :

Approval Date :

Application Number : 2484056

Regulatory Info :

Registration Country : Canada

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Olon S.p.A

Italy
Peptide Process CMC
Not Confirmed
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Olon S.p.A

Italy
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Peptide Process CMC
Not Confirmed

LENVATINIB MESYLATE

Brand Name :

Dosage Form : Capsule

Dosage Strength : 4MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : Available Dossier- US-EU-RoW

Registration Country : Italy

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Olon S.p.A

Italy
Peptide Process CMC
Not Confirmed
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Olon S.p.A

Italy
arrow
Peptide Process CMC
Not Confirmed

LENVATINIB MESYLATE

Brand Name :

Dosage Form : Capsule

Dosage Strength : 10MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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FDA Orange Book

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EISAI INC

U.S.A
Peptide Process CMC
Not Confirmed
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EISAI INC

U.S.A
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Peptide Process CMC
Not Confirmed

LENVATINIB MESYLATE

Brand Name : LENVIMA

Dosage Form : CAPSULE;ORAL

Dosage Strength : EQ 4MG BASE

Approval Date : 2015-02-13

Application Number : 206947

RX/OTC/DISCN : RX

RLD : Yes

TE Code :

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EISAI INC

U.S.A
Peptide Process CMC
Not Confirmed
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EISAI INC

U.S.A
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Peptide Process CMC
Not Confirmed

LENVATINIB MESYLATE

Brand Name : LENVIMA

Dosage Form : CAPSULE;ORAL

Dosage Strength : EQ 10MG BASE

Approval Date : 2015-02-13

Application Number : 206947

RX/OTC/DISCN : RX

RLD : Yes

TE Code :

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Peptide Process CMC
Not Confirmed
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LENVATINIB MESYLATE

Brand Name : LENVATINIB

Dosage Form : CAPSULE; ORAL

Dosage Strength : 4MG

Approval Date :

Application Number : 213092

RX/OTC/DISCN :

RLD :

TE Code :

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Peptide Process CMC
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LENVATINIB MESYLATE

Brand Name : LENVATINIB

Dosage Form : CAPSULE; ORAL

Dosage Strength : 10MG

Approval Date :

Application Number : 213092

RX/OTC/DISCN :

RLD :

TE Code :

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Europe

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Peptide Process CMC
Not Confirmed
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lenvatinibmesilat

Brand Name : LENVIMA

Dosage Form : HARD CAPSULES

Dosage Strength : 4 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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Peptide Process CMC
Not Confirmed
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Peptide Process CMC
Not Confirmed

lenvatinibmesilat

Brand Name : LENVIMA

Dosage Form : HARD CAPSULES

Dosage Strength : 10 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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Olon Spa

Italy
Peptide Process CMC
Not Confirmed
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Olon Spa

Italy
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Peptide Process CMC
Not Confirmed

LENVATINIB MESYLATE

Brand Name :

Dosage Form : Capsule

Dosage Strength : 4MG

Packaging :

Approval Date :

Application Number :

Regulatory Info : Available Dossier- US-EU-RoW

Registration Country : Italy

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Olon Spa

Italy
Peptide Process CMC
Not Confirmed
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Olon Spa

Italy
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Peptide Process CMC
Not Confirmed

LENVATINIB MESYLATE

Brand Name :

Dosage Form : Capsule

Dosage Strength : 10MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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Canada

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01

Peptide Process CMC
Not Confirmed
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Peptide Process CMC
Not Confirmed

LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 24MG/DOSE

Packaging : 90 (60 X 10MG, 30 X 4MG)

Approval Date :

Application Number : 2450291

Regulatory Info :

Registration Country : Canada

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Peptide Process CMC
Not Confirmed
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LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 20MG/DOSE

Packaging : 60

Approval Date :

Application Number : 2450305

Regulatory Info :

Registration Country : Canada

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Peptide Process CMC
Not Confirmed
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Not Confirmed

LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 14MG/DOSE

Packaging : 60 (30 X 10MG, 30 X 4MG)

Approval Date :

Application Number : 2450313

Regulatory Info :

Registration Country : Canada

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Peptide Process CMC
Not Confirmed
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LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 10MG/DOSE

Packaging : 30

Approval Date :

Application Number : 2450321

Regulatory Info :

Registration Country : Canada

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Peptide Process CMC
Not Confirmed
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LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 8MG/DOSE

Packaging : 60X4MG

Approval Date :

Application Number : 2468220

Regulatory Info :

Registration Country : Canada

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Peptide Process CMC
Not Confirmed
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Peptide Process CMC
Not Confirmed

LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 18MG/DOSE

Packaging : 60X4MG & 30X10MG

Approval Date :

Application Number : 2468239

Regulatory Info :

Registration Country : Canada

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Peptide Process CMC
Not Confirmed
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Peptide Process CMC
Not Confirmed

LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 4MG/DOSE

Packaging :

Approval Date :

Application Number : 2484056

Regulatory Info :

Registration Country : Canada

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Peptide Process CMC
Not Confirmed
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LENVATINIB (LENVATINIB MESYLATE)

Brand Name : LENVIMA

Dosage Form : CAPSULE

Dosage Strength : 12MG/DOSE

Packaging :

Approval Date :

Application Number : 2484129

Regulatory Info :

Registration Country : Canada

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ABOUT THIS PAGE

Looking for 857890-39-2 / Lenvatinib Mesylate API manufacturers, exporters & distributors?

Lenvatinib Mesylate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Lenvatinib Mesylate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Lenvatinib Mesylate manufacturer or Lenvatinib Mesylate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Lenvatinib Mesylate manufacturer or Lenvatinib Mesylate supplier.

PharmaCompass also assists you with knowing the Lenvatinib Mesylate API Price utilized in the formulation of products. Lenvatinib Mesylate API Price is not always fixed or binding as the Lenvatinib Mesylate Price is obtained through a variety of data sources. The Lenvatinib Mesylate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Lenvatinib Mesylate

Synonyms

857890-39-2, Lenvima, Lenvatinibmesylate, Lenvatinib mesilate, Lenvatinib mesylate [usan], E7080 mesylate

Cas Number

857890-39-2

Unique Ingredient Identifier (UNII)

3J78384F61

About Lenvatinib Mesylate

Lenvatinib Mesylate is a synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. E7080 blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis.

Lenvatinib Mesylate Manufacturers

A Lenvatinib Mesylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Lenvatinib Mesylate, including repackagers and relabelers. The FDA regulates Lenvatinib Mesylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Lenvatinib Mesylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Lenvatinib Mesylate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Lenvatinib Mesylate Suppliers

A Lenvatinib Mesylate supplier is an individual or a company that provides Lenvatinib Mesylate active pharmaceutical ingredient (API) or Lenvatinib Mesylate finished formulations upon request. The Lenvatinib Mesylate suppliers may include Lenvatinib Mesylate API manufacturers, exporters, distributors and traders.

click here to find a list of Lenvatinib Mesylate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Lenvatinib Mesylate USDMF

A Lenvatinib Mesylate DMF (Drug Master File) is a document detailing the whole manufacturing process of Lenvatinib Mesylate active pharmaceutical ingredient (API) in detail. Different forms of Lenvatinib Mesylate DMFs exist exist since differing nations have different regulations, such as Lenvatinib Mesylate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Lenvatinib Mesylate DMF submitted to regulatory agencies in the US is known as a USDMF. Lenvatinib Mesylate USDMF includes data on Lenvatinib Mesylate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Lenvatinib Mesylate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Lenvatinib Mesylate suppliers with USDMF on PharmaCompass.

Lenvatinib Mesylate KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Lenvatinib Mesylate Drug Master File in Korea (Lenvatinib Mesylate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Lenvatinib Mesylate. The MFDS reviews the Lenvatinib Mesylate KDMF as part of the drug registration process and uses the information provided in the Lenvatinib Mesylate KDMF to evaluate the safety and efficacy of the drug.

After submitting a Lenvatinib Mesylate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Lenvatinib Mesylate API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Lenvatinib Mesylate suppliers with KDMF on PharmaCompass.

Lenvatinib Mesylate WC

A Lenvatinib Mesylate written confirmation (Lenvatinib Mesylate WC) is an official document issued by a regulatory agency to a Lenvatinib Mesylate manufacturer, verifying that the manufacturing facility of a Lenvatinib Mesylate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Lenvatinib Mesylate APIs or Lenvatinib Mesylate finished pharmaceutical products to another nation, regulatory agencies frequently require a Lenvatinib Mesylate WC (written confirmation) as part of the regulatory process.

click here to find a list of Lenvatinib Mesylate suppliers with Written Confirmation (WC) on PharmaCompass.

Lenvatinib Mesylate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Lenvatinib Mesylate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Lenvatinib Mesylate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Lenvatinib Mesylate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Lenvatinib Mesylate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Lenvatinib Mesylate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Lenvatinib Mesylate suppliers with NDC on PharmaCompass.

Lenvatinib Mesylate GMP

Lenvatinib Mesylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Lenvatinib Mesylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Lenvatinib Mesylate GMP manufacturer or Lenvatinib Mesylate GMP API supplier for your needs.

Lenvatinib Mesylate CoA

A Lenvatinib Mesylate CoA (Certificate of Analysis) is a formal document that attests to Lenvatinib Mesylate's compliance with Lenvatinib Mesylate specifications and serves as a tool for batch-level quality control.

Lenvatinib Mesylate CoA mostly includes findings from lab analyses of a specific batch. For each Lenvatinib Mesylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Lenvatinib Mesylate may be tested according to a variety of international standards, such as European Pharmacopoeia (Lenvatinib Mesylate EP), Lenvatinib Mesylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Lenvatinib Mesylate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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