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    Chemistry

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    Also known as: 654671-78-0, Sitagliptin (phosphate), Mk-0431, Chembl393336, 494p4635i6, Mk0431
    Molecular Formula
    C16H18F6N5O5P
    Molecular Weight
    505.31  g/mol
    InChI Key
    IQFYVLUXQXSJJN-SBSPUUFOSA-N
    FDA UNII
    494P4635I6
    Sitagliptin Phosphate
    A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES.
    1 2D Structure

    Sitagliptin Phosphate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;phosphoric acid
    2.1.2 InChI
    InChI=1S/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)/t9-;/m1./s1
    2.1.3 InChI Key
    IQFYVLUXQXSJJN-SBSPUUFOSA-N
    2.1.4 Canonical SMILES
    C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N.OP(=O)(O)O
    2.1.5 Isomeric SMILES
    C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.OP(=O)(O)O
    2.2 Other Identifiers
    2.2.1 UNII
    494P4635I6
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 0431, Mk

    2. 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine

    3. Anhydrous, Sitagliptin Phosphate

    4. Januvia

    5. Mk 0431

    6. Mk-0431

    7. Mk0431

    8. Monohydrate, Sitagliptin Monophosphate

    9. Monohydrate, Sitagliptin Phosphate

    10. Monophosphate Monohydrate, Sitagliptin

    11. Phosphate Anhydrous, Sitagliptin

    12. Phosphate Monohydrate, Sitagliptin

    13. Phosphate, Sitagliptin

    14. Sitagliptin

    15. Sitagliptin Monophosphate Monohydrate

    16. Sitagliptin Phosphate Anhydrous

    17. Sitagliptin Phosphate Monohydrate

    2.3.2 Depositor-Supplied Synonyms

    1. 654671-78-0

    2. Sitagliptin (phosphate)

    3. Mk-0431

    4. Chembl393336

    5. 494p4635i6

    6. Mk0431

    7. (2r)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine Phosphate Salt

    8. (3r)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;phosphoric Acid

    9. (r)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one Phosphate

    10. 1-butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8h)-yl]-4-(2,4,5-trifluorophenyl)-, (3r)-, Phosphate (1:1)

    11. Sitagliptin Monophosphate

    12. Sitagliptin Phosphate Anhydrous

    13. (3r)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)-1-butanone; Phosphoric Acid

    14. Mk 0431

    15. Sr-05000001748

    16. Unii-494p4635i6

    17. (2r)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine Phosphate Salt

    18. Mk 431

    19. Mk-0431 Phosphate

    20. Schembl877069

    21. Dtxsid10215789

    22. Hy-13749a

    23. Mfcd09952339

    24. Akos015896098

    25. Sitagliptin Phosphate [who-dd]

    26. Ks-1214

    27. 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8h)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine Phosphate

    28. Sitagliptin Monophosphate Anhydrous [mi]

    29. 671s780

    30. A835125

    31. Sr-05000001748-2

    32. Q27259224

    33. Sitagliptin Phosphate Anhydrous Component Of Janumet

    34. (3r)-3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8h)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone Phosphate

    35. (3r)-3-azanyl-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-[2,4,5-tris(fluoranyl)phenyl]butan-1-one; Phosphoric Acid

    36. 1,2,4-triazolo(4,3-a)pyrazine, 7-((3r)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, Phosphate (1:1)

    37. 1269630-53-6

    38. 7-((3r)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazinemonophosphate

    39. 7-(3r)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Phosphate

    2.4 Create Date
    2006-04-29
    3 Chemical and Physical Properties
    Molecular Weight 505.31 g/mol
    Molecular Formula C16H18F6N5O5P
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count4
    Exact Mass505.09497466 g/mol
    Monoisotopic Mass505.09497466 g/mol
    Topological Polar Surface Area155 Ų
    Heavy Atom Count33
    Formal Charge0
    Complexity616
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameJanuvia
    PubMed HealthSitagliptin (By mouth)
    Drug ClassesAntidiabetic
    Drug LabelJANUVIA Tablets contain sitagliptin phosphate, an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahy...
    Active IngredientSitagliptin phosphate
    Dosage FormTablet
    RouteOral
    Strengtheq 100mg base; eq 50mg base; eq 25mg base
    Market StatusPrescription
    CompanyMerck Sharp Dohme

    2 of 4  
    Drug NameSitagliptin phosphate
    Active IngredientSitagliptin phosphate
    Dosage FormTablet
    Routeoral; Oral
    Strengtheq 100mg base; 25mg; eq 50mg base; 100mg; 50mg; eq 25mg base
    Market StatusTentative Approval
    CompanyMylan Pharms; Apotex; Sandoz; Sun Pharma Global; Watson Labs

    3 of 4  
    Drug NameJanuvia
    PubMed HealthSitagliptin (By mouth)
    Drug ClassesAntidiabetic
    Drug LabelJANUVIA Tablets contain sitagliptin phosphate, an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahy...
    Active IngredientSitagliptin phosphate
    Dosage FormTablet
    RouteOral
    Strengtheq 100mg base; eq 50mg base; eq 25mg base
    Market StatusPrescription
    CompanyMerck Sharp Dohme

    4 of 4  
    Drug NameSitagliptin phosphate
    Active IngredientSitagliptin phosphate
    Dosage FormTablet
    Routeoral; Oral
    Strengtheq 100mg base; 25mg; eq 50mg base; 100mg; 50mg; eq 25mg base
    Market StatusTentative Approval
    CompanyMylan Pharms; Apotex; Sandoz; Sun Pharma Global; Watson Labs

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Hypoglycemic Agents

    Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)

    Incretins

    Peptides which stimulate INSULIN release from the PANCREATIC BETA CELLS following oral nutrient ingestion, or postprandially. (See all compounds classified as Incretins.)

    Dipeptidyl-Peptidase IV Inhibitors

    Compounds that suppress the degradation of INCRETINS by blocking the action of DIPEPTIDYL-PEPTIDASE IV. This helps to correct the defective INSULIN and GLUCAGON secretion characteristic of TYPE 2 DIABETES MELLITUS by stimulating insulin secretion and suppressing glucagon release. (See all compounds classified as Dipeptidyl-Peptidase IV Inhibitors.)

    API Reference Price

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TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"XXEM XX FZXX","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"CADILA HEALTHCARE LTD","customerCountry":"INDIA","quantity":"372.00","actualQuantity":"372","unit":"KGS","unitRateFc":"1035.2","totalValueFC":"388362.9","currency":"USD","unitRateINR":"87267.9","date":"10-Jul-2024","totalValueINR":"32463673","totalValueInUsd":"388362.9","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29335990","bill_no":"1002544","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"N\/A","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721154600,"product":"RE-IMPORT- SITAGLIPTIN PHOSPHATE (EXPORT INV NO:232410369 DT:30.03.2024 VIDE SB NO:8780352 DT: 30.03.2024 )","address":"26, VANDALUR - KELAMBAKKAM ROAD,","city":"CHENNAI. TAMIL NADU.","supplier":"DLS PHARMAG DMCC","supplierCountry":"INDIA","foreign_port":"DUBAI","customer":"VENKATA NARAYANA ACTIVE INGREDIENTS PRIVATE LIMITE","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"325","totalValueFC":"332033.3","currency":"USD","unitRateINR":"27755","date":"17-Jul-2024","totalValueINR":"27755020.31","totalValueInUsd":"332033.3","indian_port":"Madras Air","hs_no":"29420090","bill_no":"4545754","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"DUBAI","supplierAddress":"2208,1 LAKE PLAZAJUMEIRAH LAKES TOWERSP B 309045 DUBAI UNITED ARAB EMIRATES","customerAddress":"26, VANDALUR - KELAMBAKKAM ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723573800,"product":"SITAGLIPTIN PHOSPHATE ANHYDROUS","address":"ALKEM HOUSE, DEVASHISH ADJACENT T","city":"MUMBAI,MAHARASHTRA","supplier":"HONOUR LAB LIMITED","supplierCountry":"INDIA","foreign_port":"HIPL SEZ","customer":"ALKEM LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"544.2","totalValueFC":"2744.5","currency":"USD","unitRateINR":"46040.5","date":"14-Aug-2024","totalValueINR":"230202.5","totalValueInUsd":"2744.5","indian_port":"Vizag-HIPL SEZ","hs_no":"29321990","bill_no":"5041630","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HIPL SEZ","supplierAddress":"HETERO INFRASTRUCTURE SEZ LTD N.NARASAPURAM VILLAGE, NAKKAPALLY M SDNF India","customerAddress":"ALKEM HOUSE, DEVASHISH ADJACENT T"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724351400,"product":"SITAGLIPTIN PHOSPHATE MONOHYDRATE","address":"SP BIOTECH,PARK-PHASE-I,BLOCK-I,TU","city":"","supplier":"HONOUR LAB LIMITED","supplierCountry":"INDIA","foreign_port":"HIPL SEZ","customer":"FINOSO PHARMA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"111.00","actualQuantity":"111","unit":"KGS","unitRateFc":"393.9","totalValueFC":"44231.4","currency":"USD","unitRateINR":"33424","date":"23-Aug-2024","totalValueINR":"3710064","totalValueInUsd":"44231.4","indian_port":"Vizag-HIPL SEZ","hs_no":"29335950","bill_no":"5202868","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HIPL SEZ","supplierAddress":"HETERO INFRASTRUCTURE SEZ LTD, N.NARASAPURAM VILLAGE,NAKKAPALLI M SDNF India","customerAddress":"SP BIOTECH,PARK-PHASE-I,BLOCK-I,TU"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729881000,"product":"SITAGLIPTIN PHOSPHATE ANH(SNP)CO USP(BR)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"MYLAN LABORATORIES LIMITED FDF UNIT-3","supplierCountry":"INDIA","foreign_port":"NASIK","customer":"MYLAN LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"446.15","actualQuantity":"446.152","unit":"KGS","unitRateFc":"638.1","totalValueFC":"287835.8","currency":"USD","unitRateINR":"54209.9","date":"26-Oct-2024","totalValueINR":"24185846.38","totalValueInUsd":"287835.8","indian_port":"Indore-EPZ\/SEZ","hs_no":"29339990","bill_no":"6350764","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NASIK","supplierAddress":"IPlot No 11,12 & 13, SEZ Phase II SEZ, Sector 3, Pithampur, Dist Dhar SDNF India","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730917800,"product":"SITAGLIPTIN PHOSPHATE ANHYDROUS","address":"SANDOZ HOUSE","city":"MUMBAI ,MAHARASHTRA","supplier":"HONOUR LAB LIMITED","supplierCountry":"INDIA","foreign_port":"HIPL SEZ","customer":"SANDOZ PRIVATE LIMITED","customerCountry":"INDIA","quantity":"171.00","actualQuantity":"171","unit":"KGS","unitRateFc":"1029","totalValueFC":"177128.3","currency":"USD","unitRateINR":"87412.5","date":"07-Nov-2024","totalValueINR":"14947537.5","totalValueInUsd":"177128.3","indian_port":"Vizag-HIPL SEZ","hs_no":"29335950","bill_no":"6547337","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HIPL SEZ","supplierAddress":"HETERO INFRASTRUCTURE SEZ LTD N.NARASAPURAM VILLAGE,NAKKAPALLY MA SDNF India","customerAddress":"SANDOZ HOUSE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731954600,"product":"SITAGLIPTIN PHOSPHATE MONOHYDRATE (USP+IH)D50 NLT 40, D90 BETWEEN 130 AND 300 MICRON BATCH NO. E\/1466\/C23003SITAGLIPTIN PHOSPHATE MONOHYDRATE (USP+IH)D50 NLT 40, D90 BE","address":"304,ATLANTA ARCADE,","city":"MUMBAI MAHARASHTRA","supplier":"MACLEODS PHARMACEUTICAL LTD","supplierCountry":"INDIA","foreign_port":"INDORE","customer":"MACLEODS PHARMACEUTICALS LTD","customerCountry":"INDIA","quantity":"6.04","actualQuantity":"6.041","unit":"KGS","unitRateFc":"502.1","totalValueFC":"3066","currency":"USD","unitRateINR":"42830.1","date":"19-Nov-2024","totalValueINR":"258736.46","totalValueInUsd":"3066","indian_port":"Indore-EPZ\/SEZ","hs_no":"29339100","bill_no":"6753636","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Micronized","supplierPort":"INDORE","supplierAddress":"PLOT NO. M-50 TO 54&54A, PHASE-II, INDORE SPECIAL ECONOMIC ZONE, PITHAMPUR, DIST. DHAR, INDIA","customerAddress":"304,ATLANTA ARCADE,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736101800,"product":"SITAGLIPTIN HYDROCHLORIDE (VIDE RE IMPORT SB NO: 1604605 DT:08.06.2023)SITAGLIPTIN HYDROCHLORIDE","address":"PLOT NO. C-24, INDUSTRIAL ESTATE,","city":"HYDERABAD. AP","supplier":"SANDOZ AG","supplierCountry":"INDIA","foreign_port":"WARSAW","customer":"MSN PHARMACHEM PRIVATE LIMITED","customerCountry":"INDIA","quantity":"200.34","actualQuantity":"200.339","unit":"KGS","unitRateFc":"459.8","totalValueFC":"92510.8","currency":"USD","unitRateINR":"39818.2","date":"06-Jan-2025","totalValueINR":"7977131.94","totalValueInUsd":"92510.8","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"7627129","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WARSAW","supplierAddress":"LICHTSTRASSE 35, CH BASEL-4056 SWIT ZERLAND SDNF Switzerland","customerAddress":"PLOT NO. C-24, INDUSTRIAL ESTATE,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740508200,"product":"SITAGLIPTIN HYDROCHLORIDE(SB NO:4004954 DTD:31.12.24)","address":"20TH K M, HOSUR ROAD,,ELECTRONIC C","city":"BANGALORE,KARNATAKA","supplier":"REMEDICA LTD","supplierCountry":"CYPRUS","foreign_port":"LARNACA","customer":"BIOCON LIMITED","customerCountry":"INDIA","quantity":"428.00","actualQuantity":"428","unit":"KGS","unitRateFc":"509.7","totalValueFC":"220122.9","currency":"USD","unitRateINR":"44726.1","date":"26-Feb-2025","totalValueINR":"19142784","totalValueInUsd":"220122.9","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"8571704","productDescription":"API","marketType":"REGULATED MARKET","country":"CYPRUS","selfForZScoreResived":"Pharma Grade","supplierPort":"LARNACA","supplierAddress":"A LIMASSOL INDUSTRIAL ESTATE,4 AHARNON STREET,P.O.BOX 51706LIMASSO SDNF Cyprus","customerAddress":"20TH K M, HOSUR ROAD,,ELECTRONIC C"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1741545000,"product":"SITAGLIPTIN PHOSPHATE ANHYDROUS WORKING STANDARD","address":"SANDOZ HOUSE","city":"MUMBAI ,MAHARASHTRA","supplier":"HONOUR LABS LIMITED","supplierCountry":"INDIA","foreign_port":"HIPL SEZ","customer":"SANDOZ PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"3","unit":"GMS","unitRateFc":"3285.8","totalValueFC":"9991.9","currency":"USD","unitRateINR":"288491","date":"10-Mar-2025","totalValueINR":"865473","totalValueInUsd":"9991.9","indian_port":"Vizag-HIPL SEZ","hs_no":"29339990","bill_no":"8791470","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HIPL SEZ","supplierAddress":"PLOT NO 4 HETERO INFRASTRUCTURE SEZ N.NARASAPURAM VILLAGE, NAKKAPALLY M SDNF India","customerAddress":"SANDOZ HOUSE"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1742236200,"product":"SITAGLIPTIN HYDROCHLORIDE MONOHYDRATE","address":"8-3-166\/7\/1, HETERO HOUSE,","city":"HYDERABAD, AP.","supplier":"HONOUR LAB LIMITED","supplierCountry":"INDIA","foreign_port":"HIPL SEZ","customer":"HONOUR LAB LIMITED","customerCountry":"INDIA","quantity":"1994.03","actualQuantity":"1994.03","unit":"KGS","unitRateFc":"341.7","totalValueFC":"690632.3","currency":"USD","unitRateINR":"30000","date":"18-Mar-2025","totalValueINR":"59820900","totalValueInUsd":"690632.3","indian_port":"Vizag-HIPL SEZ","hs_no":"29339990","bill_no":"8943986","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HIPL SEZ","supplierAddress":"HETERO INFRASTRUCTURE SEZ LTD N.NARASAPURAM VILLAGE,NAKKAPALLY MA SDNF India","customerAddress":"8-3-166\/7\/1, HETERO HOUSE,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1744655400,"product":"SITAGLIPTIN HYDROCHLORIDE MONOHYDRATE","address":"8-3-166\/7\/1, HETERO HOUSE,","city":"HYDERABAD, AP.","supplier":"HONOUR LAB LIMITED","supplierCountry":"INDIA","foreign_port":"HIPL SEZ","customer":"HONOUR LAB LIMITED","customerCountry":"INDIA","quantity":"532.33","actualQuantity":"532.33","unit":"KGS","unitRateFc":"554.3","totalValueFC":"298496.6","currency":"USD","unitRateINR":"48000","date":"15-Apr-2025","totalValueINR":"25551840","totalValueInUsd":"298496.6","indian_port":"Vizag-HIPL SEZ","hs_no":"29339990","bill_no":"9487025","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HIPL SEZ","supplierAddress":"HETERO INFRASTRUCTURE SEZ LTD N.NARASAPURAM VILLAGE,NAKKAPALLY MA SDNF India","customerAddress":"8-3-166\/7\/1, HETERO HOUSE,"}]
    03-Jan-2022
    21-Apr-2025
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    DOSAGE - TABLET;ORAL - EQ 100MG BASE

    USFDA APPLICATION NUMBER - 21995

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    DOSAGE - TABLET;ORAL - 1GM;EQ 50MG BASE

    USFDA APPLICATION NUMBER - 22044

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    DOSAGE - TABLET;ORAL - 500MG;EQ 50MG BASE

    USFDA APPLICATION NUMBER - 22044

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    ABOUT THIS PAGE

    Looking for 1269630-53-6 / Sitagliptin Phosphate API manufacturers, exporters & distributors?

    Sitagliptin Phosphate manufacturers, exporters & distributors 1

    22

    PharmaCompass offers a list of Sitagliptin Phosphate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sitagliptin Phosphate manufacturer or Sitagliptin Phosphate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sitagliptin Phosphate manufacturer or Sitagliptin Phosphate supplier.

    PharmaCompass also assists you with knowing the Sitagliptin Phosphate API Price utilized in the formulation of products. Sitagliptin Phosphate API Price is not always fixed or binding as the Sitagliptin Phosphate Price is obtained through a variety of data sources. The Sitagliptin Phosphate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Sitagliptin Phosphate

    Synonyms

    654671-78-0, Sitagliptin (phosphate), Mk-0431, Chembl393336, 494p4635i6, Mk0431

    Cas Number

    1269630-53-6

    Unique Ingredient Identifier (UNII)

    494P4635I6

    About Sitagliptin Phosphate

    A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES.

    JANUMET-1 Manufacturers

    A JANUMET-1 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of JANUMET-1, including repackagers and relabelers. The FDA regulates JANUMET-1 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. JANUMET-1 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of JANUMET-1 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    JANUMET-1 Suppliers

    A JANUMET-1 supplier is an individual or a company that provides JANUMET-1 active pharmaceutical ingredient (API) or JANUMET-1 finished formulations upon request. The JANUMET-1 suppliers may include JANUMET-1 API manufacturers, exporters, distributors and traders.

    click here to find a list of JANUMET-1 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    JANUMET-1 USDMF

    A JANUMET-1 DMF (Drug Master File) is a document detailing the whole manufacturing process of JANUMET-1 active pharmaceutical ingredient (API) in detail. Different forms of JANUMET-1 DMFs exist exist since differing nations have different regulations, such as JANUMET-1 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A JANUMET-1 DMF submitted to regulatory agencies in the US is known as a USDMF. JANUMET-1 USDMF includes data on JANUMET-1's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The JANUMET-1 USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of JANUMET-1 suppliers with USDMF on PharmaCompass.

    JANUMET-1 JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The JANUMET-1 Drug Master File in Japan (JANUMET-1 JDMF) empowers JANUMET-1 API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the JANUMET-1 JDMF during the approval evaluation for pharmaceutical products. At the time of JANUMET-1 JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of JANUMET-1 suppliers with JDMF on PharmaCompass.

    JANUMET-1 KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a JANUMET-1 Drug Master File in Korea (JANUMET-1 KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of JANUMET-1. The MFDS reviews the JANUMET-1 KDMF as part of the drug registration process and uses the information provided in the JANUMET-1 KDMF to evaluate the safety and efficacy of the drug.

    After submitting a JANUMET-1 KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their JANUMET-1 API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of JANUMET-1 suppliers with KDMF on PharmaCompass.

    JANUMET-1 CEP

    A JANUMET-1 CEP of the European Pharmacopoeia monograph is often referred to as a JANUMET-1 Certificate of Suitability (COS). The purpose of a JANUMET-1 CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of JANUMET-1 EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of JANUMET-1 to their clients by showing that a JANUMET-1 CEP has been issued for it. The manufacturer submits a JANUMET-1 CEP (COS) as part of the market authorization procedure, and it takes on the role of a JANUMET-1 CEP holder for the record. Additionally, the data presented in the JANUMET-1 CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the JANUMET-1 DMF.

    A JANUMET-1 CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. JANUMET-1 CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of JANUMET-1 suppliers with CEP (COS) on PharmaCompass.

    JANUMET-1 WC

    A JANUMET-1 written confirmation (JANUMET-1 WC) is an official document issued by a regulatory agency to a JANUMET-1 manufacturer, verifying that the manufacturing facility of a JANUMET-1 active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting JANUMET-1 APIs or JANUMET-1 finished pharmaceutical products to another nation, regulatory agencies frequently require a JANUMET-1 WC (written confirmation) as part of the regulatory process.

    click here to find a list of JANUMET-1 suppliers with Written Confirmation (WC) on PharmaCompass.

    JANUMET-1 NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing JANUMET-1 as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for JANUMET-1 API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture JANUMET-1 as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain JANUMET-1 and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a JANUMET-1 NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of JANUMET-1 suppliers with NDC on PharmaCompass.

    JANUMET-1 GMP

    JANUMET-1 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of JANUMET-1 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right JANUMET-1 GMP manufacturer or JANUMET-1 GMP API supplier for your needs.

    JANUMET-1 CoA

    A JANUMET-1 CoA (Certificate of Analysis) is a formal document that attests to JANUMET-1's compliance with JANUMET-1 specifications and serves as a tool for batch-level quality control.

    JANUMET-1 CoA mostly includes findings from lab analyses of a specific batch. For each JANUMET-1 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    JANUMET-1 may be tested according to a variety of international standards, such as European Pharmacopoeia (JANUMET-1 EP), JANUMET-1 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (JANUMET-1 USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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