Hydroxy Propyl Methyl Cellulose

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

4 API Suppliers, 1 USDMF, 3 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports

DOSSIERs // Finished Dosage Formulations

4 Dossiers, 4 Listed Dossiers

MARKET PLACE

2 APIs, 1 DOSSIERS // FDF, 3 EXCIPIENTS

DIGITAL CONTENT

8 News

8 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

296

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: Hpmc, Hydroxy propyl methyl cellulose, (hydroxypropyl)methyl cellulose

Molecular Formula

C₅₆H₁₀₈O₃₀

Molecular Weight

1261.4 g/mol

InChI Key

PUSNGFYSTWMJSK-GSZQVNRLSA-N

Polymeric compounds that contain repeating units of hydroxypropyl methylcellulose. The properties of hypromellose polymers can vary greatly and are defined by their molecular weight, the percentage of hydroxyl groups, the percentage of hydroxypropyl groups, and viscosity measurements. They are found a broad variety of commercial products such as FOOD ADDITIVES; EXCIPIENTS; and LUBRICANTS.

1 2D Structure

Hydroxy Propyl Methyl Cellulose

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2R,3R,4S,5R,6R)-2,3,4-trimethoxy-6-(methoxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[(2R,3R,4S,5R,6S)-3,4,5-tris(2-hydroxypropoxy)-6-[(2R,3R,4S,5R,6R)-4,5,6-tris(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]propan-2-ol

2.1.2 InChI

InChI=1S/C36H70O19.C20H38O11/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41;1-21-9-11-13(23-3)15(24-4)18(27-7)20(30-11)31-14-12(10-22-2)29-19(28-8)17(26-6)16(14)25-5/h19-44H,9-18H2,1-8H3;11-20H,9-10H2,1-8H3/t19?,20?,21?,22?,23?,24?,25?,26?,27-,28-,29-,30-,31+,32+,33-,34-,35-,36+;11-,12-,13-,14-,15+,16+,17-,18-,19-,20+/m11/s1

2.1.3 InChI Key

PUSNGFYSTWMJSK-GSZQVNRLSA-N

2.1.4 Canonical SMILES

CC(COCC1C(C(C(C(O1)OC2C(OC(C(C2OCC(C)O)OCC(C)O)OCC(C)O)COCC(C)O)OCC(C)O)OCC(C)O)OCC(C)O)O.COCC1C(C(C(C(O1)OC2C(OC(C(C2OC)OC)OC)COC)OC)OC)OC

2.1.5 Isomeric SMILES

CC(COC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2OCC(C)O)OCC(C)O)OCC(C)O)COCC(C)O)OCC(C)O)OCC(C)O)OCC(C)O)O.COC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2OC)OC)OC)COC)OC)OC)OC

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Derivative, Hypromellose

2. Derivatives, Hypromellose

3. Hpmc 2910

4. Hpmc K 100 M

5. Hpmc-k-100 M

6. Hpmck100 M

7. Hydroxypropyl Methylcellulose

8. Hypromellose

9. Hypromellose Derivative

10. Hypromellose Derivatives

11. K 8515

12. K-8515

13. K8515

14. Methocel E

15. Methoxyhydroxypropylcellulose

16. Methyl Hydroxypropyl Cellulose

17. Methyl-hydroxypropyl-cellulose

18. Mhpc Polymer

2.2.2 Depositor-Supplied Synonyms

1. Hpmc

2. Hydroxy Propyl Methyl Cellulose

3. (hydroxypropyl)methyl Cellulose

2.3 Create Date

2012-08-08

3 Chemical and Physical Properties

Molecular Formula	C₅₆H₁₀₈O₃₀
Molecular Weight	1261.4 g/mol
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	30
Rotatable Bond Count	40
Exact Mass	1260.69254202 g/mol
Monoisotopic Mass	1260.69254202 g/mol
Topological Polar Surface Area	365 Å²
Heavy Atom Count	86
Formal Charge	0
Complexity	1480
Isotope Atom Count	0
Defined Atom Stereocenter Count	20
Undefined Atom Stereocenter Count	8
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2