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Chemistry

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Also known as: 51-77-4, Geranyl farnesylacetate, Gefanil, 3,7-dimethylocta-2,6-dien-1-yl 5,9,13-trimethyltetradeca-4,8,12-trienoate, Da-688, [(2e)-3,7-dimethylocta-2,6-dienyl] (4e,8e)-5,9,13-trimethyltetradeca-4,8,12-trienoate
Molecular Formula
C27H44O2
Molecular Weight
400.6  g/mol
InChI Key
ZPACYDRSPFRDHO-ROBAGEODSA-N
FDA UNII
1ISE2Y6ULA

Gefarnate
A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function of mucosal tissue.
1 2D Structure

Gefarnate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(2E)-3,7-dimethylocta-2,6-dienyl] (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoate
2.1.2 InChI
InChI=1S/C27H44O2/c1-22(2)12-8-14-24(5)16-10-17-25(6)18-11-19-27(28)29-21-20-26(7)15-9-13-23(3)4/h12-13,16,18,20H,8-11,14-15,17,19,21H2,1-7H3/b24-16+,25-18+,26-20+
2.1.3 InChI Key
ZPACYDRSPFRDHO-ROBAGEODSA-N
2.1.4 Canonical SMILES
CC(=CCCC(=CCCC(=CCCC(=O)OCC=C(C)CCC=C(C)C)C)C)C
2.1.5 Isomeric SMILES
CC(=CCC/C(=C/CC/C(=C/CCC(=O)OC/C=C(\C)/CCC=C(C)C)/C)/C)C
2.2 Other Identifiers
2.2.1 UNII
1ISE2Y6ULA
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Farnesylacetate, Geranyl

2. Gefarnil

3. Gepharnate

4. Geranyl Farnesylacetate

5. Ulco

2.3.2 Depositor-Supplied Synonyms

1. 51-77-4

2. Geranyl Farnesylacetate

3. Gefanil

4. 3,7-dimethylocta-2,6-dien-1-yl 5,9,13-trimethyltetradeca-4,8,12-trienoate

5. Da-688

6. [(2e)-3,7-dimethylocta-2,6-dienyl] (4e,8e)-5,9,13-trimethyltetradeca-4,8,12-trienoate

7. Da 688

8. 1ise2y6ula

9. Gefarnyl

10. Ncgc00182546-01

11. Gefarnil

12. Trans-3,7-dimethyl-2,6-octadienyl 5,9,13-trimethyl-4,8,12-tetradecatrienoate

13. Dsstox_cid_28562

14. Dsstox_rid_82834

15. Dsstox_gsid_48636

16. Gefarnatum

17. Gefarnato

18. Gefarnatum [inn-latin]

19. Gefarnato [inn-spanish]

20. 5,9,13-trimethyl-4,8,12-tetradecatrienoic Acid 3,7-dimethyl-2,6-octadienyl Ester

21. Cas-51-77-4

22. Gefarnate [inn:ban:jan]

23. 4,8,12-tetradecatrienoic Acid, 5,9,13-trimethyl-, (2e)-3,7-dimethyl-2,6-octadienyl Ester, (4e,8e)-

24. Einecs 200-121-0

25. Unii-1ise2y6ula

26. Osteol

27. Geranyl-farnesylacetate

28. Gefarnate [inn]

29. Gefarnate [jan]

30. Gefarnate [mi]

31. Gefarnate [mart.]

32. Gefarnate [who-dd]

33. (e,e,e)-5,9,13-trimethyl-4,8,12-tetradecatrienoic Acid 3,7-dimethyl-2,6-octadienyl Ester

34. Schembl148495

35. 3,7-dimethylocta-2,6-dienyl 5,9,13-trimethyltetradeca-4,8,12-trienoate

36. Chembl2105085

37. Dtxsid0048636

38. Chebi:31646

39. Hy-b2206

40. Zinc3872668

41. Tox21_112983

42. Mfcd00129086

43. Nsc138947

44. S5477

45. Akos015966756

46. Tox21_112983_1

47. Ac-2134

48. Ccg-268656

49. Cs-7652

50. Db12079

51. Nsc-138947

52. Ncgc00182546-02

53. 111ge003

54. 4,8,12-tetradecatrienoic Acid, 5,9,13-trimethyl-, 3,7-dimethyl-2,6-octadienyl Ester, (e,e,e)-

55. As-15887

56. C75428

57. 051g774

58. Q5530013

59. (4e,8e)-(e)-3,7-dimethylocta-2,6-dien-1-yl 5,9,13-trimethyltetradeca-4,8,12-trienoate

60. 4,8,12-tetradecatrienoic Acid, 5,9,13-trimethyl-, (2e)-3,7-dimethyl-2,6-octadien-1-yl Ester, (4e,8e)-

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 400.6 g/mol
Molecular Formula C27H44O2
XLogP39.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count15
Exact Mass400.334130642 g/mol
Monoisotopic Mass400.334130642 g/mol
Topological Polar Surface Area26.3 Ų
Heavy Atom Count29
Formal Charge0
Complexity619
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count3
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)


4.2 ATC Code

A - Alimentary tract and metabolism

A02 - Drugs for acid related disorders

A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)

A02BX - Other drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)

A02BX07 - Gefarnate


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ABOUT THIS PAGE

Looking for 51-77-4 / Gefarnate API manufacturers, exporters & distributors?

Gefarnate manufacturers, exporters & distributors 1

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API | Excipient name

Gefarnate

Synonyms

51-77-4, Geranyl farnesylacetate, Gefanil, 3,7-dimethylocta-2,6-dien-1-yl 5,9,13-trimethyltetradeca-4,8,12-trienoate, Da-688, [(2e)-3,7-dimethylocta-2,6-dienyl] (4e,8e)-5,9,13-trimethyltetradeca-4,8,12-trienoate

Cas Number

51-77-4

Unique Ingredient Identifier (UNII)

1ISE2Y6ULA

About Gefarnate

A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function of mucosal tissue.

Gefarnil Manufacturers

A Gefarnil manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Gefarnil, including repackagers and relabelers. The FDA regulates Gefarnil manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Gefarnil API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Gefarnil Suppliers

A Gefarnil supplier is an individual or a company that provides Gefarnil active pharmaceutical ingredient (API) or Gefarnil finished formulations upon request. The Gefarnil suppliers may include Gefarnil API manufacturers, exporters, distributors and traders.

Gefarnil GMP

Gefarnil Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Gefarnil GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Gefarnil GMP manufacturer or Gefarnil GMP API supplier for your needs.

Gefarnil CoA

A Gefarnil CoA (Certificate of Analysis) is a formal document that attests to Gefarnil's compliance with Gefarnil specifications and serves as a tool for batch-level quality control.

Gefarnil CoA mostly includes findings from lab analyses of a specific batch. For each Gefarnil CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Gefarnil may be tested according to a variety of international standards, such as European Pharmacopoeia (Gefarnil EP), Gefarnil JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Gefarnil USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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