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Chemistry

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Also known as: Neuraceq, Florbetaben (18f), Florbetaben f18, Florbetaben, Florbetaben f 18, 18f-florbetaben
Molecular Formula
C21H26FNO3
Molecular Weight
358.4  g/mol
InChI Key
NCWZOASIUQVOFA-FWZJPQCDSA-N
FDA UNII
TLA7312TOI

Florbetaben
Florbetaben (18F) is a stilbene derivative labeled with the positron-emitting isotope fluorine F 18, that may be used for positron emission tomography (PET) detection of beta-amyloid neuritic plaques and other amyloid protein deposits. Upon administration, F 18-florbetaben exhibits differential retention in regions that contain certain amyloid deposits. Differences in signal intensity between tissues showing specific and non-specific uptake of F 18-florbetaben allows for the detection of amyloid neuritic plaques in patients being evaluated for Alzheimer's disease, and potentially the detection of amyloid deposits in amyloidosis.
Florbetaben f-18 is a Radioactive Diagnostic Agent. The mechanism of action of florbetaben f-18 is as a Positron Emitting Activity.
1 2D Structure

Florbetaben

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[(E)-2-[4-[2-[2-(2-(18F)fluoranylethoxy)ethoxy]ethoxy]phenyl]ethenyl]-N-methylaniline
2.1.2 InChI
InChI=1S/C21H26FNO3/c1-23-20-8-4-18(5-9-20)2-3-19-6-10-21(11-7-19)26-17-16-25-15-14-24-13-12-22/h2-11,23H,12-17H2,1H3/b3-2+/i22-1
2.1.3 InChI Key
NCWZOASIUQVOFA-FWZJPQCDSA-N
2.1.4 Canonical SMILES
CNC1=CC=C(C=C1)C=CC2=CC=C(C=C2)OCCOCCOCCF
2.1.5 Isomeric SMILES
CNC1=CC=C(C=C1)/C=C/C2=CC=C(C=C2)OCCOCCOCC[18F]
2.2 Other Identifiers
2.2.1 UNII
TLA7312TOI
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 18f-bay94-9172

2. 18f-florbetaben

3. 4-(n-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene

4. Bay 94-9172

5. Bay94 9172

6. Bay94-9172

7. Florbetaben

2.3.2 Depositor-Supplied Synonyms

1. Neuraceq

2. Florbetaben (18f)

3. Florbetaben F18

4. Florbetaben

5. Florbetaben F 18

6. 18f-florbetaben

7. Unii-tla7312toi

8. 902143-01-5

9. Florbetaben ((sup 18)f)

10. Florbetaben (18f) [inn]

11. Bay94-9172

12. Bay 94-9172

13. Chebi:79033

14. Florbetaben F18 [usan]

15. Bay-949172

16. 18f-bay94-9172

17. Tla7312toi

18. Av-1

19. 4-((1e)-2-(4-(2-(2-(2-((sup 18(f))fluoroethoxy)ethoxy)ethoxy)phenyl)eth-1-en-1-yl)-n-methylaniline

20. 4-[(e)-2-[4-[2-[2-(2-(18f)fluoranylethoxy)ethoxy]ethoxy]phenyl]ethenyl]-n-methylaniline

21. Neuraceq (tn)

22. Florbetaben ((18)f)

23. Florbetaben 18f [inn]

24. Florbetaben (f-18)

25. Chembl566752

26. Gtpl7769

27. Schembl11301755

28. Florbetaben F 18 [mi]

29. Dtxsid20238065

30. Florbetaben(18f) [jan]

31. Bdbm50485236

32. Florbetaben (18f) [who-dd]

33. Bay94 9172

34. Db09148

35. Florbetaben (18f) (jan/usan/inn)

36. Florbetaben F-18 [orange Book]

37. [18f]bay 94-9172

38. Zk-6013443

39. Q17014149

40. 4-[(e)-2-[4-[2-[2-(2-fluoranylethoxy)ethoxy]ethoxy]phenyl]ethenyl]-n-methylaniline

41. 4-{(e)-2-[4-(2-{2-[2-((18)f)fluoroethoxy]ethoxy}ethoxy)phenyl]ethenyl}-n-methylaniline

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 358.4 g/mol
Molecular Formula C21H26FNO3
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Exact Mass358.192206 g/mol
Monoisotopic Mass358.192206 g/mol
Topological Polar Surface Area39.7 Ų
Heavy Atom Count26
Formal Charge0
Complexity364
Isotope Atom Count1
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Florbetaben is a radioactive diagnostic agent indicated for Positron Emission Tomography (PET) imaging of the brain to estimate -amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimers Disease (AD) and other causes of cognitive decline.


FDA Label


This medicinal product is for diagnostic use only.

Neuraceq is a radiopharmaceutical indicated for Positron Emission Tomography (PET) imaging of amyloid neuritic plaque density in the brains of adult patients with cognitive impairment who are being evaluated for Alzheimers disease (AD) and other causes of cognitive impairment. Neuraceq should be used in conjunction with a clinical evaluation.

A negative scan indicates sparse or no plaques, which is not consistent with a diagnosis of AD.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Following intravenous administration, Neuraceq crosses the blood brain barrier and shows differential retention in brain regions that contain -amyloid deposits. Differences in signal intensity between brain regions showing specific and non-specific Neuraceq uptake form the basis for the image interpretation method.


5.2 FDA Pharmacological Classification
5.2.1 Active Moiety
FLORBETABEN F-18
5.2.2 FDA UNII
TLA7312TOI
5.2.3 Pharmacological Classes
Radioactive Diagnostic Agent [EPC]; Positron Emitting Activity [MoA]
5.3 ATC Code

V09AX06


V - Various

V09 - Diagnostic radiopharmaceuticals

V09A - Central nervous system

V09AX - Other central nervous system diagnostic radiopharmaceuticals

V09AX06 - Florbetaben (18F)


5.4 Absorption, Distribution and Excretion

Absorption

Ten minutes after intravenous bolus injection of 300 MBq of Neuraceq in human volunteers, approximately 6% of the injected radioactivity was distributed to the brain. Florbetaben F 18 plasma concentrations declined by approximately 75% at 20 minutes post-injection, and by approximately 90% at 50 minutes.


Route of Elimination

At 12 hours post-administration, approximately 30% of the injected radioactivity had been excreted in urine.


5.5 Metabolism/Metabolites

In vitro studies show that metabolism of florbetaben is predominantly catalyzed by CYP2J2 and CYP4F2. Almost all F18 radioactivity in urine was excreted as polar metabolites of florbetaben F18 and only trace amounts of florbetaben F18 were detected.


5.6 Biological Half-Life

1 hr


5.7 Mechanism of Action

Florbetaben F18 is a F18-labeled stilbene derivative, which binds to -amyloid plaques in the brain. The F 18 isotope produces a positron signal that is detected by a PET scanner.


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ABOUT THIS PAGE

Looking for 902143-01-5 / Florbetaben API manufacturers, exporters & distributors?

Florbetaben manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Florbetaben API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Florbetaben manufacturer or Florbetaben supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Florbetaben manufacturer or Florbetaben supplier.

PharmaCompass also assists you with knowing the Florbetaben API Price utilized in the formulation of products. Florbetaben API Price is not always fixed or binding as the Florbetaben Price is obtained through a variety of data sources. The Florbetaben Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Florbetaben

Synonyms

Neuraceq, Florbetaben (18f), Florbetaben f18, Florbetaben f 18, 18f-florbetaben, Unii-tla7312toi

Cas Number

902143-01-5

Unique Ingredient Identifier (UNII)

TLA7312TOI

About Florbetaben

Florbetaben (18F) is a stilbene derivative labeled with the positron-emitting isotope fluorine F 18, that may be used for positron emission tomography (PET) detection of beta-amyloid neuritic plaques and other amyloid protein deposits. Upon administration, F 18-florbetaben exhibits differential retention in regions that contain certain amyloid deposits. Differences in signal intensity between tissues showing specific and non-specific uptake of F 18-florbetaben allows for the detection of amyloid neuritic plaques in patients being evaluated for Alzheimer's disease, and potentially the detection of amyloid deposits in amyloidosis.

Florbetaben F 18 Manufacturers

A Florbetaben F 18 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Florbetaben F 18, including repackagers and relabelers. The FDA regulates Florbetaben F 18 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Florbetaben F 18 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Florbetaben F 18 Suppliers

A Florbetaben F 18 supplier is an individual or a company that provides Florbetaben F 18 active pharmaceutical ingredient (API) or Florbetaben F 18 finished formulations upon request. The Florbetaben F 18 suppliers may include Florbetaben F 18 API manufacturers, exporters, distributors and traders.

Florbetaben F 18 GMP

Florbetaben F 18 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Florbetaben F 18 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Florbetaben F 18 GMP manufacturer or Florbetaben F 18 GMP API supplier for your needs.

Florbetaben F 18 CoA

A Florbetaben F 18 CoA (Certificate of Analysis) is a formal document that attests to Florbetaben F 18's compliance with Florbetaben F 18 specifications and serves as a tool for batch-level quality control.

Florbetaben F 18 CoA mostly includes findings from lab analyses of a specific batch. For each Florbetaben F 18 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Florbetaben F 18 may be tested according to a variety of international standards, such as European Pharmacopoeia (Florbetaben F 18 EP), Florbetaben F 18 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Florbetaben F 18 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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