Find Ferric Carboxymaltose manufacturers, exporters & distributors on PharmaCompass

Ferric Carboxymaltose

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

23 API Suppliers, 10 USDMF, 1 JDMF, 1 KDMF, 7 NDC API, 14 Listed Suppliers, $ API Reference Price

23 API Suppliers
10 USDMF
1 JDMF
1 KDMF
7 NDC API
14 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

12 Drugs in Development

12 Drugs in Development

FINISHED DOSAGE FORMULATIONS

19 FDF Dossiers, 4 FDA Orange Book, 2 Europe, 2 Australia, 1 South Africa, 10 Listed Dossiers

19 FDF Dossiers
4 FDA Orange Book
2 Europe
2 Australia
1 South Africa
10 Listed Dossiers

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 21 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
21 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 Finished Drug Prices, 7 Annual Reports

globalSalesInformation
2 Finished Drug Prices
7 Annual Reports

MARKET PLACE

24 APIs, 5 FDF Dossiers

marketPlace
24 APIs
5 FDF Dossiers

PATENTS & EXCLUSIVITIES

95 US Patents, 8 US Exclusivities

patents
95 US Patents
8 US Exclusivities

Interquim Ferric Carboxymaltose

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

2,879

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 9007-72-1, Ex-a3450, (2s,3s,4s,5r)-4-[(2r,3r,4r,5s,6r)-5-[(2r,3r,4r,5s,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanoate;iron(3+);oxygen(2-);hydroxide;hydrate

Molecular Formula

C₂₄H₄₄FeO₂₅-

Molecular Weight

788.4 g/mol

InChI Key

MFBBZTDYOYZJGB-HAONTEFVSA-L

Ferric Carboxymaltose is an iron replacement product and chemically, an iron carbohydrate complex. FDA approved on July 25, 2013.

1 2D Structure

Ferric Carboxymaltose

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S,3S,4S,5R)-4-[(2R,3R,4R,5S,6R)-5-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanoate;iron(3+);oxygen(2-);hydroxide;hydrate

2.1.2 InChI

InChI=1S/C24H42O22.Fe.2H2O.O/c25-1-5(29)18(11(32)14(35)21(39)40)44-23-16(37)12(33)20(7(3-27)42-23)46-24-17(38)13(34)19(8(4-28)43-24)45-22-15(36)10(31)9(30)6(2-26)41-22;;;;/h5-20,22-38H,1-4H2,(H,39,40);;2*1H2;/q;+3;;;-2/p-2/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14+,15-,16-,17-,18+,19-,20-,22-,23-,24-;;;;/m1..../s1

2.1.3 InChI Key

MFBBZTDYOYZJGB-HAONTEFVSA-L

2.1.4 Canonical SMILES

C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)OC(C(CO)O)C(C(C(=O)[O-])O)O)CO)CO)O)O)O)O.O.[OH-].[O-2].[Fe+3]

2.1.5 Isomeric SMILES

C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](O[C@@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@@H](CO)O)[C@H]([C@@H](C(=O)[O-])O)O)CO)CO)O)O)O)O.O.[OH-].[O-2].[Fe+3]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Ferinject

2. Injectafer

3. Iron Carboxymaltose

4. Iron Dextri-maltose

5. Polynuclear Iron (iii)-hydroxide 4(r)-(poly-(1->4)-o-alpha-d-glucopyranosyl)-oxy-2(r),3(s),5(r), 6-tetrahydroxy-hexanoate

6. Vit 45

7. Vit-45

2.2.2 Depositor-Supplied Synonyms

1. 9007-72-1

2. Ex-a3450

3. (2s,3s,4s,5r)-4-[(2r,3r,4r,5s,6r)-5-[(2r,3r,4r,5s,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanoate;iron(3+);oxygen(2-);hydroxide;hydrate

2.3 Create Date

2014-11-22

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₄₄FeO₂₅-
Molecular Weight	788.4 g/mol
Hydrogen Bond Donor Count	16
Hydrogen Bond Acceptor Count	25
Rotatable Bond Count	13
Exact Mass	788.152102 g/mol
Monoisotopic Mass	788.152102 g/mol
Topological Polar Surface Area	382 Å²
Heavy Atom Count	50
Formal Charge	-1
Complexity	940
Isotope Atom Count	0
Defined Atom Stereocenter Count	19
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	5

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Injectafer
PubMed Health	ferric carboxymaltose
Drug Classes	Iron Supplement
Drug Label	Ferric carboxymaltose, an iron replacement product, is an iron carbohydrate complex with the chemical name of polynuclear iron (III) hydroxide 4(R)-(poly-(14)-O--D-glucopyranosyl)-oxy-2(R),3(S),5(R),6-tetrahydroxy-hexanoate. It has a relative mo...
Active Ingredient	Ferric carboxymaltose
Dosage Form	Injectable
Route	Intravenous
Strength	750mg iron/15ml (50mg iron/ml)
Market Status	Prescription
Company	Luitpold
Patent	7612109; 7754702

2 of 2
Drug Name	Injectafer
PubMed Health	ferric carboxymaltose
Drug Classes	Iron Supplement
Drug Label	Ferric carboxymaltose, an iron replacement product, is an iron carbohydrate complex with the chemical name of polynuclear iron (III) hydroxide 4(R)-(poly-(14)-O--D-glucopyranosyl)-oxy-2(R),3(S),5(R),6-tetrahydroxy-hexanoate. It has a relative mo...
Active Ingredient	Ferric carboxymaltose
Dosage Form	Injectable
Route	Intravenous
Strength	750mg iron/15ml (50mg iron/ml)
Market Status	Prescription
Company	Luitpold
Patent	7612109; 7754702

4.2 Drug Indication

Ferric carboxymaltose is a iron replacement product indicated for the treatment of iron deficiency anemia in adult patients who have intolerance to oral iron or have had unsatisfactory response to oral iron or those who have non-dialysis dependent chronic kidney disease.

FDA Label

5 Pharmacology and Biochemistry

5.1 Pharmacology

When measured using positron emission tomography (PET), the red cell uptake of 59-Fe and 52-Fe from INJECTAFER ranged from 61% to 99%. In patients with iron deficiency, the red cell uptake ranged from 91% to 99%. In patients with renal anemia, the red cell uptake ranged from 61% to 84%.

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Parenteral Iron Replacement [EPC]; Phosphate Binder [EPC]; Phosphate Chelating Activity [MoA]; Iron [CS]

5.3 Absorption, Distribution and Excretion

Absorption

When a single dose of 100 to 1000 mg of iron was given to iron deficient patients, the maximum serum concentration (Cmax) was 37 g/mL to 333 g/mL. These levels were obtained 15 minutes to 1.21 hours post dose (Tmax).

Route of Elimination

Renal elimination of iron was negligible.

Volume of Distribution

3 L

5.4 Biological Half-Life

7 to 12 hours.

5.5 Mechanism of Action

Ferric carboxymaltose is a colloidal iron (III) hydroxide in complex with carboxymaltose, a carbohydrate polymer that release iron.

API SUPPLIERS