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Chemistry

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Also known as: 693228-63-6, Cyc-116, Cyc116, Chembl482967, Kinome_636, 4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine
Molecular Formula
C18H20N6OS
Molecular Weight
368.5  g/mol
InChI Key
GPSZYOIFQZPWEJ-UHFFFAOYSA-N
FDA UNII
YAX4981K2D

CYC116
CYC116 is a novel anticancer compound with a unique target profile involving both cell cycle and angiogenesis inhibition mechanisms. In preclinical studies, CYC116 has demonstrated antitumor activity in both solid tumors and hematological cancers. Cyclacel's small molecule investigational drug, CYC116, is the third orally-available Cyclacel drug to enter development, which demonstrated anticancer activity with a mechanism consistent with inhibition of Aurora kinase.
1 2D Structure

CYC116

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine
2.1.2 InChI
InChI=1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,22,23)
2.1.3 InChI Key
GPSZYOIFQZPWEJ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4
2.2 Other Identifiers
2.2.1 UNII
YAX4981K2D
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cyc 116

2. Cyc-116

3. Cyc116

2.3.2 Depositor-Supplied Synonyms

1. 693228-63-6

2. Cyc-116

3. Cyc116

4. Chembl482967

5. Kinome_636

6. 4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine

7. 4-methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine

8. 4-methyl-5-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)thiazol-2-amine

9. Cyc 116

10. 2uue

11. 2c5t

12. Cyc-116(antitumor)

13. Mls006011244

14. Schembl2074998

15. Yax4981k2d

16. Cyc 116 [who-dd]

17. Ex-a753

18. Bcpp000273

19. Hms3244o11

20. Hms3244o12

21. Hms3244p11

22. Hms3654o14

23. Bcp01887

24. Zinc3950132

25. Bdbm50277583

26. Mfcd14155805

27. Nsc759498

28. Nsc800082

29. S1171

30. 4-(2-amino-4-methylthiazol-5-yl)-n-(4-morpholinophenyl)pyrimidin-2-amine

31. Akos015897897

32. Bcp9000562

33. Ccg-264845

34. Cs-0112

35. Nsc-759498

36. Nsc-800082

37. Sb16587

38. Ncgc00263204-01

39. Ncgc00263204-10

40. Ac-32833

41. As-16201

42. Hy-10558

43. Smr004703003

44. Ft-0700350

45. Sw219491-1

46. 228c636

47. A866869

48. J-515754

49. 2-[[4-morpholinophenyl]amino]-4-(2-amino-4-methylthiazole-5-yl)pyrimidine

50. [4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-morpholin-4-yl-phenyl)-amine

51. 2-amino-4-methyl-1,3-thiazol-5-yl)-n-[4-(morpholin-4-yl)phenyl]pyrimidin-2-amine, 5

52. 2-pyrimidinamine, 4-(2-amino-4-methyl-5-thiazolyl)-n-(4-(4-morpholinyl)phenyl)-

53. 2-pyrimidinamine,4-(2-amino-4-methyl-5-thiazolyl)-n-[4-(4-morpholinyl)phenyl]-

54. 4-(2-amino-4-methyl-5-thiazolyl)-n-[4-(4-morpholinyl)phenyl]- 2-pyrimidinamine

55. 4-(2-amino-4-methyl-5-thiazolyl)-n-[4-(4-morpholinyl)phenyl]-2-pyrimidinamine

2.4 Create Date
2006-04-27
3 Chemical and Physical Properties
Molecular Weight 368.5 g/mol
Molecular Formula C18H20N6OS
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass368.14193046 g/mol
Monoisotopic Mass368.14193046 g/mol
Topological Polar Surface Area117 Ų
Heavy Atom Count26
Formal Charge0
Complexity443
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Advanced solid tumors


5 Pharmacology and Biochemistry
5.1 Mechanism of Action

Aurora kinases are enzymes that help dividing cells share their materials between two daughter cells. In many people with cancer Aurora kinase malfunctions and normal control of cell division is lost resulting in abnormal growth. CYC116 inhibits Aurora kinase may slow down the growth of cancer cells and lead to their death by apoptosis.


ABOUT THIS PAGE

Looking for 693228-63-6 / CYC116 API manufacturers, exporters & distributors?

CYC116 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of CYC116 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right CYC116 manufacturer or CYC116 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred CYC116 manufacturer or CYC116 supplier.

PharmaCompass also assists you with knowing the CYC116 API Price utilized in the formulation of products. CYC116 API Price is not always fixed or binding as the CYC116 Price is obtained through a variety of data sources. The CYC116 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

CYC116

Synonyms

693228-63-6, Cyc-116, Chembl482967, Kinome_636, 4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine, 4-methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine

Cas Number

693228-63-6

Unique Ingredient Identifier (UNII)

YAX4981K2D

About CYC116

CYC116 is a novel anticancer compound with a unique target profile involving both cell cycle and angiogenesis inhibition mechanisms. In preclinical studies, CYC116 has demonstrated antitumor activity in both solid tumors and hematological cancers. Cyclacel's small molecule investigational drug, CYC116, is the third orally-available Cyclacel drug to enter development, which demonstrated anticancer activity with a mechanism consistent with inhibition of Aurora kinase.

CYC116 Manufacturers

A CYC116 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of CYC116, including repackagers and relabelers. The FDA regulates CYC116 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. CYC116 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

CYC116 Suppliers

A CYC116 supplier is an individual or a company that provides CYC116 active pharmaceutical ingredient (API) or CYC116 finished formulations upon request. The CYC116 suppliers may include CYC116 API manufacturers, exporters, distributors and traders.

CYC116 GMP

CYC116 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of CYC116 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right CYC116 GMP manufacturer or CYC116 GMP API supplier for your needs.

CYC116 CoA

A CYC116 CoA (Certificate of Analysis) is a formal document that attests to CYC116's compliance with CYC116 specifications and serves as a tool for batch-level quality control.

CYC116 CoA mostly includes findings from lab analyses of a specific batch. For each CYC116 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

CYC116 may be tested according to a variety of international standards, such as European Pharmacopoeia (CYC116 EP), CYC116 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (CYC116 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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