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    Chemistry

    Click the arrow to open the dropdown
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    Also known as: 934660-93-2, Gdc-0973, Xl518, Xl-518, Gdc 0973, Rg7420
    Molecular Formula
    C21H21F3IN3O2
    Molecular Weight
    531.3  g/mol
    InChI Key
    BSMCAPRUBJMWDF-KRWDZBQOSA-N
    FDA UNII
    ER29L26N1X
    Cobimetinib
    Cobimetinib is an orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types. A threonine-tyrosine kinase and a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, MEK1 is required for the transmission of growth-promoting signals from numerous receptor tyrosine kinases.
    Cobimetinib is a Kinase Inhibitor. The mechanism of action of cobimetinib is as a Kinase Inhibitor.
    1 2D Structure

    Cobimetinib

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl]methanone
    2.1.2 InChI
    InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1
    2.1.3 InChI Key
    BSMCAPRUBJMWDF-KRWDZBQOSA-N
    2.1.4 Canonical SMILES
    C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
    2.1.5 Isomeric SMILES
    C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
    2.2 Other Identifiers
    2.2.1 UNII
    ER29L26N1X
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone

    2. Cotellic

    3. Gdc-0973

    4. Xl518

    2.3.2 Depositor-Supplied Synonyms

    1. 934660-93-2

    2. Gdc-0973

    3. Xl518

    4. Xl-518

    5. Gdc 0973

    6. Rg7420

    7. Xl 518

    8. Rg 7420

    9. Er29l26n1x

    10. Chembl2146883

    11. [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2s)-piperidin-2-yl]azetidin-1-yl]methanone

    12. Cobimetinib (gdc-0973, Rg7420)

    13. (s)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone

    14. [3,4-bis(fluoranyl)-2-[(2-fluoranyl-4-iodanyl-phenyl)amino]phenyl]-[3-oxidanyl-3-[(2s)-piperidin-2-yl]azetidin-1-yl]methanone

    15. Methanone, (3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-((2s)-2-piperidinyl)-1-azetidinyl)-

    16. [3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-((s)-3-hydroxy-3-piperidin-2-yl-azetidin-1-yl)-methanone

    17. Eui

    18. Cobimetinib Butyrate

    19. Cobimetinib [usan]

    20. 934660-94-3

    21. Cobimetinib [usan:inn]

    22. Cometinib

    23. Unii-er29l26n1x

    24. C21h21f3in3o2

    25. Cobimetinib [mi]

    26. Cobimetinib [inn]

    27. Cobimetinib (usan/inn)

    28. Cobimetinib [who-dd]

    29. Schembl189565

    30. Gtpl7626

    31. Xl518;rg7420;cobimetinib

    32. Chebi:90851

    33. Dtxsid60239435

    34. Ex-a673

    35. Gdc0973

    36. Gdc0973; Xl518; Cobimetinib

    37. Bdbm50391802

    38. Mfcd22124461

    39. Nsc768068

    40. Nsc781257

    41. Nsc800075

    42. S8041

    43. Zinc60325170

    44. Bcp9000716

    45. Ccg-264727

    46. Cs-0521

    47. Db05239

    48. Nsc-768068

    49. Nsc-781257

    50. Nsc-800075

    51. Vs-0129

    52. Xl518 (gdc-0973)

    53. Ncgc00346455-03

    54. Ncgc00346455-05

    55. (3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone

    56. (s)-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone

    57. Hy-13064

    58. Ro-5514041

    59. D10405

    60. J-525162

    61. Q15708292

    62. ((3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl)(3-hydroxy-3-((2s)-piperidin-2-yl)azetidin-1-yl)methanone

    63. (3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)(3-hydroxy-3-((s)-piperidin-2-yl)cyclobutyl)methanone

    64. [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2s)-piperidin-2-yl]azetidin

    65. [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]{3-hydroxy-3-[(2s)-piperidin-2-yl]azetidin-1-yl}methanone

    66. [3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-[3-hydroxy-3-[(2s)-piperidin-2-yl]azetidin-1-yl]methanone

    67. {3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}{3-hydroxy-3-[(2s)-piperidin-2-yl]azetidin-1-yl}methanone

    2.4 Create Date
    2007-07-23
    3 Chemical and Physical Properties
    Molecular Weight 531.3 g/mol
    Molecular Formula C21H21F3IN3O2
    XLogP33.9
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count4
    Exact Mass531.06306 g/mol
    Monoisotopic Mass531.06306 g/mol
    Topological Polar Surface Area64.6 Ų
    Heavy Atom Count30
    Formal Charge0
    Complexity624
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    For the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation. Cobimetinib is used in combination with vemurafenib, a BRAF inhibitor.

    FDA Label

    Cotellic is indicated for use in combination with vemurafenib for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation.

    Treatment of all conditions included in the category of malignant neoplasms (except haematopoietic and lymphoid tissue) with Ras, Raf or MEK pathway activation

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Cobimetinib is a reversible inhibitor of mitogen-activated protein kinase 1 (MAPK)/extracellular signal regulated kinase 1 (MEK1) and MEK2. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a BRAF mutation, which has been found to be associated with many tumor types. A threonine-tyrosine kinase and a key component of the RAS/RAF/MEK/ERK signalling pathway that is frequently activated in human tumors, MEK1 is required for the transmission of growth-promoting signals from numerous receptor tyrosine kinases. Cobimetinib is used in combination with vemurafenib because the clinical benefit of a BRAF inhibitor is limited by intrinsic and acquired resistance. Reactivation of the MAPK pathway is a major contributor to treatment failure in BRAF-mutant melanomas, approximately ~80% of melanoma tumors becomes BRAF-inhibitor resistant due to reactivation of MAPK signalling. BRAF-inhibitor resistant tumor cells are sensitive to MEK inhibition, therefore cobimetinib and vemurafenib will result in dual inhibition of BRAF and its downstream target, MEK.

    5.2 FDA Pharmacological Classification
    5.2.1 Active Moiety
    COBIMETINIB
    5.2.2 FDA UNII
    ER29L26N1X
    5.2.3 Pharmacological Classes
    Kinase Inhibitors [MoA]; Kinase Inhibitor [EPC]
    5.3 ATC Code

    L01XE38

    L01XE38

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    L - Antineoplastic and immunomodulating agents

    L01 - Antineoplastic agents

    L01E - Protein kinase inhibitors

    L01EE - Mitogen-activated protein kinase (mek) inhibitors

    L01EE02 - Cobimetinib

    5.4 Absorption, Distribution and Excretion

    Absorption

    The bioavailability of cobimetinib is 46%, the AUC and Cmax is unaffected by food.

    Route of Elimination

    76% of the dose was recovered in feces with 6.6% as unchanged drug. 17.8% of the dose was recovered in urine with 1.6% as unchanged drug.

    Volume of Distribution

    806L in cancer patients based on a population PK analysis.

    Clearance

    13.9L/h

    5.5 Metabolism/Metabolites

    Cobimetinib is mainly metabolized via CYP3A oxidation and UGT2B7 glucuronidation with no major metabolites formed.

    5.6 Biological Half-Life

    Average half life was 44 hours.

    5.7 Mechanism of Action

    MEK inhibitor Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Cobimetinib and vemurafenib target two different kinases in the RAS/RAF/MEK/ERK pathway.

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    DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.

    Details:

    Vemurafenib is a Other Small Molecule drug candidate, which is currently being evaluated in phase II/ phase III clinical studies for the treatment of Neoplasms.


    Lead Product(s): Vemurafenib,Cobimetinib

    Therapeutic Area: Oncology Brand Name: Undisclosed

    Study Phase: Phase II/ Phase IIIProduct Type: Miscellaneous

    Sponsor: University of Manchester | University of Birmingham | Royal Marsden NHS Foundation Trust | F. Hoffmann-La Roche

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable March 14, 2023

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    Lead Product(s) : Vemurafenib,Cobimetinib

    Therapeutic Area : Oncology

    Highest Development Status : Phase II/ Phase III

    Partner/Sponsor/Collaborator : University of Manchester | University of Birmingham | Royal Marsden NHS Foundation Trust | F. Hoffmann-La Roche

    Deal Size : Inapplicable

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    T3011 in Combination With Cobimetinib in Patients With Advanced Melanoma

    Details:

    T3011 is a Microorganism drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Melanoma.


    Lead Product(s): T3011,Cobimetinib

    Therapeutic Area: Oncology Brand Name: Undisclosed

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    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

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    Lead Product(s) : T3011,Cobimetinib

    Therapeutic Area : Oncology

    Highest Development Status : Phase II

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Lead Product(s) : Ifebemtinib,Cobimetinib

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    Highest Development Status : Phase I

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    Cobimetinib is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Arteriovenous Malformations.


    Lead Product(s): Cobimetinib,Inapplicable

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    Details : Cobimetinib is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Arteriovenous Malformations.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    November 18, 2021

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    Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer

    Details:

    Calaspargase Pegol is a Enzyme drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Pancreatic Neoplasms.


    Lead Product(s): Peg L asparaginase,Cobimetinib

    Therapeutic Area: Oncology Brand Name: Undisclosed

    Study Phase: Phase IProduct Type: Enzyme

    Sponsor: Oregon Health and Science University | Genentech | Servier

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable September 05, 2021

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    OHSU Knight Cancer Institute

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    OHSU Knight Cancer Institute

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    Lead Product(s) : Peg L asparaginase,Cobimetinib

    Therapeutic Area : Oncology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Oregon Health and Science University | Genentech | Servier

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancre...

    Details : Calaspargase Pegol is a Enzyme drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Pancreatic Neoplasms.

    Product Name : Undisclosed

    Product Type : Enzyme

    Upfront Cash : Inapplicable

    September 05, 2021

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    Combination or Sequence of Vemurafenib, Cobimetinib, and Atezolizumab in High-risk, Resectable Melanoma

    Details:

    Cobimetinib is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Melanoma.


    Lead Product(s): Cobimetinib,Vemurafenib,Atezolizumab

    Therapeutic Area: Oncology Brand Name: Undisclosed

    Study Phase: Phase IIProduct Type: Miscellaneous

    Sponsor: Clinical Research Technology

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable January 25, 2021

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    08

    Fondazione Melanoma Onlus

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    Fondazione Melanoma Onlus

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    Lead Product(s) : Cobimetinib,Vemurafenib,Atezolizumab

    Therapeutic Area : Oncology

    Highest Development Status : Phase II

    Partner/Sponsor/Collaborator : Clinical Research Technology

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Combination or Sequence of Vemurafenib, Cobimetinib, and Atezolizumab in High-risk, Resectable Mel...

    Details : Cobimetinib is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Melanoma.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    January 25, 2021

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    Revolution Medicines to Present Interim Data from Phase 1b/2 Trial Combining RMC-4630 with Cobimetinib for RAS-Addicted Solid Tumors

    Details:

    The ongoing Phase 1b/2 RMC-4630-02 trial is designed to evaluate the safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of RMC-4630 and cobimetinib in adult patients with relapsed/refractory solid tumors that harbor specific genomic mutations.


    Lead Product(s): Vociprotafib,Cobimetinib

    Therapeutic Area: Oncology Brand Name: Undisclosed

    Study Phase: Phase I/ Phase IIProduct Type: Miscellaneous

    Sponsor: Undisclosed

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable October 12, 2020

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    Revolution Medicines

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    Lead Product(s) : Vociprotafib,Cobimetinib

    Therapeutic Area : Oncology

    Highest Development Status : Phase I/ Phase II

    Partner/Sponsor/Collaborator : Undisclosed

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Revolution Medicines to Present Interim Data from Phase 1b/2 Trial Combining RMC-4630 with Cobimet...

    Details : The ongoing Phase 1b/2 RMC-4630-02 trial is designed to evaluate the safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of RMC-4630 and cobimetinib in adult patients with relapsed/refractory solid tumors that harbor specific genomic mut...

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Inapplicable

    October 12, 2020

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    InxMed Announced the Completion of RMB 130M (~US$ 19M) Series A+ Financing

    Details:

    Funding will support the acceleration of IN10018 clinical program and expand InxMed's portfolio. IN10018 is a potent and selective ATP-competitive focal adhesion kinase small molecule inhibitor.


    Lead Product(s): Ifebemtinib,Cobimetinib

    Therapeutic Area: Oncology Brand Name: Undisclosed

    Study Phase: Phase IProduct Type: Miscellaneous

    Sponsor: Ennovation Ventures

    Deal Size: $19.0 million Upfront Cash: Undisclosed

    Deal Type: Series A Financing September 03, 2020

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    InxMed

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    InxMed

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    Lead Product(s) : Ifebemtinib,Cobimetinib

    Therapeutic Area : Oncology

    Highest Development Status : Phase I

    Partner/Sponsor/Collaborator : Ennovation Ventures

    Deal Size : $19.0 million

    Deal Type : Series A Financing

    DEALS_DEV arrow-down

    InxMed Announced the Completion of RMB 130M (~US$ 19M) Series A+ Financing

    Details : Funding will support the acceleration of IN10018 clinical program and expand InxMed's portfolio. IN10018 is a potent and selective ATP-competitive focal adhesion kinase small molecule inhibitor.

    Product Name : Undisclosed

    Product Type : Miscellaneous

    Upfront Cash : Undisclosed

    September 03, 2020

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    ABOUT THIS PAGE

    Looking for 934660-93-2 / Cobimetinib API manufacturers, exporters & distributors?

    Cobimetinib manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Cobimetinib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cobimetinib manufacturer or Cobimetinib supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cobimetinib manufacturer or Cobimetinib supplier.

    PharmaCompass also assists you with knowing the Cobimetinib API Price utilized in the formulation of products. Cobimetinib API Price is not always fixed or binding as the Cobimetinib Price is obtained through a variety of data sources. The Cobimetinib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Cobimetinib

    Synonyms

    934660-93-2, Gdc-0973, Xl518, Xl-518, Gdc 0973, Rg7420

    Cas Number

    934660-93-2

    Unique Ingredient Identifier (UNII)

    ER29L26N1X

    About Cobimetinib

    Cobimetinib is an orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types. A threonine-tyrosine kinase and a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, MEK1 is required for the transmission of growth-promoting signals from numerous receptor tyrosine kinases.

    Cobimetinib Fumarate Manufacturers

    A Cobimetinib Fumarate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cobimetinib Fumarate, including repackagers and relabelers. The FDA regulates Cobimetinib Fumarate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cobimetinib Fumarate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    Cobimetinib Fumarate Suppliers

    A Cobimetinib Fumarate supplier is an individual or a company that provides Cobimetinib Fumarate active pharmaceutical ingredient (API) or Cobimetinib Fumarate finished formulations upon request. The Cobimetinib Fumarate suppliers may include Cobimetinib Fumarate API manufacturers, exporters, distributors and traders.

    Cobimetinib Fumarate GMP

    Cobimetinib Fumarate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Cobimetinib Fumarate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cobimetinib Fumarate GMP manufacturer or Cobimetinib Fumarate GMP API supplier for your needs.

    Cobimetinib Fumarate CoA

    A Cobimetinib Fumarate CoA (Certificate of Analysis) is a formal document that attests to Cobimetinib Fumarate's compliance with Cobimetinib Fumarate specifications and serves as a tool for batch-level quality control.

    Cobimetinib Fumarate CoA mostly includes findings from lab analyses of a specific batch. For each Cobimetinib Fumarate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Cobimetinib Fumarate may be tested according to a variety of international standards, such as European Pharmacopoeia (Cobimetinib Fumarate EP), Cobimetinib Fumarate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cobimetinib Fumarate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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