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ACTIVE PHARMA INGREDIENTS

49 API Suppliers, 16 USDMF, 21 CEP/COS, 4 JDMF, 9 EU WC, 16 KDMF, 3 NDC API, 18 Listed Suppliers, $ API Reference Price

49 API Suppliers
16 USDMF
21 CEP/COS
4 JDMF
9 EU WC
16 KDMF
3 NDC API
18 Listed Suppliers
$ API Reference Price

INTERMEDIATES

6 Intermediate Suppliers

6 Intermediate Suppliers

FINISHED DOSAGE FORMULATIONS

232 FDF Dossiers, 22 FDA Orange Book, 39 Europe, 4 Canada, 5 South Africa, 162 Listed Dossiers

232 FDF Dossiers
22 FDA Orange Book
39 Europe
4 Canada
5 South Africa
162 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

FOR SUSPENSION;ORAL - 500MG/5ML, CAPSULE;ORAL - 400MG

drugProductComposition
FOR SUSPENSION;ORAL - 500MG/5ML
CAPSULE;ORAL - 400MG

RELATED EXCIPIENT COMPANIES

4 Rochem International Inc, 17 SPI Pharma, 12 DKSH, 2 Pharm-RX Chemical, 6 Faran Shimi Pharmaceutical, 5 Gangwal Healthcare, 2 Nanjing Well Pharmaceutical, 2 Pfanstiehl, 4 ACG Worldwide, 4 Actylis, 6 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 16 BASF, 1 Bioplus Life Sciences, 10 Corel Pharma Chem, 4 DFE Pharma, 2 Finar, 6 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 31 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 12 Microlex e.U, 2 Nomisma Healthcare, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 6 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 17 Roquette, 8 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 9 Sigachi Industries, 2 Silverline Chemicals, 2 The Dow Chemical Company, 1 Valens Pharmachem, 2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

70 Fillers, Diluents & Binders, 47 Coating Systems & Additives, 29 Thickeners and Stabilizers, 26 Direct Compression, 24 Controlled & Modified Release, 22 Taste Masking, 18 Granulation, 17 Chewable & Orodispersible Aids, 14 Co-Processed Excipients, 13 Topical, 13 Disintegrants & Superdisintegrants, 12 Lubricants & Glidants, 10 Film Formers & Plasticizers, 9 Empty Capsules, 8 Solubilizers, 7 Parenteral, 6 Rheology Modifiers, 5 Emulsifying Agents, 5 API Stability Enhancers, 5 Coloring Agents, 4 Vegetarian Capsules, 1 Surfactant & Foaming Agents

DIGITAL CONTENT

19 News #PharmaBuzz

media
19 News #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 39 Regulatory FDF Prices

globalSalesInformation
1 US Medicaid Prescriptions
39 Regulatory FDF Prices

MARKET PLACE

68 APIs, 15 FDF Dossiers

marketPlace
68 APIs
15 FDF Dossiers

PATENTS & EXCLUSIVITIES

1 US Patents, 3 Health Canada Patents

patents
1 US Patents
3 Health Canada Patents

REF. STANDARDS & IMPURITIES

1 EDQM , 8 Others

otherSolutions
1 EDQM
8 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

6INTERMEDIATES

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

FINISHED DOSAGE FORMULATIONS

232

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

162

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

225RELATED EXCIPIENT COMPANIES

365EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

API REF. PRICE (USD/KG)

$ 147

GLOBAL SALES INFORMATION

US Medicaid (USD)

1,622,984

Annual Reports (USD Million)

Regulatory FDF Prices

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MARKET PLACE

API

FDF

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

Chemistry

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Click the button for full data set

Also known as: Cefixime, 97164-56-2, 79350-37-1, Cefixime(e)-form, (e)-cefixime, Cefixime anhydrous, (e)-

Molecular Formula

C₁₆H₁₅N₅O₇S₂

Molecular Weight

453.5 g/mol

InChI Key

OKBVVJOGVLARMR-VINNURBNSA-N

FDA UNII

U7RWT9J78O

A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.

1 2D Structure

Cefixime

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

2.1.2 InChI

InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9+/t10-,14-/m1/s1

2.1.3 InChI Key

OKBVVJOGVLARMR-VINNURBNSA-N

2.1.4 Canonical SMILES

C=CC1=C(N2C(C(C2=O)NC(=O)C(=NOCC(=O)O)C3=CSC(=N3)N)SC1)C(=O)O

2.1.5 Isomeric SMILES

C=CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N/OCC(=O)O)/C3=CSC(=N3)N)SC1)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

U7RWT9J78O

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Cefixime

2. Cefixime Anhydrous

3. Cefixime Trihydrate

4. Fk 027

5. Fk-027

6. Fk027

7. Fr 17027

8. Fr-17027

9. Fr17027

2.3.2 Depositor-Supplied Synonyms

1. Cefixime

2. 97164-56-2

3. 79350-37-1

4. Cefixime(e)-form

5. (e)-cefixime

6. Cefixime Anhydrous, (e)-

7. U7rwt9j78o

8. Cfix

9. (6r,7r)-7-(((2e)-2-(2-amino-4-thiazolyl)-2-((carboxymethoxy)imino)acetyl)amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid

10. (6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

11. 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2e)-2-(2-amino-4-thiazolyl)-2-((carboxymethoxy)imino)acetyl)amino)-3-ethenyl-8-oxo-, (6r,7r)-

12. Cefixime Impurity D

13. Unii-u7rwt9j78o

14. (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

15. Cefiximetrihydrate

16. Prestwick2_000462

17. Epitope Id:116227

18. Schembl24946

19. Schembl49534

20. Chembl427069

21. Bdbm88962

22. Chebi:93248

23. Gtpl10898

24. Cid_56642849

25. Hms1569m06

26. (6r,7r)-7-((z)-2-(2-aminothiazol-4-yl)-2-((carboxymethoxy)imino)acetamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

27. Zinc4468778

28. Ncgc00185001-01

29. (e)-cefixime (cefixime Ep Impurity D)

30. Q163901

31. J-005196

32. J-501698

33. Brd-k04993501-001-01-9

34. [6r-[6alpha,7beta(e)]]-7-[[(2-amino-4-thiazolyl)[(car

35. (6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;hydrate

36. (6r,7r)-7-[[(2e)-2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino)-1-oxoethyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;hydrate

37. (6r,7r)-7-[[(2e)-2-(2-aminothiazol-4-yl)-2-(carboxymethyloximino)acetyl]amino]-8-keto-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;hydrate

38. (6r,7r)-7-[[(2e)-2-(2-azanyl-1,3-thiazol-4-yl)-2-(2-hydroxy-2-oxoethyloxyimino)ethanoyl]amino]-3-ethenyl-8-oxidanylidene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;hydrate

39. (6r,7r)-7-[[(2z)-2-(2-amino-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene -2-carboxylic Acid

40. (6r,7r,e)-7-(2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

2.4 Create Date

2005-11-20

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₁₅N₅O₇S₂
Molecular Weight	453.5 g/mol
XLogP3	-0.7
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	8
Exact Mass	453.04129018 g/mol
Monoisotopic Mass	453.04129018 g/mol
Topological Polar Surface Area	238 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	861
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

4.2 FDA Pharmacological Classification

4.2.1 Pharmacological Classes

Cephalosporins [CS]; Cephalosporin Antibacterial [EPC]

4.3 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01D - Other beta-lactam antibacterials

J01DD - Third-generation cephalosporins

J01DD08 - Cefixime

API SUPPLIERS

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USDMF

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CEP/COS

01

ASTELLAS PHARMA INC. Tokyo JP

Japan

Vietnam Medi Pharm

Not Confirmed

02

ASTELLAS PHARMA INC. Tokyo JP

Japan

Vietnam Medi Pharm

Not Confirmed

Not Confirmed

08

SANDOZ PRIVATE LIMITED Navi Mumbai ...

Switzerland

Vietnam Medi Pharm

Not Confirmed

09

SANDOZ PRIVATE LIMITED Navi Mumbai ...

Switzerland

Vietnam Medi Pharm

Not Confirmed

10

SURYA PHARMACEUTICAL LTD. Chandigar...

India

Vietnam Medi Pharm

Not Confirmed

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JDMF

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EU WC

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

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21 CEP/COS

4 JDMF

9 EU WC

16 KDMF

3 NDC API

18 Listed Suppliers

$ API Reference Price

INTERMEDIATES

6 Intermediate Suppliers

FINISHED DOSAGE FORMULATIONS

232 FDF Dossiers

22 FDA Orange Book

39 Europe

4 Canada

5 South Africa

162 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

FOR SUSPENSION;ORAL - 500MG/5ML

CAPSULE;ORAL - 400MG

RELATED EXCIPIENT COMPANIES

4 Rochem International Inc

17 SPI Pharma

12 DKSH

2 Pharm-RX Chemical

6 Faran Shimi Pharmaceutical

5 Gangwal Healthcare

2 Nanjing Well Pharmaceutical

2 Pfanstiehl

4 ACG Worldwide

4 Actylis

6 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

16 BASF

1 Bioplus Life Sciences

10 Corel Pharma Chem

4 DFE Pharma

2 Finar

6 Gangwal Chemicals

5 Ideal Cures Pvt Ltd

3 Ingredion Pharma Solutions

31 Kerry

3 Kima Chemical

6 Lonza Capsugel

12 Microlex e.U

2 Nomisma Healthcare

1 Novo Excipients

1 Pharmatrans-Sanaq

6 Pluviaendo

2 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

2 Qualicaps

17 Roquette

8 Seppic

5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

9 Sigachi Industries

2 Silverline Chemicals

2 The Dow Chemical Company

1 Valens Pharmachem

2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

70 Fillers, Diluents & Binders

47 Coating Systems & Additives

29 Thickeners and Stabilizers

26 Direct Compression

24 Controlled & Modified Release

22 Taste Masking

18 Granulation

17 Chewable & Orodispersible Aids

14 Co-Processed Excipients

13 Topical

13 Disintegrants & Superdisintegrants

12 Lubricants & Glidants