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1. Schembl23846781
2. Ab521
3. Ex-a9762
4. Hy-159644
5. 2709069-30-5
Molecular Weight | 439.4 g/mol |
---|---|
Molecular Formula | C21H17F4NO3S |
XLogP3 | 3 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 8 |
Rotatable Bond Count | 2 |
Exact Mass | Da |
Monoisotopic Mass | Da |
Topological Polar Surface Area | 86.5 |
Heavy Atom Count | 30 |
Formal Charge | 0 |
Complexity | 811 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 5 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Details:
Gilead's window to exercise its option to casdatifan has expired and arcus retains rights to AB521 (casdatifan), a small-molecule inhibitor of HIF-2a.
Lead Product(s): Casdatifan
Therapeutic Area: Oncology Brand Name: AB521
Study Phase: Phase IProduct Type: Other Small Molecule
Sponsor: Gilead Sciences
Deal Size: $1,600.0 million Upfront Cash: $375.0 million
Deal Type: Collaboration February 18, 2025
Lead Product(s) : Casdatifan
Therapeutic Area : Oncology
Highest Development Status : Phase I
Partner/Sponsor/Collaborator : Gilead Sciences
Deal Size : $1,600.0 million
Deal Type : Collaboration
Arcus Retains Casdatifan Rights, Prices $150M Common Stock Offering
Details : Gilead's window to exercise its option to casdatifan has expired and arcus retains rights to AB521 (casdatifan), a small-molecule inhibitor of HIF-2a.
Product Name : AB521
Product Type : Other Small Molecule
Upfront Cash : $375.0 million
February 18, 2025
Details:
The net proceeds will support the the clinical development of AB521 (casdatifan), a small-molecule inhibitor of HIF-2a, for the treatment of clear cell renal cell carcinoma.
Lead Product(s): Casdatifan
Therapeutic Area: Oncology Brand Name: AB521
Study Phase: Phase IProduct Type: Other Small Molecule
Sponsor: Goldman Sachs & Co
Deal Size: $150.0 million Upfront Cash: Undisclosed
Deal Type: Public Offering February 18, 2025
Lead Product(s) : Casdatifan
Therapeutic Area : Oncology
Highest Development Status : Phase I
Partner/Sponsor/Collaborator : Goldman Sachs & Co
Deal Size : $150.0 million
Deal Type : Public Offering
Arcus Biosciences, Inc. Announces Underwritten Offering of Common Stock
Details : The net proceeds will support the the clinical development of AB521 (casdatifan), a small-molecule inhibitor of HIF-2a, for the treatment of clear cell renal cell carcinoma.
Product Name : AB521
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
February 18, 2025
Details:
AB521 (casdatifan) is a small-molecule inhibitor of HIF-2a, which is being evaluated for the treatment of clear cell renal cell carcinoma.
Lead Product(s): Casdatifan,Cabozantinib
Therapeutic Area: Oncology Brand Name: AB521
Study Phase: Phase IProduct Type: Other Small Molecule
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable February 15, 2025
Lead Product(s) : Casdatifan,Cabozantinib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
New Data Shows Best-in-Class Potential for Casdatifan In Metastatic Kidney Cancer
Details : AB521 (casdatifan) is a small-molecule inhibitor of HIF-2a, which is being evaluated for the treatment of clear cell renal cell carcinoma.
Product Name : AB521
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
February 15, 2025
Details:
AB521 (casdatifan) is a potential best-in-class HIF-2a inhibitor, small molecule drug candidate, which is currently being evaluated for the treatment of renal cell cancer.
Lead Product(s): Casdatifan
Therapeutic Area: Oncology Brand Name: AB521
Study Phase: Phase IProduct Type: Other Small Molecule
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable October 24, 2024
Lead Product(s) : Casdatifan
Therapeutic Area : Oncology
Highest Development Status : Phase I
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Arcus Shows Promising Data for Casdatifan in Metastatic Kidney Cancer
Details : AB521 (casdatifan) is a potential best-in-class HIF-2a inhibitor, small molecule drug candidate, which is currently being evaluated for the treatment of renal cell cancer.
Product Name : AB521
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
October 24, 2024
Details:
The proceeds will be used to rapidly advance AB521 (casdatifan), its potential best-in-class HIF-2a inhibitor, for the treatment of renal cell cancer.
Lead Product(s): Casdatifan,Encoberminogene Rezmadenovec
Therapeutic Area: Oncology Brand Name: AB521
Study Phase: Phase I/ Phase IIProduct Type: Other Small Molecule
Sponsor: Hercules Capital
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Financing August 27, 2024
Lead Product(s) : Casdatifan,Encoberminogene Rezmadenovec
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Partner/Sponsor/Collaborator : Hercules Capital
Deal Size : Undisclosed
Deal Type : Financing
Arcus Biosciences Secures Up to $250 Million Term Loan Facility from Hercules Capital
Details : The proceeds will be used to rapidly advance AB521 (casdatifan), its potential best-in-class HIF-2a inhibitor, for the treatment of renal cell cancer.
Product Name : AB521
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
August 27, 2024
Details:
The collaboration aims to evaluate AB521 (casdatifan), an investigational HIF-2a inhibitor, in combination with volrustomig, AstraZeneca’s PD-1/CTLA-4 bispecific antibody, in patients with ccRCC.
Lead Product(s): Casdatifan,Volrustomig
Therapeutic Area: Oncology Brand Name: AB521
Study Phase: PreclinicalProduct Type: Other Small Molecule
Sponsor: AstraZeneca
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Collaboration February 10, 2024
Lead Product(s) : Casdatifan,Volrustomig
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Partner/Sponsor/Collaborator : AstraZeneca
Deal Size : Undisclosed
Deal Type : Collaboration
Arcus Signs Trial Collaboration For Renal Cancer Therapy Combination
Details : The collaboration aims to evaluate AB521 (casdatifan), an investigational HIF-2a inhibitor, in combination with volrustomig, AstraZeneca’s PD-1/CTLA-4 bispecific antibody, in patients with ccRCC.
Product Name : AB521
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
February 10, 2024
Details:
The companies will enter into a clinical trial collaboration evaluating XL092 (zanzalintinib), a tyrosine kinase inhibitor, in combination with AB521 in patients with advanced solid tumors including clear cell renal cell carcinoma.
Lead Product(s): Encoberminogene Rezmadenovec,Casdatifan
Therapeutic Area: Oncology Brand Name: XL092
Study Phase: IND EnablingProduct Type: Cell and Gene therapy
Sponsor: Arcus Biosciences
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Collaboration April 12, 2023
Lead Product(s) : Encoberminogene Rezmadenovec,Casdatifan
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Partner/Sponsor/Collaborator : Arcus Biosciences
Deal Size : Undisclosed
Deal Type : Collaboration
Details : The companies will enter into a clinical trial collaboration evaluating XL092 (zanzalintinib), a tyrosine kinase inhibitor, in combination with AB521 in patients with advanced solid tumors including clear cell renal cell carcinoma.
Product Name : XL092
Product Type : Cell and Gene therapy
Upfront Cash : Undisclosed
April 12, 2023
Details:
Initial pharmacokinetic /pharmacodynamic data for AB521, a Clinical-Stage, Potent, and Selective Hypoxia-Inducible Factor (HIF)-2α Inhibitor, in healthy volunteers, confirm its potential to have an improved clinical profile compared to that of only approved HIF-2a inhibitor.
Lead Product(s): Casdatifan
Therapeutic Area: Oncology Brand Name: AB521
Study Phase: Phase IProduct Type: Other Small Molecule
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable August 03, 2022
Lead Product(s) : Casdatifan
Therapeutic Area : Oncology
Highest Development Status : Phase I
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Arcus Biosciences Presents Data from its Pipeline at Multiple Scientific Conferences
Details : Initial pharmacokinetic /pharmacodynamic data for AB521, a Clinical-Stage, Potent, and Selective Hypoxia-Inducible Factor (HIF)-2α Inhibitor, in healthy volunteers, confirm its potential to have an improved clinical profile compared to that of only appr...
Product Name : AB521
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
August 03, 2022
Details:
Preclinical research related to therapeutic opportunities to enhance anti-tumor immunity and new insights into the benet of dual A2a/A2b adenosine receptor antagonism, CD39 inhibition and HPK1 inhibition will be presented at the American Association for Cancer Research.
Lead Product(s): Casdatifan
Therapeutic Area: Oncology Brand Name: AB521
Study Phase: Phase IProduct Type: Other Small Molecule
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable August 03, 2022
Lead Product(s) : Casdatifan
Therapeutic Area : Oncology
Highest Development Status : Phase I
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Arcus Biosciences Presents Data from its Pipeline at Multiple Scientific Conferences
Details : Preclinical research related to therapeutic opportunities to enhance anti-tumor immunity and new insights into the benet of dual A2a/A2b adenosine receptor antagonism, CD39 inhibition and HPK1 inhibition will be presented at the American Association for ...
Product Name : AB521
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
August 03, 2022
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