Find Casdatifan manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Schembl23846781, Ab521, Ex-a9762, Hy-159644, 2709069-30-5
Molecular Formula
C21H17F4NO3S
Molecular Weight
439.4  g/mol
InChI Key
KHBHHNNBNHHGPE-QCCZFBHPSA-N

Casdatifan
Casdatifan is an orally bioavailable allosteric inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, casdatifan targets and allosterically binds to a hydrophobic pocket on HIF-2alpha leading to a confirmational change that prevents HIF-2alpha heterodimerization with HIF-1beta and binding to the hypoxia response element (HRE) binding site on DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric transcription factor overexpressed under hypoxic conditions in many cancer cell types, promotes proliferation, progression and metastasis of tumors.
1 2D Structure

Casdatifan

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(5R,6S,8R)-3,5,6-trifluoro-8-[(1S,2R)-2-fluoro-1-hydroxy-7-methylsulfonyl-2,3-dihydro-1H-inden-4-yl]-5,6,7,8-tetrahydronaphthalene-1-carbonitrile
2.1.2 InChI
InChI=1S/C21H17F4NO3S/c1-30(28,29)17-3-2-11(13-7-16(24)21(27)19(13)17)12-6-15(23)20(25)14-5-10(22)4-9(8-26)18(12)14/h2-5,12,15-16,20-21,27H,6-7H2,1H3/t12-,15+,16-,20-,21-/m1/s1
2.1.3 InChI Key
KHBHHNNBNHHGPE-QCCZFBHPSA-N
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. Schembl23846781

2. Ab521

3. Ex-a9762

4. Hy-159644

5. 2709069-30-5

2.3 Create Date
2021-11-10
3 Chemical and Physical Properties
Molecular Weight 439.4 g/mol
Molecular Formula C21H17F4NO3S
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count2
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area86.5
Heavy Atom Count30
Formal Charge0
Complexity811
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for / Casdatifan API manufacturers, exporters & distributors?

Casdatifan manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Casdatifan API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Casdatifan manufacturer or Casdatifan supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Casdatifan manufacturer or Casdatifan supplier.

PharmaCompass also assists you with knowing the Casdatifan API Price utilized in the formulation of products. Casdatifan API Price is not always fixed or binding as the Casdatifan Price is obtained through a variety of data sources. The Casdatifan Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Casdatifan

Synonyms

Schembl23846781, Ab521, Ex-a9762, Hy-159644, 2709069-30-5

About Casdatifan

Casdatifan is an orally bioavailable allosteric inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, casdatifan targets and allosterically binds to a hydrophobic pocket on HIF-2alpha leading to a confirmational change that prevents HIF-2alpha heterodimerization with HIF-1beta and binding to the hypoxia response element (HRE) binding site on DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric transcription factor overexpressed under hypoxic conditions in many cancer cell types, promotes proliferation, progression and metastasis of tumors.

Casdatifan Manufacturers

A Casdatifan manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Casdatifan, including repackagers and relabelers. The FDA regulates Casdatifan manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Casdatifan API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Casdatifan Suppliers

A Casdatifan supplier is an individual or a company that provides Casdatifan active pharmaceutical ingredient (API) or Casdatifan finished formulations upon request. The Casdatifan suppliers may include Casdatifan API manufacturers, exporters, distributors and traders.

Casdatifan GMP

Casdatifan Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Casdatifan GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Casdatifan GMP manufacturer or Casdatifan GMP API supplier for your needs.

Casdatifan CoA

A Casdatifan CoA (Certificate of Analysis) is a formal document that attests to Casdatifan's compliance with Casdatifan specifications and serves as a tool for batch-level quality control.

Casdatifan CoA mostly includes findings from lab analyses of a specific batch. For each Casdatifan CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Casdatifan may be tested according to a variety of international standards, such as European Pharmacopoeia (Casdatifan EP), Casdatifan JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Casdatifan USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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