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Also known as: 611-75-6, Bromhexine hcl, Bisolvon, Auxit, Bromohexine hydrochloride, Bromhexine (hydrochloride)
Molecular Formula
C14H21Br2ClN2
Molecular Weight
412.59  g/mol
InChI Key
UCDKONUHZNTQPY-UHFFFAOYSA-N
FDA UNII
YC2ZOM3Z8V

Bromhexine Hydrochloride
A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
1 2D Structure

Bromhexine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride
2.1.2 InChI
InChI=1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H
2.1.3 InChI Key
UCDKONUHZNTQPY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(CC1=C(C(=CC(=C1)Br)Br)N)C2CCCCC2.Cl
2.2 Other Identifiers
2.2.1 UNII
YC2ZOM3Z8V
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Aparsonin

2. Bc, Bromhexin

3. Bisolvon

4. Bromhexin

5. Bromhexin Bc

6. Bromhexin Berlin Chemie

7. Bromhexin Berlin-chemie

8. Bromhexin Berlinchemie

9. Bromhexin Ratiopharm

10. Bromhexin Von Ct

11. Bromhexin-ratiopharm

12. Bromhexine

13. Bromhexine Monohydrochloride

14. Bromhexine, Famel

15. Bromhexinratiopharm

16. Brotussol

17. Ct, Bromhexin Von

18. Darolan

19. Dur Elix

20. Dur-elix

21. Durelix

22. Famel Bromhexine

23. Flegamin

24. Flubron

25. Hustentabs Ratiopharm

26. Hustentabs-ratiopharm

27. Hustentabsratiopharm

28. Hydrochloride, Bromhexine

29. Monohydrochloride, Bromhexine

30. Mucohexine

31. Na 274

32. Na-274

33. Na274

34. Quentan

35. Tesacof

36. Von Ct, Bromhexin

2.3.2 Depositor-Supplied Synonyms

1. 611-75-6

2. Bromhexine Hcl

3. Bisolvon

4. Auxit

5. Bromohexine Hydrochloride

6. Bromhexine (hydrochloride)

7. Broncokin

8. Viscolyt

9. 2,4-dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline Hydrochloride

10. Bromhexine Chloride

11. Bromohexine Monohydrochloride

12. Na 274

13. Bromehexine Hydrochloride

14. Mfcd00056626

15. Yc2zom3z8v

16. Nsc-758383

17. Chebi:31303

18. N-cyclohexyl-n-methyl-(2-amino-3,5-dibromobenzyl)ammonium Chloride

19. Na-274

20. 611-75-6 (hcl)

21. Ncgc00095005-01

22. 2-amino-3,5-dibromo-n-cyclohexyl-n-methylbenzylamine Hydrochloride

23. 2-amino-n-cyclohexyl-3,5-dibromo-n-methylbenzylamine Hydrochloride

24. N-(2-amino-3,5-dibromobenzyl)-n-methyl-cyclohexylammonium Chloride

25. 2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline Hydrochloride

26. Benzenemethanamine, 2-amino-3,5-dibromo-n-cyclohexyl-n-methyl-, Monohydrochloride

27. Dsstox_cid_25886

28. Dsstox_rid_81200

29. Dsstox_gsid_45886

30. Bromessina

31. Lisomucin

32. Quentan

33. 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride

34. Cas-611-75-6

35. Bromessina [italian]

36. Bromihexine Hydrochloride

37. Unii-yc2zom3z8v

38. Ophtolsol

39. Sr-05000001825

40. Bisolvon (tn)

41. Einecs 210-280-8

42. Bromhexine Hydrochloride [usan:jan]

43. Brombenzonium

44. Schembl99613

45. Bromohexine Hydrochloride,(s)

46. Spectrum1503107

47. Chembl1319139

48. Dtxsid0045886

49. Bromhexine For System Suitability

50. Hy-b0372a

51. Hms1922e19

52. Pharmakon1600-01503107

53. Tox21_111385

54. Bromhexine Hydrochloride [mi]

55. Ccg-39304

56. N-(2-amino-3,5-dibromobenzyl)-n-methylcyclohexylamine Hydrochloride

57. Nsc758383

58. S2060

59. Bromhexine Hydrochloride [jan]

60. Akos015906433

61. Benzylamine, 2-amino-n-cyclohexyl-3,5-dibromo-n-methyl-, Hydrochloride

62. Tox21_111385_1

63. Ac-6857

64. Bromhexine Hydrochloride (jp17/usan)

65. Bromhexine Hydrochloride [usan]

66. Ks-5253

67. Nsc 758383

68. Bromhexine Hydrochloride [mart.]

69. Bromhexine Hydrochloride [who-dd]

70. Ncgc00095005-02

71. Ncgc00178520-03

72. 3,5-dibromo-n(sup Alpha)-cyclohexyl-n(sup Alpha)-methyltoluene-alpha,2-diamine Monohydrochloride

73. Sy046825

74. Bromhexine Hydrochloride, >=98.0% (at)

75. B4054

76. Bromhexine Hydrochloride, Analytical Standard

77. Ft-0603492

78. Sw199599-2

79. Bromhexine Hydrochloride [ep Monograph]

80. D01778

81. D70838

82. 611b756

83. A833075

84. Q-200754

85. Sr-05000001825-2

86. Q27114269

87. Bromhexine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

88. 2,4-dibromo-6-((cyclohexyl(methyl)amino)methyl)anilinehydrochloride

89. N-(2-amino-3,5-dibromobenzyl)-n-methylcyclohexanaminium Chloride

90. Bromhexine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

91. 3,5-dibromo-n(alpha)-cyclohexyl-n(alpha)-methyltoluene-alpha,2-diamine Monohydrochloride

92. Bromhexine For System Suitability, European Pharmacopoeia (ep) Reference Standard

93. Bromhexine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

94. 2-amino-3,5-dibromo-n-cyclohexyl-n-methylbenzylamine Hydrochloride, N-(2-amino-3,5-dibromobenzyl)-n-methylcyclohexylamine Hydrochloride

95. 3,5-dibromo-n(sup .alpha.)-cyclohexyl-n(sup .alpha.)-methyltoluene-.alpha.,2-diamine Monohydrochloride

96. Toluene-alpha,2-diamine, 3,5-dibromo-n(sup Alpha)-cyclohexyl-n-(sup Alpha)-methyl-, Monohydrochloride

2.4 Create Date
2006-03-07
3 Chemical and Physical Properties
Molecular Weight 412.59 g/mol
Molecular Formula C14H21Br2ClN2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass411.97395 g/mol
Monoisotopic Mass409.97600 g/mol
Topological Polar Surface Area29.3 Ų
Heavy Atom Count19
Formal Charge0
Complexity256
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Expectorants

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (See all compounds classified as Expectorants.)


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03-Jan-2022
29-May-2025
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ABOUT THIS PAGE

Looking for 611-75-6 / Bromhexine Hydrochloride API manufacturers, exporters & distributors?

Bromhexine Hydrochloride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Bromhexine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Bromhexine Hydrochloride manufacturer or Bromhexine Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Bromhexine Hydrochloride manufacturer or Bromhexine Hydrochloride supplier.

PharmaCompass also assists you with knowing the Bromhexine Hydrochloride API Price utilized in the formulation of products. Bromhexine Hydrochloride API Price is not always fixed or binding as the Bromhexine Hydrochloride Price is obtained through a variety of data sources. The Bromhexine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Bromhexine Hydrochloride

Synonyms

611-75-6, Bromhexine hcl, Bisolvon, Auxit, Bromohexine hydrochloride, Bromhexine (hydrochloride)

Cas Number

611-75-6

Unique Ingredient Identifier (UNII)

YC2ZOM3Z8V

About Bromhexine Hydrochloride

A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)

Bromhexine Hydrochloride Manufacturers

A Bromhexine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Bromhexine Hydrochloride, including repackagers and relabelers. The FDA regulates Bromhexine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Bromhexine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Bromhexine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Bromhexine Hydrochloride Suppliers

A Bromhexine Hydrochloride supplier is an individual or a company that provides Bromhexine Hydrochloride active pharmaceutical ingredient (API) or Bromhexine Hydrochloride finished formulations upon request. The Bromhexine Hydrochloride suppliers may include Bromhexine Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Bromhexine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Bromhexine Hydrochloride JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Bromhexine Hydrochloride Drug Master File in Japan (Bromhexine Hydrochloride JDMF) empowers Bromhexine Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Bromhexine Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Bromhexine Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Bromhexine Hydrochloride suppliers with JDMF on PharmaCompass.

Bromhexine Hydrochloride CEP

A Bromhexine Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Bromhexine Hydrochloride Certificate of Suitability (COS). The purpose of a Bromhexine Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Bromhexine Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Bromhexine Hydrochloride to their clients by showing that a Bromhexine Hydrochloride CEP has been issued for it. The manufacturer submits a Bromhexine Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Bromhexine Hydrochloride CEP holder for the record. Additionally, the data presented in the Bromhexine Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Bromhexine Hydrochloride DMF.

A Bromhexine Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Bromhexine Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Bromhexine Hydrochloride suppliers with CEP (COS) on PharmaCompass.

Bromhexine Hydrochloride WC

A Bromhexine Hydrochloride written confirmation (Bromhexine Hydrochloride WC) is an official document issued by a regulatory agency to a Bromhexine Hydrochloride manufacturer, verifying that the manufacturing facility of a Bromhexine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Bromhexine Hydrochloride APIs or Bromhexine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Bromhexine Hydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Bromhexine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Bromhexine Hydrochloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Bromhexine Hydrochloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Bromhexine Hydrochloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Bromhexine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Bromhexine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Bromhexine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Bromhexine Hydrochloride suppliers with NDC on PharmaCompass.

Bromhexine Hydrochloride GMP

Bromhexine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Bromhexine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Bromhexine Hydrochloride GMP manufacturer or Bromhexine Hydrochloride GMP API supplier for your needs.

Bromhexine Hydrochloride CoA

A Bromhexine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Bromhexine Hydrochloride's compliance with Bromhexine Hydrochloride specifications and serves as a tool for batch-level quality control.

Bromhexine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Bromhexine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Bromhexine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Bromhexine Hydrochloride EP), Bromhexine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Bromhexine Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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