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Chemistry

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Also known as: 1446113-23-0, 31m3wlj3kg, 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide, Gdc-5573, 4-amino-n-[1-(3-chloro-2-fluoroanilino)-6-methylisoquinolin-5-yl]thieno[3,2-d]pyrimidine-7-carboxamide, Hm95573
Molecular Formula
C23H16ClFN6OS
Molecular Weight
478.9  g/mol
InChI Key
KVCQTKNUUQOELD-UHFFFAOYSA-N
FDA UNII
31M3WLJ3KG

Belvarafenib
Belvarafenib is an orally available inhibitor of members of the Raf family of serine/threonine protein kinases, with potential antineoplastic activity. Upon administration, belvarafenib binds to and inhibits the B-Raf mutant V600E and C-Raf. This inhibits B-Raf V600E- and C-Raf-mediated signal transduction pathways, thereby inhibiting tumor cell growth of susceptible tumor cells. In addition, belvarafenib may also inhibit mutated Ras proteins. Raf protein kinases play a key role in the Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway, which is often dysregulated in human cancers and plays a key role in tumor cell proliferation and survival. The Raf mutation B-Raf V600E, where the valine at residue 600 is substituted for glutamic acid, is frequently overexpressed in a variety of human tumors and results in the constitutive activation of the Raf/MEK/ERK signaling pathway.
1 2D Structure

Belvarafenib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-amino-N-[1-(3-chloro-2-fluoroanilino)-6-methylisoquinolin-5-yl]thieno[3,2-d]pyrimidine-7-carboxamide
2.1.2 InChI
InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
2.1.3 InChI Key
KVCQTKNUUQOELD-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C2=C(C=C1)C(=NC=C2)NC3=C(C(=CC=C3)Cl)F)NC(=O)C4=CSC5=C4N=CN=C5N
2.2 Other Identifiers
2.2.1 UNII
31M3WLJ3KG
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1446113-23-0

2. 31m3wlj3kg

3. 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

4. Gdc-5573

5. 4-amino-n-[1-(3-chloro-2-fluoroanilino)-6-methylisoquinolin-5-yl]thieno[3,2-d]pyrimidine-7-carboxamide

6. Hm95573

7. 4-amino-n-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide

8. 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno(3,2-d)pyrimidine-7-carboxamide

9. Belvarafenib [inn]

10. Unii-31m3wlj3kg

11. Belvarafenib [who-dd]

12. Chembl3977543

13. Schembl15066408

14. Gtpl11544

15. Bdbm185591

16. Bcp31233

17. Ex-a3061

18. Whc11323

19. S8853

20. Akos037648828

21. Ac-36878

22. Bs-15746

23. Example 116 [wo2013100632a1]

24. Hy-109080

25. Cs-0039257

26. D81081

27. Belvarafenib(gdc5573, Hm95573, Rg6185)

28. A930123

29. Us9156852, 116

30. 4-amino-n-(1-(3-chloro-2-fluorophenylamino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

31. Thieno(3,2-d)pyrimidine-7-carboxamide, 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methyl-5-isoquinolinyl)-

32. V1y

2.4 Create Date
2015-02-13
3 Chemical and Physical Properties
Molecular Weight 478.9 g/mol
Molecular Formula C23H16ClFN6OS
XLogP34.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass478.0778862 g/mol
Monoisotopic Mass478.0778862 g/mol
Topological Polar Surface Area134 Ų
Heavy Atom Count33
Formal Charge0
Complexity708
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1446113-23-0 / Belvarafenib API manufacturers, exporters & distributors?

Belvarafenib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Belvarafenib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Belvarafenib manufacturer or Belvarafenib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Belvarafenib manufacturer or Belvarafenib supplier.

PharmaCompass also assists you with knowing the Belvarafenib API Price utilized in the formulation of products. Belvarafenib API Price is not always fixed or binding as the Belvarafenib Price is obtained through a variety of data sources. The Belvarafenib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Belvarafenib

Synonyms

1446113-23-0, 31m3wlj3kg, 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide, Gdc-5573, 4-amino-n-[1-(3-chloro-2-fluoroanilino)-6-methylisoquinolin-5-yl]thieno[3,2-d]pyrimidine-7-carboxamide, Hm95573

Cas Number

1446113-23-0

Unique Ingredient Identifier (UNII)

31M3WLJ3KG

About Belvarafenib

Belvarafenib is an orally available inhibitor of members of the Raf family of serine/threonine protein kinases, with potential antineoplastic activity. Upon administration, belvarafenib binds to and inhibits the B-Raf mutant V600E and C-Raf. This inhibits B-Raf V600E- and C-Raf-mediated signal transduction pathways, thereby inhibiting tumor cell growth of susceptible tumor cells. In addition, belvarafenib may also inhibit mutated Ras proteins. Raf protein kinases play a key role in the Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway, which is often dysregulated in human cancers and plays a key role in tumor cell proliferation and survival. The Raf mutation B-Raf V600E, where the valine at residue 600 is substituted for glutamic acid, is frequently overexpressed in a variety of human tumors and results in the constitutive activation of the Raf/MEK/ERK signaling pathway.

Belvarafenib Manufacturers

A Belvarafenib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Belvarafenib, including repackagers and relabelers. The FDA regulates Belvarafenib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Belvarafenib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Belvarafenib Suppliers

A Belvarafenib supplier is an individual or a company that provides Belvarafenib active pharmaceutical ingredient (API) or Belvarafenib finished formulations upon request. The Belvarafenib suppliers may include Belvarafenib API manufacturers, exporters, distributors and traders.

Belvarafenib GMP

Belvarafenib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Belvarafenib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Belvarafenib GMP manufacturer or Belvarafenib GMP API supplier for your needs.

Belvarafenib CoA

A Belvarafenib CoA (Certificate of Analysis) is a formal document that attests to Belvarafenib's compliance with Belvarafenib specifications and serves as a tool for batch-level quality control.

Belvarafenib CoA mostly includes findings from lab analyses of a specific batch. For each Belvarafenib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Belvarafenib may be tested according to a variety of international standards, such as European Pharmacopoeia (Belvarafenib EP), Belvarafenib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Belvarafenib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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