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Chemistry

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Also known as: Ro-0622, 1011529-10-4, 4-amino-1-((2r,3s,4r,5r)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-one, 4-amino-1-[(2r,3s,4r,5r)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one, Chembl519846, Fncro-0622
Molecular Formula
C9H11FN6O4
Molecular Weight
286.22  g/mol
InChI Key
KTOLOIKYVCHRJW-XZMZPDFPSA-N

Azvudine
Azvudine is under investigation in clinical trial NCT04668235 (Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (Sars-cov-2 Infected)).
1 2D Structure

Azvudine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
2.1.2 InChI
InChI=1S/C9H11FN6O4/c10-5-6(18)9(3-17,14-15-12)20-7(5)16-2-1-4(11)13-8(16)19/h1-2,5-7,17-18H,3H2,(H2,11,13,19)/t5-,6-,7+,9+/m0/s1
2.1.3 InChI Key
KTOLOIKYVCHRJW-XZMZPDFPSA-N
2.1.4 Canonical SMILES
C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)F
2.1.5 Isomeric SMILES
C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@](O2)(CO)N=[N+]=[N-])O)F
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 2'-deoxy-2'-beta-fluoro-4'-azidocytidine

2. 4'-azido-2'-deoxy-2'-fluorocytidine

3. 4-amino-1-((2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-5-((imino-l,5-azanylidene)amino)tetrahydrofuran-2-yl)pyrimidin-2-one

4. 4-amino-1-((2r,3s,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-5-((imino-l,5-azanylidene)amino)tetrahydrofuran-2-yl)pyrimidin-2-one

5. Ro-0622

2.2.2 Depositor-Supplied Synonyms

1. Ro-0622

2. 1011529-10-4

3. 4-amino-1-((2r,3s,4r,5r)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-one

4. 4-amino-1-[(2r,3s,4r,5r)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one

5. Chembl519846

6. Fncro-0622

7. 4'-c-azido-2'-deoxy-2'-fluoro-beta-d-arabinocytidine

8. Schembl15866623

9. Dtxsid901027757

10. Glxc-25994

11. Hy-19314

12. Cs-0015081

13. A848947

14. 2(1h)-pyrimidinone, 4-amino-1-(4-c-azido-2-deoxy-2-fluoro-b-d-arabinofuranosyl)-

15. 4-amino-1-[(2r,3s,4r,5r)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

2.3 Create Date
2008-04-28
3 Chemical and Physical Properties
Molecular Weight 286.22 g/mol
Molecular Formula C9H11FN6O4
XLogP3-0.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass286.08258102 g/mol
Monoisotopic Mass286.08258102 g/mol
Topological Polar Surface Area123 Ų
Heavy Atom Count20
Formal Charge0
Complexity533
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Mechanism of Action

Azvudine is a nucleoside reverse transcriptase inhibitor that acts against HIV, HBV, and HCV. Some studies also show that it is able to modulate the expression of proteins like P-glycoprotein (P-gp), MRP2, and BCRP; in one instance, it was also able to increase the activity of P-gp. In 2020, the compound was tested in numerous clinical trials for the treatment of mild and common COVID-19.


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Looking for 1011529-10-4 / Azvudine API manufacturers, exporters & distributors?

Azvudine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Azvudine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Azvudine manufacturer or Azvudine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Azvudine manufacturer or Azvudine supplier.

PharmaCompass also assists you with knowing the Azvudine API Price utilized in the formulation of products. Azvudine API Price is not always fixed or binding as the Azvudine Price is obtained through a variety of data sources. The Azvudine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Azvudine

Synonyms

Ro-0622, 1011529-10-4, 4-amino-1-((2r,3s,4r,5r)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-one, 4-amino-1-[(2r,3s,4r,5r)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one, Chembl519846, Fncro-0622

Cas Number

1011529-10-4

About Azvudine

Azvudine is under investigation in clinical trial NCT04668235 (Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (Sars-cov-2 Infected)).

Azvudine Manufacturers

A Azvudine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Azvudine, including repackagers and relabelers. The FDA regulates Azvudine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Azvudine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Azvudine Suppliers

A Azvudine supplier is an individual or a company that provides Azvudine active pharmaceutical ingredient (API) or Azvudine finished formulations upon request. The Azvudine suppliers may include Azvudine API manufacturers, exporters, distributors and traders.

Azvudine GMP

Azvudine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Azvudine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Azvudine GMP manufacturer or Azvudine GMP API supplier for your needs.

Azvudine CoA

A Azvudine CoA (Certificate of Analysis) is a formal document that attests to Azvudine's compliance with Azvudine specifications and serves as a tool for batch-level quality control.

Azvudine CoA mostly includes findings from lab analyses of a specific batch. For each Azvudine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Azvudine may be tested according to a variety of international standards, such as European Pharmacopoeia (Azvudine EP), Azvudine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Azvudine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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