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12 Drugs in Development

12 Drugs in Development

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Also known as: 2171019-55-7, Afimetoran [usan], Lxp7mzl0vf, Bms-986256, Unii-lxp7mzl0vf, Afimetoran [inn]

Molecular Formula

C₂₆H₃₂N₆O

Molecular Weight

444.6 g/mol

InChI Key

SNFVHLQYHFQOEP-UHFFFAOYSA-N

FDA UNII

LXP7MZL0VF

AFIMETORAN is a small molecule drug with a maximum clinical trial phase of II (across all indications) and has 2 investigational indications.

1 2D Structure

Afimetoran

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[4-[2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]acetamide

2.1.2 InChI

InChI=1S/C26H32N6O/c1-15(2)24-20-11-19(18-7-9-31(10-8-18)13-23(27)33)5-6-22(20)30-25(24)21-12-32-26(28-14-29-32)17(4)16(21)3/h5-6,11-12,14-15,18,30H,7-10,13H2,1-4H3,(H2,27,33)

2.1.3 InChI Key

SNFVHLQYHFQOEP-UHFFFAOYSA-N

2.2 Other Identifiers

2.2.1 UNII

LXP7MZL0VF

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 2171019-55-7

2. Afimetoran [usan]

3. Lxp7mzl0vf

4. Bms-986256

5. Unii-lxp7mzl0vf

6. Afimetoran [inn]

7. Bms 986256

8. Afimetoran (usan)

9. 2-(4-(2-(7,8-dimethyl(1,2,4)triazolo(1,5-a)pyridin-6-yl)-3-(propan-2-yl)-1h-indol-5-yl)piperidin-1-yl)acetamide

10. 1-piperidineacetamide, 4-(2-(7,8-dimethyl(1,2,4)triazolo(1,5-a)pyridin-6-yl)-3-(1-methylethyl)-1h-indol-5-yl)-

11. Refchem:110007

12. 2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1h-indol-5-yl)piperidin-1-yl)acetamide

13. Who 11516

14. 2-[4-[2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-propan-2-yl-1h-indol-5-yl]piperidin-1-yl]acetamide

15. 1-piperidineacetamide, 4-(2-(7,8-dimethyl(1,2,4)triazolo(1,5-a)pyridin-6-yl)-3- (1-methylethyl)-1h-indol-5-yl)-

16. Afimetoran [who-dd]

17. Orb1303504

18. Afimetoran (bms-986256)

19. Chembl4650329

20. Schembl19761011

21. C26h32n6o

22. Bdbm273241

23. Ex-a6745

24. Us10071079, Example 15

25. Mfcd34578322

26. Akos040757385

27. Da-70624

28. Ms-28017

29. Hy-139567

30. Cs-0213544

31. D11908

32. G18517

33. 2-(4-(2-(7,8-dimethyl(1,2,4)triazolo(1,5-a)pyridin-6-yl)-3-(propan-2-yl)-1h-indol- 5-yl)piperidin-1-yl)acetamide

34. 2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1h-indol-5-yl) Piperidin-1-yl)acetamide

35. 2-[4-[2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1h-indol-5-yl]-1-piperidyl]acetamide

2.4 Create Date

2018-01-29

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₃₂N₆O
Molecular Weight	444.6 g/mol
XLogP3	3.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	Da
Monoisotopic Mass	Da
Topological Polar Surface Area	92.3
Heavy Atom Count	33
Formal Charge	0
Complexity	694
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 Mechanism of Action

Afimetoran acts as an antagonist of TLR 7/8.

Drugs in Development

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