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    Afimetoran

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    2D Structure
    Also known as: 2171019-55-7, Afimetoran [usan], Lxp7mzl0vf, Bms-986256, Unii-lxp7mzl0vf, Afimetoran [inn]
    Molecular Formula
    C26H32N6O
    Molecular Weight
    444.6  g/mol
    InChI Key
    SNFVHLQYHFQOEP-UHFFFAOYSA-N
    FDA UNII
    LXP7MZL0VF
    AFIMETORAN is a small molecule drug with a maximum clinical trial phase of II (across all indications) and has 2 investigational indications.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[4-[2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]acetamide
    2.1.2 InChI
    InChI=1S/C26H32N6O/c1-15(2)24-20-11-19(18-7-9-31(10-8-18)13-23(27)33)5-6-22(20)30-25(24)21-12-32-26(28-14-29-32)17(4)16(21)3/h5-6,11-12,14-15,18,30H,7-10,13H2,1-4H3,(H2,27,33)
    2.1.3 InChI Key
    SNFVHLQYHFQOEP-UHFFFAOYSA-N
    2.2 Other Identifiers
    2.2.1 UNII
    LXP7MZL0VF
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 2171019-55-7

    2. Afimetoran [usan]

    3. Lxp7mzl0vf

    4. Bms-986256

    5. Unii-lxp7mzl0vf

    6. Afimetoran [inn]

    7. Bms 986256

    8. Afimetoran (usan)

    9. 2-(4-(2-(7,8-dimethyl(1,2,4)triazolo(1,5-a)pyridin-6-yl)-3-(propan-2-yl)-1h-indol-5-yl)piperidin-1-yl)acetamide

    10. 1-piperidineacetamide, 4-(2-(7,8-dimethyl(1,2,4)triazolo(1,5-a)pyridin-6-yl)-3-(1-methylethyl)-1h-indol-5-yl)-

    11. Refchem:110007

    12. 2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1h-indol-5-yl)piperidin-1-yl)acetamide

    13. Who 11516

    14. 2-[4-[2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-propan-2-yl-1h-indol-5-yl]piperidin-1-yl]acetamide

    15. 1-piperidineacetamide, 4-(2-(7,8-dimethyl(1,2,4)triazolo(1,5-a)pyridin-6-yl)-3- (1-methylethyl)-1h-indol-5-yl)-

    16. Afimetoran [who-dd]

    17. Orb1303504

    18. Afimetoran (bms-986256)

    19. Chembl4650329

    20. Schembl19761011

    21. C26h32n6o

    22. Bdbm273241

    23. Ex-a6745

    24. Us10071079, Example 15

    25. Mfcd34578322

    26. Akos040757385

    27. Da-70624

    28. Ms-28017

    29. Hy-139567

    30. Cs-0213544

    31. D11908

    32. G18517

    33. 2-(4-(2-(7,8-dimethyl(1,2,4)triazolo(1,5-a)pyridin-6-yl)-3-(propan-2-yl)-1h-indol- 5-yl)piperidin-1-yl)acetamide

    34. 2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1h-indol-5-yl) Piperidin-1-yl)acetamide

    35. 2-[4-[2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1h-indol-5-yl]-1-piperidyl]acetamide

    2.4 Create Date
    2018-01-29
    3 Chemical and Physical Properties
    Molecular Weight 444.6 g/mol
    Molecular Formula C26H32N6O
    XLogP33.9
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count5
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area92.3
    Heavy Atom Count33
    Formal Charge0
    Complexity694
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 Mechanism of Action

    Afimetoran acts as an antagonist of TLR 7/8.

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