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Chemistry

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Also known as: 836683-15-9, Acumapimod (bct-197), Acumapimod [inn], 3-(5-amino-4-(3-cyanobenzoyl)-1h-pyrazol-1-yl)-n-cyclopropyl-4-methylbenzamide, Bct-197, 2f16kw647l
Molecular Formula
C22H19N5O2
Molecular Weight
385.4  g/mol
InChI Key
VGUSQKZDZHAAEE-UHFFFAOYSA-N
FDA UNII
2F16KW647L

Acumapimod
Acumapimod is under investigation in clinical trial NCT02926326 (The Effect of Azithromycin on BCT197 Exposure in Healthy Male Volunteers).
1 2D Structure

Acumapimod

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[5-amino-4-(3-cyanobenzoyl)pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide
2.1.2 InChI
InChI=1S/C22H19N5O2/c1-13-5-6-16(22(29)26-17-7-8-17)10-19(13)27-21(24)18(12-25-27)20(28)15-4-2-3-14(9-15)11-23/h2-6,9-10,12,17H,7-8,24H2,1H3,(H,26,29)
2.1.3 InChI Key
VGUSQKZDZHAAEE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C=C(C=C1)C(=O)NC2CC2)N3C(=C(C=N3)C(=O)C4=CC=CC(=C4)C#N)N
2.2 Other Identifiers
2.2.1 UNII
2F16KW647L
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-(5-amino-4-(3-cyanobenzoyl)-1h-pyrazol-1-yl)-n-cyclopropyl-4-methylbenzamide

2. Benzamide, 3-(5-amino-4-(3-cyanobenzoyl)-1h-pyrazol-1-yl)-n-cyclopropyl-4-methyl-

2.3.2 Depositor-Supplied Synonyms

1. 836683-15-9

2. Acumapimod (bct-197)

3. Acumapimod [inn]

4. 3-(5-amino-4-(3-cyanobenzoyl)-1h-pyrazol-1-yl)-n-cyclopropyl-4-methylbenzamide

5. Bct-197

6. 2f16kw647l

7. 3-(5-amino-4-(3-cyanobenzoyl)pyrazol-1-yl)-n-cyclopropyl-4-methylbenzamide

8. 3-[5-amino-4-(3-cyanobenzoyl)pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide

9. Benzamide, 3-(5-amino-4-(3-cyanobenzoyl)-1h-pyrazol-1-yl)-n-cyclopropyl-4-methyl-

10. Unii-2f16kw647l

11. Acumapimod [who-dd]

12. Bct197

13. Gtpl9203

14. Schembl1382253

15. Bct 197

16. Bcp29101

17. Ex-a1450

18. Compound A [wo2013139809]

19. Mfcd28902244

20. Zinc116024237

21. Cs-6195

22. Db15448

23. Sb18669

24. Ac-36221

25. Hy-16715

26. D84042

27. A915163

28. Q27074309

29. 3-[5-amino-4-(3-cyano-benzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methyl-benzamide

30. 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 385.4 g/mol
Molecular Formula C22H19N5O2
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass385.15387487 g/mol
Monoisotopic Mass385.15387487 g/mol
Topological Polar Surface Area114 Ų
Heavy Atom Count29
Formal Charge0
Complexity684
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


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Looking for 836683-15-9 / Acumapimod API manufacturers, exporters & distributors?

Acumapimod manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Acumapimod API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Acumapimod manufacturer or Acumapimod supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Acumapimod manufacturer or Acumapimod supplier.

PharmaCompass also assists you with knowing the Acumapimod API Price utilized in the formulation of products. Acumapimod API Price is not always fixed or binding as the Acumapimod Price is obtained through a variety of data sources. The Acumapimod Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Acumapimod

Synonyms

836683-15-9, Acumapimod (bct-197), Acumapimod [inn], 3-(5-amino-4-(3-cyanobenzoyl)-1h-pyrazol-1-yl)-n-cyclopropyl-4-methylbenzamide, Bct-197, 2f16kw647l

Cas Number

836683-15-9

Unique Ingredient Identifier (UNII)

2F16KW647L

About Acumapimod

Acumapimod is under investigation in clinical trial NCT02926326 (The Effect of Azithromycin on BCT197 Exposure in Healthy Male Volunteers).

Acumapimod Manufacturers

A Acumapimod manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Acumapimod, including repackagers and relabelers. The FDA regulates Acumapimod manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Acumapimod API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Acumapimod Suppliers

A Acumapimod supplier is an individual or a company that provides Acumapimod active pharmaceutical ingredient (API) or Acumapimod finished formulations upon request. The Acumapimod suppliers may include Acumapimod API manufacturers, exporters, distributors and traders.

Acumapimod GMP

Acumapimod Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Acumapimod GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Acumapimod GMP manufacturer or Acumapimod GMP API supplier for your needs.

Acumapimod CoA

A Acumapimod CoA (Certificate of Analysis) is a formal document that attests to Acumapimod's compliance with Acumapimod specifications and serves as a tool for batch-level quality control.

Acumapimod CoA mostly includes findings from lab analyses of a specific batch. For each Acumapimod CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Acumapimod may be tested according to a variety of international standards, such as European Pharmacopoeia (Acumapimod EP), Acumapimod JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Acumapimod USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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