Find IRX4204 manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 220619-73-8, Agn194204, Irx4204, Vtp-194204, Agn-194204, Nrx194204
Molecular Formula
C24H32O2
Molecular Weight
352.5  g/mol
InChI Key
BOOOLEGQBVUTKC-NVQSDHBMSA-N
FDA UNII
877M97Z38Y

IRX4204
Rexinoid NRX 194204 is an orally bioavailable synthetic retinoid X receptor (RXR) agonist with potential antineoplastic and anti-inflammatory activities. Rexinoid NRX 194204 selectively binds to and activates RXRs. Because RXRs can form heterodimers with several nuclear receptors (NRs), RXR activation by this agent may result in a broad range of gene expression depending on the effector DNA response elements activated. Rexinoid NRX 194204 may inhibit the tumor-necrosis factor (TNF)-mediated release of nitric oxide (NO) and interleukin 6 (IL6) and may inhibit tumor cell proliferation. This agent appears to be less toxic than RAR-selective ligands.
1 2D Structure

IRX4204

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2E,4E)-3-methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
2.1.2 InChI
InChI=1S/C24H32O2/c1-16(13-21(25)26)7-8-18-15-24(18,6)17-9-10-19-20(14-17)23(4,5)12-11-22(19,2)3/h7-10,13-14,18H,11-12,15H2,1-6H3,(H,25,26)/b8-7+,16-13+/t18-,24-/m1/s1
2.1.3 InChI Key
BOOOLEGQBVUTKC-NVQSDHBMSA-N
2.1.4 Canonical SMILES
CC(=CC(=O)O)C=CC1CC1(C)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C
2.1.5 Isomeric SMILES
C/C(=C\C(=O)O)/C=C/[C@@H]1C[C@]1(C)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C
2.2 Other Identifiers
2.2.1 UNII
877M97Z38Y
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Agn 194204

2. Agn-194204

3. Agn194204

4. Nrx 194204

5. Nrx-194204

6. Nrx194204

2.3.2 Depositor-Supplied Synonyms

1. 220619-73-8

2. Agn194204

3. Irx4204

4. Vtp-194204

5. Agn-194204

6. Nrx194204

7. Nrx-194204

8. Chembl75133

9. Iso Irx-a

10. 877m97z38y

11. Vtp 194204

12. (+)-vtp-194204

13. (2e,4e)-3-methyl-5-((1s,2s)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)penta-2,4-dienoic Acid

14. Agn 194204

15. (2e,4e)-3-methyl-5-[(1s,2s)-2-methyl-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic Acid

16. Nrx 194204

17. Schembl3437269

18. Unii-877m97z38y

19. 3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic Acid

20. Agn 4204

21. Irx-4204

22. Nrx 4204

23. Bdbm50101445

24. Akos040741057

25. Db11806

26. Da-70643

27. Hy-13717

28. Ms-25475

29. Pd119160

30. Kb-145960

31. Cs-0007745

32. Ns00068655

33. E98723

34. Irx4204;nrx194204;vtp 194204

35. Q27269803

36. (2e,4e)-3-methyl-5-[(1s,2s)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic Acid

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 352.5 g/mol
Molecular Formula C24H32O2
XLogP37.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area37.3
Heavy Atom Count26
Formal Charge0
Complexity624
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 220619-73-8 / IRX4204 API manufacturers, exporters & distributors?

IRX4204 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of IRX4204 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right IRX4204 manufacturer or IRX4204 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred IRX4204 manufacturer or IRX4204 supplier.

PharmaCompass also assists you with knowing the IRX4204 API Price utilized in the formulation of products. IRX4204 API Price is not always fixed or binding as the IRX4204 Price is obtained through a variety of data sources. The IRX4204 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

IRX4204

Synonyms

220619-73-8, Agn194204, Vtp-194204, Agn-194204, Nrx194204, Nrx-194204

Cas Number

220619-73-8

Unique Ingredient Identifier (UNII)

877M97Z38Y

About IRX4204

Rexinoid NRX 194204 is an orally bioavailable synthetic retinoid X receptor (RXR) agonist with potential antineoplastic and anti-inflammatory activities. Rexinoid NRX 194204 selectively binds to and activates RXRs. Because RXRs can form heterodimers with several nuclear receptors (NRs), RXR activation by this agent may result in a broad range of gene expression depending on the effector DNA response elements activated. Rexinoid NRX 194204 may inhibit the tumor-necrosis factor (TNF)-mediated release of nitric oxide (NO) and interleukin 6 (IL6) and may inhibit tumor cell proliferation. This agent appears to be less toxic than RAR-selective ligands.

IRX4204 Manufacturers

A IRX4204 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of IRX4204, including repackagers and relabelers. The FDA regulates IRX4204 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. IRX4204 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

IRX4204 Suppliers

A IRX4204 supplier is an individual or a company that provides IRX4204 active pharmaceutical ingredient (API) or IRX4204 finished formulations upon request. The IRX4204 suppliers may include IRX4204 API manufacturers, exporters, distributors and traders.

IRX4204 GMP

IRX4204 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of IRX4204 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right IRX4204 GMP manufacturer or IRX4204 GMP API supplier for your needs.

IRX4204 CoA

A IRX4204 CoA (Certificate of Analysis) is a formal document that attests to IRX4204's compliance with IRX4204 specifications and serves as a tool for batch-level quality control.

IRX4204 CoA mostly includes findings from lab analyses of a specific batch. For each IRX4204 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

IRX4204 may be tested according to a variety of international standards, such as European Pharmacopoeia (IRX4204 EP), IRX4204 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (IRX4204 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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