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    Chemistry

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    Also known as: 58-94-6, Diuril, Chlorothiazid, Chlorthiazide, Chlotride, Thiazide
    Molecular Formula
    C7H6ClN3O4S2
    Molecular Weight
    295.7  g/mol
    InChI Key
    JBMKAUGHUNFTOL-UHFFFAOYSA-N
    FDA UNII
    77W477J15H
    Chlorothiazide
    A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
    Chlorothiazide is a Thiazide Diuretic. The physiologic effect of chlorothiazide is by means of Increased Diuresis.
    1 2D Structure

    Chlorothiazide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    6-chloro-1,1-dioxo-4H-16,2,4-benzothiadiazine-7-sulfonamide
    2.1.2 InChI
    InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
    2.1.3 InChI Key
    JBMKAUGHUNFTOL-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2
    2.2 Other Identifiers
    2.2.1 UNII
    77W477J15H
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 58-94-6

    2. Diuril

    3. Chlorothiazid

    4. Chlorthiazide

    5. Chlotride

    6. Thiazide

    7. Chlortiazid

    8. Chlorosal

    9. Chlorurit

    10. Saluretil

    11. Warduzide

    12. Alurene

    13. Clotride

    14. Diuresal

    15. Diurilix

    16. Diurite

    17. Diutrid

    18. Salisan

    19. Salunil

    20. Saluric

    21. Yadalan

    22. Flumen

    23. Minzil

    24. Urinex

    25. Neo-dema

    26. Sk-chlorothiazide

    27. Chlorothiazidum

    28. Clorotiazida

    29. 6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    30. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide

    31. Component Of Aldoclor

    32. 6-chloro-7-sulfamoyl-2h-1,2,4-benzothiadiazine 1,1-dioxide

    33. Nsc 25693

    34. Nsc-25693

    35. Diuril (tn)

    36. Mls000028398

    37. Chebi:3640

    38. Chlorthiazid

    39. Chlorthiazidum

    40. Nsc25693

    41. 77w477j15h

    42. Cas-58-94-6

    43. Ncgc00015242-04

    44. Clorotiazide

    45. Chloriazid

    46. Chlrosal

    47. Smr000058429

    48. 6-chloro-4h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    49. Clorotiazide [dcit]

    50. Diuril Boluses

    51. 6-chloro-1,1-dioxo-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

    52. 6-chloro-1,1-dioxo-4h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

    53. Dsstox_cid_2800

    54. Dsstox_rid_76733

    55. Dsstox_gsid_22800

    56. Diuril Boluses, Veterinary

    57. Clorotiazida [inn-spanish]

    58. Chlorothiazidum [inn-latin]

    59. Ccris 5999

    60. Hsdb 3030

    61. Sr-01000075604

    62. Einecs 200-404-9

    63. Mfcd00058576

    64. 6-chloro-1,1-dioxo-2h-1,2,4-benzothiadiazine-7-sulfonamide

    65. 6-chloro-1,1-dioxo-2h-1?^{6},2,4-benzothiadiazine-7-sulfonamide

    66. Chlorothiazide (jan/usp/inn)

    67. Chlorothiazide [usp:inn:ban]

    68. Unii-77w477j15h

    69. Prestwick_56

    70. Diupres (salt/mix)

    71. Aldoclor (salt/mix)

    72. Spectrum_000134

    73. Prestwick0_000251

    74. Prestwick1_000251

    75. Prestwick2_000251

    76. Prestwick3_000251

    77. Spectrum2_000154

    78. Spectrum3_000342

    79. Spectrum4_000280

    80. Spectrum5_001446

    81. Lopac-c-4911

    82. Chembl842

    83. C 4911

    84. Chlorothiazide [mi]

    85. Cid_2720

    86. Chlorothiazide [inn]

    87. Chlorothiazide [jan]

    88. Lopac0_000254

    89. Schembl22329

    90. Bspbio_000062

    91. Bspbio_002003

    92. Chlorothiazide [hsdb]

    93. Kbiogr_000780

    94. Kbioss_000594

    95. Bidd:gt0635

    96. Chlorothiazide [vandf]

    97. Divk1c_000675

    98. Spectrum1500180

    99. Spbio_000288

    100. Spbio_002281

    101. Chlorothiazide [mart.]

    102. Bpbio1_000070

    103. Gtpl4835

    104. Chlorothiazide [who-dd]

    105. Chembl3392493

    106. Dtxsid0022800

    107. Bdbm39351

    108. Chlorothiazide, Thiazide Diuretic

    109. Hms502b17

    110. Kbio1_000675

    111. Kbio2_000594

    112. Kbio2_003162

    113. Kbio2_005730

    114. Kbio3_001223

    115. Ninds_000675

    116. Hms1568d04

    117. Hms1920k15

    118. Hms2091c18

    119. Hms2095d04

    120. Hms2232n22

    121. Hms3259k15

    122. Hms3260d10

    123. Hms3370a15

    124. Hms3655m13

    125. Hms3712d04

    126. Pharmakon1600-01500180

    127. Chlorothiazide [green Book]

    128. Bcp24474

    129. Hy-b0224

    130. Zinc3872055

    131. Chlorothiazide [ep Impurity]

    132. Chlorothiazide [orange Book]

    133. Tox21_110107

    134. Tox21_200972

    135. Tox21_500254

    136. Wln: T66 Bswm Enj Hg Iszw

    137. 6-chloro-1,1-dioxo-4h-1lambda6,2,4-benzothiadiazine-7-sulfonamide

    138. 6-chloro-4h-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

    139. Ccg-38953

    140. Chlorothiazide [usp Impurity]

    141. Nsc756682

    142. S1641

    143. Chlorothiazide [usp Monograph]

    144. Akos015896601

    145. Akos024319450

    146. Tox21_110107_1

    147. Db00880

    148. Lp00254

    149. Nc00500

    150. Nsc-756682

    151. Sdccgsbi-0050242.p005

    152. Idi1_000675

    153. Ncgc00015242-01

    154. Ncgc00015242-02

    155. Ncgc00015242-03

    156. Ncgc00015242-05

    157. Ncgc00015242-06

    158. Ncgc00015242-07

    159. Ncgc00015242-08

    160. Ncgc00015242-09

    161. Ncgc00015242-10

    162. Ncgc00015242-12

    163. Ncgc00015242-13

    164. Ncgc00015242-19

    165. Ncgc00091042-01

    166. Ncgc00091042-02

    167. Ncgc00091042-03

    168. Ncgc00091042-04

    169. Ncgc00091042-05

    170. Ncgc00258525-01

    171. Ncgc00260939-01

    172. Ac-18732

    173. As-11760

    174. Sbi-0050242.p004

    175. Eu-0100254

    176. Ft-0664953

    177. Hydrochlorothiazide Impurity, Chlorothiazide-

    178. Sw219268-1

    179. Chlorothiazide 100 Microg/ml In Acetonitrile

    180. C07461

    181. D00519

    182. D89501

    183. Ab00051940-04

    184. Ab00051940_05

    185. Ab00051940_06

    186. Hydrochlorothiazide Impurity A [ep Impurity]

    187. Q2603363

    188. Sr-01000075604-1

    189. Sr-01000075604-3

    190. Sr-01000075604-5

    191. W-105353

    192. Brd-k88682005-001-05-9

    193. Brd-k88682005-001-07-5

    194. Z1691545266

    195. 6-chloro-7-sulfamoyl-2h-1,4-benzothiadiazine 1,1-dioxide

    196. 6-chloro-2h-1,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

    197. 6-chloro-4h-1,2,4-benzathiadiazine-7-sulfonamide-1,1-dioxide

    198. Chlorothiazide, European Pharmacopoeia (ep) Reference Standard

    199. 2h-1,4-benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide

    200. 6-chloro-1,1-dioxo-2h-1lambda6,2,4-benzothiadiazine-7-sulfonamide

    201. 6-chloro-1,1-dioxo-4h-1$l^{6,2,4-benzothiadiazine-7-sulfonamide

    202. 6-chloro-2h-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

    203. Chlorothiazide, United States Pharmacopeia (usp) Reference Standard

    204. Hydrochlorothiazide Impurity, Chlorothiazide- [usp Impurity]

    205. 6-chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic Acid Amide

    206. Chlorothiazide, Pharmaceutical Secondary Standard; Certified Reference Material

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 295.7 g/mol
    Molecular Formula C7H6ClN3O4S2
    XLogP3-0.2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count1
    Exact Mass294.9488257 g/mol
    Monoisotopic Mass294.9488257 g/mol
    Topological Polar Surface Area135 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity532
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameChlorothiazide
    PubMed HealthChlorothiazide
    Drug ClassesCardiovascular Agent
    Drug LabelChlorothiazide is a diuretic and antihypertensive. It is 6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H6CIN3O4S2 and its structural formula is:It is a white, or practically white crystalline compound with a...
    Active IngredientChlorothiazide
    Dosage FormTablet
    RouteOral
    Strength250mg; 500mg
    Market StatusPrescription
    CompanyMylan

    2 of 4  
    Drug NameDiuril
    PubMed HealthChlorothiazide
    Drug ClassesCardiovascular Agent
    Drug LabelDIURIL* (Chlorothiazide) is a diuretic and antihypertensive. It is 6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H6ClN3O4S2and its structural formula is:It is a white, or practically white, crystalline pow...
    Active IngredientChlorothiazide; Chlorothiazide sodium
    Dosage FormInjectable; Suspension
    RouteInjection; Oral
    Strengtheq 500mg base/vial; 250mg/5ml
    Market StatusPrescription
    CompanySalix Pharms; Oak Pharms Akorn

    3 of 4  
    Drug NameChlorothiazide
    PubMed HealthChlorothiazide
    Drug ClassesCardiovascular Agent
    Drug LabelChlorothiazide is a diuretic and antihypertensive. It is 6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H6CIN3O4S2 and its structural formula is:It is a white, or practically white crystalline compound with a...
    Active IngredientChlorothiazide
    Dosage FormTablet
    RouteOral
    Strength250mg; 500mg
    Market StatusPrescription
    CompanyMylan

    4 of 4  
    Drug NameDiuril
    PubMed HealthChlorothiazide
    Drug ClassesCardiovascular Agent
    Drug LabelDIURIL* (Chlorothiazide) is a diuretic and antihypertensive. It is 6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H6ClN3O4S2and its structural formula is:It is a white, or practically white, crystalline pow...
    Active IngredientChlorothiazide; Chlorothiazide sodium
    Dosage FormInjectable; Suspension
    RouteInjection; Oral
    Strengtheq 500mg base/vial; 250mg/5ml
    Market StatusPrescription
    CompanySalix Pharms; Oak Pharms Akorn

    4.2 Therapeutic Uses

    Antihypertensive Agents; Diuretics, Thiazide

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    THE THIAZIDES ARE DIURETICS OF CHOICE FOR MAINTENANCE THERAPY IN AMBULATORY PATIENTS WITH EDEMA CAUSED BY CHRONIC CONGESTIVE HEART FAILURE BUT WITH NORMAL RENAL FUNCTION. ...LESS EFFECTIVE WHEN EDEMA IS ASSOCIATED WITH RENAL IMPAIRMENT. /THIAZIDES/

    American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 81

    THIAZIDES HAVE THEIR GREATEST USEFULNESS AS DIURETICS IN MGMNT OF EDEMA OF CHRONIC CARDIAC DECOMPENSATION. /THIAZIDES/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 832

    LESS COMMON USAGES OF THIAZIDES INCL TREATMENT OF DIABETES INSIPIDUS & MANAGEMENT OF HYPERCALCIURIA IN PT WITH RECURRENT URINARY CALCULI COMPOSED OF CALCIUM. /THIAZIDES/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 832

    For more Therapeutic Uses (Complete) data for CHLOROTHIAZIDE (15 total), please visit the HSDB record page.

    4.3 Drug Warning

    WHEN CARDIAC DECOMPENSATION OR HYPERTENSION IS ACCOMPANIED BY SIGNIFICANT IMPAIRMENT OF RENAL FUNCTION, THIAZIDES SHOULD BE ADMIN WITH CAUTION BECAUSE OF THEIR CAPACITY TO AGGRAVATE RENAL INSUFFICIENCY. /THIAZIDES/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 832

    VET USE: AS WITH ANY POTENT DIURETIC, FLUID & ELECTROLYTE IMBALANCE MAY OCCUR ESP AFTER PROLONGED USE.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 107

    PERIODIC SERUM ELECTROLYTE DETERMINATIONS SHOULD BE DONE ON ALL PATIENTS IN ORDER TO DETECT...HYPONATREMIA, HYPOCHLOREMIC ALKALOSIS, & HYPOKALEMIA. /THIAZIDES/

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 868

    ...CONTRAINDICATED IN ANURIA, PATIENTS HYPERSENSITIVE TO THESE & OTHER SULFONAMIDE DRUGS, & IN OTHERWISE HEALTHY PREGNANT WOMEN WITH OR WITHOUT EDEMA. ...SHOULD BE USED WITH CAUTION IN PATIENTS WITH RENAL DISEASE...ALSO... PATIENTS WITH IMPAIRED LIVER FUNCTION.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 868

    For more Drug Warnings (Complete) data for CHLOROTHIAZIDE (18 total), please visit the HSDB record page.

    4.4 Drug Indication

    Chlorothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Like other thiazides, chlorothiazide promotes water loss from the body (diuretics). It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic efficacy. Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate. After oral doses, 10-15 percent of the dose is excreted unchanged in the urine. Chlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.

    5.2 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Sodium Chloride Symporter Inhibitors

    Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA. (See all compounds classified as Sodium Chloride Symporter Inhibitors.)

    Diuretics

    Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    CHLOROTHIAZIDE
    5.3.2 FDA UNII
    77W477J15H
    5.3.3 Pharmacological Classes
    Thiazide Diuretic [EPC]; Thiazides [CS]; Increased Diuresis [PE]
    5.4 ATC Code

    C - Cardiovascular system

    C03 - Diuretics

    C03A - Low-ceiling diuretics, thiazides

    C03AA - Thiazides, plain

    C03AA04 - Chlorothiazide

    5.5 Absorption, Distribution and Excretion

    Absorption

    Rapidly absorbed following oral administration.

    Route of Elimination

    Chlorothiazide is not metabolized but is eliminated rapidly by the kidney. After oral doses, 10 to 15 percent of the dose is excreted unchanged in the urine. Chlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.

    CHLOROTHIAZIDE IS DISTRIBUTED THROUGHOUT EXTRACELLULAR SPACE & DOES NOT ACCUMULATE IN TISSUES OTHER THAN THE KIDNEY.

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 831

    ALL OF THE THIAZIDE-LIKE DRUGS CROSS THROUGH THE PLACENTA.

    Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 784

    IN NEPHRECTOMIZED ANIMAL, CHLOROTHIAZIDE MAY BE EXCRETED IN THE BILE; IT DOES NOT UNDERGO METABOLIC ALTERATION.

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 831

    CHLOROTHIAZIDE IN A 1.1 FETAL/MATERNAL CONCN RATIO REQUIRES 60 MIN TO APPEAR IN FETUS... /FROM TABLE/

    LaDu, B.N., H.G. Mandel, and E.L. Way. Fundamentals of Drug Metabolism and Disposition. Baltimore: Williams and Wilkins, 1971., p. 102

    For more Absorption, Distribution and Excretion (Complete) data for CHLOROTHIAZIDE (7 total), please visit the HSDB record page.

    5.6 Metabolism/Metabolites

    Chlorothiazide is not metabolized but is eliminated rapidly by the kidney.

    ...CHLOROTHIAZIDE...METABOLICALLY STABLE & FOLLOWING IV ADMIN TO...HUMANS...EXCRETED UNCHANGED IN URINE.

    Parke, D. V. The Biochemistry of Foreign Compounds. Oxford: Pergamon Press, 1968., p. 183

    5.7 Biological Half-Life

    45-120 minutes

    Half-life is 1.5 hours. /From Table/

    Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 703

    5.8 Mechanism of Action

    As a diuretic, chlorothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like chlorothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of chlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.

    THE MECHANISM BY WHICH THIAZIDE DIURETICS LOWER BLOOD PRESSURE HAS NOT BEEN FIRMLY ESTABLISHED. /THIAZIDE DIURETICS/

    Evaluations of Drug Interactions. 2nd ed. and supplements. Washington, DC: American Pharmaceutical Assn., 1976, 1978., p. 89

    ...INDICATED THAT BENZOTHIADIAZIDES HAVE A DIRECT EFFECT ON RENAL TUBULAR TRANSPORT OF SODIUM & CHLORIDE INDEPENDENT OF CARBONIC ANHYDRASE INACTIVATION. /THIADIAZIDES/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 712

    IRRESPECTIVE OR ULTIMATE MECHANISM, IT APPEARS THAT DIURETIC THIAZIDES RELAX PERIPHERAL ARTERIOLAR SMOOTH MUSCLE. /THIAZIDES/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 712

    CARBONIC ANHYDRASE INHIBITOR WITHOUT EXCESSIVE BICARBONATE EXCRETION WITH RESULTANT ACIDOSIS.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 107

    For more Mechanism of Action (Complete) data for CHLOROTHIAZIDE (10 total), please visit the HSDB record page.

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    ABOUT THIS PAGE

    Looking for 58-94-6 / Chlorothiazide API manufacturers, exporters & distributors?

    Chlorothiazide manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Chlorothiazide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Chlorothiazide manufacturer or Chlorothiazide supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Chlorothiazide manufacturer or Chlorothiazide supplier.

    PharmaCompass also assists you with knowing the Chlorothiazide API Price utilized in the formulation of products. Chlorothiazide API Price is not always fixed or binding as the Chlorothiazide Price is obtained through a variety of data sources. The Chlorothiazide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Chlorothiazide

    Synonyms

    58-94-6, Diuril, Chlorothiazid, Chlorthiazide, Chlotride, Thiazide

    Cas Number

    58-94-6

    Unique Ingredient Identifier (UNII)

    77W477J15H

    About Chlorothiazide

    A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)

    Chlorothiazide Manufacturers

    A Chlorothiazide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chlorothiazide, including repackagers and relabelers. The FDA regulates Chlorothiazide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chlorothiazide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Chlorothiazide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Chlorothiazide Suppliers

    A Chlorothiazide supplier is an individual or a company that provides Chlorothiazide active pharmaceutical ingredient (API) or Chlorothiazide finished formulations upon request. The Chlorothiazide suppliers may include Chlorothiazide API manufacturers, exporters, distributors and traders.

    click here to find a list of Chlorothiazide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Chlorothiazide USDMF

    A Chlorothiazide DMF (Drug Master File) is a document detailing the whole manufacturing process of Chlorothiazide active pharmaceutical ingredient (API) in detail. Different forms of Chlorothiazide DMFs exist exist since differing nations have different regulations, such as Chlorothiazide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Chlorothiazide DMF submitted to regulatory agencies in the US is known as a USDMF. Chlorothiazide USDMF includes data on Chlorothiazide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Chlorothiazide USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Chlorothiazide suppliers with USDMF on PharmaCompass.

    Chlorothiazide WC

    A Chlorothiazide written confirmation (Chlorothiazide WC) is an official document issued by a regulatory agency to a Chlorothiazide manufacturer, verifying that the manufacturing facility of a Chlorothiazide active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Chlorothiazide APIs or Chlorothiazide finished pharmaceutical products to another nation, regulatory agencies frequently require a Chlorothiazide WC (written confirmation) as part of the regulatory process.

    click here to find a list of Chlorothiazide suppliers with Written Confirmation (WC) on PharmaCompass.

    Chlorothiazide NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Chlorothiazide as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Chlorothiazide API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Chlorothiazide as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Chlorothiazide and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Chlorothiazide NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Chlorothiazide suppliers with NDC on PharmaCompass.

    Chlorothiazide GMP

    Chlorothiazide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Chlorothiazide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Chlorothiazide GMP manufacturer or Chlorothiazide GMP API supplier for your needs.

    Chlorothiazide CoA

    A Chlorothiazide CoA (Certificate of Analysis) is a formal document that attests to Chlorothiazide's compliance with Chlorothiazide specifications and serves as a tool for batch-level quality control.

    Chlorothiazide CoA mostly includes findings from lab analyses of a specific batch. For each Chlorothiazide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Chlorothiazide may be tested according to a variety of international standards, such as European Pharmacopoeia (Chlorothiazide EP), Chlorothiazide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chlorothiazide USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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